Matches 551 - 600 out of 804 < 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >
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5108991 Vehicle composition containing 1-substituted azacycloalkan-2-ones  
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound...
5106407 Iodones and methods for antimicrobial use  
The present invention discloses the antimicrobial utility of certain iodonium ylide compounds. The particular iodonium ylide compounds are phenyl iodonium ylides having an ortho substituent that...
5102884 Substituted benzoylurea compounds or their salts, processes for their production and antitumour compositions containing them  
A substituted benzoylurea compound of the formula (I): ##STR1## wherein R 1 is a hydrogen atom, a halogen atom or a nitro group, each of R 2 and R 3 is a hydrogen atom, an alkyl group, --COR 6 ...
5098907 Powdery pharmaceutical composition containing benzoyl urea, a dispersant and silicic acid  
A powdery pharmaceutical composition comprising a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or...
5091385 Pre-activated therapeutic agents derived from photoactive compounds  
A pre-activated therapeutic agent derived from a photoactive compound for destroying tumor or other pathogenic biological contaminants infecting animal body tissues. The activation of the...
5089502 Method for preventing or treating anxiety employing a calcium channel blocker  
A method is provided for inhibiting onset of or treating anxiety by administering a calcium channel blocker such as diltiazem or nifedipine, over a prolonged period of treatment.
5089503 Temperature stable 5-fluorouracil compositions  
Temperature stable 5-fluorouracil compositions are disclosed. A solution of 5-fluorouracil and a base forms the composition. The pH of the composition is about 9.1 to about 9.3. The composition is...
5082852 Cyclopropanecarboxamides and their use for controlling pests  
Cyclopropanecarboxamides of the general formula I ##STR1## wherein R 1 is hydrogen, halogen or low-molecular-weight alkyl, R 2 and R 3 are hydrogen or low-molecular-weight alkyl, R 4 to R 8 ...
5081142 Derivatives of 1-hydroxy-1,2,4-triazole and fungicides and growth regulators containing them  
Compounds of the formula I ##STR1## where Ar is unsubstituted or substituted phenyl, pyridyl, thienyl or napthyl, R 1 is hydrogen or CN, R 2 is unsubstituted or substituted aryl, hetaryl,...
5077280 Treatment of viral infections  
Treatments for viral infections are disclosed based on the finding that uridine can selectively protect and/or rescue uninfected cells, particularly human bone marrow progenitor cells, from the...
5066656 Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives  
(6,7-dihydro-5H-pyrrolo[1,2-c]imidazolyl-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridinyl-5-yl) substituted 1H-benzotriazole derivatives, compositions containing the same and methods of...
5066658 Substituted hydroxyureas  
The present invention relates to substituted hydroxyureas. These compounds inhibit the enzyme 5-lipoxygenase. In addition, certain of the compounds also inhibit the enzyme-cyclooxygenase. The...
5059605 Pyrimidine derivatives useful as fungicides  
Fungicidal compounds having the formula (I): ##STR1## in which any two of K, L and M are nitrogen and the other is CE; X and Y are independently hydrogen, halogen, C 1 -4 alkyl, C 3 -6 cycloalkyl,...
5053228 Polymeric temperature sensitive drug carrier  
The drug carrier of this invention provides a temperature-sensitive polymer chemically bonded to a drug. The drug carrier is capable of releasing a drug continuously in the body. The drug carrier...
5051425 Therapeutic composition for combatting AIDS  
A therapeutic composition for combatting acquired immune deficiency syndrome (AIDS) comprising: (A) a pharmaceutically effective amount of at least one carcinostatic agent selected from alkylating...
5043352 Chroman derivatives for the treatment of depressive states  
A method of treatment of depressive states which comprises administering in mammals in need thereof an effective amount of a compound ##STR1## R 1 represents hydrogen, a halogen atom, a cyano...
5041458 Fungicidal aminotriazoles and aminoimidazoles  
Substituted N-aminotriazoles and N-aminoimidazoles having selected substituents on the amino group and azole rings, agriculturally useful composition comprising such compounds and the use of such...
5041454 Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides  
Substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides, their N-oxide forms, their pharmaceutically acceptable acid addition salts and stereochemically isomeric forms having gastrointestinal...
5041449 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections  
There are provided novel 2-substituted-4-substituted-1,3-dioxolanes which are particularly useful as antiviral agents.
5037830 Novel thiouracyl derivatives, pharmaceutical compositions containing them and process for preparing same  
The present invention relates to novel compounds of the formula (I), ##STR1## wherein R 1 and R 2 stand independently from each other, for hydrogen, C 1 -4 alkyl, phenyl, phenyl-C 1 -4 alkyl,...
5036072 Antiviral agent  
Use of a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z 1 is a...
5032590 Substituted hydroxylamines  
Substituted hydroxylamines of the formula ##STR1## in which R 1 stands for an aromatic or heterocyclic radical, are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia...
5025015 Thioformamidines, and use as medicaments  
Formamidine compounds of general formula I ##STR1## in which: R 1 represents H or C 1 -4 alkyl, R 2 represents benzoyl, benzyl, or alphahydroxybenzyl, the aromatic ring being optionally...
5025016 Pyrimidine-thioalkyl pyridine derivatives, medicaments containing these compounds, and method of treatment  
The invention relates to pyrimidine-thioalkyl pyridine derivatives corresponding to the following general formula ##STR1## in which R 1 to R 4 , independently of one another, represent hydrogen,...
5023260 Substituted uracils, processes for their preparation and their use against parasitic protozoa  
A substituted uracil useful for combating parasitic protozoa of the formula ##STR1## in which R 1 represents a carbocyclic aromatic or heteroaromatic radical, which are optionally substituted, ...
5008267 Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same  
A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain containing at least two...
5002952 Readily absorbed pharmaceutical composition  
A pharmaceutical composition comprising a benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a...
5002944 Compounds having cardiotonic activity  
Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general...
4999042 Phenyl oximino-acetate fungicides  
Compounds of the fomrula (I): ##STR1## and sterioisomers thereof, wherein X is halogen, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, alkenyl, alkynyl, aryl, amino, arylazo, heteroarylalkyl,...
4994465 Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds  
Certain trisubstituted urea compounds as potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase, their method of manufacture, pharmaceutical compositions containing such compounds as...
4990512 Pyridyl-pyrimidones  
An insecticidal compound of formula (I): ##STR1## wherein R 1 and R 3 are independently selected from hydrogen; halogen; nitro; cyano; or alkyl, alkoxy, alkylthio or cycloalkyl any of which can...
4990513 Antihypoxic drug and method of its application  
The antihypoxic drug with verebroprotective and hepatoprotective action contains piracetam and orotic acid or their pharmaceutically tolerable salts in a weight ratio of from 500:1 to 1:2. This...
4988678 Combinations of FU and BVU as anti-adenocarcinoma agents  
The antitumor activity of 5-fluorouracil and its precursors against adenocarcinomas can be potentiated without a corresponding increase in toxicity by combining these compounds with...
4988703 Carbocyclic nucleoside analogs with antiviral activity  
An antiviral compound of the formula: ##STR1## wherein A is selected from a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group and a heterocyclic isostere of a...
4987146 N-hetaryl imidazole derivatives  
N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R 3 represents hydrogen, a...
4987135 Substituted benzene derivatives, processes for their production and antitumor compositions containing them  
A substituted benzene derivative represented by a formula: ##STR1## where A represents: ##STR2## wherein X is a hydrogen atom, a halogen atom or a nitro group, R 1 is --X 1 Z 1 (X 1 is an...
4985430 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient  
There are disclosed a 9-acylamino-tetrahydroacridine derivative represented by the following formula (I): ##STR1## wherein R ##STR2## are as defined in the specification, its optical antipode or...
4983610 Pyrimidine carboxylic acids and esters  
Heterocyclic acids and esters useful as inhibitors of mammalian blood platelet aggregation characterized by Formula I are disclosed. HET 1 --(CH 2 ) n CO 2 R (I) Formula I...
4983605 Pharmaceutical composition  
A pharmaceutical composition comprising a benzoyl urea compound (A) selected from the group consisting of a benzoyl urea compound (I) having the formula: ##STR1## wherein X is a halogen atom, a...
4978382 Pesticides based on 2-halogenoalkylthio-substituted pyrimidine derivatives  
A method of combating pests which comprises applying to such pests or to a pest habitat a pesticidally effective amount of a 2-halogenoalkylthio-substituted pyrimidine of the formula ##STR1## in...
4975434 Antiviral and anticancer cyclopentenyl cytosine  
Cyclopentenyl pyrimidine compounds have potent anti-viral, anti-tumor and differentiating activity. Of these compounds, cyclopentenyl cytosine has proved to be particularly effective in a variety...
4975433 Aminomethyl derivatives of biologically active substances and enhanced delivery thereof across topical membranes  
A compound of the formula: ##STR1## wherein: R and R 1 may be the same or different and are selected from the group consisting of H; cycloalkyl groups having up to 10 carbon atoms; or straight or...
4973599 Phenylthioheterocyclic derivatives  
Compounds of the formula ##STR1## wherein n is a integer of 0 to 2; R 1 ' and R 2 ' are, independently, hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl; and X is pyrimidinyl,...
4968688 Pyrimidines and their use as fungicides  
Compounds of the formula: ##STR1## and stereoisomers thereof where W is pyridyl or pyrimidinyl linked to A by any one of its ring carbon atoms. A is an oxygen atom or S(O) n where n is 0, 1 or 2;...
4968690 3-deazaneplanocin, intermediates for it, and antiviral composition and method of treatment using it  
The new compound 3-deazaneplanocin A has been discovered to have potent anti-viral, anti-tumor activity and differentiating activity. A simple method for preparing 3-deazaneplanocin A has been...
4962109 Insecticidally and acaricidally active pyrimidine esters and intermediates therefor  
This invention provides novel insecticidally and acaricidally active pyrimidine derivatives of formula (I): ##STR1## and stereoisomers thereof, wherein R 1 is selected from alkyl; alkenyl;...
4960777 Heteroaryloxy-β-carboline derivatives, their preparation and their use as medicinal agents  
Heteroaryloxy-β-carboline derivatives of general Formula I ##STR1## wherein R 1 is an optionally substituted heteroaryl residue, R 2 is hydrogen, lower alkyl or lower alkoxyalkyl, X is a...
4956369 2-dithioalkyl-dihydropyridines and pharmaceutical compositions containing them  
Compounds of formula I ##STR1## wherein R 1 and R 3 , which are the same or different, are alkoxycarbonyl, acetyl, cyano, nitro, benzoyl or amino-carbonyl groups, R 2 is differently...
4940712 Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors  
2-Amino and 2-thio-4-substituted-5-(hydroxy or alkoxy)-pyrimidines, which may be 6-substituted, and derivatives thereof are disclosed. The compounds are inhibitors of leukotriene synthesis and are,...
4937255 Disubstituted pyrroles  
For inhibiting 3-hydroxy-3-methylglutaryl coenzyme A and cholesterol biosynthesis, the novel disubstituted pyrroles of the formula ##STR1## in which R 1 is aryl or heteroaryl, R 2 is...
Matches 551 - 600 out of 804 < 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >