Patents in Class 514/263.38

Matches 1 - 50 out of 90

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Match	Document	Document Title
1	8168643	Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof The present invention provides compositions and methods for reversibly inhibiting S-adenosyl-L-homocysteine (SAH) hydrolase. The compounds of the present invention can be used in combination with...
2	8138172	8-oxoadenine derivatives acting as modulators of TLR7 The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as...
3	8124609	Acyclic nucleoside derivatives Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1...
4	8067413	9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators The present invention provides compounds of formula (I) wherein R1, Y1, X1, L and R2 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for...
5	8067411	Compounds The present invention provides compounds of formula wherein R1, Y1, X1, Z1, X2, Y2, A, n and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions...
6	8063051	9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7) modulators The present invention provides compounds of formula where n, R1, R2, A, X1, Y1, Z1, X2 and Y2 are as defined in the specification, processes for their preparation, pharmaceutical compositions...
7	7846937	Cyclopropanecarboxylate esters of acyclovir The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, methods of using the same, processes for preparing the same, and intermediates thereof.
8	7569574	Purine derivatives, the preparation thereof and their use as pharmaceutical compositions The invention relates to new purine derivatives of general formula wherein R1 to R4 are defined as in the claims, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts...
9	7432274	Acyclic nucleoside derivatives Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1...
10	7419967	Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
11	7388002	Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases Compounds represented by the formula: A is (CH2)nR2, —CH═CH2, CH2—CH═CH2, O(CH2)nR2, CH(OH)CH3, CH(OH)CH2OH, CH2—CH(OH)CH3, CH2CH(OH)CH2OH, or CH(OH)CH(OH)CH3,R,R1 individually is H, NH2OH, Cl...
12	7273864	Compositions and methods for inducing osteogenesis The present invention provides compositions and methods for differentiating and transdifferentiating mammalian cells into cells of an osteoblast lineage, using compounds of the following formula:...
13	7256196	Purine cytokine inhibitors The present invention relates to 2,8,9-substituted purines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian...
14	7238700	A2B adenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists of Formula I: A compound of the formula: wherein: R1 is optionally substituted alkyl or a group —Y-Z, in which Y is a covalent bond or o...
15	7229961	Compositions and methods for enhancing drug delivery across and into ocular tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions...
16	7196093	Reversible inhibitors of SAH hydrolase and uses thereof 1. The present invention provides compositions and methods for reversibly inhibiting S-adenosyl-L-homocysteine (SAH) hydrolase. The compounds of the present invention can be used as an...
17	7189730	A2A adenosine receptor antagonists Disclosed are novel A2A adenosine receptor antagonists of the formula: wherein: R1 is optionally substituted aryl or optionally substituted heteroaryl;R2 is optionally substituted lower alkyl or...
18	7045525	Use of (R)-peniciclovir triphosphate for the manufacture of a medicament for the treatment of viral diseases A method of treatment of: i) HIV-1 infections in mammals, including humans; or ii) HBV infections in mammals, including humans; which method comprises the administration to the human in need of...
19	7041305	Stable water in oil aminophylline emulsions A water in oil emulsion system and a process for preparing such a emulsion has been provided for topically applying aminophylline for reducing cellulite conditions.
20	6958344	Pyrimidine compounds and their use as modulators of chemokine receptor activity The invention provides certain heterocyclic compounds, processes, and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy; in formula (I),...
21	6855736	Molecular target of neurotoxicity The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterization and/or treatment (or management) of neuro...
22	6747016	Substituted purine derivatives as inhibitors of cell adhesion The present invention relates to compounds of formula (I), in which B, D, E, G, X, Y, Z, R1, R2 and s have the meanings indicated in the claims, their physiologically tolerable salts and their...
23	6696454	Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation This invention provides a method for the treatment of a subject in need of treatment for osteoarthritis comprising administering to said subject an amount of an inhibitor of spermidine biosynthesis...
24	6693106	Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (AGE's) Pentoxifylline, pioglitazone and metformin have been found to inhibit the nonenzymatic glycation of proteins which often results in formation of advanced glycation endproducts and crosslinks. The...
25	6683084	Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections The use of a compound of formula (A) or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing for use in the prophylactic...
26	6579981	Antiviral guanine derivatives A compound of formula (I) or a salt or acyl derivative thereof, in which X represents chlorine, C1-6 alkoxy, phenoxy, phenyl C1-6 alkoxy, NH2, —OH or —SH, is useful in treating viral infections.
27	6576636	Method of treating a liver disorder with fatty acid-antiviral agent conjugates The invention provides conjugates of fatty acids and antiviral agents useful in treating liver disorders.
28	6548486	Fatty acid esters of nucleoside analogs New compounds of the general formula (I): Nu-O-Fa, wherein O represents an oxygen, Nu is a nucleoside or nucleoside analogue, and Fa is an acyl group of a mono-unsaturated C18 or 20 fatty acid. The...
29	6512004	Promoters of neural regeneration The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent...
30	6489330	Use of penciclovir for the treatment of human herpes-virus-8 The present invention is directed to the use of a compound of Formula (A), or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the...
31	6465473	Method for treatment of reactive arthritis or bursitis An improved method for treatment of conditions in human beings associated with either or both reactive arthritis or bursitis comprising administration of a combination of L-lysine, minocycline...
32	6448227	Therapeutically effective substance mixture A substance mixture, containing S-acetyl glutathione and Aciclovir, is effective as a medication against the Herpes Simplex virus and the Varicella Zoster virus.
33	6440979	Aryl isoguanines Disclosed are compounds having formula (II): wherein: Q3, Q6a, Q6b and Q8 are independently a bond, C1-8 alkylene, C2-8 alkenylene and C2-8 alkynylene, and R3, R6a, R6b and R8 are independently...
34	6297226	Synthesis and methods of use of 9-substituted guanine derivatives The present invention is directed to 9-substituted guanine derivatives in which the guanine moiety is linked to another moiety with physiological or pharmacological activity through a carboxamide...
35	6191151	Therapy for herpes neurological viral conditions utilizing 1,4-dihydropyridine calcium channel blockers A therapy for Bells Palsy in mammals is proposed that rests on a causal hypothesis involving both endothelin and the herpes virus, particularly the herpes simplex virus for Bell's Palsy. Similarly,...
36	6136813	Pharmaceutical treatment Pharmaceutical use of a compound of formula (A): ##STR1## or a pro-drug, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing; in the treatment...
37	6136814	Aqueous acyclovir product The present invention provides a pharmaceutical product comprising an aqueous solution of acyclovir sodium contained within a sealed container constructed of an alkali resistant polymer having a...
38	6124304	Penciclovir for the treatment of zoster associated pain A method for the treatment of ZAP, in particular PHN, in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of penciclovir...
39	6107303	Treatment of Epstein Barr infection A method of treating Epstein Barr virus infection in humans by administering a pharmaceutically effective amount of an antiviral agent selected from a group consisting of acyclovir, famciclovir,...
40	6107302	Guanine derivative The invention relates to an anhydrous crystalline form of (2-[2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy]ethyl L-valinate hydrochloride (otherwise known as valaciclovir hydrochloride) and a...
41	6083953	2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propaned iol and its pharmaceutically acceptable salts are of value as antiviral agents with improved...
42	6027936	Carbon monoxide dependent guanyly cyclase modifiers and methods of use Disclosed herein are methods directed generally to the control of neural activity and for selectively and controllably inducing the in vivo genetic expression of one or more naturally occurring...
43	6017923	Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents
44	6015573	Nucleoside phosphate therapy for viral infection Compositions for topical use in herpes virus infections comprising anti-herpes nucleoside analogue phosphate esters, such as acyclovir monophosphate and acyclovir diphosphate, which show increased...
45	5994361	Substituted purinyl derivatives with immunomodulating activity The present invention comprises a compound of formula I: ##STR1## R1 of Formula I is substituted amino represented by formula NR5 R6 wherein R5 and R6 are independently selected from the group...
46	5968940	Retinoids and methods of use of same New purine retinoid compounds according to the formula: ##STR1## wherein R is a purine derivative, and pharmaceutical compositions thereof, are provided which exhibit cancer-inhibiting activity.
47	5958932	Substitutes O6 -benzylguanines, compositions, and methods of using same The present invention provides AGT inactivating compounds such as substituted O6 -benzylguanines of the formula ##STR1## wherein, for example, R1 is amino, hydroxy, or alkylamino, R2 is aminoalkyl,...
48	5922696	Ethylenic and allenic phosphonate derivatives of purines Disclosed are novel unsaturated phosphonate derivatives of certain purines or pyrimidines useful as antiviral agents, methods useful for their preparation and use of these compounds as antiviral...
49	5916893	Treatment of a latent infection of herpes virus A method for the treatment of latent infection of herpesviruses in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of a...
50	5912252	Purine and guanine derivatives as PNP inhibitors The subject invention concerns compounds of formula (I): wherein n=1 or 2; R1 is H, NH2 or halogen; R2 is H or NH2 ; R3 represents the group CR6 R7 R8 where R6, R7 and R8 are the same or different...

Matches 1 - 50 out of 90

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