Patents in Class 514/264.11

Matches 1 - 50 out of 106

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Match	Document	Document Title
1	8101622	Pyridopyrimidinone inhibitors of PI3Kα and mTOR The invention is directed to Compounds of Formula I: optionally as a single stereoisomer or mixture of stereoisomers thereof, and additionally optionally as a pharmaceutically acceptable salt...
2	8076345	2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof Fused heterocyclic compounds are provided according to formula 1: where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the...
3	8058282	2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
4	8058283	7H-pyrido[3,4-D]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds,...
5	8044062	Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
6	8030318	Fused bicyclic inhibitors of HCV Substituted fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine ring are useful in the treatment of conditions associated with HCV.
7	8030317	MAPK/ERK kinase inhibitors Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture...
8	8022077	Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof The present invention relates to the use of pyrido[2,3-d]pyrimidines of formula (I) wherein L, R1, R2 and R3 have specific meaning. The present invention also relates to the use of the compounds of...
9	8008310	Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same Derivatives of pyrido[2,3-d]pyrimidine are provided having formula (I) with Ar1, Ar2 and R1 as defined herein, which are useful for treating cell proliferative conditions, and to the preparation...
10	7923450	Modulators for amyloid beta The invention relates to compounds of formula wherein R1, R2, R3, R4, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used for the...
11	7910595	Anti-viral compounds Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-...
12	7879866	Inhibition of the activity of the capsaicin receptor in the treatment of obesity or obesity-related diseases and disorders The present invention provides a method of treating diseases or disorders benefiting from inactivating or down regulating the activity of the capsaicin receptor in a mammal by inhibiting the...
13	7868018	Compounds and compositions as protein kinase inhibitors The invention provides compounds of Formula I: wherein R1-R6 are described in the Summary of the Invention; the pharmaceutical compositions comprising such compounds and methods of using such...
14	7851468	Substituted pyrazolo[3,4-d]pyrimidines The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that...
15	7846927	N,N′-diphenylurea derivatives suitable as kinase inhibitors Compounds of the formula (I), in which R1, R3 and X have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia,...
16	7842698	Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors The present invention relates to pyridine methylene azolidinone compounds of Formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular...
17	7750016	Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones Compounds of the Formula: where X1, Ar1, R1, and R2 are as defined herein, and compositions comprising the same. Also provided are methods for using compounds of Formula I in treating p38 mediated...
18	7745451	Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4′, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for t...
19	7696213	4-methylpyridopyrimidinone compounds The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha...
20	7687502	Substituted quinazoline or pyridopyrimidine derivative The present invention provides a compound having a glucokinase activating action being useful for prevention or treatment of diabetes mellitus, etc. being represented by the formula (I): X is...
21	7678801	Compounds Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use use in therapy as CSBP/RK/p38 kinase inhibitors.
22	7662828	Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds Substituted 5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl and 5,6,7,8-tetrahydro-quinazolin-2-yl compounds, corresponding to formula I processes for the production thereof, pharmaceutical...
23	7662827	Pyrazole derivatives having tyrosine kinase inhibitory activity Compounds of the formula (I), in which R, X, R1, R2, R3 and R4 have the meanings indicated in Claim (1), are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be...
24	7648986	Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating...
25	7645764	Kinase inhibitors and methods for using the same Compounds of formula I: wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds, pharmaceutical compositions, methods of using the compounds for...
26	7622470	Treatment of T-cell lymphoma using 10-propargyl-10-deazaaminopterin T cell lymphoma is treated by administering to a patient suffering from T cell lymphoma a therapeutically effective amount of 10-propargyl-10-deazaaminopterin. Remission is observed in human...
27	7618975	4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of...
28	7601713	Kinase inhibitors and their uses The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein...
29	7582643	Heterocyclic compounds useful in treating diseases and conditions The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such...
30	7572801	Pyridopyrimidinone derivatives which are HM74A agonists The invention is concerned with novel pyridopyrimidinone derivatives of formula (I): wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims. The compounds of the...
31	7547695	Pyridopyrimidinones The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and X′ have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine k...
32	7544682	Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I) and acid addition salts, hydrates and solvates thereof, as...
33	7531545	2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of β-secretase (BACE) The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease...
34	7524852	Bicyclic pyrimidine derivatives [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each r...
35	7504406	Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same.
36	7456168	2-(pyridin-2-ylamino)-pyrido[2,3, d]pyrimidin-7-ones The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent...
37	7442710	Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ andR1, R2,R3, R4,R5, and R6 are as defined in the specification and to pha...
38	7361662	Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same A compound of formula (I): wherein: R1, R2, R3, R4 are defined in the description, its enantiomers, diastereoisomers, tautomers and also addition salts thereof with a pharmaceutically acceptable...
39	7348331	Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones Compounds of the Formula: where X1, Ar1, R1, and R2 are as defined herein, and compositions comprising the same. Also provided are methods for using compounds of Formula I in treating p38 mediated...
40	7329664	Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and...
41	7323472	2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds The present invention is directed to the novel use of a CSBP/p38 inhibitor for the treatment, including prophylaxis of inflammation enhanced cough in a mammal in need thereof.
42	7279484	Heterocyclic compounds The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally...
43	7235551	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases Novel substituted pyrimidol[4,5-d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
44	7232824	Quinazoline derivatives as medicaments Quinazoline derivatives have the formula: or the pharmaceutically acceptable salts thereof;wherein each of Z5, Z6, Z7 and Z8 is N or CH and wherein one or two Z5, Z6, Z7 and Z8 are N and wherein...
45	7208489	2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent...
46	7202249	Antagonists of chemokine receptors Compounds are provided which are antagonists of chemokine receptor activity. The compounds thereof have the structure including enantiomers, diastereomers, tautomers, pharmaceutically acceptable...
47	7189731	Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors Compounds having the formula (I) or (II), are useful as p38 kinase inhibitors, wherein R is an optionally substituted alkyl, cycloalkyl, or aryl; R6 is hydrogen or lower alkyl; R7 is hydrogen or a...
48	7189732	Pyrido[2,3-d]pyrimidine dichloro-phenyl derivatives The invention describes compounds of the general formula I a process for their manufacture, compositions containing them and their manufacture as well as the use of these compounds as...
49	7163941	Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents The invention describes compounds of the general formula I a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as...
50	7157466	Quinazoline ditosylate salt compounds Ditosylate salts of 4-quinazolineamines are described as well as methods of using the same in the treatment of disorde4rs characterized by aberrant erbB family PTK activity.

Matches 1 - 50 out of 106

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