Patents in Class 514/270

Matches 1 - 50 out of 141

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Match	Document	Document Title
1	7601723	Pyridyl substituted xanthines The present invention provides compounds and pharmaceutical compositions that are substituted pyridyl-linked-xanthines of formula I which are selective antagonists of A 2B adenosine receptors...
2	7534859	Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse The present invention is directed to the production of PKC isozyme ε (PKCε)-deficient cells and non-human animals. The present invention is further directed to the identification of PKCε as a...
3	7354943	Statine derivatives for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
4	7288546	Method and compound for inhibition of cell death This invention relates to a chemical compound that inhibits the apoptotic activity of the protease Omi/HtrA2 and homologous proteins. This protease Omi/HtrA2 is present in all mammalian cells so...
5	7166610	Method of treating movement disorders using barbituric acid derivatives A method of treating movement disorders comprises administering to a human or animal subject in need of treatment a therapeutically effective amount of at least one compound according to the...
6	7041673	Ultrashort acting hypnotic barbiturates The subject invention concerns novel compounds that are useful as ultrashort acting hypnotic barbiturates. Specifically exemplified are derivatives of barbituric and thiobarbituric acids. They are...
7	RE38934	Method and reagents for N-alkylating ureides A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I with an alkylating agent of structure III in the presence of a basic catalyst...
8	6939873	Non-sedating barbituric acid derivatives The present invention relates to novel non-sedating barbituric acid derivatives, pharmaceutical compositions containing them and methods of neuroprotection in cases of cerebral ischemia, head...
9	6919332	N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, and R 1 are as defined in the...
10	6833372	Non-peptide GnRH agents, Pharmaceutical compositions, and methods for their use Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent...
11	6756379	Non-sedating barbiturate compounds as neuroprotective agents Methods of providing neuroprotection are disclosed comprising administering a non-sedative barbiturate compound in an amount sufficient to achieve neuroprotection in a mammalian subject. Preferred...
12	6716845	Barbituric acid derivatives The present invention pertains to derivatives of 5,5-disubstituted pyrimidine-2,4,6,-trianones having the formula: wherein R 1 , R 2 , R 3 , and R 4 are described herein. These compounds have...
13	6706723	Pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, A, B and R 1 are as defined in the specification, and to pharmaceutical...
14	6664262	N-methoxymethyl-5,5-diphenylbarbituric acid A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I: with an alkylating agent of structure III: in the presence of a basic catalyst in...
15	6649614	Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent for treatment of depression or anxiety The present invention relates to the treatment of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or...
16	6573269	Pyrimidine-2,4,6-trione light screening compositions The present invention provides compounds of formula I, which are effective in absorbing ultraviolet radiation and can be used as sunscreen agents: wherein R 1 and R 2 are each independently C...
17	6559136	Fungicidal active substance combinations Novel active compound combinations of compounds of the formula (I) in which Z, X and A are each as defined in the description with known active compounds and their use for controlling...
18	6545006	Process for obtaining L-dihydroorotic acid and use thereof The invention relates to a process for obtaining L-dihydroorotic acid by chromatography on an anionic exchange material in a base water mixture under a pressure from about 1.1 MPa to about 40 MPa....
19	6541523	Methods for treating or preventing fibromyalgia using very low doses of cyclobenzaprine The present invention relates to methods and compositions comprising a very low dose of cyclobenzaprine or metabolite thereof for preventing and treating sleep disturbances and illnesses manifested...
20	6509343	Fungicidal active substance combinations Active compound combinations comprising a compound of the formula (I) and known fungicidally active compounds, and their use for controlling phytopathogenic fungi, are described.
21	6498164	Barbituric acid derivative and preventive and therapeutic agent for bone and cartilage containing the same A compound of the formula wherein the substituents are as defined in the specification and solvates and salts thereof useful for treating bone and cartilage diseases.
22	6472396	Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds Compounds of formula I, useful as matrix metalloprotease inhibitors, wherein X, Y and Z are each oxygen; R 1 is selected from the group consisting of (a) n-octyl, (b) n-decyl, (c) biphenyl and...
23	6469017	Method of inhibiting interleukin-12 signaling A method for blocking IL-12 signaling by administration of the following compound: wherein, R 1 is H, CH 3 , sulfate, phosphate, or salt thereof; R 2 is alkyl (C 1-12 ), alkoxyalkyl (C 1-11 ),...
24	6440985	Methods for treating viral infections Methods are provided for the treatment and prophylaxis of viral infection and disease associated with such infection.
25	RE37623	Enzyme inhibitors, their synthesis, and methods for use Novel compounds are provided that are effective to inhibit the activity of DHUDase or UrdPase. Such compounds have the general formula where X is S or Se; Y is H, I, F, Cl, Br, methoxy,...
26	6335332	Barbituric acid derivatives with antimetastatic and antitumor activity The invention is directed to barbituric acid derivatives having inhibitory activity for matrix maetalloproteases comprised of formula (I): pharmaceutical compositions thereof, processes for...
27	6294520	Material for passage through the blood-brain barrier A material which has the ability to effect it's passage, at least in part, and the ability to transport other materials through the blood-brain barrier which includes any one or more pure sugars or...
28	6288071	1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in...
29	6242455	Pyrimidin-2,4,6-trion derivatives, method for producing the same and medicinal products containing these compounds Compounds of formula I ##STR1## wherein R1, R2, R3 and R4 have the meanings indicated in the specification. The compounds are useful as inhibitors of metalloproteases of the M2, M3 family and...
30	6174890	Anti-stress, anti-impairment and anti-aging drug and process for manufacturing thereof
31	6133276	Compounds and methods for increasing endogenous levels of corticotropin-releasing factor Ligand inhibitors for increasing levels of free corticotropin-releasing factor (CRF) in the brain are disclosed. Such ligand inhibitors cause release of CRF from the CRF/CRF-bind protein complex....
32	6087356	Rapid narcotic detoxification Methods for rapid detoxification of patients addicted to opioid narcotics are provided. The methods include administering nalmefene to induce acute withdrawal, and administering dextromethorphan...
33	6028073	N-substituted 3-azabicyclo (3.2.0)heptane derivatives useful as neuroleptics N-substitued 3-azabicyclo[3.2.0]heptane derivatives of formula (I) ##STR1## in which R 1 , R 2 , A, X, Y and Z have the meanings given in the description, their method of preparation and their use...
34	6013626	Cryptophycins from synthesis A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals....
35	5965564	Enantiomerically pure hydroxylated xanthine compounds There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an ω-1 alcohol of a straight chain alkyl (C 5 -8) substituted at the 1-position...
36	5958946	Modulation of hair growth Mammalian hair growth may be modulated by applying to the skin a compound that induces or activates the conjugation of an androgen.
37	5942497	Purine compound and catecholamine compound containing compositions and methods for administration A purine compound, which has a desired and an undesired effect when a dosage sufficient to induce the desired effect is administered to a mammal, is combined with a counteracting agent, wherein the...
38	5889013	Pyrimidine acyclonucleoside derivatives The present invention relates to novel pyrimidine acyclonucleoside derivatives represented by the following general formula (I), antiviral agents containing the derivatives as the active...
39	5869494	Uses for barbituric acid analogs Previously unknown anti-tumor, anti-infectious, immune system modulatory and anti-depressive properties of a family of barbituric acid derivatives are provided herein. Preferred derivatives are...
40	5837703	Amino-alcohol substituted cyclic compounds Therapeutic compounds have the formula: (X)j-(core moiety), j being an integer from one to three, the core moiety comprising a core moiety, the core moiety being a heterocycle having one ring or...
41	5834465	Treatment with combined NMDA and non-NMDA antagonists to reduce excitotoxic CNS damage This invention involves a pharmaceutical mixture for preventing or reducing excitotoxic brain damage caused by hypoxia/ischemia (such as stroke) and various other factors. This mixture comprises an...
42	5763476	Sublingual or buccal pharmaceutical composition The invention relates to a sublingual or buccal pharmaceutical composition comprising trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz 2,3:6,7!oxepino- 4 ,5-c!pyrrole or a pharmaceutically...
43	5731337	Conformationally rigid bicycle and adamantane derivatives useful as α 2 A compound of formula I ##STR1## in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond...
44	5696125	Substance abuse-induced hemorrhagic stoke in an animal model The present invention is an substance-induced-hemorrhagic stroke animal model. The substance-induced-hemorrhagic stroke animal model is useful in screening therapeutics for the prevention and/or...
45	5679650	Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine A purine compound, which has a desired and an undesired effect when a dosage sufficient to induce the desired effect is administered to a mammal, is combined with a counteracting agent, wherein the...
46	5674870	Anti-cancer uses for barbituric acid analogs Previously unknown anti-tumor, anti-infectious, immune system modulatory and anti-depressive properties of a family of barbituric acid derivatives are provided herein. Preferred derivatives are...
47	5614541	Pharmacologically active catechol derivatives New catechol derivatives and pharmaceutically acceptable salts and esters thereof useful as pharmaceutical antioxidants are disclosed. Cellular damage by oxygen derived radicals is a significant...
48	5543147	Crystalline modification of 2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine, a method for the preparation thereof and a medicinal preparation based on it A crystalline modification of 2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine prepared by cooling a solution of 2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine in water, an organic solvent or in a...
49	5489590	Method of treating with therapeutic composition comprising photoactive compound A therapeutic composition derived from a pre-activated photoactive compound and a conveyor for destroying tumor or other pathogenic biological contaminants infecting animal body tissues. The...
50	5474996	Pyrimidine derivatives Novel pyrimidine derivatives of the formula ##STR1## represents: either a group: ##STR2## or a group: ##STR3## having angiotensin II inhibiting activity.

Matches 1 - 50 out of 141

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