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9040516 Uracil derivative and use thereof for medical purposes  
The present invention provides: an uracil derivative represented by general formula (I) or a physiologically acceptable salt thereof (in the formula, R1 represents a hydrogen atom, a C1-10 alkyl...
9034851 Substituted pyrimidines  
The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
9018200 Substituted piperidinyl compounds useful as GPR119 agonists  
Substituted piperidinyl compounds of the formula (I): are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as...
9012451 Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists  
The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the...
8993584 Control agent for soft rot and control method for the same  
Providing a novel control agent for soft rot and a novel control method for the same. A compound having no antibacterial activity against Erwinia carotovora but having a control activity against...
8986740 Anti-infective agents and uses thereof  
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such...
8980885 Plant disease controlling composition and method for controlling plant disease  
A plant disease controlling composition comprising, as active ingredients, a compound represented by the formula (I), as well as at least one compound A selected from the group consisting of...
8980871 Methods of treatment for hemolysis  
Provided herein are methods of treating hemolysis by administering an active compound in an amount sufficient to treat said hemolysis. It has been found that nitroxyl donors or similar compounds...
8980837 Inhibitors of IAP  
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′,...
8980867 Biocide compositions comprising alkoxylated oligoglycerol esters  
Suggested are biocide compositions, comprising (a) Alkoxylated oligoglycerol esters; (b) Biocides and optionally (c) Oil components or co-solvents and/or (d) Emulsifiers. The compositions show...
8975261 Aryloxmethyl cyclopropane derivatives as PDE10 inhibitors  
The present invention is directed to aryloxymethyl cyclopropane derivatives which are useful as therapeutic agents for the treatment of central nervous system disorders associated with...
8969364 Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders  
The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric...
8962641 Pyrimidine-substituted pyrrolidine derivatives, pharmaceutical compositions and uses thereof  
The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R3, Ar, L T and n are as defined in the description and claims, to their use as medicaments, to methods for their...
8962640 Method for treating liver diseases of various origins  
The invention relates to medicine, in particular to gastroenterology, and lies in the field of treatment of liver diseases of various origins. For this purpose, the hepatoprotective agent that is...
8957062 Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment  
Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The...
8952026 PRMT1 inhibitors and uses thereof  
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1...
8952024 Herbicidal pyrimidone derivatives  
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, X is CH or N;Y is C(O) or S(O)2; provided that when Y is S(O)2, then X is CH;A is a radical selected...
8952025 Multifunctional radical quenchers and their uses  
The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these...
8946219 Combination therapy with a compound acting as a platelet ADP receptor inhibitor  
The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing...
8940740 Small molecule inhibitors of bacterial motility and a high throughput screening assay for their identification  
Certain compounds are provided that can selectively inhibit motile bacteria such as V. cholerae motility. These compounds can indirectly diminish production of cholera toxin and other major...
8940735 Metalloenzyme inhibitor compounds  
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
8937080 Pyrimidine substituted macrocyclic HCV inhibitors  
Compounds of the formula I: including a stereoisomer thereof, or an N-oxide, a pharmaceutically acceptable addition salt, or a pharmaceutically acceptable addition solvate thereof; useful as HCV...
8933088 Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl) oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide  
Crystalline forms of the p38 kinase inhibitor 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H) -yl]-N-(2-hydroxyethyl)-4-methylbenzamide is provided. Also provided are combinations and...
8927551 Isoxazolines as inhibitors of fatty acid amide hydrolase  
The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The...
8912206 Pyrimidine ether derivatives and methods of use thereof  
The present invention relates to Pyrimidine Ether Derivatives, compositions comprising a Pyrimidine Ether Derivative, and methods of using the Pyrimidine Ether Derivatives for treating or...
8906906 Viral replication inhibitors  
The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also...
8901120 Substituted N-phenylpyrimidin-2-amine analogs as inhibitors of the Axl kinase  
In one aspect, the invention relates to substituted N-phenylpyrimidin-2-amine analogs, derivatives thereof, and related compounds, which are useful as inhibitors of Axl kinase; synthetic methods...
8895573 Phenoxy-substituted pyrimidines as opioid receptor modulators  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:...
8895574 Benzyloxypyrimidine derivative, agricultural/ horticultural insecticide comprising derivative and method for using same  
A benzyloxypyrimidine derivative represented by the formula (I) wherein R1 is an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a haloalkyl group, a haloalkenyl group, a...
8889197 Plant pathogen inhibitor combinations and methods of use  
Combinations, compositions and methods of use for modulating plant pathogen infection using plant extracts containing anthraquinone derivatives which induce resistance to plant phytopathogens and...
8883811 Synergistic fungicidal mixtures for fungal control in cereals  
A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole,...
8877734 Seleny-methyluracil compounds, radiosensitizer and pharmaceutical composition using them  
Provided are novel selenyl-methyluracil compounds and a pharmaceutical composition for enhancing the effect of radiation treatment. The composition contains at least one compound selected from the...
8877767 Polymorphs of methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phyenyl}-3-methoxyacrylate  
The present invention relates to novel crystalline polymorphic and amorphous forms of the compound methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-meth oxyacrylate (azoxystrobin)....
8877751 Benzothiazolone derivatives  
Compounds of the formula I, in which R1, R2, R3, R3′, R4, R4′, E, E′, E″ and E′″ have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be...
8877766 Neuroprotective multifunctional antioxidants and their monofunctional analogs  
The neuroprotective multifunctional antioxidants are compounds that contain a 2-diacetylamino-5-hydroxypyrimidine moiety, having the structural formula: wherein R1 is CH2 or C2H4; R2 is H or —OR4...
8871777 Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof  
The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates...
8865704 Wnt pathway antagonists  
The present invention relates to known and novel compounds of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) have inhibitory effect on the...
8841310 Combinations of a pyrimidine containing NNRTI with RT inhibitors  
The present invention concerns combinations of a pyrimidine containing NNRTI with nucleoside reverse transcriptase inhibitors and/or nucleotide reverse transcriptase inhibitors useful for the...
8841296 Substituted 1, 4-dioxa-8-azaspiro[4,5]decanes useful as fungicides and a process for the preparation thereof  
This invention provides novel substituted 1,4-dioxa-8-azaspiro[4,5]decane compounds of the general formula (1), wherein R1 is selected from phenethyl, 4,6-dimethoxypyrimidin-2-yl and...
8841313 CCR2 antagonists and uses thereof  
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases...
8835448 Methods and formulations for modulating lyn kinase activity and treating related disorders  
The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising the compounds or a pharmaceutically acceptable salts thereof that are useful in...
8822485 Amino heteroaryl compounds as beta-secretase modulators and methods of use  
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including...
8815883 Compounds and methods for inhibiting serotonin synthesis  
Compounds having the structures below that are TPH1 inhibitors are provided: The compounds are useful of, e.g., to increase bone mass. In preferred embodiments, the patient is known to have, or to...
8815864 Indanyloxydihydrobenzofuranylacetic acids  
The present invention relates to compounds of general formula I, wherein the group (Het)Ar is defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40...
8809356 Inhibitors of NEDD8-activating enzyme  
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound...
8802593 Composition and method for controlling plant diseases  
The present invention provides: a composition for controlling plant diseases comprising, as active ingredients, 4-oxo-4-[(2-phenylethyl)amino]-butyric acid and a quinone outside inhibitor; a...
8802657 Compounds useful as Raf kinase inhibitors  
The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
8802686 Sulfone-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as a medicine  
The invention relates to sulphone-substituted anilinopyrimidine derivatives of the formula (I), to its preparation processes, and to its use as medicament for treating various diseases.
8796001 Metalloenzyme inhibitor compounds  
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
8796295 Substituted benzamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same  
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the...