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7608601 4′-Substituted nucleoside derivatives as inhibitors of HCV RNA replication  
The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula...
7589075 Use of an adenosine A3 receptor agonist for inhibition of viral replication  
The present invention concerns the use of an active ingredient selected from the group consisting of agonists of the adenosine receptor system, for inhibiting viral replication in cells. In...
7572800 Combination therapy to treat hepatitis B virus  
The present invention is directed to a method for treating hepatitis B virus infection in humans comprising administering a synergistically effective amount of agents having known anti-hepatitis B...
7569574 Purine derivatives, the preparation thereof and their use as pharmaceutical compositions  
The invention relates to new purine derivatives of general formula wherein R 1 to R 4 are defined as in the claims, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and...
7498334 Pyrrolopyrimidines as phosphodiesterase VII inhibitors  
Pyrrolopyrimidine derivatives of the formula I in which R 3 , R 4 , R 5 , R 6 and X are as defined in claim 1 , act as phosphodiesterase VII inhibitors and can be employed for the treatment...
7495004 Purine derivatives as liver X receptor agonists  
The invention relates to methods for the treatment or prevention of an LXR mediated disease or condition, including cardiovascular disease and atherosclerosis, novel compounds of formula (I) for...
7256196 Purine cytokine inhibitors  
The present invention relates to 2,8,9-substituted purines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian...
7253154 Substituted thiazolopyrimidines as xanthine oxidase inhibitors  
The invention relates to compounds of the following formula (I) or their salts: in which R 1 represents OR 4 or others, in which R 4 is an alkyl group having 1-8 carbon atoms which may have...
7253175 Method for treating athlete's foot  
A method of treating a patient having a fungal infection comprises administering an effective fungal infection treatment amount of an antiviral agent, such as valacyclovir, to eliminate the...
7115614 Method of treating brain ischemia  
The present invention relates to a method of treating brain ischemia in which a xanthine derivative represented by formula (I): or a pharmaceutically acceptable salt thereof, as an active...
RE39112 Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes  
The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonist action. A purine...
7005430 Fused purine derivatives  
A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R 1 N—C═O or N═C—W, R 2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl...
6998404 Treatment or prevention of acute renal failure  
Adenosine receptor antagonists, especially aminophyllline, are used to treat or prevent acute renal failure. In the preferred embodiment, aminophylline is administered by infusion so that it does...
6962921 Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient  
Medicines for treatment or prevention of dementia comprising 2-aryl-8-oxodihydropurine derivatives of the formula (I): wherein W is H, C 1-6 alkyl, halogen, C 1-6 alkoxy, or the like; X is...
6936618 Cystic fibrosis medicaments  
The use of a type V cyclic nucleotide phosphodiesterase inhibitor for the preparation of a medicament for the treatment of cystic fibrosis.
6894045 Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands  
Compounds provided herein are novel substituted tetrahydropurinones of Formula (I): wherein R 3 is aryl substituted with 0-5 X Ar or heteroaryl substituted with 0-4 X hAr . Such compounds...
6790841 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents  
Compounds which are active against viruses have the following Formulas: wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of...
6770645 Pharmaceutically active compounds  
Compound of general formula I: wherein R 1 , R 2 , R 3 , R 4 , X, Y and R 5 have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for...
6747016 Substituted purine derivatives as inhibitors of cell adhesion  
The present invention relates to compounds of formula (I), in which B, D, E, G, X, Y, Z, R 1 , R 2 and s have the meanings indicated in the claims, their physiologically tolerable salts and their...
6734187 Purine derivatives and medicaments comprising the same as active ingredient  
Purine derivatives represented by the following formula and salts thereof: wherein R 1 represents a C 1 -C 4 alkyl group or difluoromethyl group; R 2 represents tetrahydrofuranyl group, a C 1...
6730677 Benzofurazan compounds which enhance AMPA receptor activity  
Compounds of general structural formula ( 1 ) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors...
6693105 Hydroxyl-containing compounds  
Disclosed are therapeutic compounds having the formula: (R) j —(CORE MOIETY), including resolved enantiomers, diastereomers, hydrates, salts, solvates or mixtures thereof where j is an integer...
6630478 Methods for treatment of drug-induced peripheral neuropathy  
A method of treating drug-induced peripheral neuropathy comprising administering to a patient with drug-induced peripheral neuropathy an effective quantity of...
6630490 Methods for treatment of disease-induced peripheral neuropathy and related conditions  
A method of treating disease-induced peripheral neuropathy comprises administering to a patient with disease-induced peripheral neuropathy an effective quantity of a purine derivative or analogue,...
6548490 Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction  
A method is provided for treating erectile dysfunction in a mammalian male individual. The method involves the transmucosal administration of a phosphodiesterase inhibitor or a pharmaceutically...
6514980 Nucleoside analogs in combination therapy of herpes simplex infections  
A pharmaceutical product comprising a nucleoside analogue active against herpes simplex virus, such as acyclovir/valaciclovir or penciclorivir/famciclovir, and an immunosuppressant, as a combined...
6486166 Suppression of cyclin kinase 2 activity for prevention and treatment of DNA viral infections  
An important aspect of the present invention is a method for inhibiting proliferation of a DNA virus dependent upon events associated with cell proliferation for replication. The DNA virus includes...
6476037 L-arginine and phosphodiesterase (PDE) inhibitor synergism  
This invention pertains to the discovery that L-arginine and type V phosphodiesterases act synergistically to inhibit vasospasm and/or to induce vasodilation. Methods are provided using...
6440981 Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones  
A method for inhibiting the growth of neoplastic cells by exposure to 2,9-disubstituted purin-6-ones.
6432967 Enema and enterically-coated oral dosage forms of azathioprine  
This invention relates to enema and enterically-coated dosage forms having an amount of azathioprine effective to prevent colorectal adenomas without dose-limiting systemic toxicity.
6372740 2-aryl-8-oxodihydropurine derivative, process for the producing the same, medicinal compositions containing the same, and intermediates thereof  
2-Aryl-8-oxodihydropurine derivative of the following formula (I): wherein W is H, lower alkyl, halogen, lower alkoxy, amino, mono- or di-lower alkylamino, or substituted or unsubstituted...
RE37650 Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase  
This invention relates to the treatment of intimation in a patient suffering from such disorder. More specifically, the invention relates to mono- and/or bicyclic aryl or heteroaryl quinazoline...
6333331 Substituted O6-benzylguanines  
The present invention provides AGT inactivating compounds such as substituted O 6 -benzylguanines of the formula ##STR1## 7- or 9-substituted 8-aza-O 6 -benzylguanines, 7,8-disubstituted O 6 ...
6310070 Purine derivatives and medicinal use thereof  
A novel purine derivative exhibiting an effect to control inflammatory symptoms characteristic to nephritis and a medicine comprising this compound as an effective ingredient are provided. The...
6288069 Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue  
The present invention comprises a method of stimulating regeneration or survival of a mammalian motor neuron or of a mammalian sensory neuron comprising administering to a mammal an effective...
6268373 Trisubstituted thioxanthines  
Disclosed is a compound selected from the group consisting of 1,3,8-triethyl-2,6-dithioxanthine; 1,3,8-triethyl-2-thioxanthine; 8-cyclopropyl-1-ethyl-3-(2-methyl-butyl)-6-thioxanthine;...
6258809 6-aryloxy and arylthiopurines  
Novel compounds and pharmaceutical compositions thereof, and methods of using same in treating anxiety, depression, and other psychiatric and neurological disorders. The novel compounds provided by...
RE37234 Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses  
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO n -PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such...
6110923 Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity  
The present invention covers a method of treatment of cancer, in particular, colon carcinoma, comprising the step of administering the compound N2-(6-dimethylamino...
6103729 Cathecol derivatives and a method for the preparation thereof and a pharmaceutical composition containing the same  
A phosphodiesterase IV inhibiting cathecol derivatives of the general formula I: ##STR1## or a pharmaceutically acceptable salt thereof in which R1 is C 1 -7 alkyl; C 3 -7 cycloalkane; phenyl...
5958932 Substitutes O.sup.6 -benzylguanines, compositions, and methods of using same  
The present invention provides AGT inactivating compounds such as substituted O 6 -benzylguanines of the formula ##STR1## wherein, for example, R 1 is amino, hydroxy, or alkylamino, R 2 is...
5912252 Purine and guanine derivatives as PNP inhibitors  
The subject invention concerns compounds of formula (I): wherein n=1 or 2; R 1 is H, NH 2 or halogen; R 2 is H or NH 2 ; R 3 represents the group CR 6 R 7 R 8 where R 6 , R 7 ...
5905081 Topical formulations of azathioprine to treat inflammatory bowel disorders  
A method is provided to treat inflammatory bowel disease by topically administering to the colon an effective amount of azathioprine or a pharmaceutically acceptable salt thereof, preferably via...
5866571 9-substituted 2-(2-n-alkoxyphenyl)-purin-6-ones  
9-Substituted 2-(2-n-alkoxyphenyl)purin-6-ones are prepared by cyclizing correspondingly substituted imidazoles and derivatizing the purines thus obtained. The 9-substituted 2 ...
5863921 Purine and guanine derivatives  
Compounds of formula (I) ##STR1## wherein n=1 or 2; R 1 is H, NH 2 or halogen; R 2 is H or NH 2 ; R 3 represents the group ##STR2## where m=0 or 1; R 4 and R 5 are the same or...
5861404 2,9-disubstituted purin-6-ones  
2,9-Disubstituted purin-6-ones are prepared by acylating correspondingly substituted aminoimidazoles in a first step and then cyclizing the product to the purine. The new 2,9-disubstituted...
5773424 Treatment of toxoplasmosis  
Pharmaceutical compositions comprising a pharmaceutical composition comprising a compound which is an α or β anomer, a D(+) or L(-) enantiomer of the following structural formula: ##STR1##...
5736549 Hypoxanthine and guanine compounds  
Compounds of formula I ##STR1## where n=0-2; R 1 is H, NH 2 or a halogen; R 2 is H or NH 2 ; R 3 is any of the four groups ##STR2## where m=0 or 1; and X is O, NR 5 , or S(O) 0 -2...
5733915 Use of azathioprine to treat crohn's disease  
A therapeutic method for the treatment of Crohn's disease is provided, comprising administering to a patient in need of said treatment an intravenous dose of azathioprine or a pharmaceutically...
5733916 Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists  
Methods of preventing or treating ischemia-reperfusion injury in an organ by administration of a composition containing a selective A 1 adenosine receptor antagonist and/or a P 2X purinoceptor...
Matches 1 - 50 out of 80 1 2 >