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5096892 |
Arylsulfatase inhibition and potentiation of angiostatic steroids and heparin
Anigiogenesis is controlled by administering to a mammal an effective amount of an inhibitor of arylsulfatase. Preferably, the arylsulfatase inhibitor is administered in a pharmaceutically...
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5089482 |
Pharmaceutical compositions for nasal administration containing steroid hormones and dimethyl-β-cyclodextrin
Pharmaceutical compositions having a formulation and form suitable for nasal administration, and containing 17β-estradiol and/or progesterone. According to the invention, the composition also...
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5071839 |
Safe pharmaceutical composition for decreasing side effects of antiviral drugs and increasing the immune function (SDI) II
The new safe pharmaceutical composition (SDI II) and processes are provided for decreasing side effects of antiviral drugs and increasing the immune function. The pharmaceutical composition is...
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5062959 |
Process for the enrichment and/or isolation of heart glycosides with the use of non-polar absorber resins
Enrichment and purification of heart glycosides from mixtures of mother liquors is achieved by absorption on non-polar, large-pored resins from aqueous solution with possible addition of solvents...
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5057540 |
Saponin adjuvant
Substantially pure saponins are disclosed. The saponins of the present invention are useful as immune adjuvants. Disclosed as well are immune response-provoking compositions comprising an antigen...
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5053394 |
Targeted forms of methyltrithio antitumor agents
This disclosure describes a method for constructing carrier-drug conjugates from the family of methyltrithio antibacterial and antitumor agents.
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5034381 |
2-(substituted amino) adenosines as antihypertensives
Disclosed are 2-substituted adenosine derivatives of the formula ##STR1## in which R represents a substituted amino grouping of the formula ##STR2## as defined herein; pharmaceutically acceptable...
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5028438 |
Biologically active agent having anti-hypertensive activity in mammals
A biologically active agent extracted from female breast cyst fluids displays anti-hypertensive activity in mammals. The agent is also useful in the treatment of congestive heart disease, atrial...
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5023239 |
Sialosyl cholesterol, process for producing the same, and neuropathy remedy comprising the same
The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be...
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5021404 |
Angiostatic collagen modulators
Angiostatic compounds are potentiated by collagen matrix metabolism modulators including: a) proline analogs which inhibit proline hydroxylation when substituted for proline in collagen; b)...
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5017562 |
Crystalline saponin-containing complex
A composition of matter is provided comprising a crystalline saponin-containing complex, wherein said crystalline complex is derived from a steroidal-saponin-containing plant material. Said...
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4999341 |
Appetite moderating and anti-gastritis composition
The association of chitin or chitosan with soy saponins in an orally administered composition has appetite moderating and antigastritis activity. The objectionable side effects of the two active...
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4980344 |
Compositions for improving circulatory performance
Compositions having a compound from the family of protoberberines, especially coreximine, are used in conjunction with a cardiac glycoside. The composition and therapeutic method of administering...
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4959355 |
Method of inhibiting osmotic water flow
This invention provides a method of inhibiting osmotic water flow across mammalian cell membranes which involves contacting the water channels of the cell membranes with an effective amount of a...
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4937232 |
Inhibition of protein kinase C by long-chain bases
Compositions for inhibiting protein kinase C, comprising an inhibitory amount of a compound having the formula: ##STR1## wherein Q is a hydrophobic group; wherein X is --CH 2 --CH 2 -- or...
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4929603 |
Use of phytosteryl glycosides for the treatment of epoxycholesterol levels
The invention relates to the use of phytosteryl glycoside or their esters for the treatment of conditions caused by increased endogenous epoxycholesterol levels in human organs and organ fluids...
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4920099 |
Aminoglycoside steroids, a process for their preparation, their use and pharmaceutical compositions containing them
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4895836 |
Nor-cholanic acid derivatives, a process for their preparation, their use and pharmaceutical compositions containing them
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4885280 |
Novel 14-amino steroids
The invention relates to androstane-17-carboxylic acid esters, represented by general formula (I): ##STR1## wherein R 1 represents a lower alkyl group containing 1 to 4 carbon atoms, a lower alkyl...
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4879376 |
Triterpene saponins having anti-inflammatory, mucolytic and antiedemic activities, process for the preparation thereof and pharmaceutical compositions containing them
Triterpene saponins of formula ##STR1## wherein R 1 is H or OH and R 2 is a tetrasaccharide, or alternatly pentasaccharide, chain have antiinflammatory, mucolytic and antiedemic activities. Said...
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4877774 |
Administration of steroid hormones
Crystalline complexes of steroid hormones with gamma-cyclodextrin are prepared by mixing the components together. Tablets can be formed from the complexes, which can be administered by contact with...
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4859709 |
Pharmaceutical composition
A pharmaceutical composition comprising a freely flowable powder, the powder comprising a porous, high absorption silica or silicate having absorbed therein at least 10% by volume of a liquid,...
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4814324 |
Sterol inhibitors of testosterone 5α-reductase
The compounds of Formula I are produced by the aerobic fermentation of a fungus of the genus GLIOCLADIUM, ATCC No. 20826. ##STR1## The compounds of Formula I are inhibitors of testosterone...
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4795742 |
Therapeutic composition from plant extracts
Therapeutic compositions are composed of four plant extracts: ginsenoside, tetramethyl pyrazine, astragalan and atractylol. Pharmaceutical dosage units are prepared by conventional means with...
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4794106 |
Cream
An oil-in-water type cream comprising (a) 0.01 to 0.5% by weight of hydrocortisone butyrate proponate, (b) 5 to 50% by weight of a higher paraffinic hydrocarbon, (c) 3 to 15% by weight of...
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4794107 |
Ointment
An oily ointment comprising (a) 0.01 to 0.5% by weight of hydrocortisone butyrate propionate, (b) 2 to 10% by weight of a mixture of propylene glycol and purified water in a weight ratio of...
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4788180 |
Pharmaceutical compositions
A pharmaceutical composition comprises magnesium oxide, hydroxide or a non-toxic salt of magnesium in a slow-release carrier; this material may be combined with or co-prescribed with a diuretic or...
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4764601 |
Composition for assaying cardiac glycosides from serum or plasma
A fluorescent compound is made from the reaction of naphthoyl chloride and a cardiac glycoside derived from serum or plasma. The method of carrying out the reaction provides a product which allows...
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4755504 |
Pharmaceutical composition from Tienchi
A pharmaceutical composition containing saponin and quercetin, derived from Tienchi, is effective in treatment of circulatory disease and as health food. Processes for producing these components...
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4751219 |
Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides
Synthetic glycolipides having the general formula lipidyl-O-R wherein the lipidyl moiety is selected from the group consisting of 5-cholestene-3β-yl, ceramidyl, phosphatidylethanolamine and...
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4722837 |
Medicated shampoo composition
A medicated shampoo composition for treating scalp disorders comprising a safe and effective combination of pharmacologically active ingredients is disclosed. The active ingredients comprise...
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4707469 |
Gangliosides mixture, useful as a therapeutical tool for eliminating painful effects or peripheral neuropathies
A ganglioside mixture, comprised of the gangliosides GM 1 , GD 1a , GD 1b and GT 1b , has been found to possess significant analgesic or pain relieving activity. The mixture is, therefore, useful...
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4687761 |
Pharmaceutical composition for increasing immunity and decreasing side effects of anticancer chemotherapy
A new pharmaceutical composition for treatment and prevention of side effects of anticancer chemotherapy and radiotherapy and increasing the immune function contains Ferulic acid, Ginsenoside,...
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4684628 |
Pharmaceutical composition containing pure San-Mai-Sen
A new pharmaceutical composition for treatment and prevention of cardiovascular disease, and increasing immune function contains Ginsenoside, Ophiopogonin, Sesquicarene and Chamigrene. Processes...
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4663311 |
Derivatives of muramyl-peptides and of steroids having macrophage-activating properties
The invention relates to compounds resulting from a covalent conjugation of the muramyl-peptide and the steroid particularly with membranal tropism, such as cholesterol, a precursor of its...
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4652553 |
Steroidal glycolipids as host resistance stimulators
Described are derivatives of glycolipids with substituted steroids bridged via a medium length hydrocarbon chain to 1-thio-D-mannopyranoses or 1-thio-L-fucopyranoses. These compounds protect an...
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4613504 |
Pyridine-soluble extracts of microorganisms
A purified pyridine-soluble extract of a microorganism is disclosed. The extract in a pharmaceutically acceptable medium is useful as an anti-animal tumor agent in the treatment of animals.
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4602003 |
Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
Synthetic sapogenin and sterol compounds, administered orally to warm-blooded animals, inhibit the absorption of cholesterol and are useful in the treatment of hypercholesterolemia. Particular...
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4602005 |
Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis
This invention discloses novel glycosides which are potent inhibitors of cholesterol absorption and therefore useful in treating hypercholesterolemia and atherosclerosis. Particularly useful in...
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4568667 |
Aqueous preparation containing vitamin E and saponins
An aqueous preparation containing vitamin E prepared by emulsifying or solubilizing vitamin E in an aqueous phase in the presence of a saponin shows excellent transparency and thermal stability,...
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4555504 |
Inclusion complex of β-cyclodextrin and digoxin
Inclusion complexes of cyclodextrins, particularly β-cyclodextrin, and cardiac glycosides, particularly digoxin, are disclosed. The complexes have high aqueous solubility and are useful in the...
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4552868 |
14-Amino steroid derivatives, a process for the preparation thereof and method of use thereof
The invention relates to 14-amino steroid derivatives of formula (I): ##STR1## wherein R represents a hydrogen atom or a lower alkyl group with 1 to 4 carbon atoms, R 1 represents a substituted or...
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4546097 |
Saponin-based polyether polyols, pharmaceutical compositions and a method of using same
Digitonin and digitonin-related saponins are derivatized by alkoxylation. The adducts have lower toxicity, higher solubility, and reduced ability to form insoluble complexes with cholesterol, as...
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4521410 |
Vitamin D glycosyl orthoesters
A compound which is biologically active in maintaining calcium and phosphorous metabolism in animals, selected from the group consisting of formula (IA) and (IB): ##STR1## wherein the bond between...
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4505910 |
Amino-pyrimidine derivatives, compositions and use
Herein is disclosed amino-pyrimidine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical...
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4461763 |
Oximes of 3'"-dehydrocardenolide tridigitoxosides
The present invention provides 3'"-dehydrocardenolide tridigitoxoside oximes of the general formula: ##STR1## in which R 1 is a hydrogen atom or an alkyl radical containing up to 3 carbon atoms, R...
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4456596 |
Wound healing glycoside compositions
Compositions which stimulate tissue regeneration and whose active components are substances present in mammalian tissues and fluids are described. The active substances are a polypeptide consisting...
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4436735 |
Ketals of 3'"-dehydrocardenolide tridigitoxosides
The present invention provides ketals of 3'"-dehydrocardenolide tridigitoxosides of the general formula: ##STR1## in which R 1 and R 2 are identical alkyl radicals containing up to 3 carbon atoms...
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4427668 |
26-Hydroxycholesterol and derivatives and analogs thereof in regulation of cholesterol accumulation in body tissue
Use of 26-hydroxycholesterol for reducing cholesterol synthesis and/or accumulation in body tissues.
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4416872 |
Treatment of malaria with liposomes containing 8-aminoquinoline derivatives and glycoconjugates
A novel treatment has been discovered for interrupting the life cycle of malaria parasite during its development in the liver of the vertebrate host. The subject invention involves a method of...
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