Patents in Class 514/258.100

Matches 1 - 50 out of 105

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Match	Document	Document Title
1	7348326	Heteroaryl fused aminoalkyl imidazole derivatives: selective modulators of GABA_areceptors Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , are variables defined...
2	7345045	Pyrido-pyrimidine compounds as medicaments The invention is directed to methods to inhibit TGF-β and/or p38-α kinase using compounds of the formula or the pharmaceutically acceptable salts thereof wherein R 3 is a...
3	7338955	Medicament for treatment of neuropathies Compounds of formula (I) in which R 1 =C 1-6 alkyl, optionally halosubstituted; R 2 =H, C 1-4 alkyl, optionally halosubstituted or replaced by halogen; R 3 =C 2-4 alkyl, optionally...
4	7297700	Bicycloheteroaryl compounds as P2X7 modulators and uses thereof Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and...
5	7253155	Combinations for the treatment of immunoinflammatory disorders The invention features a method for treating a patient having an immunoinflammatory disorder, by administering to the patient (i) a tetra-substituted pyrimidopyrimidine, and (ii) a corticosteroid...
6	7232828	PPAR Ligands that do not cause fluid retention, edema or congestive heart failure Methods are provided for treating or prophylactically preventing metabolic disorders in humans without causing, promoting, or aggravating fluid retention, peripheral edema, pulmonary edema, or...
7	7223767	Tetrahydroquinazolines and dihydrocyclopentapyrimidines as CRF antagonists Compounds of the formula (I): and pharmaceutically acceptable salts or prodrugs thereof, wherein m, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. The invention also provides...
8	7223766	Bi-cyclic pyrimidine inhibitors of TGFβ Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating...
9	7211587	Quinoline derivatives and quinazoline derivatives having azolyl group An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or...
10	7208498	Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in...
11	7205289	Combinations of active ingredients with insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties.
12	7192949	Substituted bicyclic pyrimidinones as a mitotic kinesin KSP inhibitors The present invention relates to cycloalkylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
13	7166595	Compounds, methods and compositions Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
14	7160890	Compounds specific to adenosine A3 receptor and uses thereof This invention pertains to compounds which specifically inhibit the adenosine A 3 receptor and the use of these compounds to treat a disease associated with A 3 adenosine receptor in a subject,...
15	7153861	5,6 -Trimethylenepyrimidin-4-one compounds Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA 2 and are of use is treating atheroscelerosis.
16	7138398	Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of formula (I) wherein R 1 , R 2 and R 3 have the meanings given in the claims. Said compounds are valuable active agents in medicaments for the...
17	7125880	Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the application, and...
18	7115658	Inhibitors of hepatitis C virus RNA-dependent RNA polymerase Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
19	7112590	Thrombin inhibitors The invention relates to compounds that are heterocyclic derivatives of dipeptides and dipeptides mimetics and pharmaceutically acceptable salts thereof. The compounds are used as thrombin inhibitors
20	7105525	6-alkoxy-pyrido-pyrimidines The present invention provides compounds of the Formula I: wherein R 1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH 2 -alkenyl, X 1 is O, NH, N(alkyl), S or —C(═O), Z is N or CH; and R...
21	RE39265	Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
22	7091207	Method of treating myocardial infarction with PDE-5 inhibitors A method is provided for the prevention of ischemia/reperfusion injury, for example, in patients undergoing heart surgery, and involves the administration of a phosphodiesterase-5 (PDE-5) inhibitor...
23	7071190	Inhibitors to tubulin polymerization The invention relates to the inhibition of tubulin polymerization. The invention provides compounds and methods for inhibiting tubulin polymerization. The invention also provides compositions and...
24	7064130	Use of radical-scavenging compounds for treatment and prevention of NO-dependent microcirculation disorders A method of treatment of the human or non-human animal body for treating NO-dependent microcirculation disorders is disclosed, for example microcirculation disorders caused by metabolic diseases,...
25	7019003	Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided.
26	7001887	Peptide derivatives A compound of Formula (1): wherein R 1 represents an amidinophenyl group, etc.; R 2 represents a hydrogen atom, etc.; R 3 represents a carbamoylalkyl group, etc.; R 4 represents a...
27	6964968	Method for the treatment or prevention of viral infection using nucleoside analogues Viral infections selected from the group consisting of herpes simplex virus, varicella zoster virus, respiratory syncytial virus and cytomegalovirus can be treated by administering to the host a...
28	6962919	Nitrogen-containing heterocyclic compounds, their production and use A compound of the formula: wherein one of A and D is N and the other is C, or both are N; B is N or C; m is 0-3; R 1 , R 2 and R 3 each is (i) H or (ii) a group bound via C, N, O or S; R 4 ...
29	6943172	Rho-kinase inhibitors Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and...
30	6911449	Inhibition of matrix metalloproteases by substituted biaryl oxobutyric acids Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have the...
31	6881753	Potassium channel inhibitors and method Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure: where A, B, D, Q, X 1 , R, R 1 , X 2 and R 2 are as defined herein....
32	6872727	Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation Polycyclic pyrimidine-2,4(1H,3H)-diones with functionalized alkyl residues at the 1-, the 3-, or both position(s); methods for their synthesis, production, and pharmaceutical preparation. The...
33	6867201	Heteroaromatic bicyclic derivatives useful as anticancer agents The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R 1 , R 3 and R 4 are as defined herein. The invention also...
34	6858611	Potassium channel inhibitors Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
35	6852722	Compositions and methods for stimulating gastrointestinal mobility The present invention is directed to methods for stimulating the motility of the gastrointestinal system in a patient which comprises administering a growth hormone secretagogue, a prodrug thereof...
36	6849634	Potassium channel inhibitors Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
37	6787553	Methods for remodeling neuronal and cardiovascular pathways The present invention provides a method of administration of an agent which acts to remodel neuronal or vascular pathways for the long term management of sexual dysfunction in both males and...
38	6787541	Thieno-and furopyrimidine derivatives as A2A-receptor antagonists Compounds of formula (I): wherein X is S. Compounds can be used for treating a disorder in which the blocking of purine receptors is beneficial.
39	6743799	Use of PDE V inhibitors for improved fecundity in mammals The invention relates to the use of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase type five (cGMP PDE V) inhibitor for increasing fecundity in a mammal by one or more of (a)...
40	6740654	Squaric acid derivatives Squaric acid derivatives of formula (1) are described: wherein Het is an optionally substituted bicyclic fused ring heteroaromatic group; L 2 is a covalent bond or an atom or group —O—,...
41	6686382	Sulfonamides and derivatives thereof that modulate the activity of endothelin Thienyl-, furyl-, pyrrolyl- and phenylsulfonamides, formulations of pharmaceutically-acceptable derivatives thereof and methods for modulating or altering the activity of the endothelin family of...
42	6660746	Substituted 4-amino-2-aryl-tetrahydoquinazolines, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of formula I: wherein R 1 , R 2 , and R 3 have the meanings indicated in the specification, which are valuable pharmaceutical active compounds for the...
43	6653309	Inhibitors of IMPDH enzyme technical field of the invention The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
44	6653295	Inhibitors of hepatitis C virus NS3 protease The present invention relates generally to a novel class of pyrimidinones of Formula (I): that are useful as serine protease inhibitors, and more particularly as Hepatitis C virus NS3 protease...
45	6649619	Compounds Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA 2 and are of use in treating atheroscelerosis.
46	6649618	Substituted amidoalkyl-uracils and their use Novel amidoalkyl-uracil derivatives of the formula (I) in which A represents 1-3 ring atoms and X represents optionally substituted (C 2 -C 10 )alkylene or (C 3 -C 8 )cycloalkylene as defined in...
47	6645971	Quinazolinone derivatives A compound given by general formula (1): [wherein T represents oxygen or sulfur atom, Y represents alkyl, cycloalkyl group, etc., ring W represents benzene ring, etc., R 1 and R 2 represent...
48	6627628	Substituted 4-amino-2-aryl-cyclopenta&lsqb d&rsqb pyrimidines, their production and use and pharmaceutical preparations containing same The present invention relates to compounds of formula (I) wherein R 1 , R 2 and R 3 have the meanings given in the claims. Said compounds are valuable active agents in medicaments for the...
49	6617330	Pyrimidin-4-enamine as fungicide Novel pyrimidine derivatives of formula I as well as possible isomers and mixtures of isomers thereof. The novel compounds have plant-protective properties and are suitable for protecting plants...
50	6617325	Biphenyl derivatives, production thereof and uses as medicines The present invention relates to biphenyl derivatives of general formula wherein R a to R g and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically...

Matches 1 - 50 out of 105

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