Patents in Class 514/257

Matches 51 - 100 out of 166

< 1 2 3 4 >

Match	Document	Document Title
51	6420365	Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein A, B, C, D, Y, R 1 , R 3 , R 4 , R 5 , and R 6 are variables defined herein, which...
52	6407088	Method of analgesia This invention relates to a method of producing analgesia in a mammal experiencing pain by systemically administering an effective amount of a composition comprising essentially of a sodium channel...
53	6391872	Indazole bioisostere replacement of catechol in therapeutically active compounds Therapeutically active compositions of matter and member species thereof are described which comprise indazole-containing compounds, said compounds and their therapeutic activity resulting directly...
54	6380193	Fused tricyclic compounds, methods and compositions for inhibiting PARP activity A compound of formula I: or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof.
55	6342499	Parasitic and saprophagous mite control in beneficial insects The present invention provides a method to control parasitic and saprophagous mites on beneficial insects such as honeybees via the application of a parasiticidally or saprophagouscidally effective...
56	6337331	Triazolo-pyrimidine as ligands for GABA receptors Substituted or 6,7-ring fused 1,2,3-triazolo[1,5-α]-pyrimidine derivatives are selective ligands for GABA A receptors useful in the treatment of disorders of the central nervous system, including...
57	6291453	4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
58	6288094	Polycyclic thiazol-2-ylidene amines, processes for their preparation and their use as medicaments The invention relates to polycyclic thiazolidin-2-ylidene amines and their physiologically tolerated salts and physiologically functional derivatives. Polycyclic thiazolidin-2-ylidene amines of the...
59	6214831	Pharmaceutical composition containing evodiamine compound and method for improving lipid metabolism or antiobesity The present invention relates to a food and a feed having lipid metabolism improving activity or anti-obesity activity, and a lipid metabolism improving agent or an anti-obesity agent for humans or...
60	6211189	Amino-spiro-quinazoline compounds There are provided novel compounds of formula (I) ##STR1## wherein A represents an aromatic carbocyclic ring or a 5- or 6-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms which may...
61	6210687	Fat emulsion containing xanthine derivative An oil-in-water emulsion containing a xanthine derivative represented by ##STR1## or its pharmacologically acceptable salt, wherein the xanthine derivative or salt is present within an oil phase of...
62	6207701	Urokinase inhibitors Compounds having formula I ##STR1## are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and...
63	6184221	Sulfonamide-substituted compounds, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and for...
64	6159996	Polycyclic thiazolidin-2-ylidene amines, process for their preparation, and their use as pharmaceuticals Polycyclic thiazolidin-2-ylidene amines and their physiologically tolerable salts and physiologically functional derivatives of the formula I ##STR1## in which the radicals have the meanings...
65	6124306	Thioalkyl alpha substituted pyrimidine compounds The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R 4 is selected from the group...
66	6114339	Derivatives of pyrido [2,3-D] and [3,2-D] pyrimidine method of using these derivatives The invention also discloses compounds and pharmaceutically acceptable salts having the generic formula (2) ##STR1## wherein X and Y may be the same or different and are selected from the group...
67	6107304	Thieno[2,3-b]pyrazolo[3,4-d]pyridine-3-ones to enhance erythropoiesis Invented are substituted thieno (2,3-b)pyrazolo(3,4-d)pyridin-3-ones, pharmaceutical compositions containing these compounds, and methods of using these compounds to enhance erythropoiesis. Also...
68	6083952	Compounds There are provided novel compounds of formula (I) ##STR1## wherein A represents an aromatic carbocyclic ring or a 5- or 6-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms which may...
69	6046183	Method of synergistic treatment for benign prostatic hyperplasia Disclosed is an improved treatment for men with benign prostatic hyperplasia (BPH), involving combination therapy of a 5α-reductase inhibitor, e.g. a 17β-substituted 4-azasteroid, a...
70	6030972	Dipeptide amidines as thrombin inhibitors Compounds of the formula ##STR1## where A, B, D, R 1 and R 2 have the meanings stated in the description, are described. The compounds are suitable for controlling diseases. The novel compounds...
71	6028077	Crambescidin compounds The present invention is directed to the isolation and characterization of six new crambescidin compounds, the structures of which are shown below: ##STR1## .
72	6022895	Substituted amino compounds and their use as substances having an analgesic effect Substituted amino compounds of general formula (I) ##STR1## are described, as are a method of preparing them and their use as drugs, especially as analgesics.
73	5998421	Lipid metabolism ameliorants The present invention relates to a food and a feed having lipid metabolism improving activity or anti-obesity activity, and a lipid metabolism improving agent or an anti-obesity agent for humans or...
74	5952332	Antiviral and cytotoxic compounds from the sponge crambe crambe The present invention is directed to several novel compounds isolated from the sponge Crambe crambe, and designated herein as Crambescidin 816 (Compound 1), Crambescidin 830 (Compound 2),...
75	5952331	Aryl pyrimidine derivatives The aryl pyrimidine derivatives and pharmaceutically acceptable salts and N-oxides thereof, exhibit useful pharmacological properties, including utility as selective 5HT 2B -antagonists.
76	5939419	2-benzyl-polycyclic guanine derivatives and process for preparing them Antihypertensive and bronchodilating compounds of the formula or a pharmaceutically acceptable salt thereof, and a process for preparing them are disclosed, wherein: R 1 , R 2 , R 3 , R a , R b ...
77	5939442	Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof In accordance with the present invention, there is provided a class of compounds which are capable of modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-γ)....
78	5880135	Substituted 4-phenylaminothiazoles, their process of preparation and the pharmaceutical compositions containing them A compound, as well as its stereoisomers and addition salts, possssing antagonist activity with respect to corticotropin releasing hormone (CRF) has the formula: ##STR1## in which R 1 , and R 21 ...
79	5874451	Propanolamine derivatives, processes for their preparation, pharmaceuticals comprising these compounds, and their use The invention relates to substituted propanolamine derivatives and their acid addition salts. Propanolamine derivatives of formula I, ##STR1## in which R 1 to R 8 have the meanings indicated in...
80	5859016	Memory enhancing and anti-dementia agent containing dehydroevodiamine HC1 as active ingredient Dehydroevodiamine-HCl, a constituent of Evodia rutaecarpa Benth. (DHED) exhibits anti-AChE activity and improves the memory impairment of animals produced by scopolamine in the passive avoidance...
81	5856322	Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and...
82	5824683	2'- 4'-h alo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones Antihypertensive and bronchodilating phosphoclusterose inhibitory compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein X is fluoro, chloro or bromo.
83	5786361	Pyridazino-, pyrimido-, pyrazino- and triazinoindoles, -pyrrolocycloalkenes or pyrrolooxocycloalkenes, or pyridopyrrolylpyrido compounds, compositions containing them, and use thereof to treat atherosclerosis Compounds of the formula (I): ##STR1## are prepared by reaction of the phenylacetic acid derivatives substituted by the appropriate heterocycles, optionally in an activated form, with...
84	5753663	Pyrimidine derivatives The disclosed pyrimidine derivatives, and pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, in particular use as 5HT 2C - antagonists. The invention is also...
85	5728684	Determination of prodrugs metabolizable by the liver and therapeutic use thereof A method of ascertaining if a prodrug is useful for treating a disease is disclosed. The prodrug is acceptable if it is metabolized in liver cells by aldehyde oxidase to produce an active drug or...
86	5667792	Derivatives of 2,5-dihydroxyphenylcarboxylic acids, and their utilization in cosmetic or dermatological compositions with a depigmenting action A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the...
87	5654310	Triazolopyrimidones their preparation and use Triazolopyrimidines of the formula ##STR1## where A, D and X have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling...
88	5646154	Pharmaceutical compositions for inhibiting the formation of tumor necrosis factor Quinazoline compounds represented by general formula (1) or (2) possess an activity of significantly inhibiting the production or secretion of a tumor necrosis factor and are useful as drugs for...
89	5639756	Benzimidazole compounds An antidiabetic compound selected from those of formula (I): ##STR1## wherein A, B, C, D, n, R 1 , R 2 , R 3 , R 4 , X, Y and Z are as defined in the description. Medicaments containing the same.
90	5631261	Triazoloquinazolines, their preparation and use Novel triazoloquinazolines of the formula I ##STR1## where A, X R 1 and R 2 have the meanings stated in the description, and their preparation are described. The compounds are suitable for...
91	5612344	Triazoloquinazolines for the treatment of central nervous disorders The use of triazoloquinazolines for the production of drugs for controlling central nervous disorders is described. The triazoloquinazolines have the formula ##STR1## where R 1 , R 2 and X have...
92	5604224	Substituted heterocyclylisoquinolinium salts and compositions and methods of use thereof Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
93	5602137	Pyrimidine compounds and their use as pharmaceuticals Compounds for treating cardiovascular or circulatory disorders of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R 1 , R 2 , R 3 , R 7 , Ar 1 , Ar 2 , X, Y, and n are...
94	5574039	Antiproliferative compounds having nitrogen-containing tricyclic ring systems and phenyl substituents The invention relates to TS-inhibiting compounds of the formula ##STR1## where W is an alkylene group; D is a structure having two rings that are unsubstituted or substituted, where (i) one ring is...
95	5574038	5,6-cyclicimidazo [1,5-a] Quinoxalines The invention discloses imidazo[1,5-a]quinoxalines (I) ##STR1## which do not contain an endocyclic carbonyl group that are useful as anxiolytic and sedative/hypnotic agents.
96	5571813	Fused pyrimidine compounds and their use as pharmaceuticals Pharmaceutical compounds which are azolo-fused pyrimidine compounds having the formula ##STR1## in which A--B-- together with the pyrimidine ring forms a) a pyrazolo[1,5-a]pyrimidine of formula...
97	5569655	Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
98	5565460	Therapeutic purine agents for parkinson's disease The present invention relates to a therapeutic agent for Parkinson's disease containing as an active ingredient a polycyclic compound or a pharmaceutically acceptable salt thereof, the compound...
99	5532366	Heterocyclic amides The present invention relates to certain novel amide derivatives which are pyrido[3,4-d]pyrimidin-7-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human...
100	5510370	Parathyroid hormone and raloxifene for increasing bone mass The present invention includes a method for increasing bone mass in a subject by administration of PTH and raloxifene. Another aspect of the invention is a method for treating bone loss in a...

Matches 51 - 100 out of 166

< 1 2 3 4 >