AcclaimIP-ad

Match Document Document Title
9018222 Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy  
The present invention refers to the use of sodium channel blockers such as tetrodotoxin or saxitoxin, its analogues/derivatives as well as their acceptable salts, for the production of a...
9012465 Compounds useful for treating disorders related to TRPA1  
Compounds and compositions for treating disorders related to TRPA1 are described herein.
9012466 Substituted tricyclic pyrazolo-pyrimidine compounds  
The present invention relates to substituted tricyclic pyrazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions...
9006258 Method of treating female sexual dysfunction with a PDE1 inhibitor  
The present invention relates to a new use for compounds that inhibit phosphodiesterase 1 (PDE1), e.g., that inhibit PDE1-mediated suppression of the dopamine D1 receptor and/or progesterone...
9000001 Organic compounds  
The invention provides novel 7,8-dihydro-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4-one compounds and 7,8,9-trihydro-[1H or 2H]-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one compounds,...
8987286 Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway  
Compounds of Formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. The compounds of formula (I) a: useful for the...
8980902 Poly (ADP-ribose) polymerase (PARP) inhibitors  
Compounds of the following formula are provided for use with PARP: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture...
8980903 Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors  
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and...
8975268 Neosaxitoxin combination formulations for prolonged local anesthesia  
Since each of the site I sodium channel blockers have a unique activity and cannot be used to extrapolate the same effective dosage for another site I sodium channel blocker, studies were...
8975269 Six-membered N-heterocyclic carbene-based catalysts for asymmetric reactions  
The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a...
8975267 Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors  
The present invention relates to tricyclic pyrrolo derivatives of Formula (I), which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated...
8952023 Compounds useful for treating injuries from warfare agents  
Compounds and compositions for treating disorders related to TRPA1 are described herein.
8933087 Tricyclic proteasome activity enhancing compounds  
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of...
8927543 Dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders  
A compound according to Formula Ia: wherein L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a...
8927561 Pyrimidinedione anti-viral compounds  
Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells,...
8927562 Fused tricyclic inhibitors of mammalian target of rapamycin  
This invention relates to novel fused tricyclic compounds that are inhibitors of mammalian Target of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP, and are useful in the...
8927560 4-Aza-2, 3-didehydropodophyllotoxin compounds and process for the preparation thereof  
The present invention provides 4-Aza-2,3-didehydropodophyllotoxin compound of general formula A (4a-4z and 4aa-4ae) as useful potential antitumour agents against human cancer cell lines. The...
8916577 Tricyclic derivatives, process for their preparation and their use as kinase inhibitors  
New substituted tricyclic compounds of formula (I) are described, wherein R1, R2, X, Y, Z are herein defined, having protein kinase inhibiting activity. The invention includes methods to prepare...
8901141 Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them  
There is provided a compound of the formula (I′): wherein X is a nitrogen or CRx, Rx is a hydrogen, etc., R1 is an optionally substituted hydrocarbon group, etc., R2 is an optionally substituted...
8901142 Fused tricyclic compounds as mTOR inhibitors  
The present invention relates to certain pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine and dipyrazolopyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase,...
8895549 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis  
This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for...
8889666 Quinolyl pyrrolo pyrimidyl condensed-ring compound and salt thereof  
The present invention provides a new compound that has an inhibitory action against EGFR and that has cell growth inhibitory effects. The present invention further provides a pharmaceutical...
8883810 Aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators  
The present invention is directed to benzoquinazolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the...
8883781 Thienopyrimidines useful as modulators of ion channels  
The present invention relates to compounds of formula IA-i useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of...
8877765 Highly soluble pyrimido-dione-quinoline compounds and their use in the treatment of cancer  
The present invention features pyrimido-dione-quinoline compounds having improved solubility, pharmaceutical compositions of substituted pyrimido-dione-quinoline compounds and methods of treating...
8871776 Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof  
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase...
8859572 Sulfone substituted 2,3-dihydroimidazo [1,2-C] quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis  
This invention relates to novel sulfone 2I3-dihydroimidazo[1 l2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for...
8858911 Phosphodiesterase 1-targeting tracers and methods  
Tracers targeting phosphodiesterase 1 for use in gamma radiation detection-based diagnostic techniques, particularly gamma-emitter labeled tracers for SPECT and positron emitter-labeled...
8853227 Methotrexate adjuvants to reduce toxicity and methods for using the same  
Methods are provided for using methotrexate (MTX) active agents in which reduced host toxicity is observed. Aspects of the methods include administering to a subject an effective amount of an MTX...
8853226 Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors  
The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by...
8853220 Synthesis of 2,6,9-tri-substituted-4,8-dinitro-2,6,9-triazabicyclo[3.3.1]nona-3,7-diene intermediates toward the preparation of polyaza-adamantanes  
The present invention relates to methods for synthesizing energetic compounds and intermediates thereof. Specifically, the present invention relates to methods for synthesizing adamantanes and...
8846703 Crystal of a free tricyclic pyrazolopyrimidine derivative  
To provide a crystal of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90. The present invention provides a crystal of...
8846702 Pyranyl aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators  
The present invention is directed to pyranyl aryl methyl benzoquinazolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of...
8846701 Pyrazolo-quinazolines  
The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted-arylamino, heterocyclylamino- or C3-C7 cycloalkylamino residue at 8 position and an aryl, heterocyclyl...
8841312 Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors  
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and...
8822483 Six-membered N-heterocyclic carbene-based catalysts for asymmetric reactions  
The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a...
8822484 Fused thiazolo and oxazolo pyrimidinones  
The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, steroisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present...
8822482 Icotinib hydrochloride, synthesis, crystalline forms, pharmaceutical compositions, and uses thereof  
The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase...
8815880 Crystal of tricyclic pyrazolopyrimidine derivative  
To provide a hydrochloride of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90 and a crystal thereof. The present invention provides a hydrochloride of...
8809355 GABAA receptor modulators  
The present invention relates to novel compounds of the general formula (I) having anxiolytic, anticonvulsant, sedative-hypnotic and myorelaxant conditions as well as anxiogenic, somnolytic and...
8785460 Tricyclic compounds and use thereof  
There is provided a compound of the formula (I′): wherein x is a nitrogen or CRx, Rx is a hydrogen, etc., R1 is an optionally substituted hydrocarbon group, etc., R2 is an optionally substituted...
8772301 Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof  
Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as...
8765757 3-heterocyclic substituted indole derivatives and methods of use thereof  
The present invention relates to 3-Heterocyclic Substituted Indole Derivatives, compositions comprising at least one 3-Heterocyclic Substituted Indole Derivative, and methods of using the...
8765775 Anti-angiogenic compounds  
The invention relates to compounds of formula 1, tautomers and salts thereof, wherein R1, R2, R3, R4, and R5 have the meanings indicated in the specification. These compounds are receptor tyrosine...
8754073 Substituted piperazino-dihydrothienopyrimidines  
Piperidinodihydrothienopyrimidines of formula 1 wherein X is SO or SO2 (preferably SO), and R1, R2, R3, and R4 may have the meanings given in the disclosure and claims, pharmacologically...
8735411 Macrocyclic benzofused pyrimidine derivatives  
Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases,...
8735386 Aminopyrazoloquinazolines  
Compounds of general formula (I) wherein the groups R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell...
8729090 Compositions and methods for inhibiting collagen production  
Embodiments of the invention include compositions effective for inhibiting collagen production and related methods. A preferred method comprises contacting at least one cell capable of producing...
8722708 Substituted isoindolines as aspartyl protease inhibitors  
Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Q is a bond or —N(R5)—;T is a bond, —O—, —C(O)—; S, —N(R5)—,...
8710065 Tricyclic inhibitors of kinases  
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X, Y, Z, R3 and R4 are defined in the description. The present invention relates also to...