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7388005 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo [1,2-a]pyrimidin-5(1H)one derivatives for neurodegenerative disorders  
The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein: X represents two hydrogen atoms, a sulphur atom, an oxygen atom or a C 1-2 alkyl group and a...
7192948 Bicyclic heterocycles as HIV integrase inhibitors  
The invention encompasses a series cyclic bicyclic heterocyclic compounds of Formula I which are inhibitors of HIV integrase and prevent viral integration into human DNA. This action makes the...
7141564 Nitrogen-containing bicyclic heterocycles for use as antibacterials  
Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
6900216 Dihydroimidazo[2,1-b]thiazole and dihydro-5h-thiazolo[3,2-A]pyrimidines as antidepressant agents  
The present invention relates to certain novel substituted dihydroimidazo[2,1-b]thiazole and dihydro-5H-thiazolo[3,2-a]pyrimidine compounds including pharmaceutically acceptable salts thereof which...
6838462 Insecticidal azoles  
The present invention relates to novel heterocyclic compounds of formula (I) where A, R1, R2, Y, Z, and n are defined in the disclosure, to processes for their preparation, and to their use as...
6833371 Pyrazolopyrimidines  
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More...
6828326 Pyrimidinone fused bicyclic metalloproteinase inhibitors  
The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R 1 are as defined in the specification, and to pharmaceutical compositions...
6800628 N-substituted 4-((-4′-aminobenzoyl)-oxymethyl)-piperidines having gastric prokinetic properties  
This invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R 1 is C 1-6...
6747032 Pyrimidin-4-one compounds  
Compound of formula (I): wherein: R 1 , R 2 , R 3 and R 4 , which may be the same or different, each represent a hydrogen atom, a halogen atom or a group selected from alkyl, alkoxy,...
6740654 Squaric acid derivatives  
Squaric acid derivatives of formula (1) are described: wherein Het is an optionally substituted bicyclic fused ring heteroaromatic group; L 2 is a covalent bond or an atom or group —O—,...
6670365 Substituted imidazo 1,2a&rcub azines as selective inhibitors of cox-2  
The invention refers to new compounds of formula (I), wherein A and B are selected from the group consisting of N and CH, with the condition that when A is N, B is N; R 1 is selected from the...
6635643 Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives  
The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R 1 and R 2 ...
6583146 Thiazolopyrimidine compounds, its production and use  
Compounds represented by general formula (I): and salts thereof, exhibiting excellent adenosine A 3 receptor antagonism: wherein A is an optionally substituted benzene ring; B may be further...
6525056 Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (CRH) antagonists, useful for treating cns and stress-related disorders  
Corticotropin releasing factor (CRF) antagonists of Formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress...
6348457 4-&lsqb 3-benzofuranyl&rsqb piperidinyl and 4-&lsqb 3-benzothienyl&rsqb piperidinyl derivatives  
The invention is concerned with novel compounds of the formula the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, wherein X is oxygen or...
6303614 Tetrahydro gamma-carbolines  
The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R 1 is...
6187802 Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use  
Compounds of Formula I ##STR1## including pharmaceutically acceptable salts thereof in the form of individual enantiomers, racemates, or other mixtures of enantiomers, in which Ar is phenyl,...
6096761 Esters of 3-hydroxy-piperidinemethanol derivatives  
The present invention of compounds of formula (I), ##STR1## a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R 1 is C...
6057325 Hexahydro-pyrido(4,3-b)indole derivatives as antipsychotic drugs  
This invention concerns the compounds of formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C 1 -6 alkanediyl; R 1 is...
5958931 Phenyl-substituted 5H-thiazolo 3,2-A!pyrimidine derivative glutamate receptor antagonists  
The invention is concerned with compounds of the general formula ##STR1## wherein R 1 is hydrogen, lower alkyl, phenyl or benzyl, R 2 is lower alkyl, lower alkoxy, --O(CH 2 ) n N(R 13 )(R 14...
5929114 Arylthio compounds  
Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O,...
5919788 4-(1H-indol-1-yl)-1-piperidinyl derivatives  
The present invention concerns the compounds of formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein the dashed line designates...
5869492 Condensed thiazole derivatives, having 5-HT receptor affinity  
Compounds of formula I ##STR1## in which A is S(O) p or O; p is 0, 1 or 2; g is 0, 1, 2, 3, or 4; n is 2 or 3; and R 1 , R 2 , R 3 , R 4 and R 5 are optional substituents have utility in the...
5798361 5H-thiazolo 3,2-a!pyrimidin-5-one derivatives  
The present invention relates to new 5H-thiazolo 3,2-a!pyrimidin -5-one derivatives having the formula (I): ##STR1## wherein Ar is phenyl optionally substituted by one or two groups selected from...
5688801 Method of inhibiting neurotransmitter activity using microencapsulated 3-piperidiny2-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles  
A pharmaceutical composition comprising a biodegradable and biocompatible composition comprising a 1,2 benzazole within a polymeric matrix. The 1,2 benzazole composition, pharmaceutically...
5610157 N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzo-dioxin) carboxamide derivatives  
N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal...
5599813 Thiazolopyrimidine derivatives  
Thiazolopyrimidine derivatives represented by the formula ##STR1## and salts thereof are provided, which are characterized by a carboxamide residue substituted with R 4 and R 5 . The derivatives...
5532243 Antipsychotic nitrogen-containing bicyclic compounds  
There are provided nitrogen-containing bicyclic compounds, pharmaceutical compositions containing these compounds and methods of using these compounds to treat physiological or drug-induced...
5397782 Method of treating addiction to alcohol  
Method of treating addiction to alcohol and symptoms related to withdrawal of said alcohol comprising the administration of certain 4-[bis(halophenyl)methylene]-1-piperidinyl derivatives.
5321028 Antihypertensive 3-piperidinyl-indazole derivatives  
3-Piperidinyl-indazole derivatives and their pharmaceutically acceptable acid addition salts being useful antagonists of neurotransmitters; pharmaceutical compositions containing the same and a...
5300509 2-furyl-oxazolo[5,4-d]-pyrimidines  
Compounds of formula I, and pharmaceutically acceptable salts thereof, ##STR1## in which R1 is hydrogen (1-6C)alkyl or (1-4C)alkanoyl; A is --NCQ--O--, NCQ--NR 8 --, --NCQ--CHN-- ...
5272150 Hydroxyalkylfuranyl derivatives  
Hydroxyalkylfuranyl derivatives, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof having antiallergic properties, compositions containing the same and...
5262418 N-(4-piperidinyl) (dihydroxybenzofuran or dihydro-2H-benzopyran)carboxamide derivatives  
Piperidine derivatives of formula ##STR1## wherein A is a radical of formula --CH 2 --CH 2 -- (a-1), --CH 2 --CH 2 --CH 2 -- (a-2),...
5082838 Sulfur-containing fused pyrimidine derivatives, their production and use  
Disclosed is a compound represented by the formula (I) or a salt thereof: ##STR1## wherein R 1 represents an aliphatic hydrocarbon, aralkyl or aryl group which may be substituted; R 2 represents...
4996208 Pesticidal thiazolopyrimidine derivatives  
Fungicidal thiazolopyrimidine derivatives of the formula ##STR1## in which R 1 stands for hydrogen or alkyl, R 2 stands for hydrogen, alkyl or optionally substituted aryl, R 3 stands in...
4985432 5H-1,3,4-thiadiazolo(3,2-A)pyrimidin-5-one derivatives and agricultural-horticultural fungicide composition containing the same  
A new class of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one derivatives were synthesized. They are useful as agricultural-horticultural fungicides.
4971971 5H-1,3,4-thiadiazolo(3,2-A)pyrimidin-5-one derivatives and functional compositions containing the same  
A class of novel 5H-1,3,4-thiadiazolo[3,2-a]-pyrimidin-5-one derivatives are disclosed. These compounds exhibit remarkable fungicidal activities for pathogenic fungi of cucumber gray mold, cucumber...
4921854 Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds  
The compounds of the general formula I ##STR1## and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy. In the...
4908379 Nitrogen-containing heterocyclic compounds and compositions for controlling and/or preventing pests and blights (diseases)  
A nitrogen-containing heterocyclic compound of the following formula: ##STR1## wherein D represents --N or ##STR2## E represents N--, ##STR3## G represents --N, ##STR4## with proviso that...
4874766 Method of promoting wound-healing  
Method of promoting wound-healing by topically applying a serotonin-antagonistic compound.
4866064 5H-1,3,4-thiadiazolo(3,2-A)pyrimidin-5-one derivatives and fungicidal compositions containing the same  
A class of novel 5H-1,3,4-thiadizaolo[3,2-a]pyrimidin-5-one derivatives are disclosed. These compounds exhibit remarkable fungicidal activities for pathogenic fungi of cucumber gray mold, cucumber...
4839374 4-((Bicyclic heterocyclyl)-methyl and -hetero)-piperidines  
4-[Bicyclic heterocyclyl)methyl and -hetero]-piperidines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases.
4804663 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles  
3-Piperdinyl-1,2-benzisothiazoles and 3-piperidinyl-1,2-benzisoxazoles and their pharmaceutically acceptable acid addition salts having useful antipsychotic properties and being useful in the...
4609660 Substituted carboxy-thiazolo[3,2-a]pyrimidine derivatives  
Carboxy-thiazolo[3,2-a]pyrimidine derivatives, and pharmaceutical compositions containing them. The compounds and compositions possess anti-allergic activity.
4551457 Substituted thiazolo[3,2-a]pyrimidines and process for their preparation  
Pharmacologically active thiazolo[3,2-a]pyrimidines of the formula ##STR1## wherein A is a bond between the α- and β-carbon atoms or (--CH 2 --) group; R 1 and R 2 represent hydrogen, C 1 -C...
4548938 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds  
Novel 5H-thiazolo- and 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one and 3,4-dihydro-2H,6H-pyrimido[2,1-b] [1,3]-thiazin-6-one derivatives, which compounds are useful psychotropic agents.
4535081 Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor  
Antiallergy and antiulcer agents having the formula (I), ##STR1## and their pharmaceutically acceptable salts, wherein R 1 and R 2 taken separately are each hydrogen or lower alkyl; and R 1 and...
4525357 Derivatives of bicyclic 2-iminothiazolidine oximes  
Novel derivatives of bicyclic 2-iminothiazolidine oximes and methods of preparing same. This invention is also directed to an insecticidal composition comprising an acceptable carrier and an...
4522944 Carboxamido-derivatives of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidines, compositions and use  
The present invention relates to new carboxamido-derivatives of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidines, to a process for their preparation and to pharmaceutical (i.e. anti-inflammatory and...
4476127 7-Diethylamino-5-methyl-thiazolo[5,4-d]pyrimidine and pharmaceutical composition containing same  
The compound related to this invention is 7-diethylamino-5-methyl-thiazolo[5,4-d]pyrimidine. The compound related to this invention possesses vasodilating action, hypotensive action, inhibitory...
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