|
Match
|
Document |
Document Title |
|
|
7326711 |
Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents
Pyridin[1,2-a]pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the...
|
|
|
7256195 |
Preparation of risperidone
The present invention is directed to the novel forms of risperidone, designated Form A, Form B and Form E. Methods for their preparation are also disclosed. The present invention also relates to...
|
|
|
7247638 |
8-Substituted-6,7,8,9-tetrahydropyrimido [1,2-a] pyrimidin-4-one derivatives.
The invention relates to substituted-pyrimidone derivatives represented by formula (I) or a salt thereof:
wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as defined herein. The invention...
|
|
|
7232827 |
Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one derivatives
The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein: (I) X represents two hydrogen atoms, a sulphur atom, an oxygen atom or a C 1-2 alkyl group...
|
|
|
7217715 |
Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives
The invention relates to a substituted-pyrimidone derivative represented by formula (I) or a salt thereof:
wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as described herein. The invention...
|
|
|
7118763 |
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than...
|
|
|
RE39181 |
Aqueous risperidone formulations
The present invention is concerned with physicochemically stable aqueous solutions of risperidone for oral and parenteral administration; processes for preparing such formulations.
|
|
|
6974819 |
2-pyridinyl-6,7,8,9-tetrahydropyrimido{1,2-a}pyrimidin-4-one and 7-pyridinyl-2,3-dihydoimidazo{1,2-a}pyrimidin-5(1H)one derivatives
Imidazo[1,2-α]pyrimidinones and pyrimido[1,2-α]pyrimidinones useful for preventive and/or therapeutic treatment of neurodegenerative diseases, such as Alzheimer's disease, caused by abnormal...
|
|
|
6964962 |
Combinations of reboxetine and neuroleptic agents
A composition comprising:
(a) a pharmaceutically effective amount of reboxetine; and selected from the group consisting of clozapine, olanzapine, risperidone and mixtures thereof (b) a...
|
|
|
6875771 |
Pyridopyrimidine derivatives as 5-HT6 antagonists
Novel pyridopyrimidine derivatives which have a binding affinity for the human 5-HT 6 receptor and, therefore, are useful in treating disorders responsive to antagonism of the 5-HT 6 receptor...
|
|
|
6864259 |
Antibacterial agents
The present invention provides compounds of Formula (I):
wherein R 1 -R 6 and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
|
|
|
6800639 |
Pharmaceutical combination for the treatment of cancer
In accordance with the present invention there is provided a pharmaceutical combination useful for the treatment of cancer comprising at least one active compound of formula (I): and at least...
|
|
|
6747032 |
Pyrimidin-4-one compounds
Compound of formula (I): wherein: R 1 , R 2 , R 3 and R 4 , which may be the same or different, each represent a hydrogen atom, a halogen atom or a group selected from alkyl, alkoxy,...
|
|
|
6723726 |
Protein tyrosine kinase inhibitors
Substituted heteroaromatic compounds, and in particular substituted bicyclic heteroaromatic compounds of formula (I), wherein X is N or CH; A represents a fused 5, 6 or 7-membered heterocyclic ring...
|
|
|
6649604 |
Substituted pyridone compounds and methods of use
Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other...
|
|
|
6620819 |
Anticonvulsant derivatives useful in treating psychosis
The anticonvulsant derivative topiramate useful in treating dementia and/or behavioral and psychotic disturbances in dementia is disclosed.
|
|
|
6599532 |
Osmotic device containing alprazolam and an antipsychotic agent
The present invention provides an osmotic device containing controlled release alprazolam in the core optionally in combination with an anti-psychotic agent, in a rapid release external coat. A...
|
|
|
6566389 |
Therapeutic uses of melatonin
A method for treating or preventing symptoms of tardive dyskensia comprises administering melatonin to patient exhibiting or liable to develop such symptoms. The melatonin is administered in an...
|
|
|
6555544 |
Aqueous suspensions of submicron 9-hydroxyrisperidone fatty acid esters
The present invention is concerned with a pharmaceutical composition suitable as a depot formulation for administration via intramuscular or subcutaneous injection, comprising: (1) as an active...
|
|
|
6544559 |
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than...
|
|
|
6500833 |
(&plus )-Hydroxyrisperidone compositions and methods
Methods and compositions utilizing a compound represented by Formula III, wherein R is chosen from —OH, —P(O)(OH) 2 and —SO 3 H, or pharmaceutically acceptable salts thereof, for the...
|
|
|
6444665 |
Method for treating pain
The present invention provides a method for treating pain using an atypical antipsychotic compound.
|
|
|
6420369 |
Anticonvulsant derivatives useful in treating dementia
Anticonvulsant derivatives useful in treating dementia and/or behavioral and psychotic disturbances in dementia are disclosed.
|
|
|
6395727 |
Method of treating Bulimia Nervosa and related eating disorders by administration of atypical antipsychotic medications
The invention relates to a method of treating non-psychotic disorders by administration of atypical antipsychotic medications, in particular, risperidone. More specifically, the invention relates...
|
|
|
6348457 |
4-&lsqb 3-benzofuranyl&rsqb piperidinyl and 4-&lsqb 3-benzothienyl&rsqb piperidinyl derivatives
The invention is concerned with novel compounds of the formula the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, wherein X is oxygen or...
|
|
|
6342488 |
Phosphonorisperidone and sulforisperidone compositions and methods
Methods and compositions utilizing compounds represented by Formula III, wherein R is chosen from —P(O)(OH) 2 and —SO 3 H, or pharmaceutically acceptable salts thereof, for the treatment...
|
|
|
6303614 |
Tetrahydro gamma-carbolines
The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R 1 is...
|
|
|
6150353 |
Therapeutic combinations of mirtazapine and antipsychotic agents, for the treatment or prophylaxis of psychotic disorders
This application relates to a combination of the antidepressant mirtazapine and an antipsychotic agent such as haloperidol for the treatment of psychotic disorders.
|
|
|
6077843 |
Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
The present invention is concerned with a pharmaceutical composition suitable as a depot formulation for administration via intramuscular or subcutaneous injection, comprising: (1) as an active...
|
|
|
6057325 |
Hexahydro-pyrido(4,3-b)indole derivatives as antipsychotic drugs
This invention concerns the compounds of formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C 1 -6 alkanediyl; R 1 is...
|
|
|
6028073 |
N-substituted 3-azabicyclo (3.2.0)heptane derivatives useful as neuroleptics
N-substitued 3-azabicyclo[3.2.0]heptane derivatives of formula (I) ##STR1## in which R 1 , R 2 , A, X, Y and Z have the meanings given in the description, their method of preparation and their use...
|
|
|
5919788 |
4-(1H-indol-1-yl)-1-piperidinyl derivatives
The present invention concerns the compounds of formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein the dashed line designates...
|
|
|
5902807 |
Method for the treatment of mental illness in mammals and a composition therefor
The invention relates to a method for treating a mammal suffering from mental illness induced by propagation of stress, said method comprising the step of removing or diminishing the tone of the...
|
|
|
5723467 |
Method of treating psychotic disorders using risperidone pamoate
A method of treating psychotic disorders by administering an effective amount of a permeate acid addition salt of risperidone having the formula: ##STR1##
|
|
|
5688801 |
Method of inhibiting neurotransmitter activity using microencapsulated 3-piperidiny2-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
A pharmaceutical composition comprising a biodegradable and biocompatible composition comprising a 1,2 benzazole within a polymeric matrix. The 1,2 benzazole composition, pharmaceutically...
|
|
|
5688799 |
9-Hydroxy-pyrido 1,2-a!pyrimidin-4-one ether derivatives
The present invention is concerned with novel compounds having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof,...
|
|
|
5677307 |
Substituted tetrahydro-5-nitro-pyrimidines
The present invention relates to novel substituted in that one tetrahydro-5-nitro-pyrimidine of the formula (I), according to claim 1, ##STR1## in which n, R 1 , R 2 have the meaning given in the...
|
|
|
5658916 |
Drug active on the central nervous system, a process for the preparation thereof and pharmaceutical compositions containing it
The agent is the compound 3-{2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-3,6-dihydro-2H-pyri
din-1-yl]-ethy l}-2-methyl-6,7,8,9-tetrahydropyrido [1,2-a]pyrimidin-4-one having the formula (I) ##STR1## and...
|
|
|
5622956 |
Nitro-substituted heterocyclic compounds
Nitro-substituted heterocyclic compounds of the formula (I) ##STR1## wherein R is hydrogen or alkyl, Z is an optionally substituted aryl or optionally substituted heterocyclic group containing...
|
|
|
5616587 |
Aqueous risperidone formulations
The present invention is concerned with physicochemically stable aqueous solutions of risperidone for oral and parenteral administration; processes for preparing such formulations.
|
|
|
5612347 |
Agents for preserving or restoring the soundness of the skin
Agents for preserving or restoring the soundness of the skin by administering a serotonin antagonist which in particular is a compound of formula ##STR1## a salt or a stereoisomeric forms thereof;...
|
|
|
5612346 |
Risperidone pamoate
A compound which is a pamoate acid addition salt of risperidone, compositions comprising the same and processes for preparing said compound and compositions.
|
|
|
5610157 |
N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzo-dioxin) carboxamide derivatives
N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal...
|
|
|
5532243 |
Antipsychotic nitrogen-containing bicyclic compounds
There are provided nitrogen-containing bicyclic compounds, pharmaceutical compositions containing these compounds and methods of using these compounds to treat physiological or drug-induced...
|
|
|
5527802 |
New uses of 3-tetrazolo -5,6,7,8- substituted-pyrido (1,2-a) pyrimidin-4-ones
New uses of certain substituted pyrido[1,2-a]pyrimidin-4-one anti-allergy drugs are made possible by the provision of clear, stable aqueous solutions of same. The aqueous solutions contain novel...
|
|
|
5525605 |
Remedy for inflammatory intestinal diseases
A remedy for inflammatory intestinal diseases which contains as the active ingredient 9-(4-acetyl-3-hydroxy-2-n-propylphenoxymethyl)-3-(1H-tetrazo
l-5-yl)-4H-pyr ido[1,2-a]pyrimidine-4-one...
|
|
|
5512576 |
2-substituted 1,2,5,-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
2-Substituted 1,2,5-thiadiazolidin-3-one 1,1-dioxides, pharmaceutical compositions containing them and methods for the treatment of degenerative diseases utilizing them.
|
|
|
5482943 |
(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-(2, 9-disubstituted-4H-pyrido[1,2-a]pyrimidin-4-one) derivatives
Novel 2,9-disubstituted-4H-pyrido[1,2-a]pyrimidin-4-ones having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof,...
|
|
|
5475000 |
3-(substituted tetrazolyl)-4-oxo-4H-pyrido-[1,2-a]pyrimidines, salts thereof, pharmaceutical compositions containing them and process for preparing same
4-oxo-4H-pyrido[1,2-a]-pyrimidines are disclosed of the formula ##STR1## wherein R is a C 1 -6 alkyl, C 3 -6 alkenyl, C 3 -6 alkynyl, C 3 -7 cycloalkyl, --(CH 2 ) n --COOR 3 wherein R 3 is C 1 ...
|
|
|
5453425 |
Risperidone oral formulation
The present invention is concerned with physicochemically stable aqueous solutions of risperidone for oral administration which do not contain sorbitol.
|