Matches 151 - 200 out of 241 < 1 2 3 4 5 >
Match Document Document Title
5977102 Pyrimido [5, 4-d] pyrimidines, pharmaceuticals containing these compounds, their use and processes for their preparation  
Pyrimido[5,4-d]pyrimidines of the general formula ##STR1## which have an inhibitory effect on signal transduction mediated by tyrosine kinases, their use for the treatment of oncoses, and their...
5958929 6-aryl pyrazolo 3,4-d! pyrimidin-4-ones and compositions and methods of use thereof  
6-Aryl pyrazolo 3,4-d!pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or...
5925644 Substituted nitrogen heterocycles, processes for their preparation and their use as pesticides  
Compounds of the formula I ##STR1## in which A is CH and D is N + R, A is nitrogen and D is N + R or A is N + R and D is nitrogen, R is --CR 4 R 5 --E--R 6 , Q n - is an inorganic or organic...
5889012 Substituted cycloalkylamino and cycloalkoxy heterocycles, processes for preparing them and their use as pesticides  
Substituted cycloalkylamino and cycloalkoxy heterocycles, processes for preparing them and their use as pesticides The invention relates to (I) ##STR1## in which R 1 to R 5 , A, X, E, U, p and n...
5859009 Substituted spiroalkylamino and alkoxy heterocycles, processes for their preparation, and their use as pesticides and fungicides  
Substituted spiroalkylamino and -alkoxy heterocycles, processes for their preparation, and their use as pesticides and fungicides The invention relates to compounds of the formula ##STR1## in which...
5821240 Pyrimido 5,4!-dipyrimidines, pharmaceuticals containing them, their use and processes for the preparation thereof  
Pyrimido 5,4-d!pyrimidines of the general formula ##STR1## which have an inhibitory effect on signal transduction mediated by tyrosine kinases, their use for the treatment of disorders, in...
5780450 Use of adenosine uptake inhibitors for treating retinal or optic nerve head damage  
Compositions and methods directed to the use of adenosine uptake inhibitors for the treatment of retinal and optic nerve head damage following acute or chronic glaucoma, edema, ischemia, hypoxia or...
5760028 Integrin receptor antagonists  
This invention relates to novel heterocycles including 3- 1- 3-(imidazolin-2-ylamino)propyl!indazol-5-ylcarbonylamino!-2- (benzylo xycarbonylamino)propionic acid, which are useful as antagonists of...
5756502 Quinazolinone derivatives as cholyecystokinin (CCK) ligands  
Novel quinazolinone derivatives with good binding affinity for the CCK-A and CCK-B receptors, pharmaceutical compositions containing them, methods of using them and a novel process for their...
5747495 Method for treating hypertension using pyrazolopyrimidine derivatives  
Antihypertensive agents containing as its active ingredient the 4-amino-6-hydroxypyrazolo 3,4-d!pyrimidine(AHPP) or its derivatives represented by the general formula (I) below. ##STR1## where R...
5707989 Pyrimido 5,4-D!pyrimidines, medicaments comprising these compounds, their use and processes for their preparation  
The present invention relates to pyrimido 5,4-d!pyrimidines of the general formula ##STR1## in which R a to R c are as defined herein, their tautomers, their stereoisomers and their salts, in...
5679650 Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine  
A purine compound, which has a desired and an undesired effect when a dosage sufficient to induce the desired effect is administered to a mammal, is combined with a counteracting agent, wherein the...
5648314 Slow-dissolving multi-functional sanitizer and clarifier  
A slow-dissolving sanitizing and clarifying puck for use in water such as swimming pool water preferably includes about 63% to about 80% trichloro-s-triazinetrione, about 4% to about 12% sodium...
5631258 Method of effecting immunosuppression by administering carbocyclic adenosine analogs  
This invention relates to methods of effecting immunosuppression and inhibiting tumor necrosis factor α in a patient in need thereof comprising administering to said patient an effective...
5629298 Adenosine as a positive inotrop in the compromised heart  
Disclosed are methods of increasing the contractile performance of a compromised myocardium in a mammal. The methods include administering a therapeutically affective amount of an adenosine A 2 ...
5614528 Compositions and methods for inhibiting the formation of chloramines and trihalomethanes in aqueous media  
Compositions and methods are disclosed for sanitizing aqueous media, which combine a chlorine-source composition and a glycoluril-source composition. The compositions are added together or...
5593997 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors  
Certain 4-aminopyrazolo[3,4-d]pyrimidine compounds, and their pharmaceutically-acceptable salts and prodrugs, are inhibitors of tyrosine kinase enzymes and are useful for immunoregulation and for...
5543433 Azine-substituted phenylacetic acid derivatives and fungicides containing these  
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
5541187 6-heterocycyclyl pyrazolo[3,4-d]pyrimidin-4-ones and compositions and method of use thereof  
Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclyl-carboxaldehyde or by...
5508045 Method and agents for control and management of labor during pregnancy  
A method for control, management and inhibition of a preterm labor by providing to a pregnant woman a donor of nitric oxide. Management and inhibition of preterm labor is achieved by administering...
5508277 Bicyclic pyrimidines  
Novel bicyclic pyrimidine compounds for use as drugs and having formula (I). Said novel compounds and physiologically tolerable salts thereof may be used in therapeutics, particularly for...
5498613 Dipyridamole and analogs thereof in preventing adhesion formation  
Compositions and methods for prevention of adhesion formation, whereby an effective amount of at least one compound selected from dipyridamole and analogs thereof is administered as active agent...
5478830 Fused-ring heterocycles for the treatment of atherosclerosis  
This invention relates to pyrazolo pyrimidines for the treatment of atherosclerosis as inhibitors of acyl--CoA, cholesterol acyetransferase (ACAT), and their use as antihypercholesterolemic agents,...
RE35072 4-substituted pyrazolo[3,4-d]pyrimidine derivatives  
4-Substituted pyrazolo[3,4-d]pyrimidine derivatives and a method of synthesis for the derivatives are described. The 4-substituted pyrazolopyrimidine derivatives are useful as cardiotonic agents...
5438060 Method of reducing elevated intraocular pressure  
A method of reducing elevated intraocular pressure which comprises administering the compound of the formula (1): ##STR1## or a pharmaceutically acceptable salt thereof to patients suffering from...
5426107 Pyrazolopyrimidinone antianginal agents  
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof are selective cGMP PDE inhibitors which are useful in the treatment of such diseases and adverse conditions as...
5371098 Use of oxazole compounds to treat osteoporosis  
An oxazole compound having the formula (I): ##STR1## in which A is a group of the formula --CH 2 OR 2 (wherein R 2 is a hydrogen atom, an optionally substituted hydrocarbon residue, an...
5350749 Pteridine derivatives  
4-substituted-pyrido[3,2-d]pyridmidine, -pyrido[4,3-d]pyrimidine, -pyrido[3,4-d]pyrimidine, pyrido[2,3-d]pyrimidine, -pteridine, -pyrimido[4,5-d]pyrimidine, -pyrimido[4,5-c]pyridazine,...
5338740 Angiotensin II receptor antagonists  
The present invention relates to novel heterocyclic derivatives of the formula Ar--W--Het wherein Ar, W and Het are as defined below, and related compounds, pharmaceutical compositions comprising...
5326764 Method for the treatment of hyperproliferative disorders  
The present invention provides new methods for the treatment of hyperproliferative disorders of skin epidermal cells, particularly psoriasis, by administering 5-fluorouracil and dipyridamole, with...
5294612 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof  
Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclylcarboxaldehyde or by...
5272151 Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharmaceutical formulations containing these substances  
The present invention concerns aminoacyl and oligopeptidyl derivatives of allopurinol (1,5-dihydro-4H-pyrazolo-[3,4-d]-pyrimidin-4-one) of general formula (I), and related salts with ##STR1##...
5242921 Compositions and methods for treating cutaneous hyperproliferative disorders  
The present invention provides new methods for the treatment of hyperproliferative disorders of skin epidermal cells, particularly psoriasis, by administering methotrexate and dipyridamole, with...
5202328 Substituted fused pyrimidinones  
Novel substituted fused pyrimidinones of formula (I), which are useful as angiotensin II antagonists, are disclosed. ##STR1##
5151426 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties  
Methods and compositions for preventing or treating human immunodeficiency virus (HIV) infections characterized by 2-substituted-5-substituted-1,3-oxathiolanes.
5093116 Method of treating viral infection utilizing inteferon α and pipyridamole  
A method of enhancing the antiviral activity of IFN-α and especially human IFN-α is disclosed which comprises administration of Dipyridamole or a pharmaceutically acceptable salt thereof to a...
5084482 Methods for inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response with methionine compounds  
This invention concerns novel methods employing compositions containing as an active antioxidant or antiinflammatory agent the amino acid methionine, and/or one or more related compounds including...
5075310 Pyrimidone derivatives as bronchodilators  
This invention relates to fused pyrimidine derivatives which have bronchodilator activity. A compound of this invention is 2-(2-propoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one.
5075290 Use of adenosine, adenosine analogs or nucleoside uptake blockers, e.g. dipyridamole, as drug treatments for obstructive sleep apnea and snoring  
Infusion of adenosine, adenoside analogs and nucleoside uptake blockers, e.g. dipyridamole, will decrease the number of apneas and associated oxyhemoglobin desaturation during sleep in patients...
5034393 Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives  
Fungicidal compositions contain as active ingredient a 4-substituted-pyrido[3,2-d]pyrimidine, -pyrido[4,3-d]pyrimidine, -pyrido[3,4-d]pyrimidine, pyrido[2,3-d]pyrimidine, -pteridine,...
5010064 Inclusion complexes of dipyridamole with cyclodextrins  
Inclusion complexes of dipyridamole with beta cyclodextrins in the molar ratio of dipyridamole to cyclodextrin ranging from 1:1 to 1:12 provides higher and more consistent blood concentrations than...
4981855 Medicament for psoriasis  
Disclosed is a method of using medicaments for psoriasis containing 3-aminopyrazolo[3,4-d]pyrimidine compounds or their derivatives such as their salts and their glucuronides, which potently...
4980379 Use of adenosine antagonists in the treatment of bradyarrhythmias and hemodynamic depression associated with cardiopulmonary resucitation and/or cardiovascular collapse  
A method to enhance the efficacy of cardioversion, defibrillation, cardiac pacing, and cardiopulmonary resuscitation and to treat post-resuscitation asystole, bradyarrhythmias, electromechanical...
4978668 Treatment to reduce ischemic tissue injury  
Intravenous administration of allopurinol, oxypurinol or deferoxamine to a patient suffering a condition of tissue ischemia is effective to reduce damage to affected tissues. The invention has...
4963541 Pyrimido-pyrimidine lipoxygenase inhibiting compounds  
Compounds of the formula: ##STR1## wherein A is selected from NR 1 R 2 and N(OR 6 )R 2 ; and B and C are chloro when A is N(OR 6 )R 2 or are independently selected from NHR 3 and NR 4 R 5 ...
4950648 Analgesic  
New analgesic compositions containing a compound of the formula I ##STR1## wherein A--B is CH--CH or --N--CR 2 , Alk is an alkylene group having 2-4 C atoms, R 1 is H,...
4950466 Reduction of the severity of 3'-azido-3'-deoxythymidine-induced anemia using a combination of benzylacyclouridine and dipyridamole  
The invention is directed to a method of inhibiting anemia caused by the administration of AZT to a patient which comprises administering to said patient an effective anemia-inhibiting amount of a...
4918075 Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents  
Antiviral activity is exhibited by compounds having the formula ##STR1## its pharmaceutically acceptable salts thereof wherein R 2 and R 3 are independently hydrogen, --PO 3 H 2 or ##STR2## and...
4904666 Pyrazolo(3,4-d)pyrimidine compounds, compositions and method of use  
The present invention provides pyrazolo[3,4-d]-pyrimidines of the general formula: ##STR1## wherein R 1 is a C 1 to C 6 -alkyl radical, a C 2 to C 6 -alkenyl radical, a C 3 to C 7 ...
4897394 Antiviral combinations  
This invention relates to synergistic combinations of nucleoside analogues, which are converted to viral DNA polymerase inhibitors through the action of at least one virus-induced enzyme, and...
Matches 151 - 200 out of 241 < 1 2 3 4 5 >