Patents in Class 514/263.2

Matches 1 - 50 out of 210

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Match	Document	Document Title
1	8163761	Methods and compositions for treating disorders Compounds and compositions for treating disorders related to TRPA1 are described herein.
2	8163762	Purine derivatives having, in particular, anti-proliferative properties, and their biological uses This invention provides 2-, 6, and 9-substituted purine derivatives, particularly 2(1-R hydroxymethylpropylamino)-6-benzylamino-9-isopropyl purine, having, in particular, antiproliferative...
3	8163754	Purine derivatives for use as adenosine A-2A receptor agonists Compounds of formula I in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine...
4	8153640	HIV inhibiting bicyclic pyrimdine derivatives HIV replication inhibitors of formula N-oxides, pharmaceutically acceptable addition salts, quaternary amines or stereoisomeric forms thereof, wherein-a1=a2-a3=a4- is —CH═CH—CH═CH—, —N═CH—CH═...
5	8153628	Pyrazolyl substituted xanthines The present invention provides compounds and pharmaceutical compositions that are substituted xanthines of formula I: or pharmaceutically acceptable salts thereof, wherein: Z is selected from the...
6	8143249	Prodrugs of A2B adenosine receptor antagonists Disclosed are prodrugs of A2B adenosine receptor antagonists of the formula: wherein R1 and R2 are independently lower alkyl; R4 is optionally substituted phenyl; X is hydrogen or methyl; and Y is...
7	8143264	Xanthine derivatives as selective HM74A agonists The present invention relates to a xanthine compound derivative which is 3-butyl-8-chloro-1-(3-{5-[(4-fluorophenyl)methyl]-2H-tetrazo l-2-yl}propyl)-3,7-dihydro-1H-purine-2,6-dione: a...
8	8138172	8-oxoadenine derivatives acting as modulators of TLR7 The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as...
9	8114877	Organic compounds Compounds of formula I in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine...
10	8071565	Purine derivatives as a2a agonists Compounds of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein W, R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating...
11	8071609	Unsaturated heterocyclic derivatives This invention relates to compounds of the general formula: in which Q is an ethynyl or ethenyl moiety; Ring A is an aryl, heteroaryl or heterocyclic ring or ring system; and the remaining variable...
12	8067413	9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators The present invention provides compounds of formula (I) wherein R1, Y1, X1, L and R2 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for...
13	8067411	Compounds The present invention provides compounds of formula wherein R1, Y1, X1, Z1, X2, Y2, A, n and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions...
14	8063051	9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7) modulators The present invention provides compounds of formula where n, R1, R2, A, X1, Y1, Z1, X2 and Y2 are as defined in the specification, processes for their preparation, pharmaceutical compositions...
15	8058281	Use of adenine-derived compounds for the treatment of lupus The present invention is directed to a method of treating systemic lupus erythematosus comprising administering a compound of formula (I) whereinR1 is selected from the group consisting of CF3, a...
16	8044056	Adenine compound A novel adenine compound represented by the formula (1): [wherein R1 is substituted or unsubstituted alkyl, etc., X is oxygen, etc., A1 is 4- to 8-membered substituted or unsubstituted saturated...
17	8044061	8-alkynylxanthines and derivatives Disclosed are novel compounds of the general formula (Ia), and pharmaceutically acceptable salts, isomers, diastereomers or enantiomers thereof and their use as medicines, for example in the...
18	8026244	Thioxanthine derivatives and their use as inhibitors of MPO There are disclosed novel compounds of Formula (I) wherein L, R1, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their...
19	7989459	Purinones and 1H-imidazopyridinones as PKC-theta inhibitors A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKCθ. inhibitors, and their methods of use are disclosed. The genus is represented by the formula I: whereinR1 is ...
20	7968544	Modulators of toll-like receptor 7 The present application includes a compound of Formula I or II: or a pharmaceutically acceptable-salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods...
21	7968556	Heteroaryl compounds, compositions thereof, and methods of treatment therewith Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl...
22	7919490	6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection....
23	7915268	8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression The present invention provides novel purines useful for the prevention and treatment of autoimmune diseases, inflammatory diseases, mast cell mediated disease and transplant rejection. The...
24	7902187	6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection....
25	7888343	Substituted, bicyclic 8-pyrrolidinoxanthines, and methods for their use as inhibitors of dipeptidyl peptidase The present invention involves substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: wherein the various R groups are defined herein. The present invention also comprises...
26	7884109	Purine and imidazopyridine derivatives for immunosuppression The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and...
27	7879864	Substituted 8-aminoalkoxy-xanthine compounds and compositions useful in the treatment of hyperlipidemia and diabetes Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed which are inhibitors of the enzyme dipeptidyl peptidase IV...
28	7837998	Anti-cancer activity of an anti-thymidine kinase monoclonal antibody Monoclonal antibodies to thymidine kinase 1 are disclosed which are useful in methods of detecting, diagnosing, and treating cancer.
29	7838528	Substituted bicyclic 8-pyrrolidinoxanthines, methods for their production, pharmaceutical formulations and their use Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed and comprise novel substituted bicyclic...
30	7795269	A2B adenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal...
31	7795268	Method of treating hepatic disease using A2B adenosine receptor antagonists The invention is related to methods of treating hepatic fibrosis using A2B adenosine receptor antagonists and utility in the treatment of liver damage caused by alcohol abuse, surgical...
32	7790730	Imidazo[4,5-d]pyrimidines, their uses and methods of preparation The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one compound having the general formula...
33	7781432	Analogs of nitrobenzylthioinosine Analogs or derivatives of nitrobenzylthioinosine corresponding to formula I: in which R represents an unsubstituted or mono- or polysubstituted phenyl, benzyl or heteroaryl group or a phenyl group...
34	7772226	Condensed imidazole derivatives The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein,T1 represents a 4- to 12-membered heterocyclic group containing one or two...
35	7767685	Adenosine A2B receptor antagonists The present invention provides compounds of the formula which are adenosine A2B receptor antagonists and, thus, may be employed for the treatment of conditions and diseases mediated by the...
36	7767670	Substituted 3-carboxamido isoxazoles as kinase modulators The invention provides methods and compositions for treating conditions mediated by various kinases wherein substituted 3-carboxamido isoxazoles compounds are employed. The invention also provides...
37	7763625	Agents for treating migraine A method for treating migraine comprising administering, as an active ingredient, a xanthine derivative represented by the following formula or a pharmaceutically acceptable salt thereof.
38	7759355	Adenosine A2A receptor antagonists for treating restless legs syndrome or nocturnal myoclonus The present invention provides methods of treating restless legs syndrome or related disorders, comprising administering an effective amount of at least one adenosine A2A receptor antagonist to a...
39	7754728	Adenine compound and use thereof A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an adenine compound represented by the...
40	7741331	A2B adenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal...
41	7732455	Substituted 8-heteroaryl xanthines Selective antagonists of A2B adenosine receptors like those of formula I are provided. These compounds and compositions are useful as pharmaceutical agents.
42	7723340	Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and...
43	7662827	Pyrazole derivatives having tyrosine kinase inhibitory activity Compounds of the formula (I), in which R, X, R1, R2, R3 and R4 have the meanings indicated in Claim (1), are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be...
44	7659278	Use of low molecular weight compounds for preparing a medicament useful in treating mutant p53 mediated diseases The present invention provides novel compounds, corresponding to formulae I and II, respectively, which are able to reactivate the apoptosis-inducing function of mutant p53 proteins. This...
45	7642267	Benzimidazole and pyridylimidazole derivatives This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I. The invention is particularly related to such...
46	7625881	Prodrugs of A2B adenosine receptor antagonists Disclosed are prodrugs of A2B adenosine receptor antagonists, having the following structure and their use in treating mammals for various disease states.
47	7618962	Pyrazolyl substituted xanthines The present invention provides compounds and pharmaceutical compositions that are substituted pyridyl-linked-xanthines of formula I which are selective antagonists of A2B adenosine receptors (ARs)....
48	7601713	Kinase inhibitors and their uses The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein...
49	7579348	Derivatives of 8-substituted xanthines The present invention provides compounds and pharmaceutical compositions that are substituted pyridyl-linked-xantbines of formula I which are selective antagonists of A2B adenosine receptors (ARs)....
50	7572800	Combination therapy to treat hepatitis B virus The present invention is directed to a method for treating hepatitis B virus infection in humans comprising administering a synergistically effective amount of agents having known anti-hepatitis B...

Matches 1 - 50 out of 210

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