Matches 201 - 241 out of 241 < 1 2 3 4 5
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4886807 Novel pyrimidopyrimidine derivative, process for producing it and pharmaceutical composition  
Pyrimidopyrimidine derivatives having the general formula ##STR1## wherein R 1 is an alkyl group; R 2 is an alkyl or phenyl group; R 3 is a hydrogen atom, an alkyl or lower alkylamino...
4879274 External medication for skin  
Novel external medications comprise, as essential components, the following three components (A) to (C): (A) an α-monoglyceryl ether represented by the following formula (I): ##STR1## wherein R...
4866066 Thiomethylpyridine derivatives and their use for eliciting a bronchosecretolytic or mucolytic response  
Thiomethylpyridine derivatives having bronchosecretolytic and mucolytic activity according to the formula: ##STR1## wherein R is a group attached in the 2-, 3- or 4-position of the pyridine ring...
4824848 Pyrazolo[3,4-d]pyrimidine derivatives, their production and use  
Novel pyrazolo[3,4-d]pyrimidine derivatives represented by the general formula (I) ##STR1## wherein R 1 is an aryl or heteroaryl group which may be substituted by one to three members selected...
4751224 Treatment of metastasis  
A method for reducing the incidence of metastasis in tumor victims without treating the primary tumor per se resides in the administration of forskolin or its analogs which are potent inhibitors of...
4746663 Pyrazolo[4,3-d]pyrimidine derivative, process for its production, and antihyperlipidemic or antiatherosclerotic agent containing it  
A pyrazolo[4,3-d]pyrimidine derivative having the formula: ##STR1## wherein R 1 is lower alkyl or phenyl which is unsubstituted or substituted by lower alkyl, lower alkoxy or halogen; R 2 is a...
4722941 Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof  
A readily absorbable pharmaceutical composition of pharmacologically active agents, which per se are poorly absorbable, is disclosed which comprises a pharmacologically effective amount of at least...
4714698 8-alkylthio-2-piperazino-pyrimido[5,4-d]-pyrimidines  
The invention relates to new compounds of general formula ##STR1## wherein R 1 represents an alkyl group, R 2 represents a hydrogen atom, an alkyl group optionally substituted (except at the...
4694006 Acyl- or acyloxymethyl-allopurinol prodrugs  
Compounds of the formula Ia and Ib ##STR1## are prodrugs of allopurinol and have i.a. a much higher solubility in water and/or a higher lipophilicity than allopurinol, which makes such compounds...
4666908 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use  
The present invention relates to novel 5-substituted pyrazolo[4,3-d]pyrimidine-7-one compounds, and compositions, methods of use and processes to make therefor. The novel compounds are useful in...
4665088 (E-Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxides  
This invention relates to compounds of the structures: ##STR1## which structure includes its isomers, conventionally designated (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide and commonly termed...
4663326 Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one analogs  
Various novel analogs of pyrazolo[4,3d]pyrimidine-5,7-(4H,6H)diones and also 5-thione-7-ones, novel methods of synthesis therefor, compositions and uses are the present invention. For example, the...
4643994 Novel organic trithio oxides and method for the preparation thereof  
This invention relates to novel organic trithio oxides of the formula: R 1 --X --R--X 1 --R 1 wherein R is selected from --CH 2 CHCH--, ##STR1## and (CH 2 ) 3 ; X is selected from ##STR2##...
4608383 Cardioactive pyrazole and imidazole aryloxypropanolamines  
The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 , which may be the same or different, are hydrogen or halogen atoms or lower...
4568676 Method of inhibiting aggregation using thromboxane synthetase inhibitor in combination with a cyclic AMP phosphodiesterase inhibitor  
A novel method of inhibiting blood platelet aggregation is disclosed which comprises the use of a CAMP inhibitor together with an inhibitor of thromboxane synthesis. While inhibitors of thromboxane...
4511557 Pharmaceutical composition  
Compositions for increasing oxygen supply in tissue of warm-blooded animals comprising at least one vasoactive compound selected from the group consisting of (a) calcium...
4499093 Interferon induction method  
Interferon is produced in vivo or in vitro by administration of dipyridamole as interferon inducer to cellular material. Interferon may be induced in warm blooded animals by administration of...
4460590 Diglycidyl substituted heterocyclic compounds  
Diclycidyl substituted heterocyclic compounds of the formula: ##STR1## wherein X and Y can be the same or different and are either nitrogen or the radical C-R, where R is a hydrogen, or a...
4438128 Cardioactive aryloxypropanolamines  
The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 , which may be the same or different, are hydrogen or halogen atoms or lower...
4427648 Dipyridamole-containing pharmaceutical form  
This invention relates to vehicles for the administration of dipyridamole. More specifically, this invention relates to a method of treating cardiovascular disorders in a host in need of such...
4426384 Treatment of rheumatoid arthritis and related diseases  
It is believed that rheumatoid arthritis and related collagen and auto-immune diseases are an infection and that various species of free-living (limax) amoebae are the aetiological agent of these...
4425346 Pharmaceutical compositions  
The present invention relates to pharmaceutical compositions adapted for topical administration to the eye and to their preparation and use. More specifically this invention relates to...
4393063 Treatment for gastric lesions  
Pharmaceutical combinations comprising (a) prostacyclin, dihydroprostacyclin or a pharmaceutically acceptable salt of either of these, and (b) a phosphodiesterase inhibitor. Pharmaceutical...
4388318 Method of treating endotoxin shock with a pyrimido-pyrimidine derivative  
The method of treating endotoxin shock with 2,2'-[(4,8-bis(diethylamino)-pyrimido[5,4-d]pyrimidine-2,6-d iyl)di-(2-meth oxyethyl)imino]diethanol or a non-toxic, pharmacologically acceptable acid...
4337254 Pharmaceutical compositions  
Pharmaceutical combinations comprising (a) prostacyclin, dihydroprostacyclin or a pharmaceutically acceptable salt of either of these, and (b) a phosphodiesterase inhibitor. Pharmaceutical...
4329346 Pharmaceutical compositions containing 2,6-bis-(diethanolamino)-4-piperidino-pyrimido[5,4-d]pyrimidine  
This invention is directed to a pharmaceutical composition for inhibiting the growth of L-1210 leukemia cells which comprises as active ingredient...
4285945 Antithrombotic pharmaceutical compositions and method of use  
Antithrombotic pharmaceutical compositions containing, as a combination of active ingredients, 2,6-bis-(diethanolamino)-4-piperidino-pyrimido[5,4-d]pyrimid ine and sulfinpyrazone, and a method of...
4248872 Method for the treatment of anxiety  
A method for the treatment of anxiety which consists of administering dipyridamole or imidazole or a derivative thereof. It has been found that known anti-anxiety agents appear to act as...
4206214 Antithrombotic pharmaceutical compositions containing dipyridamole and sulfinpyrazone  
Pharmaceutical dosage unit compositions containing, as a combination of active ingredients, dipyridamole and sulfinpyrazone, and a method of using the same as antithrombotics.
4147789 6-Methyl-8-thiomethyl-ergolene derivatives  
This invention provides new compounds of formula I, ##STR1## wherein X Y IS THE GROUP ##STR2## and R is hydrogen, cyano, a 5- or 6-membered unsaturated heterocyclic radical attached through a ring...
4100286 2-(Substituted heterocyclic amine)benzoic acids  
Heterocyclic compounds of the formula: ##STR1## WHEREIN ONE OF Y and Z is CH, the other being N, A is a straight or branched saturated hydrocarbon chain from C 2 to C 6 inclusive, X is chlorine,...
4044130 Compositions for the control of microorganisms  
Compounds of the class of substituted or unsubstituted 4-amino-3-(5-nitro-2-furyl)-1H-pyrazolo[3,4-d]pyrimidine and their 5-N oxides have antimicrobial properties and are active ingredients in...
4038394 Substituted pyrimido-[4,5-d]-pyrimidine compounds useful for repelling insects, rodents or animals from substrates  
Pest repellency afforded by the presence of an effective amount of 2,7-dioxo (or dithio) decahydropyrimido-[4,5-d]-pyrimidines; compositions and treatments therewith; and pest repellent structures.
4004013 2,4,6,8-Tetra-methyl-2,4,6,8-tetraazabicyclo-[3.3.0]-octanedi-3,7-one in treating psychic disorders  
A pharmaceutical composition for use in psychic disorders, containing, as active ingredient, 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo-[3.3.0]-octanedi -3,7-one, is described.
3626064 TREATMENT OF HYPERURICEMA WITH 4-AMINO-6-HYDROXY-1-H-PYRAZOLO(3,4-D)PYRIMIDINE  
The method of treatment and prophylaxis for hyperuricemia, which comprises administering to a mammal a therapeutically effective amount of a compound 4-amino-6-hydroxy-1-H-pyrazolo(3,4-d)pyrimidine.
3624205 TREATMENT OF HYPERURICEMIA IN HUMANS  
The method of treatment and prophylaxis for hyperuricemia, which comprises administering to a human patient a therapeutically effective amount of a compound selected from the class consisting of...
3544683 ACTIVE-CHLORINE-CONTAINING COMPOUND  
3497307 METHOD OF PREVENTING OXIDATION OF 6-SUBSTITUTED PURINES WITH 4-HYDROXY-1H-PYRAZOLO(3,4-D)PYRIMIDINE AND 4,6 - DIHYDROXY-1H-PYRAZOLO(3,4-D)PYRIMIDINE  
3300380 Diminishing toxicity of antiviral nu6-(hydroxyalkyl) adenines with 4-hydroxypyrazolo(3, 4-d) pyrimidine  
3019075 Methods of bleaching with haloglycoluril compositions  
3821382 Title is not available  
Matches 201 - 241 out of 241 < 1 2 3 4 5