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5677308 |
Method for alleviating spasmodic torticollis
A method for alleviating spasmodic torticollis with the administration of antiviral agents. Based on clinical tests, spasmodic torticollis is a persistent herpes simplex virus infection and thus...
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5674869 |
Pharmaceutical treatment
Use of a guanine derivative or a prodrug thereof in the treatment of viral infections.
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5646155 |
Drugs to prevent recurrent herpes virus infections
N 2 -substituted alkylguanine and N 2 -substituted phenylguanine compounds which prevent recurrent herpes simplex infections are disclosed. By virtue of their ability to inhibit herpes virus...
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5612348 |
Method of treating warts
A method of treating a viral infection in a human manifested as at least one of warts, carcinomas, cancer of the cervix, Bowenoid papulosis and epidermal dysplasia verruciformis is disclosed. This...
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5585379 |
Acyclovir antiviral gel composition
An antiviral topical pharmaceutical composition for treating viral diseases of the skin or mucosa comprises a poorly soluble antiviral nucleoside derivative, dispersed in an aqueous gel carrier...
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5585363 |
Circumvention of human tumor drug resistance
A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function...
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5559114 |
Treatment of autoimmune disease using 2-amino purine derivatives
A method for treating autoimmune disease in a mammalian subject, particularly a human, which method comprises administering a therapeutically effective amount of certain 2-amino purine compounds to...
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5543414 |
Achiral amino acid acyl esters of ganciclovir and its derivatives
Compounds of the Formula I ##STR1## wherein X is hydrogen, chloro, amino or hydroxy; R 1 is an achiral amino acid acyl residue with a tertiary α-carbon atom. Preferred achiral amino acid acyl...
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5380727 |
Synergistic combination for treating herpes infections
Disclosed herein is a combination of an antiviral nucleoside analog and a ribonucleotide reductase inhibiting peptide derivative. The combination is useful for treating herpes infections.
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5318974 |
Antiviral compounds
The present invention relates to amino acid esters of pyrimidine and purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment of herpes...
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5252575 |
Antiviral purine derivatives with improved gastrointestinal absorption
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R 1 is hydrogen or hydroxy; and R 2 is C 1 -6 alkyl; which are pro-drugs for...
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5250535 |
Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R 1 is hydrogen or --C(O)R 7 wherein R...
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5166140 |
Use of certain nucleoside analogs to attenuate cancer cell resistance to DNA damaging chemotherapy
A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function...
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5098906 |
Purine derivatives
Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the...
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5079252 |
Therapeutic compounds
The present invention relates to the valeryl ester of acyclovir and pharmacologically acceptable salts thereof and their use in medical therapy particularly in the treatment of viral infections....
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5077296 |
Method for treating equine navicular disease with pentoxifylline, and composition containing pentoxifylline for administrating to horses
A method of treating a horse suffering from navicular disease which involves administering an amount of a composition including pentoxifylline in a daily dose for a sufficient period of time...
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5061708 |
Therapeutic guanine esters
The present invention relates to certain amino acid esters of the purine nucleoside acyclovir, pharmaceutically acceptable salts thereof and their use in the treatment and prophylaxis of herpes...
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4963555 |
Formulations of heterocyclic compounds
A topical pharmaceutical formulation for use in treating virus infections of the skin or mucosa and containing 9-(2-hydroxyethoxymethyl) guanine or a salt or ester thereof which comprises a...
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4957924 |
Therapeutic valine esters of acyclovir and pharmaceutically acceptable salts thereof
The present invention relates to certain amino acid exters of the purine nucleoside acyclovir, pharmaceutically acceptable salts thereof and their use in the treatment of herpes virus infections....
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4942166 |
Crystalline purine compounds
A crystalline monohydrate of the compound of formula (A) or a crystalline sodium salt monohydrate of the compound of formula (A): ##STR1## having antiviral activity, processes for their preparation...
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4829055 |
Method of treatment for herpes infections of external tissues
A method of treatment is disclosed for herpes infections of external tissues and method of preventing the occurrence of blisters and ulcerations in herpes disease in humans. The method consists of...
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4798833 |
Guanine derivative
Antivirally active compounds of the formula ##STR1## wherein A is ##STR2## wherein m is 1 or 2, n is 1 or 2, whereby m is 1 when n is 2 and m is 2 when n is 1, R a ' is (CH 2 ) p OH, NHCONH...
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4755516 |
Antiviral compounds
4-(Guanin-9-yl)butanals and their 3-oxa, 3-thia, and 2-ene counterparts and derivatives thereof, wherein the aldehyde is protected, which have antiviral activity, and are useful in treating viral...
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4745119 |
Method for using purine derivatives
The novel 2-aminopurine derivatives disclosed herein which have a hydrogen atom in the 6-position and an acyclic chain ##STR1## in the 9-position [wherein X=O or S, Y=H or CH 2 OR and R=H or...
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4579849 |
N-alkylguanine acyclonucleosides as antiviral agents
Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R 1 and R 2 are independently alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or...
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4567182 |
Compounds endowed with immunomodulating activity
The invention relates to a series of purine derivatives of formula (I) ##STR1## wherein R is hydrogen or NH 2 , n is an integer from 1 to 6, R 1 is one of the following chains: ##STR2## wherein R...
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4556659 |
Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
Compounds useful as antiviral agents are defined by the following formula: ##STR1## wherein R 1 is hydrogen, --C(Y)OR 7 or --C(O)NHR 7 wherein R 7 is alkyl of one to twelve carbon atoms,...
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4548819 |
Derivatives of 9-(2-hydroxyethoxymethyl) guanine
Compounds of the general formula ##STR1## (wherein X represents an oxygen or sulphur atom, R 1 represents a hydroxy or amino group, R 2 represents a hydrogen atom or a group of formula --CH 2 OR...
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4544634 |
Method of producing acyclovir
The novel compound 6-deoxyacyclovir is enzymatically converted to acyclovir by xanthine oxidase/dehydrogenase or aldehyde oxidase in vivo, i.e. within the body of the animal being treated. The...
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4507305 |
9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.
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4495190 |
Derivatives of guanine for combating herpes virus infections
Novel antiviral compounds of the formula ##STR1## wherein each of R 1 and R 2 , which are the same or different is hydrogen, hydroxy or fluoro; provided that R 1 or R 2 is hydrogen when R 1 and...
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4199574 |
Methods and compositions for treating viral infections and guanine acyclic nucleosides
9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically...
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4060616 |
Purine derivatives with repeating unit
9-[2-(2-Hydroxyethoxy)ethoxymethyl] and related derivatives of certain 2-amino-6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their...
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