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7608594 |
Novobiocin analogues as anticancer agents
Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present...
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7608593 |
Resin composition with biodegradable non-liquid-crystalline and liquid-crystalline polymers
Processes for producing and recycling resin composition, which comprises a biodegradable polymer and a biodegradable liquid crystalline polymer, are provided. Also, a process for recycling waste...
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7595347 |
Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone...
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7576064 |
Pyrazole derivative, drug composition containing the same and production intermediate therefor
The present invention provides pyrazole derivatives represented by the general formula:
wherein R 1 represents H, an optionally substituted C 1-6 alkyl, etc.; one of Q and T represents a...
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7576063 |
Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same
The present invention provides pyrazole derivatives represented by the general formula:
wherein R 1 represents H, an optionally substituted C 1-6 alkyl group etc.; one of Q and T represents a...
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7572774 |
Methods for treating glutamate cytotoxicity with beta-naphthoquinone compounds
The present invention relates to the use of beta-naphthoquinone derivatives, and salts thereof, for the prevention and/or the treatment of glutamate cytotoxicity. It further relates to the use of...
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7566699 |
Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof
The present invention provides fused heterocyclic derivatives represented by the general formula:
wherein R 1 represents H, halogen, OH, etc.; R 2 represents H, halogen or an alkyl group; R 3...
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7566698 |
2-O-(β-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it
The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known...
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7550160 |
Composition for treating cancer cells and preparation method for the same
A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a...
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7544668 |
Saponins derived from Ilex pubescens and method of purifying the same
Two hitherto unreported novel triterpene saponins were isolated in substantially pure form from the root of Ilex pubescens . The chemical structures and some properties of the triterpene saponin...
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7534768 |
Treatment of DNA viral infections
The synergistic combination of a loop diuretic and a cardiac glycoside is useful in the treatment of DNA viral infections.
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7531162 |
Transcobalamin receptor binding conjugates useful for treating abnormal cellular proliferation
An agent, composition and method for the treatment, prophylaxis and/or diagnosis of proliferative disorders, which is highly and efficiently absorbed at the site of abnormal cellular proliferation...
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7524822 |
Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments
The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]
-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation...
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7514442 |
Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7511022 |
Substituted indole-O-glucosides
Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
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7511020 |
Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides
This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for...
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7510710 |
Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor
Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a...
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7501399 |
Immunoeffector compounds
This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to an cyclic aminoalkyl (aglycon) group. The invention further provides methods...
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7494674 |
Nutraceutical with tart cherries and method of treatment therewith
The present disclosure provides a nutraceutical for the use of a vacuolar flavonoid pigment from a natural source such as tart cherries as an additional compound as part of a mixture including at...
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7470695 |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7470671 |
Thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therapeutics
The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the method for their preparation and to their use as active principles of drugs...
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7468355 |
Methods for inhibiting cancer and scar formation
Methods for inhibiting cancer, scar formation, disrupting the cellular cytoskeleton, and conferring resistance from infection are disclosed. Such methods comprise the administration of oleuropein...
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7465712 |
Glucopyranosyloxy benzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula:
wherein R 1 represents a hydrogen atom or a hydroxy(lower alkyl) group; and R 2 ...
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7445794 |
Methods for treating human proliferative diseases, with a combination of fatty acid metabolism inhibitors and glycolytic inhibitors
The present invention generally relates to systems and methods for treating inflammatory and proliferative diseases, and wounds, using a combination of (1) fatty acid metabolism inhibitors and (2)...
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7399783 |
Methods for the treatment of scar tissue
A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids...
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7387805 |
Flavonoid solubilizion agent and method of solubilizing flavonoid
A flavonoid solubilization agent capable of highly solubilizing flavonoids such as isoflavone, baicalin, rutin and naringin whose solubility is generally low; and a method of effecting the above...
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7387790 |
Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells
Nanoparticles made from a select group of lipids and optionally containing a therapeutically active agent are employed in pharmaceutical compositions for delivery to targeted tissues and/or cells...
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7384920 |
Use of stilbene compounds in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus-associated diseases
This invention relates to a new use of stilbene derivatives or pharmaceutically acceptable salts thereof, especially in the manufacture of medicament for the prevention and treatment of diabetes or...
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7381744 |
Method of treating osteoporosis comprising vacuolar-type (H+)-ATPase-inhibiting compounds
The present invention provides vacuolar-type (H+)-ATPase-inhibiting compounds, compositions thereof, and methods of using them to treat or prevent a condition treatable by the inhibition of a...
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7375090 |
Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof
The present invention relates to glucopyranosyloxy-pyrazoles of general formula
wherein
R 1 to R 6 and R 7a , R 7b , R 7c are defined as in claim 1 , the tautomers, the stereoisomers, the...
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7375089 |
Rehydration composition
The invention relates to a fluid that can be used for preventing or treating hypohydration and the secondary consequences thereof. The fluid comprises one or more carbohydrates and minerals and is...
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7375087 |
Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
The present invention provides pyrazole derivatives represented by the general formula:
wherein R 1 represents H, an optionally substituted C 1-6 alkyl group etc.; one of Q and T represents a...
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7371733 |
Anti bacterial compounds
The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are...
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7371730 |
Crystals of glucopyranosyloxybenzyl benzene derivative
The present invention provides crystals of 2-(4-methoxybenzyl)phenyl 6-O-ethoxycarbonyl-β-D-glucopyranoside, pharmaceutical compositions containing the same and their uses, which exhibit excellent...
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7368434 |
Compounds useful for the inhibition of ALDH
The present invention provides novel antidipsotropic compounds. The invention further provides methods of inhibiting ALDH-2 using the compounds described herein. Methods for modulating alcohol...
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7365055 |
Derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses
The invention relates to novel derivatives of morphine-6-glucuronide, the preparation method thereof and the uses of same in therapy, for example, as analgesics.
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7358232 |
Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage
The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in...
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7354928 |
Small molecule inhibitors targeted at Bcl-2
The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-X L . In particular, the present invention provides non-peptide cell permeable small...
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7341752 |
Antibacterial treatment and composition
A method for treating a bacterial infection in a subject by administration of an effective amount of centaurein alone or in combination with a bacteriocide. Also described is a composition...
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7338941 |
Pharmaceutical compositions for lowering blood glucose and blood cholesterol levels
Methods of treating a mammal with high blood-glucose, or high blood-cholesterol, levels with isovitexin, and pharmaceutical compositions comprising the same are disclosed.
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7335683 |
Compositions and methods for cystic fibrosis therapy
Compositions and methods for therapy of cystic fibrosis and other conditions are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones capable of stimulating...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7306815 |
Compositions enriched in phenolic compounds and methods for producing the same
Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin...
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7271153 |
Nitrogenous heterocyclic derivatives, medicinal compositions containing the same, medicinal uses thereof, and intermediates therefor
The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula:
wherein X 1 and X 3 independently represent N or CH; X 2 represents N or CR 2...
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7261909 |
Method of obtaining a hydroxytyrosol-rich composition from vegetation water
The invention provides olive-derived hydroxytyrosol. According to one aspect of the invention, vegetation water is collected from olives. Acid is added to stabilize the vegetation water and prevent...
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7259148 |
Hepatoprotective activity of 2′-p-hydroxybenzoylmussaenosidic acid
The present invention provides a method for treating and/or preventing hepatic disease conditions in a subject mammals including human beings, said method comprising the steps of administering to...
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7217770 |
Stable polymeric micelle-type drug composition and method for the preparation thereof
A biocompatible stable composition containing a hydrophobic drug, such as paclitaxel. The composition, which forms a syringeable polymeric micellar solution in aqueous or body fluids, is a...
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7217697 |
Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:
wherein R 1 is a hydrogen atom or a hydroxyalkyl group; one of Q and T is a group...
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7208477 |
Treatments for benign tumors, cancers, neoplasias, and/or other inflammatory disorders or diseases
The subject invention provides methods and compositions for the treatment of benign tumors, cancers, neoplasias, and/or other inflammatory disorders or diseases. In the practice of the subject...
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7199152 |
TNF-α production inhibitor comprising kavalactone as an active ingredient
The present invention provides a TNF-α production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-α...
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