Matches 101 - 150 out of 166 < 1 2 3 4 >
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5500230 Method for treatment of glaucoma with nitrogen containing guanylate cyclase activators  
The present invention relates to a method of treating cranial fluid volume dysfunctions such as glaucoma in an individual, comprising administering compounds which effect an increase in cyclic GMP...
5482936 Imidazo[4,5-C]quinoline amines  
Compounds and pharmaceutically acceptable salts thereof formally derived by bridging the 1- and 2-positions of 1H-imidazo[4,5-c]quinolin-4-amines. Also, methods of using such compounds and...
5478825 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives  
The disclosed compounds have the formula ##STR1## wherein Q is a 6-membered saturated heterocyclic group or a group S(O)pR 3 , wherein p is 0, 1, or 2, and R 3 is alkyl, alkenyl, or phenyl-,...
5441955 Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof  
Methods, compounds and compositions are provided form inhibiting the growth of pathogenic mycobacteria in vitro and of treatment of pathogenic mycobacterial infections in vivo using...
5420129 Phenylsulfonylamide pyrimidine  
The invention is concerned with novel sulphonamides and their use as medicaments. In particular, the invention is concerned with compounds of the formula ##STR1## wherein R 1 is hydrogen,...
5418252 Method for inhibiting cartilage degradation  
A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR1## wherein R 1 and...
5393755 Polycyclic guanine derivatives  
Novel polycylic guanine derivatives of the formula: ##STR1## wherein J is oxygen or sulfur, R 1 is hydrogen, alkyl or alkyl substituted with aryl or hydroxy; R 2 is hydrogen, aryl, heteroaryl,...
5368864 Formulation of oxypurinol and/or its alkali and alkaline earth salts  
Formulations of oxypurinol and/or its alkali or alkaline earth salts in non-crystalline form, containing the active substance in the form of a solids dispersion with pharmacologically harmless...
5302589 Heterocyclic inhibitors of 5-α-testosterone reductase  
The present invention relates to certain substituted 17 β-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I): ##STR1## wherein R 1 and R 2 are i) independently hydrogen or lower...
5292741 Macrocycles incorporating quinazolinones  
Macrocyclic compounds of general Structure I: ##STR1## Wherein M is C or N are angiotensin II receptor (A-II) antagonists useful in the treatment of certain cardiovascular dysfunctions and ocular...
5284854 2-aminopyrimidinone derivatives  
2-Amino-pyrimidininone derivatives possessing serotonin-antagonistic and anti-histaminic properties. Compositions containing these compounds as the active ingredient. Method of treating subjects...
5268375 Dinitrogen heterocyclic derivatives N-substituted by a biphenylmethyl group, and the pharmaceutical compositions in which they are present  
This invention relates to compounds of formula ##STR1## in which: R 1 and R 2 are similar or different and are each independently hydrogen or a group selected from CO 2 NC(NH 2 ) 2 ,...
5260298 Imidazatriazoloquinazoline compounds and their use  
Imidazotriazoloquinazoline compounds having the general formula ##STR1## wherein A together with the α-marked carbon atom and the β-marked nitrogen atom is one of the groups ##STR2## cyano or CO...
5232915 9α-hydroxy-19,11β-bridged steroids, their production and pharmaceutical preparations containing these steroids  
9α-Hydroxy-19,11β-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R 1 , R 2 , G, Z, R 4 --Y and R 4 ' --Y' follows from the description. The...
5227387 Quinoline nematicidal method  
A method of inhibiting a nematode population which comprises applying to the locus of a nematode, a nematode inactivating amount of a compound of the formula (1): Het--X--CH 2 --CH 2 --Ar ...
5214047 Tetracyclic quinazoline derivatives, effective as antiarrythmic agents  
A tetracyclic quinazoline derivative of the formula I: ##STR1## wherein A is C 2 -3 -alkylene or C 2 -3 -alkylene which is substituted by one or two C 1 -4 -alkyl radicals or A is cyclohexylene; X...
5188833 Freeze-dried pharmaceutical preparations for parenteral use  
Freeze-dried pharmaceutical preparation containing antibacterial quinolinecarboxylic acid derivatives are provided. These preparations are characterized by their stability against light and heat...
5152988 Imidazole compounds in compositions and methods in thrombolytic therapy  
The use of imidazoles of the formula ##STR1## and imidazolium salts of the formula ##STR2## in thromobolytic therapy are described.
5137888 N,N- substituted amines and use thereof in hair growth promotion  
Novel compounds are provided having the general formula RB n wherein R is a multi-functional amine moiety having at least n amine-functional nitrogen sites, n equals 2 to about 8, and B are...
5126339 Anti-allergic bicyclic heterocyclyl-containing N-(bicyclic heterocyclyl)-4-piperidinamines  
Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of...
5100895 Heterocyclic compounds and their preparation and use  
New imidazoquinazoline compounds having the general formula ##STR1## wherein A together with the α-marked carbon atom and the β-marked nitrogen atom is one of the groups ##STR2## wherein R 4 , R...
5084457 Benzoylaminoquinazolinones  
This invention is compounds of the formula: ##STR1## and a method of treating cognitive and related neuronal behavioral problems in mammals using the compounds.
5077288 4-fluorobenzoic compounds with 5-HT.sub.2 - and α.sub.1 -antagonistic activities  
The invention relates to the compounds of general formula I: ##STR1## in which: m represents an integer from 2 to 4, n and p, which may be identical or different, each represent an integer from...
5070086 Imidazo- and pyrimido-quinoline, naphthyridine and pyridopyrazine compounds  
Imidazo- and pyrimido-quinoline, naphthyridine and pyridopyrazine compounds, methods of making said compounds and their use as anti-allergy, antiinflammatory and/or agents for the treatment of...
5008279 Circulation-active fluoromethoxyphenyl dihydropyridine compounds  
Circulation-active fluoromethoxyphenyldihydropyridines of the formula ##STR1## in which X stands for hydrogen or fluorine and R stands for straight-chain, branched or cyclic alkyl or alkenyl...
4925846 2-thiazolyl-imidazo[1,2,-a]pyrimidines  
A compound selected from the group consisting of a compound of the formula ##STR1## wherein R 1 is thiazol-2-yl optionally substituted by 1 or 2 alkyl of 1 to 3 carbon atoms optionally substituted...
4873247 Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents  
Paraherquamide is a fungal metabolite isolated from the known fungus Penicillium paraherquei, and from a newly isolated strain of the fungus Penicillium charlesii. Additional compounds are...
4831013 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmaceutical compositions, and uses thereof  
Compounds of the formula ##STR1## wherein R 1 is optionally substituted phenyl, pyridyl, thienyl, furyl, pyrrolyl, thiazolyl, or ribofuranosyl; X is oxygen, NR, or sulfur; R is hydrogen, lower...
4824849 α.sub.2 -adrenoceptor antagonistic arylquinolizines  
Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective α 2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives,...
4814335 Antiviral compounds  
In one aspect, compounds having antiviral activity and having the general formula: ##STR1## wherein each R 2 , independently, is H or lower (fewer than 6 carbon atoms) alkyl; each R 3 ,...
4806525 Formulation comprising gelatin and glycine for treating the dryness of skin  
A formulation comprised of soft gelatin and glycine in a proportion of about 3:1 to 2:1 by weight, to which can be added mineral oligoelements and vitamins, which, when administered orally, exerts...
4778511 Fluorine-containing N-sulphenylated indazoles for use as bactericides and fungicides  
Novel fluorine-containing N-sulfenylated indazoles are prepared by reacting the corresponding indazoles with sulfenyl halides in the presence of a solvent and/or diluent and in the presence of an...
4772622 3,5-diamino-1,2,4-oxidiazoles as gastric secretion inhibitors  
Novel diamino oxadiazoles, wherein one of the amine functions is connected to a basicly-substituted heterocyclic group through a linear or cyclic connecting group, which are useful for the...
4760065 Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity  
Trifluoromethyl substituted tetracyclic compounds including optical isomers thereof having the formula: ##STR1## wherein n is 1 or 2 and p is 0 or 1, are useful as CNS agents with tranquilizing...
4757072 Carcinostatic agent  
A carcinostatic composition useful in inhibiting the growth of colon and/or rectal tumors comprising 8-amino-12-oxo-10, 12-dihydroindolo [1,2-b]-quinazoline of the formula: ##STR1##
4720496 Pyridotriazoloquinazolines and triazolopyridoquinazolines useful as antiallergics  
Compounds of the formula ##STR1## wherein (a) R 1 is hydrogen, lower alkyl, lower alkoxy or 8-halo; R 2 is hydrogen, lower alkyl, lower alkoxy or a fused benzene ring; and R 3 and R 4 ,...
4710504 Anti-depressant spiro hexahydro arylquinolizine derivatives, composition, and method of use therefor  
Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective α 2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives,...
4656034 Absorption enhancing agents  
The absorption of a scavenger of oxygen free radicals generated at the time of reperfusion or the absorption of an agent preventing the cytotoxic effects on healthy cells in a mammal. e.g....
4616019 Naphthyridine antibacterial compounds  
Naphthyridine compounds having the formula: ##STR1## wherein Z is an amine or an aliphatic heterocyclic group, R is a phenyl group or an aromatic heterocyclic group and R 1 is hydrogen or a...
4578380 5H-[1]benzopyrano[2,3-d]pyrimidine derivatives useful for controlling lesions of the gastric and duodenal mucous membranes  
The invention relates to 5H-[1]benzopyrano-[2,3-d]pyrimidine derivatives of the general formula I ##STR1## which may be prepared by means of a new chemical process and have a protective effect...
4510144 Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives  
There are prepared compounds of the formulae ##STR1## Where R 1 is H, lower alkyl S--, ##STR2## NH 2 or halogen, R 2 is OH, lower alkyl S--, halogen, NH 2 or SH, R is OH, SH, lower alkyl...
4489078 Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators  
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase...
4472399 Indolo[2',3';3,4]pyrido[2,1-b]quinazoline-5-ones, a process for the preparation thereof, and diuretic compositions and methods using them  
New Rutecarpine analogs are disclosed having Rutecarpine-like activity, especially diuretic activity. Also a novel process for the preparation of the Rutecarpine analogs is disclosed.
4451466 Use of pyrroloquinazolinediamines as pesticides  
Certain 7H-pyrrolo[3,2-f]quinazoline-1,3-diamines are useful as pesticides.
4412995 Pentacyclic phenylpyrazole compounds as anti-inflammatory agents  
Compounds of the formula ##STR1## where R is hydrogen, methyl, ethyl, propyl, 2-propenyl or 2-propynyl; and R' is hydrogen or fluoro possess anti-inflammatory activity. The compounds where R is H...
4390540 Imidazoquinazolines having pharmaceutical activity  
Imidazoquinazolines of the formula ##STR1## wherein R 1 , R 2 and R 3 are hydrogen, halogen, C 1 -4 -alkyl, C 1 -4 -alkoxy or C 2 -5 -alkoxyalkyl; or two of R 1 , R 2 and R 3 on adjacent carbon...
4372956 5, 10-Dihydroimidazo[2,1-b]quinazolines and pharmaceutical compositions containing them  
A 5,10-dihydroimidazo[2,1-b]quinazoline in which at least one ring carbon atom, other than the carbon atom in the 2-position, bears a substituent, or a pharmaceutically acceptable acid addition...
4367230 Novel triazafluoranthene compound and processes for preparing the same  
A triazafluoranthene compound of the formula: ##STR1## wherein R 1 is hydrogen, phenyl, cycloalkyl having 3 to 6 carbon atom, (lower alkoxy)carbonyl, lower alkoxy or (lower alkyl)carbonyl, R 2 is...
4360521 7[3,6-Dihydro-1(2H)-p yridyl]-2-oxo-2H-[1,2,4]oxadiazolo[2,3-c]pyrimidine-5-carbamate compounds  
Oxadiazolo[2,3-c]pyrimidine derivatives of the formula ##STR1## wherein R is alkyl, alkenyl, alkynyl or alkoxyalkyl, as well as their salts, are described. The compounds of formula I have valuable,...
4341780 Substituted pyrido [1,2-a] pyrimidines useful as anti-allergic, anti-ulcer and anti-diabetic agents  
Substituted pyrido [1,2-a] pyrimidines and pharmaceutical compositions containing them, suitable for use as anti-allergy, anti-ulcer, and anti-diabetic agents.
Matches 101 - 150 out of 166 < 1 2 3 4 >