|
Match
|
Document |
Document Title |
|
|
7388014 |
Quinazoline derivatives and therapeutic use thereof
Quinazoline derivatives represented by the general formula
pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for using the compounds...
|
|
|
7378422 |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life...
|
|
|
7368453 |
Quinazolinone compounds with reduced bioaccumulation
A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to...
|
|
|
7361663 |
N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa
This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing...
|
|
|
7358239 |
Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
|
|
|
7345049 |
Phenylalanine derivatives
Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
|
|
|
7342022 |
Compounds in the treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3
The present invention relates to new compounds of formula I wherein R 1 , R 2 , R 3 , n, m are defined as in claim 1, a process for their preparation and new intermediates used in the preparation...
|
|
|
7332493 |
Substituted bicyclic derivatives for the treatment of abnormal cell growth
The invention relates to compounds of the formula 1
and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 3 , R 4 , R 5 , R 11 , m and p are as defined...
|
|
|
7326712 |
Substituted tricyclic compounds as protein kinase inhibitors
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following...
|
|
|
7314883 |
Anti-migraine treatments
The present invention relates to methods of treating neurogenic vasodilation, neurogenic inflammaton, migraine and other headaches, thermal injury, circulatory shock, flushing associated with...
|
|
|
7312211 |
Pryanone compounds useful as reversible inhibitors of cysteine proteases
Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R 2 , R 3 , R 4 , R 6 , R 8 and Y are defined herein. The compounds are useful for...
|
|
|
7304059 |
Substituted quinazolin-4-ylamine analogues
Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the...
|
|
|
7294629 |
Quinazoline derivatives
A compound of the formula (I)
or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer...
|
|
|
7285557 |
Pyrimidinones as melanin concentrating hormone receptor 1
A compound of formula (Ia) comprising a pharmaceutically acceptable salt or solvate thereof, formulations, processes of preparing, and methods of administering to mammals are provided
|
|
|
7265125 |
Neuropeptide Y antagonists
Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases,...
|
|
|
7262201 |
Quinazoline derivatives
The invention relates to the use of compounds of the formula I:
wherein: ring C is a 5-6 membered heterocyclic moiety; Z is —O—, —S—, or —CH 2 —; R 1 is hydrogen, C 1-4 alkyl, C...
|
|
|
7259155 |
Phosphonic diester derivatives
The present invention provides a phosphonic acid diester compound represented by General Formula
wherein R 1 , R 2 , R 3 and R 4 are the same or different, and represent hydrogen, halogen,...
|
|
|
7244738 |
Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists
Compounds represented by Formula I:
which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and...
|
|
|
7235559 |
Therapeutic quinazoline derivatives
A compound of formula (I) or a salt, ester, amide or prodrug thereof; where X is O, or S, S(O), S(O) 2 or NR 6 where R 6 is hydrogen of C 1-6 alkyl; R 5 is an optionally substituted 6-membered...
|
|
|
7223767 |
Tetrahydroquinazolines and dihydrocyclopentapyrimidines as CRF antagonists
Compounds of the formula (I):
and pharmaceutically acceptable salts or prodrugs thereof, wherein m, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. The invention also provides...
|
|
|
7220751 |
Quinazoline derivatives and drugs
The invention provides an excellent novel analgesic which acts on a nociceptin receptor to exhibit a wide range of the analgesic effect for example on a chronic pain as well as an allodynia...
|
|
|
7214674 |
Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed:
wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl,...
|
|
|
7205309 |
Quinazoline derivatives
Compounds of formula I
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 , R 2 , R 3 and A have the significance given in the specification are provided. The...
|
|
|
7189733 |
Compositions and methods for inhibiting TGF-β
This invention provides compounds that are useful for treating patients having a TGF-β-mediated disease, particularly an ALK5-mediated disease. The compounds are represented by formula I:
...
|
|
|
7160891 |
Quinazoline derivatives for the treatment of T cell mediated diseases
The invention concerns the use of the quinazoline derivatives of Formula (I) wherein each of Q 1 , Z, m, R 1 , R 2 , R 3 and Q 2 have any of the meanings defined in the description in the...
|
|
|
7160882 |
Long acting β-2-agonists and their use as medicaments
The present invention relates to compounds of formula 1
wherein the groups X, R a , R b , R 1 , R 1′ , R 2 , R 2′ , R 2″ , R 2′″ , V and n may have the meanings given in the claims...
|
|
|
7157467 |
Therapeutic use
The invention concerns the use of the quinazoline derivatives of Formula (I) Wherein each of m, R 1 , n, R 2 and R 3 have any of the meanings defined in the description in the manufacture of a...
|
|
|
7157466 |
Quinazoline ditosylate salt compounds
Ditosylate salts of 4-quinazolineamines are described as well as methods of using the same in the treatment of disorde4rs characterized by aberrant erbB family PTK activity.
|
|
|
7141576 |
Cancer treatment method
A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as pharmaceutical combinations and compositions...
|
|
|
7138405 |
Pharmaceutical combinations
Pharmaceutical combinations suitable for treating the lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in men are described herein. The combinations contain an...
|
|
|
7138403 |
2,4,5-trisubstituted thiazolyl derivatives and their antiinflammatory activity
This invention concerns the use of a compound of formula (I)
a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z...
|
|
|
7132427 |
Quinazolines and uses thereof
This invention relates to compounds of the general formula:
in which R A , R B , R C and R D are as defined herein, and to their preparation and use.
|
|
|
7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
|
|
|
7122544 |
Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure:
wherein R 1 ...
|
|
|
7119084 |
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the...
|
|
|
7115615 |
Quinazoline derivatives
The invention concerns quinazoline derivatives of Formula (I)
wherein each of m, R 1 , n, R 2 and R 3 have any of the meanings defined in the description; processes for their preparation,...
|
|
|
RE39266 |
Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their...
|
|
|
7094780 |
3-aminoquinazolin-2,4-dione antibacterial agents
Antibacterial 3-aminoquinazolin-2,4-diones have formula (I) wherein: R 1 and R 3 include alkyl, alkenyl, cycloalkyl, aryl, hetero-cyclic, and heteroaryl; R 5 , R 6 , and R 8 include H, alkyl,...
|
|
|
7084147 |
Anilinoquinazaolines as protein tyrosine kinase inhibitors
Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates...
|
|
|
7081460 |
Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
The invention is directed to novel quinazoline and quinazoline-like derivatives of Formula (I):
useful as integrin antagonists and methods for the treatment of integrin-mediated disorders.
|
|
|
7074800 |
Quinazoline derivatives as angiogenesis inhibitors
The invention relates to the use of compounds of formula (I), wherein ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which optionally may contain 1–3 heteroatoms selected...
|
|
|
7074799 |
Substituted quinazolin-4-ylamine analogues
Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the...
|
|
|
7060705 |
Mitotic kinesin inhibitors
The present invention relates to quinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7056917 |
Drug efflux pump inhibitor
A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I):
wherein,...
|
|
|
7045526 |
Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them
The present invention relates to compounds of formula I:
wherein R 1 , R 2 , and R 3 have the meanings indicated in the specification, which are valuable pharmaceutical active compounds for...
|
|
|
RE39096 |
Treatment of skin disorders
An effective treatment for skin disorders characterized by abnormal skin cell behavior, including a pharmaceutically effective amount of Halofuginone. Skin disorders which can be treated include...
|
|
|
7041675 |
Heterocyclic compounds and their use as PARP inhibitors
The invention relates to compounds of the formula I
and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.
|
|
|
7037916 |
Pyrimidine derivatives as IL-8 receptor antagonists
Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I...
|
|
|
7034033 |
Substituted quinazolinone compounds
A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have...
|
|
|
7022678 |
Pregabalin lactose conjugates
In accordance with the present invention, there is provided pregabalin lactose conjugate compounds. Also provided as part of the present invention is a novel method of central nervous system...
|