Patents in Class 514/262.100

Matches 1 - 50 out of 207

1 2 3 4 5 >

Match	Document	Document Title
1	7384952	Pyrazolopyrimidine compound and a process for preparing the same The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic...
2	7378409	Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
3	7371750	Compounds and compositions as protein kinase inhibitors The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated...
4	7345048	Heterocyclic compounds and uses thereof as D-alanyl-D-alanine ligase inhibitors The invention relates to D-Ala-D-Ala ligase inhibitors having the formula: wherein R 1 is NH 2 ; R 2 is NH 2 ; R 3 is selected from hydrogen, alkyl, amino, hydroxy, alkoxy, and alkylamino;...
5	7332498	Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically...
6	7332497	Pyrazolopyrimidines as therapeutic agents The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R a , R 2 , and R 3 are defined as described herein.
7	7323471	Topical azathioprine for the treatment of oral autoimmune diseases A method for treating or preventing symptoms associated with oral autoimmune diseases comprises treating a patient with an oral topical formulation of azathioprine or a pharmaceutically acceptable...
8	7285558	Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections Compounds having the general formula and pharmaceutical compositions containing them, and their use in the treatment or prophylaxis of H. pylori infection.
9	7276491	Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
10	7268133	Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein
11	7268128	1,3,5-trisubstituted-5-phenyl and 5-pyridyl pyrazolopyrimidinone derivatives having PDE7 inhibiting action Pyrazolopyrimidinone derivatives expressed by the following general formula (IA) or (IB): where the symbols are as disclosed in the specification, are provided as desired compounds. These...
12	7262200	Indazolinone compositions useful as kinase inhibitors The present invention provides compounds of formula I: These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as...
13	7262192	Substituted pyrazolo[4,3-d]pyrimidines and their use as PDE-5 inhibitors The present invention comprises a class of 5,7-diaminopyrazolo[4,3-d]pyrimidine compounds. These compounds are useful as phosphodiesterase type 5 inhibitors. The present invention further comprises...
14	7259157	N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
15	7235551	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases Novel substituted pyrimidol[4,5-d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
16	7223387	Antiviral formulations comprising propylene glycol and an isopropyl alkanoic acid ester A topical composition comprising an antiinflammatory glucocorticoid and a nucleoside analogue antiviral agent in a pharmaceutical carrier characterized in that the carrier comprises about 15 to...
17	7173039	Protein kinase inhibitors Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand...
18	7157449	Medicament for the treatment of diseases caused by parasitic protozoa The present invention relates to the use of an inhibitor of CTP synthetase, such as a glutamine analogue, and a substance capable of suppressing toxic effects thereof in vivo, in the manufacture of...
19	7148228	Pyrazolopyrimidines and related analogs as HSP90-inhibitors A compound represented by Formula I, or a polymorph, ester, tautomer, enantiomer, pharmaceutically acceptable salt or prodrug thereof: wherein: R 1 is halogen, —OR 1 , —SR 11 or...
20	7135493	HDAC inhibitor A compound having the following formula (I): wherein R 1 is N-containing heterocyclic ring optionally substituted with one or more suitable substituent(s), R 2 is hydroxyamino, R 3 is...
21	7132426	Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the...
22	7115658	Inhibitors of hepatitis C virus RNA-dependent RNA polymerase Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
23	7091209	Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatized at...
24	7078408	[1,2,4]-Triazole bicyclic adenosine A2a receptor antagonists Compounds having the structural formula I wherein: n is 0, 1, 2 or 3; A is C(R 1 ) or N; R 1 and R 1a are H, (C 1 –C 6 )-alkyl, halo, CN or —CF 3 ; X is —C(O)—, —O—, —SO...
25	7074797	Pyrazolopyrimidines as CRF receptor antagonists This invention concerns compounds of formula including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein R 1 is NR 4 R 5 or OR 5 ; R 2 is C 1-6...
26	7064119	Fused bicyclic pyrimidine derivatives A novel fused bicyclic pyrimidine derivative or a salt thereof that acts as a tachykinin receptor antagonist and, in particular, as an NK1 receptor antagonist is represented by the following...
27	7053073	Treatment for reactive arthritis or bursitis A treatment for conditions in human beings associated with either or both reactive arthritis or bursitis comprising a combination of valacyclovir hydrochloride, minocycline hydrochloride, and...
28	7041666	Adenosine A2a receptor antagonists Disclosed are compounds having the structural formula or pharmaceutically acceptable salts or solvates thereof, wherein R is optionally substituted heteroaryl, optionally substituted...
29	7030129	Method of reducing and treating UVB-induced immunosuppression Methods of preventing and/or treating UV-induced immunosuppression by administration of immune response modifier compounds are disclosed herein. Suitable immune response modifier compounds include...
30	7022709	Selective PDE 2 inhibitors as pharmaceuticals for improving perception The invention relates to the use of selective phosphodiesterase 2 (PDE 2) inhibitors for producing pharmaceuticals for improving perception, concentration, learning and/or memory.
31	RE39056	4-Azasteroids for treatment of hyperandrogenic conditions Compounds of structural Formula (I) and pharmacologically acceptable salts and esters thereof possess 5α-reductase inhibitory activity. These compounds inhibit 5α-reductase type 1 and type...
32	6989386	Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same In one embodiment, the present invention relates to a new class of ammonium salts of N δ -acyl derivatives of N α -(4-amino-4-deoxypteroyl)-L-ornithine compounds having a structure according to...
33	6967204	Treatment of insulin resistance syndrome and type 2 diabetes with PDE9 inhibitors This invention is directed to a method of treating insulin resistance syndrome (IRS), hypertension and/or type 2 diabetes in a mammal comprising administering to said mammal a cGMP PDE9 inhibitor...
34	6964957	Fused pyrazole compounds, pharmaceutical compositions, and methods for modulating or inhibiting ERAB or HADH2 activity Pyrazole compounds represented by the formula: are described. The pyrazole compounds and pharmaceutical compositions containing them may be used in inhibiting ERAB or HADH2 activity and in...
35	6962915	Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts or prodrugs thereof, are useful as kinase inhibitors, wherein Y is —C(═O)NR 1 —, —NR 1 C(═O)—, —NR 1...
36	6960592	1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one compound for the treatment of impotence The present invention relates to new 1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one compounds of formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, useful for treatment of...
37	6939884	Pharmaceutical agents containing acyclovir, fusaric acid and derivatives thereof Compositions are provided, which comprise at least one nucleoside analogue inhibitor, pharmaceutically acceptable salts, solvates, or prodrugs thereof and fusaric acid, derivatives, or...
38	6930113	Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase...
39	6903096	Quinazoline derivatives as medicaments The invention is directed to methods to inhibit TGF-β and/or p38-α kinase using compounds of the formula or the pharmaceutically acceptable salts thereof wherein R 3 is a...
40	6894054	Heterocyclic inhibitors of glycine transporter 2 Compounds, compositions, and methods for inhibiting the glycine transporter 2 and for inhibiting glycine transporter mediated neuronal activity. These compounds are particularly useful for...
41	6894041	Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
42	6894021	Method for identifying and using A2B adenosine receptor antagonists to mediate mammalian cell proliferation This invention concerns methods for identifying A 2B adenosine receptor agonists and antagonists as well as methods for using A 2B adenosine receptor antagonists to treat cell proliferation...
43	6875772	[1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists Compounds having the structural formula I wherein: n is 0, 1, 2 or 3; A is C(R 1 ) or N; R 1 and R 1a are H, (C 1 -C 6 )-alkyl, halo, CN or —CF 3 ; X is —C(O)—, —O—, —SO...
44	6875745	Method and composition for the treatment of cancer We have discovered that the administration of a G1 and/or S phase drug such as β-lapachone in combination with a G2/M drug such as a taxane derivative such as paclitaxel resulted in a greater than...
45	6869945	Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
46	6867208	Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I A—B—D—E—F—G (I)
47	6864254	Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
48	6858616	Nitrogen containing heterobicycles as factor Xa inhibitors The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
49	6815434	Methods for treating hearing loss In one aspect, the present invention provides otoprotectant compositions useful for ameliorating hearing loss. In some embodiments, the otoprotective compositions comprise at least one glutathione...
50	6784174	Pyridine and pyrimidine derivatives and their use as inhibitors of cytokine mediated disease This invention concerns a bicyclic compound of Formula (I), wherein: G is N, CH or C(CN); ring X is a 5- or 6-membered fused heteroaryl ring which contains 1, 2, or 3 heteroatoms selected from...

Matches 1 - 50 out of 207

1 2 3 4 5 >