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9029334 Pharmaceutical composition for prevention or treatment of bone diseases comprising spinasterol glucoside derivative  
Disclosed is a pharmaceutical composition for the prevention or treatment of metabolic bone diseases, comprising a spinasterol glucoside derivative, or an optical isomer, a pharmaceutically...
9029414 Triterpenoid compounds and methods of use thereof  
The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain,...
9018175 3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives  
The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
8987217 Modified saponins for the treatment of fungal infections  
Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
8962574 Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy  
A method for preventing stroke in a patient suffering from atrial fibrillation, wherein the patient has at least one risk factor for major bleeding events, the method comprising administering to...
8921320 Targeted osmotic lysis of cancer cells  
A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gated sodium channels (VGSCs) has been developed that uses a combined therapy of a drug that blocks sodium,...
8906867 Production method of solid preparation and the solid preparations produced by the method  
The production method prepares a solid preparation by dissolving water-insoluble and/or water indissolvable alkaline active pharmaceutical ingredient in an acidifier-containing acid solution to...
8901169 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have...
8900589 Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds  
The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic...
8846626 Drug composition for treating chronic liver disease and its application  
A drug composition for treating chronic liver diseases, consists of: Astragalus Astragalosides and Glycyrrhiza Acid by weight ratio of 3˜6:1. By testing and validating with classic animal model,...
8841262 Agent for inhibiting peritoneal membrane thickening  
The present invention is directed to an agent for inhibiting peritoneal membrane thickening which enables inhibition/prevention or treatment of the peritoneal membrane thickening and which...
8828953 Chemosensory receptor ligand-based therapies  
Provided herein are methods for treating diabetes, obesity, and other metabolic diseases, disorders or conditions comprising chemosensory receptor ligands. Also provided herein are chemosensory...
8791079 Methods for treating heart failure by inhibiting the mitochondrial sodium-calcium exchanger (mNCE)  
Methods and compounds for preventing or reducing the toxic side effects of cardiac glycosides by inhibiting the mitochondrial sodium-calcium exchanger (mNCE) are provided. Methods and compositions...
8765695 Use of ginsenoside RG1, its metabolites ginsenoside RH1 and/or PPT  
The present invention relates to use of an active ingredient selected from ginsenoside Rg1, its metabolites ginsenoside Rh1 and Ppt for preparing a medicament and a health care product for...
8765696 Steroid compound  
A steroid compound of the Formula (1): [wherein R1 represents a group selected from the group consisting of H, CH3, C2H5, C3H7 and CH (CH3)2, R2 represents a group selected from NH2, NHAc and...
8758822 Method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs  
The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size...
8759304 Compositions and methods for increasing telomerase activity  
The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations....
8722634 Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity  
The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation...
8703723 Glycoside compounds and pharmaceutical compositions thereof  
The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative...
8697660 Compounds and compositions for treating infection  
Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.
8658605 Bioactivity composition of Reevesia formosana  
A series cardenolide derivatives including structure of formula I from the root of Reevesia formosana have provided. In formula (1) and (2), where R3, R5, R10 and R16 are as defined in the...
8642568 Method of diagnosing and therapeutically treating a patient for a traumatic brain injury  
Known or suspected traumatic brain injuries may be treated therapeutically by administering a therapeutically effective dose of resibufogenin. A preferred method for determining if a patient has a...
8642567 Receptor modulators exhibiting neuroprotective and memory enhancing activities  
The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in treating central nervous system disorders by...
8637474 Receptor modulators exhibiting neuroprotective and memory enhancing activities  
The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in treating central nervous system disorders by...
8614196 Treatment and/or prevention of inflammation and cutaneous photodamage and photoprotection of the skin with a water-soluble extract from plant of Solanum genus  
The present invention relates to a pharmaceutical composition for preventing and treating inflammation and cutaneous photodamage, which contains a water-soluble extract from a plant of Solanum...
8586536 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds...
8569248 Cardiac glycosides to treat cystic fibrosis and other IL-8 dependent disorders  
A method of inhibiting the secretion of IL-8 and other pro-inflammatory cytokines from cells secreting elevated levels of these compounds is provided. The method includes contacting the cell with...
8569376 Methods and compositions for reducing body fat and adipocytes  
Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I) and/or (V): or a pharmaceutically acceptable...
8551961 Localized delivery of cardiac inotropic agents  
The present invention provides novel methods for the localized delivery of inotropic agents to the heart, including specific regions of the heart, such as the ventricles, for example in a subject...
8541381 Process for producing enriched fractions containing up to 100% of bacopasaponins from the plant materials of bacopa species  
This invention describes a process for producing a fraction enriched with jujubogenin and psudojujubogenin lycosides from Bacopa species, wherein the total Bacopa saponin concentration is up to...
8541382 Cardiac glycoside analogs in combination with emodin for cancer therapy  
A method and medicine for treating leukemia or other cancer includes administering to a patient diagnosed with leukemia or other cancer a treatment regimen that includes periodic doses of a...
8513203 Composition and method thereof  
The present disclosure relates to a composition comprising Trigoneoside Ib and Vicenin-1 for treatment and management of Goodpasture's disease, Glomerulonephritis, Rheumatoid Arthritis, Systemic...
8497249 Fungicidal properties of three saponins from Capsicum frutescens  
CAY-1 is a fungicidal saponin from the cayenne pepper (Capsicum frutescens) fruit. The saponins 1081 and 919, closely elute with, and are close structural relatives of, CAY-1. Saponin 1081 is...
8486899 Antioxidant  
To provide an antioxidant which is highly safe, inhibits oxidation of a biological component, in particular, a lipid, and is used as a drug, food or drink, a food additive, an external preparation...
8486900 Method for preparing a Centella asiatica extract rich in madecassoside and in terminoloside  
The invention concerns an extract of Centella asiatica comprising more than 75 wt. % of a mixture of madecassoside, terminoloside and asiaticoside, relative to the extract total weight, an extract...
8466140 Mitochondria-targeted anti-tumor agents  
Described are mitochondria-targeted anti-tumor agents, and methods of making and using the same for the treatment of disorders associated with unwanted cell proliferation.
8455252 Materials and methods for sensitizing multidrug resistant cells  
Disclosed herein are materials and methods for sensitizing multidrug resistant cancer cells that express ABCG2 and related proteins members of a family of ATP-binding transporter superfamily that...
8440632 Protopanaxadiol-type ginsenoside compositions and uses thereof  
Provided herein are ginsenoside compositions comprising at least 10% (w/w) of a protopanaxadiol type of ginsenoside suitable for administration to a subject. Also provided are methods using the...
8426471 Methods and compositions for reducing body fat and adipocytes  
Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I): or a pharmaceutically acceptable salt, hydrate,...
8377894 Drug and food or drink for improving pancreatic functions  
Compounds having a cyclolanostane skeleton such as 9,19-cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol are used as an active ingredient of a drug and food or drink for improving...
8361973 Glycoside compounds and pharmaceutical compositions thereof  
The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative...
8236769 Agent for improving insulin resistance  
To inhibit production of adipocytokines, in particular, adipocytokines that elicit insulin resistance and to prevent onset of pathosis caused by the insulin resistance, or improve the pathosis,...
8173607 Promoter for the production of hyaluronic acid containing ginsenoside compound K  
There are provided a promoter containing ginsenoside compound K for the production of hyaluronic acid, and more particularly, a new efficacy of 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol...
8168596 Use of cycloartane compounds for treating arthritis  
A method of treating a disease associated with cartilage defect in a subject in need thereof by administering to the subject an effectively amount of a cycloartane compound of Formula (I).
8163706 Method for preparing a centella asiatica extract rich in madecassoside and in terminoloside  
The invention concerns an extract of Centella asiatica comprising more than 75 wt. % of a mixture of madecassoside, terminoloside and asiaticoside, relative to the extract total weight, an extract...
8148336 Sterol glucoside toxins  
The invention relates to the identification of sterol glucoside toxins, and provides methods for detecting and detoxifying the compounds, as well as therapeutic methods for treating subjects...
8088744 Cholestanol derivative for combined use  
The invention provides a cancer chemotherapeutic agent which has fewer side effects and excellent efficacy. The cancer chemotherapeutic agent of the invention includes a cholestanol derivative...
8080539 Method of treating human preeclampsia employing resibufagenin  
A method of treating preeclampsia including administering a therapeutically effective dose of resibufagenin to a patient having preeclampsia. Effecting the determination of the presence of...
8048868 Method of preventing preeclampsia  
A method of preventing preeclampsia including administering to a patient during an early stage of pregnancy a prophylactically-effective amount of resibufogenin. The administration of...
8022044 Compositions and methods for therapeutic use  
A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I:...

Matches 1 - 50 out of 328 1 2 3 4 5 6 7 >