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7320985 |
Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an...
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7192962 |
Xanthine phosphodiesterase V inhibitor polymorphs
Crystalline polymorphs of 1-ethyl-3,7-dihydro-8-[(1R,2R) -(hydroxycyclopentyl)amino]-3-(2-hydroxyethyl)-7-[(3-bromo-4
-methoxyphenyl)methyl]-1H-Purine-2,6-dione in Form 1 and Form 2, which exhibit...
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6995164 |
Methods of treating tumors
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof....
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6624181 |
Synergistic combination
The invention relates to the combined administration of PDE inhibitors and β 2 adrenoceptor agonists for the treatment of respiratory tract disorders.
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6589941 |
Utilization of 5′ substituted nucleosides for resistance formation in cytoclastic treatment, and drug containing these nucleosides, polymers, methods of use and compositions
The invention relates to a method of producing a composition and to a composition for preventing or reducing formation of resistance in cytostatic treatment comprising combining BVDU, a salt...
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6579895 |
Use of a celecoxib composition for fast pain relief
There is provided a method of rapidly relieving pain in a mammalian, preferably human, subject. The method comprises orally administering to the subject an effective pain-relieving amount of a...
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6503950 |
Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms
A triple drug, pharmaceutical kit, composition, and method of treatment containing a combination of effective amounts of at least one anxiolytic agent, at least one centrally acting alpha...
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6479466 |
Compositions for treating viral infections, and methods therefor
Methods and combinations of an agent that promotes DNA synthesis in a virally-targeted cell and a nucleoside analogue having antiviral activity are provided for treating a viral infection in a...
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6462051 |
Composition for reducing mental fatigue, composition for maintaining and enhancing concentration, and composition for maintaining and enhancing mental vigor
The present invention is intended to provide compositions which exert excellent effects allowing improvement in the mental function of humans and animals other than humans, such as reduction of...
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6440980 |
Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
The present invention is related to antiviral compositions comprising long-chain aliphatic compounds in combination with a nucleoside analog or phosphonoformic acid, in a pharmaceutically...
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6432968 |
Combination preparation, containing cyclosporin a or FK506 or rapamycin and a xanthine derivative
Xanthines of the formula I are useful in producing a superadditive increase in immunosuppressive action when combined with immunosuppressive compounds such as CysA or FK506.
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6432966 |
Antiviral combinations
The present invention relates to therapeutic combinations comprising (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-pyr
imidin-2-one (lamivudine) and BMS-200475 which have anti-hepatitis...
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6380267 |
Composition and method for decreasing neurologic symptomatology
A method of decreasing the signs or symptomatology in a patient with a neurologic condition or disease, or in a patient due to effects of exposure to an exogenous substance, such as a...
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6284765 |
(+) naloxone and epinephrine combination therapy
A composition formulated for dose-wise delivery to a breathing passageway of a human, the composition comprising a carrier solution containing (+)naloxone and a pharmacologically effective amount...
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6204245 |
Treatment of narcolepsy with immunosuppressants
The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one...
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6166025 |
Pharmaceutical compositions containing eletriptran hemisulphate and caffeine
The present invention provides an aqueous pharmaceutical composition comprising 5 to 200 mg/ml of eletriptan hemisulfate and from 0.5 to 2.0% weight/volume of caffeine.
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6159953 |
Anti-malarial composition and method of use
Anti-malarial compositions for prophylactic or therapeutic treatment of vertebrates exposed to malaria parasites are disclosed. These compositions comprise one or more pyrimidine analogue...
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6140324 |
Use of a tachykinin antagonist and a muscarinic antagonist and/or an antihistamine to treat motion sickness
The present invention relates to the use of a tachykinin antagonist and a muscarinic antagonist and/or an antihistamine for the treatment or prevention of motion sickness. There is also provided...
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6110955 |
Metabolically stabilized oxyalkylene esters and uses thereof
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
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6093389 |
Methods and compositions for attracting and controlling termites
The present invention provides a composition for attracting termites containing a steroid derivative of formula I ##STR1## The present invention also provides a method for attracting or controlling...
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6037347 |
Combination preparation for use in dementia
The invention relates to a composition which is a pharmaceutical combination preparation comprising a compound which has an acetylcholinesterase-inhibitory action or exhibits muscarinergic action...
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5990103 |
Combination preparation for use in immunological diseases
A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca 2 + content, is suitable...
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5981536 |
Use of xanthine derivatives for the modulation of apoptosis
Compounds of the formula I ##STR1## where one of the radicals R 1 and R 3 is a radical of the formula II --(CH 2 ) n --A--CH 3 (II) in which A is a covalent bond,--C(O)-- or --C(R 4 )(OH)--,...
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5900416 |
Aqueous caffeine dosage forms
Aqueous caffeine solutions containing a co-solubilizing agent selected from niacinamide, nicotinic acid and mixtures thereof present at a level up to the maximum concentration soluble in water and...
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5869479 |
Treatment of upper airway allergic responses
Relief from the symptoms of rhinitis is obtained by treatment with: (a) an antihistaminic effective amount of a histamine H 1 receptor antagonist; together with (b) a sufficient amount of a...
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5856330 |
Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
Compounds of the formula I ##STR1## where one of the radicals R 1 and R 3 is a radical of the formula II --(CH 2 ) n --A--CH 3 (II) in which A is a covalent bond, --C(O)-- or --C(R 4 )(OH)--,...
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5811423 |
Benzoxazinones as inhibitors of HIV reverse transcriptase
Certain benzoxazinones are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS,...
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5795897 |
Oxohexyl methylxanthine compounds
There is disclosed a pharmaceutical composition comprising 1-(5-oxohexyl)-3-methylxanthine in admixture with a pharmaceutically acceptable excipient, wherein the pharmaceutical composition is...
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5731304 |
Potentiation of temozolomide in human tumour cells
The toxicity of temozolomide, an anti-tumour agent useful in the treatment of various mammalian neoplasms, can be potentiated by the prior administration of an ATase inhibiting agent, i.e., O 6 ...
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5726180 |
Stabilized solid pharmaceutical preparation and method of producing the same
To stabilize the active ingredients, a caffeine is incorporated into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanolamine. The pharmaceutical preparation may...
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5691338 |
1,2-dithiole-3 thiones for the treatment of reverse transcriptase-dependent viral infections
This invention provides a method of inhibiting the replication of a reverse transcriptase-dependent virus in cells which comprises contacting infected cells with an effective amount of a...
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5663175 |
Prodrugs of herpes TK inhibitors
Certain prodrugs such as ##STR1## are useful in the inhibition of herpes virus thymidine kinase, the prevention or treatment of recurrent infection by herpes virus, either as compounds,...
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5648358 |
Compositions and methods for treating respiratory disorders
The present invention relates to compositions and methods for providing improved treatment, management or mitigation of cold, cold-like, allergy, sinus and/or flu symptoms by administering a safe...
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5627161 |
Method for treating tumors with UDPG
UDPG shows tumor-specific inhibition of PRPP and this suggests that this action might prove to be useful in combination therapy with inhibitors of purine and pyrimidine nucleotide synthesis in...
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5618819 |
1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds
The invention relates to a compound selected from those of formula (I): ##STR1## wherein R 1 , W and Y are as defined in the description, its geometric and/or optical useful as anti-algies.
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5616578 |
Method of treating human immunodeficiency virus infection using a cyclic protease inhibitor in combination with a reverse transcriptase inhibitor
This invention relates to a method of treating human immunodeficiency virus (HIV) infection in a mammal comprising administering to the mammal a therapeutically effective amount of a combination...
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5605892 |
Compositions of arginine amide with cyclodextrin of caffeine, and methods of use
An aqueous agent comprising at least one arginine amide selected from the group consisting of (2R,4R)-4-methyl-1-[N 2 -((RS)-3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-ar
ginyl]-2-piper...
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5585380 |
Modulation of cellular response to external stimuli
The specification discloses methods for modulating cellular metabolism in a subject, modulating being desirable to mitigate a condition of the subject. Disclosed methods include processes for...
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5543405 |
Composition and method for weight reduction and long term management of obesity
A weight reduction composition comprises a sympathomimetic agent and a mineral cation salt or chelate capable of enhancing carbohydrate metabolism, protein or fatty acid synthesis, retarding...
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5502056 |
Caffeine containing composition
A composition containing caffeine solubilized with para-amino benzoic acid is described. Preferably the caffeine is delivered in the form of an aqueous microdispersion including a non-metallic...
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5434170 |
Method for treating neurocognitive disorders
A method for treating a central nervous system or peripheral nervous system cholinergic deficit state in a mammalian organism in need of such treatment, said method comprising administering to said...
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5405850 |
Antiviral compositions consisting of acyclovir and a 2-acetyl pyridine derivative
The present invention relates to a novel ribonucleotide reductase inhibitor and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide...
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5350753 |
Pharmaceutical combination preparations containing cephalosporin and xanthine derivatives and their use
Pharmaceutical combination preparations containing cefotaxime and at least one xanthine derivative are suitable for the treatment of bacterial infectious diseases and for the treatment of septic...
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5288721 |
Substituted epoxyalkyl xanthines
Compounds of the formula ##STR1## including the resolved enantiomers and/or diastereomers and mixtures thereof wherein each of one or two R is independently ##STR2## wherein n is 1-16 and R' is H...
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5250529 |
Method alleviating migraine headache with mast cell degranulation blocking agents
A method of preventing or alleviating a migraine headache which comprises administering a pharmaceutically effective amount of a mast cell degranulation blocking agent just prior to or during the...
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5248678 |
Methods for increasing arousal and alertness and for the amelioration of comatose states
A method of treating comatose patients or near-comatose patients to increase their arousal and alertness as measured by the Glascow Coma Score by administering effective amounts of an adenosine...
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5229390 |
Physiologically active dietetic composition
An edible composition comprising an amino acid capable of accelerating a release of glucagon, known as an adipokinetic hormone, a xanthine derivative capable of degrading body fats, and a thiamine...
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5219858 |
Method and compositions for effecting withdrawal from drug dependency
Methods and compositions are provided for treating drug-dependent individuals so as to effect withdrawal from the drug of abuse, e.g., natural and synthetic narcotics, or stimulant-type drugs such...
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5190753 |
3-phenyl-5,6-dihydrobenziciacridine-7-carboxylic acids and related compounds as immunosuppressive agents
Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune...
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5176912 |
Method of treating psoriasis
A method of treating psoriasis which includes subcutaneously injecting into the tissue of a person a dose of cc of a mixture composed of 0.1 milligrams histamine phosphate, 9.25 milligrams...
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