Patents in Class 514/266.220

Matches 1 - 50 out of 181

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Match	Document	Document Title
1	7384940	Method of treating cancer using kinase inhibitors Described herein are methods for treating cancer and other disease conditions in individuals who have either developed a resistance to conventional tyrosine kinase inhibitor (TKI) therapy or who...
2	7358256	ATP competitive kinase inhibitors The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as...
3	7345049	Phenylalanine derivatives Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
4	7329665	Quinazolinone derivative An optically active form of the quinazolinone derivatives represented by the general formula (1): [wherein Y represents a phenyl group or C2-C7 alkyl group; E represents —CH═ or nitrogen...
5	7304059	Substituted quinazolin-4-ylamine analogues Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the...
6	7285557	Pyrimidinones as melanin concentrating hormone receptor 1 A compound of formula (Ia) comprising a pharmaceutically acceptable salt or solvate thereof, formulations, processes of preparing, and methods of administering to mammals are provided
7	7265125	Neuropeptide Y antagonists Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases,...
8	7230001	Arylalkane, arylalkene and aryl azaalkane, medicaments containing said compounds and method for the production thereof The present invention relates to compounds of general formula R—Z 1 —Z 2 —Z 3 —R 1 , (I)
9	7230000	Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity
10	7223756	Quinazoline compounds with therapeutic use The invention concerns the use of the quinazoline derivatives of Formula (I) wherein each of m, R 1 , Z, n and R 3 have any of the meanings defined in the description in the manufacture of a...
11	7214674	Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl,...
12	RE39574	Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies The invention provides a composition for attenuating neovascularization and treating malignancies, including a pharmaceutically effective amount of a compound having a formula: wherein: ...
13	7183274	Piperidine-2,6-diones heterocyclically substituted in the 3-position Piperidine-2,6-diones heterocyclically substituted in the 3-position corresponding to formula I Also the production and use of such compounds in pharmaceutical formulations and related methods...
14	7173038	Quinazoline derivatives as VEGF inhibitors The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R 1 represents halogeno or C 1-3 alkyl; X 1 represents —O—; R 2 is selected from one of...
15	7148230	Quinazoline derivatives The invention concerns quinazoline derivatives of Formula I wherein R 1 and R 2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical...
16	7112590	Thrombin inhibitors The invention relates to compounds that are heterocyclic derivatives of dipeptides and dipeptides mimetics and pharmaceutically acceptable salts thereof. The compounds are used as thrombin inhibitors
17	7094780	3-aminoquinazolin-2,4-dione antibacterial agents Antibacterial 3-aminoquinazolin-2,4-diones have formula (I) wherein: R 1 and R 3 include alkyl, alkenyl, cycloalkyl, aryl, hetero-cyclic, and heteroaryl; R 5 , R 6 , and R 8 include H, alkyl,...
18	7060705	Mitotic kinesin inhibitors The present invention relates to quinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
19	RE39096	Treatment of skin disorders An effective treatment for skin disorders characterized by abnormal skin cell behavior, including a pharmaceutically effective amount of Halofuginone. Skin disorders which can be treated include...
20	7019012	Quinazoline derivatives and pharmaceutical compositions containing them A compound of general formula I wherein: R a is a benzyl, 1-phenylethyl, or 3-chloro-4-fluorophenyl group; R b is a dimethylamino, N-methyl-N-ethylamino, diethylamino,...
21	7001904	Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases The invention concerns quinazoline and quinoline derivatives of Formula (I) wherein Q 1 includes a quinazoline or quinoline ring optionally substituted with a group such as halogeno,...
22	6982260	Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney...
23	6949541	Substituted piperidines, medicaments containing these compounds, and methods for the production thereof The present invention relates to substituted piperidines of general formula wherein A 1 , A 2 , R, R 1 and R 2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers,...
24	6939866	Quinazoline derivatives The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R 1 , n, R 2 and R 3 have any of the meanings defined in the description; process for the preparation,...
25	6930113	Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase...
26	6900222	Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein...
27	6844350	Febrifugine, isofebrifugine and method for producing the same A febrifugine represented by Formula (A): and an isofebrifugine represented by Formula (B): which exhibit extremely strong activities against tropical malarial protozoan are provided,...
28	6844338	Piperidyindoles as serotonin receptor ligands A pharmaceutical compound of the formula (I) in which R 1 and R 2 are each hydrogen or C 1-6 alkyl, R 3 is —SR 10 , —SOR 10 , —SO 2 R 10 , —COR 10 , —CH 2 OH or —CONHR 11 , where R...
29	6800628	N-substituted 4-((-4′-aminobenzoyl)-oxymethyl)-piperidines having gastric prokinetic properties This invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R 1 is C 1-6...
30	6699861	Anti-quinazoline compounds Dihydroquinazoline derivatives of the formula where R 3 is —(CH 2 ) p —A where p is from 1 to 4 and A is a 5- or 6-membered N-containing heterocyclic ring attached via the N atom or A is...
31	6680329	N-(heterocyclyl)benzene or pyridinesulphonamides as antithrombotic agents and anticoagulants Compounds of formula [I] in which: W may represent a —(CH 2 ) 2 —, —(CH 2 ) 3 —, —CH 2 —C≡C— or —CH 2 —CH═CH— group, R 2 may in particular represent a piperidyl group, an...
32	6645971	Quinazolinone derivatives A compound given by general formula (1): [wherein T represents oxygen or sulfur atom, Y represents alkyl, cycloalkyl group, etc., ring W represents benzene ring, etc., R 1 and R 2 represent...
33	6617325	Biphenyl derivatives, production thereof and uses as medicines The present invention relates to biphenyl derivatives of general formula wherein R a to R g and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically...
34	6602882	Quinoline derivatives and their use as antibacterial agents Piperidine derivatives and pharmaceutical derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
35	6583155	Method for treating allergies using substituted pyrazoles A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
36	6562829	Treatment of hepatic cirrhosis A composition for treating hepatic fibrosis and a method of using and manufacturing the composition are provided. The composition includes a quinazolinone derivative, preferably Halofuginone.
37	6559153	Quinazoline derivatives as alpha-1 adrenergic antagonists This invention relates to compounds which are generally alpha-1B adrenergic receptor antagonists and which are represented by Formula (I): wherein R′, R″, R 1 , R 2 , m, n, and A are as...
38	6559136	Fungicidal active substance combinations Novel active compound combinations of compounds of the formula (I) in which Z, X and A are each as defined in the description with known active compounds and their use for controlling...
39	6479499	2-phenyl-4-quinazolinone compounds, 2-phenyl-4-alkoxy-quinazoline compounds and their pharmaceutical compositions Two series of 6,7,2′,3′,4′,5′-substituted 2-phenyl-4-quinazolinones and 6,2′,3′,4′,5′-substituted 2,3-dihydro-2-phenyl-4-quinazolinones are synthesized and evaluated for...
40	6472394	MCH antagonists and their use in the treatment of obesity Disclosed are compounds represented by structural formula I: or a pharmaceutically acceptable salt, ester or solvate thereof, wherein W is R 1 —CR 3 R 12 NR 4 C(O)— or R 11 C(O)NR 4 —; the...
41	6448270	4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using the 4-substituted piperidine analogs as selectively active antagonists of...
42	RE37828	Treatment and prevention of adhesions An inhibitor of adhesion formation which can be used to prevent adhesions within the abdominal cavity, particularly following surgical intervention, trauma or inflammation in the area is disclosed....
43	6417194	Quinolines and quinazolines useful in therapy Compounds of formula I, wherein R 1 represents C 1-4 alkoxy optionally substituted by one or more fluorine atoms; R 2 and R 3 independently represent H or C 1-6 alkoxy (which is optionally...
44	6417178	Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other...
45	6407116	Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs A compound represented by the formula: [wherein ring A represents a homocycle optionally having substituents or a nitrogen-containing heterocycle optionally having substituents; D and E are O or...
46	6391874	Fused heterocyclic compounds as protein tyrosine kinase inhibitors Substituted heteroaromatic compounds of formula (I) and in particular substituted quinolines and quinazolines, are protein tyrosine kinase inhibitors. The compounds are described as are methods for...
47	6376503	Alpha 1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the...
48	6358959	Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists Dihydro-polyazanaphthalen-2-one compounds (e.g., dihydroquinazolin-2-one and dihydropteridin-2-one derivatives) and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these...
49	6339089	Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same A pyrimidine nucleus-containing compound represented by the formula (I): wherein ring A represents the ring of the formula (a): in which R 1 is a nitro group, an amino group, a substituted...
50	6337332	Neuropeptide Y receptor antagonists Compounds of the structures are useful for treating conditions related to an excess of neuropeptide Y including obesity and circulatory disorders.

Matches 1 - 50 out of 181

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