Matches 601 - 650 out of 804 < 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >
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4935424 4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents  
Substituted 2-aminothiazoles are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the...
4935427 Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents  
Compounds which are active against retroviruses have the following formula HOH 2 C--CHCCH--B wherein B is a purine or pyrimidine heterocyclic ring which is preferably selected from the...
4933345 Isoxazole-β-carboline derivatives  
β-Carbolines of general Formula I ##STR1## wherein Y represents the residue ##STR2## and R a and R b , being identical or different, mean respectively hydrogen, C 1 -6 -alkoxy, phenyl, C 3 -7...
4933356 Diflunisal potentiation of acetazolamide in the control of intraocular pressure  
The invention relates to an improved therapy to control intraocular pressure (IOP). More specifically, the present invention relates to an improved treatment of glaucoma patients to control ocular...
4931454 Azachroman derivatives with effects on the cardiovascular system  
An azachroman derivative of the formula ##STR1## wherein Z is (a) --NCH--CHCH--, (b) --CHN--CHCH--, (c) --CHCH--NCH-- or (d) --CHCH--CHN--; R 1 is A, R 2 ...
4929620 5-pyrimidinyl-3,5-dihydroxy-6-heptenoic acid compounds useful as inhibitors of cholesterol biosynthesis  
Certain trans-6-[[(substituted)pyrimidin-5-yl]-ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding dihydroxy ring-opened acids derived therefrom are potent inhibitors of the...
4927826 Cycloproylpropenamides useful as platelet activing factor (PAF) antagonists  
The invention relates to compounds of the formula ##STR1## Y is O or S, *A is paraphenylene or *--(CH 2 ) n --(X) m --(CH 2 ) r --, X is O, S or --CHCH--, n or r, independently, are integers...
4920126 Barbituric acid derivative and treatment of leukemia and tumors therewith  
N-(2-Fluorophenyl)-1,2,3,4-tetrahydro-6-hydroxy-2,4-dioxo-5- pyrimidinecarbo xamide, useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compound has the formula:...
4918075 Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents  
Antiviral activity is exhibited by compounds having the formula ##STR1## its pharmaceutically acceptable salts thereof wherein R 2 and R 3 are independently hydrogen, --PO 3 H 2 or ##STR2## and...
4915683 Antiviral method, agents and apparatus  
A method of treating a body fluid which is to be infused so as to inactivate any enveloped viruses in said fluid comprises mixing the body fluid with an effective amount of a photosensitizing agent...
4916131 Naphthyridine derivatives and method for treating allergic reactions  
1-Substituted naphthyridines and pyrido-pyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and hyperproliferative skin diseases and in suppressing...
4914116 Nitrogen-containing heterocyclic compounds, and their use as insecticides  
A nitrogen-containing heterocyclic compounds are representable by the formula: ##STR1## wherein R 1 is either one of the following groups: ##STR2## (in which R 4 is a hydrogen atom, a halogen...
4914105 Anti-cancer compositions for delivering 5-fluorouracil  
An anti-cancer composition which comprises at least one 5-fluorouracil derivative, and a uracil derivative.
4914098 Substituted thioureas, isothioureas and carbodiimides and their use as pesticides  
Substituted N-phenylthioureas, N-phenylisothioureas and N-phenylcarbodiimides of formula ##STR1## wherein R 1 is C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl, polycyclic alkyl containing a total of 7...
4908368 Pyrimidine compounds as antagonists of SRS-A  
Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of...
4908379 Nitrogen-containing heterocyclic compounds and compositions for controlling and/or preventing pests and blights (diseases)  
A nitrogen-containing heterocyclic compound of the following formula: ##STR1## wherein D represents --N or ##STR2## E represents N--, ##STR3## G represents --N, ##STR4## with proviso that...
4904668 Benzoyl urea compound  
A benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro...
4902676 Compositions comprising N,N-dialkylalkanamides  
This invention provides compositions comprising a physiologically-active agent and a compound represented by the general formula ##STR1## wherein R 1 and R 2 are independently selected from the...
4892881 Dihydropyridine anti-ischaemic and antihypertensive agents  
1,4-Dihydropyridine anti-ischaemic and antihypertensive agent of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is 2-chlorophenyl, 2,3-dichlorophenyl or...
4886817 Imidazolidinones as brain activators  
This invention relates to imidazolidinone compounds of the formula ##STR1## wherein Q is methylene group or a single bond: R is a heterocyclic group selected from the group consisting of...
4886803 Benzimidazole derivatives  
Compounds are described of formula (I) ##STR1## wherein R 1 is a hydrogen atom, an alkyl group, an alkoxy group, a dialkylamino group or a halogen atom; n is 1 to 4; R 2 is a hydrogen atom, an...
RE33125 3- and 5-[3-(1-arylureido)]-1,2,4-triazoles  
4883786 Derivatives of L-carnitine  
Novel derivatives of L-carnitine or of L-acylcarnitines or of esters thereof, obtained by salification with suitable acids or acidic aminoacids, monosalified with potassium ion. These derivatives...
4880805 Use of alkylenediamine derivatives for the treatment of blood flow disturbances and pharmaceutical compositions containing them  
The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein A is an optionally substituted phenyl or heteroaromatic radical, R 6 and R 7 are hydrogen or...
4879274 External medication for skin  
Novel external medications comprise, as essential components, the following three components (A) to (C): (A) an α-monoglyceryl ether represented by the following formula (I): ##STR1## wherein R...
4877792 Heteroaryloxy-beta-carboline derivatives, their preparation and their use as medicinal agents  
Heteroaryloxy-β-carboline derivatives of general Formula I ##STR1## wherein R 1 is an optionally substituted heteroaryl residue, R 2 is hydrogen, lower alkyl or lower alkoxyalkyl, X is a...
4876264 Pyridine derivatives and their use as fungicides  
Acrylic acid derivatives of the formula: ##STR1## an stereoisomers thereof wherein W is pyridyl or pyrimidinyl, A is oxygen or S(O) n where n is 0, 1 or 2; X, Y and X are, for example, hydrogen,...
4876259 3,3-disubstituted indolines  
Cognitive deficiencies and/or neurological function deficits and/or mood and/or mental disturbances are treated by the administration of 3,3-disubstituted indolines. The indolines have the formula:...
4874768 1,2-disubstituted ergolines useful for producing central antidopanminergic or α2-receptor-blocking activity  
The disclosure relates to 1,2-substituted ergoline derivatives of general Formula I ##STR1## wherein X is an oxygen or sulfur atom, R 1 is a lower alkyl group, R 2 is halogen, acyl, a...
4873228 2-oxo-4-carboxy-pyrimidines and their use as anti-malaria and anti-cancer agents  
A compound for use as an inhibitor for the enzyme dihydroorotase and which is of general formula (I) ##STR1## where either (i) A and B together are S or (ii) A is --H, and B is --COR 2 or...
4870088 1-[1-aryl-1-hydroxy-2-azolyl-ethyl]-1-aryl-cyclopropane derivatives, and their fungicidal use thereof  
Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R 1 where X=oxygen or sulfur and R 1 equals (cyclo)alkyl or...
4868189 Uracil derivatives for use as anti-tumor agents having silicon containing side chains  
An organo-silicone compound of the formula ##STR1## wherein X is a methylene or carbonyl radical, Y is an NH or O, n is an integer, R 1 is a hydrogen atom, halogen atom or alkyl group, R 2 , R 3 ...
4868187 Anti-viral N-substituted pyrimidines  
Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an...
4866066 Thiomethylpyridine derivatives and their use for eliciting a bronchosecretolytic or mucolytic response  
Thiomethylpyridine derivatives having bronchosecretolytic and mucolytic activity according to the formula: ##STR1## wherein R is a group attached in the 2-, 3- or 4-position of the pyridine ring...
4863947 N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides and methods of their production  
This invention relates to novel N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests...
4863945 Pyrrolobenzimidazoles and pharmaceutical compositions containing them  
Pyrrolobenzimidazoles of the formula: ##STR1## are useful for treatment of heart and circulatory diseases. R 1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered...
4863927 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils  
1-[2-(Hydroxymethyl)cycloalkylmethyl]-5-substituted uracils which are herpes simplex viral thymidine kinase inhibitors, their acyl derivatives, and their pharmaceutically-acceptable salts;...
4863924 N-benzoyl urea compounds, antitumorous compositions containing them  
An N-benzoyl urea compound having the formula: ##STR1## wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is ##STR2## wherein Y 1 is an...
4859672 Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone  
Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general...
4859680 Pyrimidine derivatives as antiviral compounds  
Pyrimidines having a fused cyclopropane ring in the side chain and the heterocyclic isosteres of said pyrimidines, which have antiviral activity, especially against viruses of the herpes class.
4855309 Pyridine derivatives, agents containing same, and the use thereof as pesticides  
The compounds of the formula (I) ##STR1## in which A denotes N or N➝0, R denotes a radical of the formula R 4 --CY 1 --NR 5 --CY 2 --NR 6 --, ##STR2## R 1 denotes halogen, alkyl,...
4853221 Method for treating non-small cell lung cancer, head and neck cancers and breast cancer  
5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]-methyl]-2,4-quin azolinediamine (trimetrexate) has been shown to possess clinical activity against non-small cell lung cancer, head and neck squamous...
4853388 Method for treating psoriasis with cytotoxic agents  
A method for treating psoriasis comprising applying an effective amount of a cytotoxic drug dispersed in a pharmaceutically acceptable vehicle containing a penetrating solvent for the drug, the...
4851406 Heterocyclic-substituted indoles and pharmaceutical compositions containing them  
The present invention provides indole derivatives of the general formula: ##STR1## wherein R 1 is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, carboxyl, cyano, alkylcarbonyl,...
4849424 Pyrimidine derivatives  
The present invention relates to novel pyrimidine derivatives of the general formula ##STR1## wherein R 1 represents a pyrazolyl, imidazolyl, or triazolyl group, R 2 represents hydrogen atom or...
4849425 Readily absorbable pharmaceutical composition  
A pharmaceutical composition comprises a benzoyl urea compound having the formula: ##STR1## wherein X is a nitro group, Y is a chlorine atom, Z 2 is a hydrogen atom, Z 1 is a halogen atom, and A...
4847259 Nitrogen-containing heterocyclic compounds, and use as insecticide  
Nitrogen-containing heterocyclic compounds are represented by the formula: ##STR1## wherein R 1 is either one of the following groups: ##STR2## in which R 4 is a hydrogen atom, a halogen atom or...
4847258 Substituted benzoylphenylureas compounds useful as pesticides  
The invention relates to novel N-benzoyl-N,-4-(5-phenylpyrimid-2-yloxy)phenylureas of formula ##STR1## wherein X 1 is hydrogen, halogen, C 1 -C 3 alkoxy or C 1 -C 3 alkylthio, X 2 is...
4845106 Heterocyclic thiazole compounds  
Novel insecticides of the formula ##STR1## in which n is 0 or 1, X is S, O, ##STR2## Y is N or ##STR3## Z is a 5- or 6-membered nitrogen-containing heterocyclic ring, and R to R 9 variously...
4840662 N-(2-nitrophenyl)-5-aminopyrimidine derivatives and useful for controlling harmful micro-organisms  
The invention discloses novel N-(2-nitrophenyl)-5-aminopyrimidine derivatives of the general formula ##STR1## wherein R 1 and R 2 are each independently NO 2 or CF 3 , or one of R 1 and R 2 is...
Matches 601 - 650 out of 804 < 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >