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7388002 |
Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
Compounds represented by the formula:
A is (CH 2 ) n R 2 , —CH═CH 2 , CH 2 —CH═CH 2 , O(CH 2 ) n R 2 , CH(OH)CH 3 , CH(OH)CH 2 OH, CH 2 —CH(OH)CH 3 , CH 2 CH(OH)CH 2 OH, or...
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7273864 |
Compositions and methods for inducing osteogenesis
The present invention provides compositions and methods for differentiating and transdifferentiating mammalian cells into cells of an osteoblast lineage, using compounds of the following formula: ...
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7256196 |
Purine cytokine inhibitors
The present invention relates to 2,8,9-substituted purines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian...
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7238700 |
A2B adenosine receptor antagonists
Disclosed are novel A 2B adenosine receptor antagonists of Formula I:
A compound of the formula:
wherein:
R 1 is optionally substituted alkyl or a group —Y-Z, in which Y is...
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7229961 |
Compositions and methods for enhancing drug delivery across and into ocular tissues
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions...
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7196093 |
Reversible inhibitors of SAH hydrolase and uses thereof
1. The present invention provides compositions and methods for reversibly inhibiting S-adenosyl-L-homocysteine (SAH) hydrolase. The compounds of the present invention can be used as an...
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7189730 |
A2A adenosine receptor antagonists
Disclosed are novel A 2A adenosine receptor antagonists of the formula:
wherein:
R 1 is optionally substituted aryl or optionally substituted heteroaryl; R 2 is optionally substituted...
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7045525 |
Use of (R)-peniciclovir triphosphate for the manufacture of a medicament for the treatment of viral diseases
A method of treatment of: i) HIV-1 infections in mammals, including humans; or ii) HBV infections in mammals, including humans; which method comprises the administration to the human in need of...
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7041305 |
Stable water in oil aminophylline emulsions
A water in oil emulsion system and a process for preparing such a emulsion has been provided for topically applying aminophylline for reducing cellulite conditions.
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6958344 |
Pyrimidine compounds and their use as modulators of chemokine receptor activity
The invention provides certain heterocyclic compounds, processes, and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy; in formula (I),...
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6855736 |
Molecular target of neurotoxicity
The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterization and/or treatment (or management) of neuro...
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6747016 |
Substituted purine derivatives as inhibitors of cell adhesion
The present invention relates to compounds of formula (I), in which B, D, E, G, X, Y, Z, R 1 , R 2 and s have the meanings indicated in the claims, their physiologically tolerable salts and their...
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6696454 |
Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation
This invention provides a method for the treatment of a subject in need of treatment for osteoarthritis comprising administering to said subject an amount of an inhibitor of spermidine biosynthesis...
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6693106 |
Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (AGE's)
Pentoxifylline, pioglitazone and metformin have been found to inhibit the nonenzymatic glycation of proteins which often results in formation of advanced glycation endproducts and crosslinks. The...
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6683084 |
Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections
The use of a compound of formula (A) or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing for use in the prophylactic...
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6579981 |
Antiviral guanine derivatives
A compound of formula (I) or a salt or acyl derivative thereof, in which X represents chlorine, C 1-6 alkoxy, phenoxy, phenyl C 1-6 alkoxy, NH 2 , —OH or —SH, is useful in treating viral...
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6576636 |
Method of treating a liver disorder with fatty acid-antiviral agent conjugates
The invention provides conjugates of fatty acids and antiviral agents useful in treating liver disorders.
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6548486 |
Fatty acid esters of nucleoside analogs
New compounds of the general formula (I): Nu-O-Fa, wherein O represents an oxygen, Nu is a nucleoside or nucleoside analogue, and Fa is an acyl group of a mono-unsaturated C18 or 20 fatty acid. The...
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6512004 |
Promoters of neural regeneration
The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent...
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6489330 |
Use of penciclovir for the treatment of human herpes-virus-8
The present invention is directed to the use of a compound of Formula (A), or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the...
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6465473 |
Method for treatment of reactive arthritis or bursitis
An improved method for treatment of conditions in human beings associated with either or both reactive arthritis or bursitis comprising administration of a combination of L-lysine, minocycline...
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6448227 |
Therapeutically effective substance mixture
A substance mixture, containing S-acetyl glutathione and Aciclovir, is effective as a medication against the Herpes Simplex virus and the Varicella Zoster virus.
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6440979 |
Aryl isoguanines
Disclosed are compounds having formula (II): wherein: Q 3 , Q 6a , Q 6b and Q 8 are independently a bond, C 1-8 alkylene, C 2-8 alkenylene and C 2-8 alkynylene, and R 3 , R 6a , R 6b and R...
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6297226 |
Synthesis and methods of use of 9-substituted guanine derivatives
The present invention is directed to 9-substituted guanine derivatives in which the guanine moiety is linked to another moiety with physiological or pharmacological activity through a carboxamide...
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6191151 |
Therapy for herpes neurological viral conditions utilizing 1,4-dihydropyridine calcium channel blockers
A therapy for Bells Palsy in mammals is proposed that rests on a causal hypothesis involving both endothelin and the herpes virus, particularly the herpes simplex virus for Bell's Palsy. Similarly,...
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6136814 |
Aqueous acyclovir product
The present invention provides a pharmaceutical product comprising an aqueous solution of acyclovir sodium contained within a sealed container constructed of an alkali resistant polymer having a CO...
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6136813 |
Pharmaceutical treatment
Pharmaceutical use of a compound of formula (A): ##STR1## or a pro-drug, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing; in the treatment...
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6124304 |
Penciclovir for the treatment of zoster associated pain
A method for the treatment of ZAP, in particular PHN, in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of penciclovir...
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6107303 |
Treatment of Epstein Barr infection
A method of treating Epstein Barr virus infection in humans by administering a pharmaceutically effective amount of an antiviral agent selected from a group consisting of acyclovir, famciclovir,...
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6107302 |
Guanine derivative
The invention relates to an anhydrous crystalline form of (2-[2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy]ethyl L-valinate hydrochloride (otherwise known as valaciclovir hydrochloride) and a...
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6083953 |
2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative
The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propaned
iol and its pharmaceutically acceptable salts are of value as antiviral agents with improved...
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6027936 |
Carbon monoxide dependent guanyly cyclase modifiers and methods of use
Disclosed herein are methods directed generally to the control of neural activity and for selectively and controllably inducing the in vivo genetic expression of one or more naturally occurring...
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6017923 |
Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents
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6015573 |
Nucleoside phosphate therapy for viral infection
Compositions for topical use in herpes virus infections comprising anti-herpes nucleoside analogue phosphate esters, such as acyclovir monophosphate and acyclovir diphosphate, which show increased...
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5994361 |
Substituted purinyl derivatives with immunomodulating activity
The present invention comprises a compound of formula I: ##STR1## R 1 of Formula I is substituted amino represented by formula NR 5 R 6 wherein R 5 and R 6 are independently selected from the...
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5968940 |
Retinoids and methods of use of same
New purine retinoid compounds according to the formula: ##STR1## wherein R is a purine derivative, and pharmaceutical compositions thereof, are provided which exhibit cancer-inhibiting activity.
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5958932 |
Substitutes O.sup.6 -benzylguanines, compositions, and methods of using same
The present invention provides AGT inactivating compounds such as substituted O 6 -benzylguanines of the formula ##STR1## wherein, for example, R 1 is amino, hydroxy, or alkylamino, R 2 is...
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5922696 |
Ethylenic and allenic phosphonate derivatives of purines
Disclosed are novel unsaturated phosphonate derivatives of certain purines or pyrimidines useful as antiviral agents, methods useful for their preparation and use of these compounds as antiviral...
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5916893 |
Treatment of a latent infection of herpes virus
A method for the treatment of latent infection of herpesviruses in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of a...
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5912252 |
Purine and guanine derivatives as PNP inhibitors
The subject invention concerns compounds of formula (I): wherein n=1 or 2; R 1 is H, NH 2 or halogen; R 2 is H or NH 2 ; R 3 represents the group CR 6 R 7 R 8 where R 6 , R 7 ...
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5883103 |
Oral acyclovir delivery
A pharmaceutical preparation for oral acyclovir delivery comprising a stable, hydrophobic emulsion comprising continuous phase of a hydrophobic material selected from the group consisting of a long...
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5866581 |
Penciclovir for the treatment of post therapeutic neuralgia
A method for the treatment of PHN in mammals, including humans, which method comprises administering an effective amount of a compound of formula (A), or a pharmaceutically acceptable salt thereof....
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5863921 |
Purine and guanine derivatives
Compounds of formula (I) ##STR1## wherein n=1 or 2; R 1 is H, NH 2 or halogen; R 2 is H or NH 2 ; R 3 represents the group ##STR2## where m=0 or 1; R 4 and R 5 are the same or...
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5840763 |
Treatment of a latent infection of herpes viruses
A method for the treatment of latent infection of herpesviruses in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of a...
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5817647 |
Unsaturated acetylene phosphonate derivatives of purines
Disclosed are novel unsaturated acetylene phosphonate derivatives of certain purines or pyrimidines useful as antiviral agents, methods useful for their preparation and use of these compounds as...
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5786359 |
N.sup.9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines
Immunostimulating 7,8-disubstituted guanine derivatives that also contain a 9-alkyl, 9-alkoxy or 9-aralkyl substituent are disclosed whose structures are represented by Formula I ##STR1## wherein X...
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5691307 |
O.sup.6 -substituted guanine compositions and methods for depleting O.sup.6
Novel O 6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O 6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful...
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5677308 |
Method for alleviating spasmodic torticollis
A method for alleviating spasmodic torticollis with the administration of antiviral agents. Based on clinical tests, spasmodic torticollis is a persistent herpes simplex virus infection and thus...
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5674869 |
Pharmaceutical treatment
Use of a guanine derivative or a prodrug thereof in the treatment of viral infections.
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5646155 |
Drugs to prevent recurrent herpes virus infections
N 2 -substituted alkylguanine and N 2 -substituted phenylguanine compounds which prevent recurrent herpes simplex infections are disclosed. By virtue of their ability to inhibit herpes virus...
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