|
Match
|
Document |
Document Title |
|
|
7317017 |
A2B adenosine receptor antagonists
Disclosed are novel A 2B adenosine receptor antagonists having the structure of Formula I or Formula II
The compounds are particularly useful for treating asthma, inflammatory gastrointestinal...
|
|
|
7312243 |
Materials and methods for treatment of gastrointestinal disorders
The subject invention pertains to materials and methods for the prevention and treatment of gastrointestinal diseases, including inflammatory bowel diseases such as Crohn's disease and ulcerative...
|
|
|
7312223 |
Metabolite of xanthine Phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction
The present invention is directed to a metabolite of a xanthine Phosphodiesterase type 5 inhibitor having the following structure
derivatives, and formulations thereof, and processes for...
|
|
|
7148229 |
Sulfonamide substituted xanthine derivatives
The present invention is a sulfonamide substituted xanthine derivative of formula I:
or a pharmaceutically acceptable salt thereof, wherein R1 is lower alkyl, lower alkyl substituted by phenyl,...
|
|
|
7135475 |
Amide substituted xanthine derivatives
The present invention is a 1,3,8 substituted xanthine derivative of formula I
or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 and R 3 are as defined in the specification.
...
|
|
|
7129239 |
Purine compounds and uses thereof
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein. ...
|
|
|
7115285 |
Composition and method for appetite and craving suppression and mood enhancement
A composition for suppressing appetite and cravings for substances such as nicotine, coffee, sweets or chocolate while improving energy and enhancing mood comprises theobromine or a salt thereof at...
|
|
|
7101572 |
Taste masked aqueous liquid pharmaceutical composition
A substantially taste masked liquid pharmaceutical composition containing a pharmaceutically effective amount of an unpleasant tasting drug dissolved or dispersed in an aqueous excipient base, said...
|
|
|
7098217 |
3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands
3,7-Dihydro-purine-2,6-dione derivatives of Formula (I) are provided
wherein R 1 , R 2 , R 3 and R 4 are herein defined for use as CRF receptor ligands in the treatment of disorders...
|
|
|
7097859 |
Indium supplement compositions and methods therefor
A tablet for oral administration of nutritional indium comprises about 10–50 mg indium sulfate, about 4–20 mg caffeine, about 2–10% by weight cocoa powder, and about 5–10% by weight ethyl...
|
|
|
7063865 |
Composition and method for substantially reducing the deleterious effects of alcohol on the body
A composition that will substantially reduce the deleterious effects of alcohol on the body and substantially reduce the side effects associated with hangovers (i.e. headaches, dizziness, nausea,...
|
|
|
7019010 |
Combinations
The present invention relates to a pharmaceutical composition, comprising
(a) a phosphodiesterase 5 inhibitor or a pharmaceutically acceptable salt thereof and (b) at least one of the active...
|
|
|
6979687 |
Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities
The invention pertains to theophylline (1-methyl, 3-methyl xanthine) and IBMX (1-methyl, 3-isobutyl xanthine) derivatives of formulas I and II:
where R 1 is —CH 3 or —CH 2 CH(CH 3 ) 2 ,...
|
|
|
6878715 |
Therapeutic compounds for inhibiting interleukin-12 signals and method for using same
Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations...
|
|
|
6855736 |
Molecular target of neurotoxicity
The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterization and/or treatment (or management) of neuro...
|
|
|
6815446 |
Selective antagonists of A2B adenosine receptors
A compound of the following formula: wherein R is an aliphatic or cycloaliphatic amine group or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable salt thereof. The...
|
|
|
6790841 |
2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents
Compounds which are active against viruses have the following Formulas: wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of...
|
|
|
6734187 |
Purine derivatives and medicaments comprising the same as active ingredient
Purine derivatives represented by the following formula and salts thereof: wherein R 1 represents a C 1 -C 4 alkyl group or difluoromethyl group; R 2 represents tetrahydrofuranyl group, a C 1...
|
|
|
6727259 |
Remedial agent for neural degeneration
The present invention relates to a therapeutic agent for neurodegenerative disorders, comprising a xanthine derivative represented by formula (I): or a pharmaceutically acceptable salt thereof...
|
|
|
6693106 |
Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (AGE's)
Pentoxifylline, pioglitazone and metformin have been found to inhibit the nonenzymatic glycation of proteins which often results in formation of advanced glycation endproducts and crosslinks. The...
|
|
|
6693104 |
Theobromine with an anti-carcinogenic activity
Disclosed is theobromine with an anti-carcinogenic activity which inhibits the suppression of GJIC (gap junctional intercellular communication), a pathological phenomenon occurring during...
|
|
|
6680323 |
Dihydropyrimidines and uses thereof
This invention is directed to dihydropyrimidines which are selective antagonists for human α 1a receptors. This invention is also related to uses of these compounds for relaxing lower urinary...
|
|
|
6653312 |
Amidine derivatives, their preparation and application as medicines and pharmaceutical compositions containing same
Amidine compounds of the formula wherein the substituents are defined as in the application useful as NO-synthase enzyme inhibitors.
|
|
|
6649600 |
Adenosine receptor antagonists and methods of making and using the same
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A 1 receptor. Adenosine A 1 antagonists can be usefull...
|
|
|
6642243 |
Migraine medicine and method for treating same
This invention is a safe and effective composition and method for treating acute migraine attacks using pseudoephedrine, acetaminophen, and other agents in an orally administrated form to alleviate...
|
|
|
6608069 |
Phenyl xanthine derivatives
The present invention relates to novel compounds of formula (I): wherein Z represents a 5 or 6 membered cycloalkyl, aryl, substituted cycloalkyl, or substituted aryl, said cycloalkyl, aryl,...
|
|
|
6605600 |
Adenosine receptor antagonists and methods of making and using the same
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A 1 receptor. Adenosine A 1 antagonists can be useful...
|
|
|
6555545 |
Adenosine A2A receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver
Hepatic cirrhosis and fibrosis and fatty liver can be prevented and treated by administering to a subject in need thereof an effective amount of at least one adenosine A 2A receptor antagonist or...
|
|
|
6545002 |
Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors
The present invention provides compounds having the formula I: X is (C 1 -C 8 )alkylene, (C 2 -C 8 )alkenylene, (C 2 -C 8 )alkynylene, wherein one of the carbon atoms in the alkylene, alkenylene...
|
|
|
6472425 |
Methods for treating female sexual dysfunctions
The present invention provides methods for treating female sexual dysfunctions by administering to a female individual a therapeutically effective amount of at least one compound that donates,...
|
|
|
6461591 |
Medical aerosol formulations
A pressure-liquefied propellant mixture for aerosols, comprising a fluorinated alkane, in particular 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, and carbon dioxide, makes...
|
|
|
6365593 |
Methylxanthines in the diagnosis and treatment of autistic disorder
The invention is based on the discovery that the levels of one or more methylxanthines in urine samples are significantly decreased in children diagnosed with symptoms of autistic disorder,...
|
|
|
6348470 |
Antitussive compositions
The invention relates to the use of theobromine and/or its salts and/or its complexes optionally in admixture with other known active ingredients and inert solid or liquid carriers, additives and...
|
|
|
6337325 |
Combined preparation for the therapy of immune diseases
A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca 2+ content, is suitable...
|
|
|
6316457 |
Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO n -PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such...
|
|
|
6303619 |
Meta-substituted acidic 8-phenylxanthine antagonists of A3 human adenosine receptors
The invention concerns the use of a xanthine or a xanthine derivative having a meta-substituted acidic aryl at the 8-position to specifically modulate the physiologic role of adenosine activation...
|
|
|
6268373 |
Trisubstituted thioxanthines
Disclosed is a compound selected from the group consisting of 1,3,8-triethyl-2,6-dithioxanthine; 1,3,8-triethyl-2-thioxanthine; 8-cyclopropyl-1-ethyl-3-(2-methyl-butyl)-6-thioxanthine;...
|
|
|
6258809 |
6-aryloxy and arylthiopurines
Novel compounds and pharmaceutical compositions thereof, and methods of using same in treating anxiety, depression, and other psychiatric and neurological disorders. The novel compounds provided by...
|
|
|
6248746 |
3-(arylalkyl) xanthines
With the above and other objects in view, the present invention comprises compounds having the general formula (I): ##STR1## wherein: R 1 is a C 2 -8 alkyl, C 2 -8 alkenyl, C 2 -8 alkynyl, C 3...
|
|
|
6221874 |
Method of treating bone loss by stimulation of calcitonin
Compounds of the formula ##STR1## R 1 and R 2 are independently alkyl of 1 to 6 carbon atoms, allyl, or substituted allyl of 3 to 6 carbon atoms; R 3 is hydrogen, alkyl of 1 to 6 carbon atoms,...
|
|
|
6204245 |
Treatment of narcolepsy with immunosuppressants
The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one...
|
|
|
6187780 |
Assymetrically substituted xanthine derivatives having adenosine A1 antagonistic activity
Asymmetrically substituted xanthine derivatives having adenosine A 1 antagonistic activity. These are useful as pharmaceuticals. Exemplary are: (a)...
|
|
|
6127363 |
Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
A method is provided for treating erectile dysfunction, e.g., vasculogenic erectile dysfunction such as vasculogenic impotence. The method involves the administration of a Type IV phosphodiesterase...
|
|
|
6117878 |
8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
The invention concerns the use of 8-phenylxanthines, 8-cyloalkylxanthines or 8- substituted xanthine derivatives to specifically modulate the physiologic role of the A2B adenosine receptor.
|
|
|
6110923 |
Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity
The present invention covers a method of treatment of cancer, in particular, colon carcinoma, comprising the step of administering the compound N2-(6-dimethylamino...
|
|
|
6090816 |
Aryl thioxanthines
Disclosed are compounds having the formulae: ##STR1## wherein: Q 3 ,Q 6a ,Q 6b and Q 8 are independently a bond, C 1 -8 alkylene, C 2 -8 alkenylene and C 2 -6 alkynylene, and R 3 , R 6a , R 6b...
|
|
|
6083954 |
Method of treating cystic fibrosis
The present invention provides a method of identifying CFTR-binding compounds for treating cells having a reduced apical Cl - conductance, such as cystic fibrosis cells. This identification method...
|
|
|
6060481 |
Method for improving insulin sensitivity using an adenosine receptor antagonist
Methods for improving insulin sensitivity in a patient using one or more A 2B adenosine receptor antagonists are disclosed. These methods stimulate insulin dependent glucose uptake in muscle.
|
|
|
6025362 |
Uses of xanthine compounds
Xanthine compounds are utilized to accelerate anesthetic recovery from the effects of certain compounds as propofol, etomidate, barbiturates, opioids, isoflurane, enflurane, halothane, desflurane,...
|
|
|
6025360 |
Use of theophylline for the manufacture of a medicament for the treatment of asthma
A prophylactic treatment for the inflammatory condition associated with chronic asthma is disclosed comprising administering theophyline or pharmaceutically acceptable salts thereof to provide a...
|