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9051277 |
Phenyl(oxy/thio)alkanol derivatives
The present invention relates to novel phenyl(oxy/thio)alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically... |
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9040529 |
4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity
The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a... |
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9040541 |
4,6-disubstituted pyrimidines useful as kinase inhibitors
The present invention provides 4,6-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same. |
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9040542 |
Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical... |
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9040543 |
Compositions and methods for inhibition of the JAK pathway
The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of... |
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9034880 |
Tetracyclic compounds
This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3-b]indoles.... |
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9034881 |
Treatment for vitiligo
Compounds I and II, as well as prodrugs, hydrates, solvates, N-oxides, salts and pharmaceutical compositions containing them, are useful for treating vitiligo. In certain embodiments, the... |
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9023850 |
Nematocidal sulfonamides
Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S;A1, A2, A3 and A4 are independently N or CR1, provided that only one of A1, A2, A3 and A4 is N; andR1, R2, R3... |
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9023836 |
Use of substituted heterocyclic compounds to control sea lice on fish
The present invention relates to the use of compounds of formula wherein the variables are as defined in the description, in the free form or in salt form, for controlling sea lice on fish. |
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9023874 |
Fluorinated oxa or thia heteroarylalkylsulfide derivatives for combating invertebrate pests
The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or... |
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9018217 |
Phenylimidazole derivatives as PDE10A enzyme inhibitors
This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the... |
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9018216 |
Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
The invention relates to solid forms of the Formula (I) wherein X is —PO(OH)2, —PO(OH)O−M+, or —PO(O−)2.2M+, wherein M is a monovalent cation such as Na+, K+, Li+, or NH4+. The invention also... |
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9018224 |
Substituted cyclopropyl compounds useful as GPR119 agonists
Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The... |
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9012443 |
Bicyclic aryl and heteroaryl sodium channel inhibitors
The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are... |
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9012461 |
FAK inhibitors
A compound of the formula (I): where R1 or R2 is a cyclc amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor. |
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9006249 |
Substituted aminobutyric derivatives as neprilysin inhibitors
The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for... |
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9006250 |
4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
Novel 4-amino-6-(heterocyclic)picolinic acids and their derivatives and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives are useful to control undesirable vegetation. |
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8999956 |
N-[(het)arylalkyl)] pyrazole(thio)carboxamides and their heterosubstituted analogues
The present invention relates to fungicidal N-[(het)arylalkyl)]pyrazolecarboxamide or thiocarboxamide and their heterosubstituted analogs, their process of preparation and intermediate compounds... |
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8999984 |
Macrophage migration inhibitory factor antagonists and methods of using same
Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic... |
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8999966 |
Compounds that are ERK inhibitors
Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl... |
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8999957 |
Heterocyclic compounds as ERK inhibitors
The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as... |
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8993542 |
Methods of treating viral infections
The present invention provides methods of treating human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, including administering a compound described in the invention in an... |
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8993567 |
Cyclic protein tyrosine kinase inhibitors
Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated... |
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8987276 |
Substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
The present invention is concerned with novel substituted triazolyl piperazine and triazolyl piperidine derivatives of Formula (I) wherein R1, R2, R3, R4a, R4b, R5, X, Y1, Y2, L1, and L2 have the... |
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8987250 |
Therapeutic compounds
Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds... |
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8987277 |
Fungicide
The invention relates to fungicides and can be used for treating diseases caused by fungi, and also for preventing damage to various materials and agricultural products by fungi. The fungicide is... |
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8980871 |
Methods of treatment for hemolysis
Provided herein are methods of treating hemolysis by administering an active compound in an amount sufficient to treat said hemolysis. It has been found that nitroxyl donors or similar compounds... |
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8980886 |
Anthranilic acid derivatives
The present invention relates to novel anthranilic acid derivatives of the general formula (I) in which R1, R2, R3, R4, R5, Qx, A, Qy and n have the meanings given in the description, to their use... |
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8980888 |
Pyrazole derivative
It has been desired to develop a pharmaceutical composition, which is used in agents for preventing and/or treating various diseases related to PDE10 (e.g. mental disorder and neurodegenerative... |
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8980935 |
HCV protease inhibitors and uses thereof
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. |
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8975286 |
Ether benzotriazole derivatives
The present invention is directed to ether benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the... |
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8975262 |
Synthetic mimetics of host defense and uses thereof
The present invention provides arylamide compounds and methods of making and using them as antibiotics. |
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8975263 |
Phenylxanthene derivatives
The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent glucose lowering effect. A compound represented by the following general formula (I)... |
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8969359 |
Gyrase and topoisomerase IV inhibitors
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase... |
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8969352 |
Substituted 2-azabicycles and their use as orexin receptor modulators
The present invention is directed to compounds of Formula I: wherein X is N or CR1; Y is N or CR2; R1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl; R2... |
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8969383 |
Picolinamide derivatives as TTX-S blockers
The present invention relates to picolinamide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention... |
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8969338 |
Ethynyl derivatives
The present invention relates to ethynyl derivatives of formula I wherein U, V, Y, R1, R2, R2′, R3, R3′ and R8 are described herein. It has been found that the compounds of general formula I are... |
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8962640 |
Method for treating liver diseases of various origins
The invention relates to medicine, in particular to gastroenterology, and lies in the field of treatment of liver diseases of various origins. For this purpose, the hepatoprotective agent that is... |
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8957073 |
Unsaturated nitrogen heterocyclic compounds useful as PDE10 inhibitors
Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are... |
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8957083 |
Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A1, A3, A4,... |
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8951999 |
Compounds
This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as... |
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8952014 |
Pyrimidine derivatives which are CGRP—antagonists
The present invention relates to the new compounds of general formula I wherein A, U, V, X, Y, R1, R2 and R3 are defined as stated hereinafter, the tautomers, the isomers thereof, the... |
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8946234 |
Halogen-substituted compounds
The invention relates to compounds of the general formula (I), in which the radicals A1, A2, A3, A4, Lm, Q, R1, T and U have the meaning given in the description and to the use of the compounds... |
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8946230 |
Aryl- and heteroaryl- nitrogen-heterocyclic compounds as PDE10 inhibitors
Aryl- and heteroaryl-nitrogen heterocyclic compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein m, p, q, R1, R2, R3, X1, X2, X3, Y1 and Y2 are defined herein; and... |
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8946236 |
Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents
The present invention relates to new insecticides of the formula (I) in which R1, R2, R3, R4, R5, R6, A, Q and n can have the definitions stated in the description, to a number of processes for... |
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8946233 |
Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These... |
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8946218 |
CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases... |
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8946235 |
2-(2,4,5-substituted-anilino) pyrimidine compounds
The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a... |
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8946219 |
Combination therapy with a compound acting as a platelet ADP receptor inhibitor
The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing... |
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8946231 |
P2X3, receptor antagonists for treatment of pain
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or... |