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Document Title |
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8173637 |
Stabilized atypical antipsychotic formulation
A pharmaceutical composition that contains an atypical antipsychotic drug and succinic acid, fumaric acid or a mixture of succinic acid and fumaric acid.
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8114883 |
Polymer formulations for delivery of bioactive materials
Delivery of drugs in association with PLGA polymers which have crystallinity resulting from the presence of long chain alkyl groups in terminal units.
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8093256 |
Use of 8-substituted-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives
The invention relates to use of substituted-pyrimidone derivatives represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as defined herein. More...
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8076448 |
Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
The invention provides methods of extracting a biodegradable polyester with a supercritical fluid effective to obtain a purified biodegradable polyester, such as a purified biodegradable...
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8067457 |
Compounds useful as antagonists of CCR2
The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the...
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8003637 |
Stabilized atypical antipsychotic formulation
A pharmaceutical composition that contains an atypical antipsychotic drug and succinic acid, fumaric acid or a mixture of succinic acid and fumaric acid.
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7973043 |
Combination therapy for depression, prevention of suicide, and various medical and psychiatric conditions
The present invention relates to a new method of treatment for persons meeting diagnoses for major depressive disorder, or other unipolar (non-bipolar, non-psychotic and non-treatment resistant)...
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7968553 |
Tetrahydro-4H-pyrido[1,2-a] pyrimidines useful as HIV integrase inhibitors
Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds of Formula A: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein n is an integer equal to zero, 1,...
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7951809 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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7776866 |
Deuterium-enriched risperidone
The present application describes deuterium-enriched risperidone, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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7645750 |
Method of treating symptoms of hormonal variations
A method for treating or preventing symptoms of hormonal variation includes administering an effective amount of a receptor antagonist to a subject having one or more symptoms of hormonal...
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7547452 |
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
Sustained-release microparticle composition. The microparticle composition can be formulated to provide extended release over a period of from about 7 days to about 200 days. The microparticles may...
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7504403 |
Substituted heterocyclic compounds and methods of use
The present invention relates to pyrimidinones and pyridones and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation,...
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7504405 |
Mitotic kinesin inhibitors
The present invention relates to compounds that are useful for treating cellular proliferative diseases, for treating disorders mediated, at least in part, by KSP, and for inhibiting KSP. The...
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7414045 |
Substituted pyrimido[1,2-a]azepines useful as HIV integrase inhibitors
Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds of Formula (A): are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein n is an integer equal to zero,...
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7393853 |
Use of substituted 8-Perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives as therapeutic agents
The invention relates to use of a substituted-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as described herein for treating a...
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7326711 |
Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents
Pyridin[1,2-a]pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the...
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7256195 |
Preparation of risperidone
The present invention is directed to the novel forms of risperidone, designated Form A, Form B and Form E. Methods for their preparation are also disclosed. The present invention also relates to...
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7247638 |
8-Substituted-6,7,8,9-tetrahydropyrimido [1,2-a] pyrimidin-4-one derivatives.
The invention relates to substituted-pyrimidone derivatives represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as defined herein. The invention relates...
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7232827 |
Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one derivatives
The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein: (I) X represents two hydrogen atoms, a sulphur atom, an oxygen atom or a C1-2 alkyl group and...
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7217715 |
Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives
The invention relates to a substituted-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as described herein. The invention...
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7118763 |
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than...
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RE39181 |
Aqueous risperidone formulations
The present invention is concerned with physicochemically stable aqueous solutions of risperidone for oral and parenteral administration; processes for preparing such formulations.
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6974819 |
2-pyridinyl-6,7,8,9-tetrahydropyrimido{1,2-a}pyrimidin-4-one and 7-pyridinyl-2,3-dihydoimidazo{1,2-a}pyrimidin-5(1H)one derivatives
Imidazo[1,2-α]pyrimidinones and pyrimido[1,2-α]pyrimidinones useful for preventive and/or therapeutic treatment of neurodegenerative diseases, such as Alzheimer's disease, caused by abnormal G...
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6964962 |
Combinations of reboxetine and neuroleptic agents
A composition comprising: (a) a pharmaceutically effective amount of reboxetine; and selected from the group consisting of clozapine, olanzapine, risperidone and mixtures thereof(b) a...
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6875771 |
Pyridopyrimidine derivatives as 5-HT6 antagonists
Novel pyridopyrimidine derivatives which have a binding affinity for the human 5-HT6 receptor and, therefore, are useful in treating disorders responsive to antagonism of the 5-HT6 receptor such as...
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6864259 |
Antibacterial agents
The present invention provides compounds of Formula (I): wherein R1-R6 and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as...
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6800639 |
Pharmaceutical combination for the treatment of cancer
In accordance with the present invention there is provided a pharmaceutical combination useful for the treatment of cancer comprising at least one active compound of formula (I): and at least one...
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6747032 |
Pyrimidin-4-one compounds
Compound of formula (I): wherein:R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen atom, a halogen atom or a group selected from alkyl, alkoxy, polyhaloalkyl,...
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6723726 |
Protein tyrosine kinase inhibitors
Substituted heteroaromatic compounds, and in particular substituted bicyclic heteroaromatic compounds of formula (I), wherein X is N or CH; A represents a fused 5, 6 or 7-membered heterocyclic ring...
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6649604 |
Substituted pyridone compounds and methods of use
Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other m...
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6620819 |
Anticonvulsant derivatives useful in treating psychosis
The anticonvulsant derivative topiramate useful in treating dementia and/or behavioral and psychotic disturbances in dementia is disclosed.
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6599532 |
Osmotic device containing alprazolam and an antipsychotic agent
The present invention provides an osmotic device containing controlled release alprazolam in the core optionally in combination with an anti-psychotic agent, in a rapid release external coat. A...
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6566389 |
Therapeutic uses of melatonin
A method for treating or preventing symptoms of tardive dyskensia comprises administering melatonin to patient exhibiting or liable to develop such symptoms. The melatonin is administered in an...
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6555544 |
Aqueous suspensions of submicron 9-hydroxyrisperidone fatty acid esters
The present invention is concerned with a pharmaceutical composition suitable as a depot formulation for administration via intramuscular or subcutaneous injection, comprising: (1) as an active...
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6500833 |
(&plus )-Hydroxyrisperidone compositions and methods
Methods and compositions utilizing a compound represented by Formula III, wherein R is chosen from —OH, —P(O)(OH)2 and —SO3H, or pharmaceutically acceptable salts thereof, for the treatment of ps...
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6444665 |
Method for treating pain
The present invention provides a method for treating pain using an atypical antipsychotic compound.
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6420369 |
Anticonvulsant derivatives useful in treating dementia
Anticonvulsant derivatives useful in treating dementia and/or behavioral and psychotic disturbances in dementia are disclosed.
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6395727 |
Method of treating Bulimia Nervosa and related eating disorders by administration of atypical antipsychotic medications
The invention relates to a method of treating non-psychotic disorders by administration of atypical antipsychotic medications, in particular, risperidone. More specifically, the invention relates...
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6348457 |
4-&lsqb 3-benzofuranyl&rsqb piperidinyl and 4-&lsqb 3-benzothienyl&rsqb piperidinyl derivatives
The invention is concerned with novel compounds of the formula the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, whereinX is oxygen or...
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6342488 |
Phosphonorisperidone and sulforisperidone compositions and methods
Methods and compositions utilizing compounds represented by Formula III, wherein R is chosen from —P(O)(OH)2 and —SO3H, or pharmaceutically acceptable salts thereof, for the treatment and pre...
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6303614 |
Tetrahydro gamma-carbolines
The present invention concerns the compounds of formula ##STR1##the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is...
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6150353 |
Therapeutic combinations of mirtazapine and antipsychotic agents, for the treatment or prophylaxis of psychotic disorders
This application relates to a combination of the antidepressant mirtazapine and an antipsychotic agent such as haloperidol for the treatment of psychotic disorders.
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6077843 |
Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
The present invention is concerned with a pharmaceutical composition suitable as a depot formulation for administration via intramuscular or subcutaneous injection, comprising: (1) as an active...
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6057325 |
Hexahydro-pyrido(4,3-b)indole derivatives as antipsychotic drugs
This invention concerns the compounds of formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C1-6 alkanediyl; R1 is...
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6028073 |
N-substituted 3-azabicyclo (3.2.0)heptane derivatives useful as neuroleptics
N-substitued 3-azabicyclo[3.2.0]heptane derivatives of formula (I) ##STR1## in which R1, R2, A, X, Y and Z have the meanings given in the description, their method of preparation and their use as...
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5919788 |
4-(1H-indol-1-yl)-1-piperidinyl derivatives
The present invention concerns the compounds of formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein the dashed line designates...
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5902807 |
Method for the treatment of mental illness in mammals and a composition therefor
The invention relates to a method for treating a mammal suffering from mental illness induced by propagation of stress, said method comprising the step of removing or diminishing the tone of the...
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5723467 |
Method of treating psychotic disorders using risperidone pamoate
A method of treating psychotic disorders by administering an effective amount of a permeate acid addition salt of risperidone having the formula: ##STR1##
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5688799 |
9-Hydroxy-pyrido 1,2-a!pyrimidin-4-one ether derivatives
The present invention is concerned with novel compounds having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof,...
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