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6846827 |
Pyrimidine derivatives
The invention concerns pyrimidine derivatives of Formula (I) wherein m is 0-3 and each R 1 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R 3 is hydrogen, halogeno or...
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6846818 |
Selective inhibitors of cyclooxygenase-2
The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I:
pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The...
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6846817 |
Nicotine receptor ligands
The invention provides nicotine receptor agonists of formula I:
wherein R 1 , x, y, and n have any of the values given in the specification, or a pharmaceutically acceptable salt thereof, as...
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6844347 |
Substituted 4-amino-2aryl-pyrimidines, their production and use and pharmaceutical preparations containing same
The invention relates to compounds of formula I,
in which R 1 , R 2 , R 3 and R 4 have the meanings given in the claims. Said compounds are valuable active ingredients for the treatment and...
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6835726 |
Pyrimidine derivatives
Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
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6833364 |
Substituted pyrazole derivatives
The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which the substituents R 1 , R 2 , R 3 , A, X and Y are each as defined, and to processes...
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6833371 |
Pyrazolopyrimidines
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More...
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6833370 |
Heterocycle substituted aminoazacycles useful as central nervous system agents
Heterocyclic substituted aminoazacyclic compounds of formula I Z—R 3 I, wherein Z is a defined aminoazacycle and R 3 is a defined heterocycle moiety, pharmaceutical compositions of these...
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6833369 |
Angiogenesis inhibiting 5-substituted-1,2,4,-thiadiazolyl derivatives
This invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; R 1 is...
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6831081 |
4-Oxo-4,7-dihydrothieno&lsqb 2,3-b&rsqb pyridine-5-carboxamides as antiviral agents
The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6831080 |
Cinnamide derivatives as KCNQ potassium channel modulators
There is provided novel cinnamide derivatives of Formula I: wherein R is C 1-4 alkyl or trifluoromethyl; R 1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl,...
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6831075 |
Heterocyclic substituted pyrazolones
The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods...
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6825185 |
Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
The invention describes novel substituted aryl compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective...
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6818642 |
Benzylaminopyrimidines
Benzylaminopyrimidine compounds of a certain general formula I, in which the substituents and symbols are as defined in the description, are suitable for controlling Helicobacter bacteria.
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6818631 |
Fungicidal pyrimidine derivatives
Fungicidal pyrimidine derivatives and the use as a fungicide of the compounds of formula (1): wherein R 1 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl C 3 -C 6 cycloalkyl, C 1 -C 6...
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6818646 |
Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.
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6815459 |
Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
The present invention provides novel seleno compounds containing nitrone moiety, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing...
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6812229 |
Carbamate derivative and agricultural/horticultural fungicide
It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate...
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6812231 |
Benzamidine derivative
Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated...
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6809102 |
Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer...
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6809101 |
Compounds having anti-hepatitis C virus effect
It is found out that compounds represented by the formula (I): wherein R 1 is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; and R 2 and R 3 ...
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6806230 |
Pyrimidine derivatives and herbicides containing them
Pyrimidine derivatives having excellent herbicidal activities for crop plants and selectivity between crop plants and weeds, are presented. Pyrimidine derivatives represented by the following...
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6803368 |
Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta&lsqb a&rsqb naphthalene
Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced...
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6800631 |
Method of producing a concentrate comprising a sulfonamide in solution, a 2,4-diaminopyrimidine in stable suspension within said solution
A palatable antimicrobial drug concentrate comprising: (a) a sulfonamide and/or sulfonamide salt in aqueous solution; (b) a 2,4-diaminopyrimidine in stable suspension within said solution; and (c)...
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6800646 |
Sulfamato hydroxamic acid metalloprotease inhibitor
A sulfamato hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses,...
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6800652 |
Diaryl compounds
The invention relates to compounds of formula I
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6800630 |
Pyrimidine derivatives having antitumor effect
A compound represented by the formula (I) wherein, for example, R 1 , R 2 , R 3 , and R 4 are each independently hydrogen atom, alkyl, and the like, R 5 and R 6 are each independently...
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6797708 |
Inhibitors of cytosolic phospholipase A2
This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity...
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6797709 |
Aromatic nitrogen-containing 6-membered cyclic compounds
An aromatic nitrogen-containing 6-membered cyclic compound of the formula (I): wherein Ring A is a substituted or unsubstituted nitrogen-containing heterocyclic group; R 1 is a substituted or...
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6797714 |
Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
This invention is related to novel carboxyl substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
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6797712 |
Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain
Compounds of formula I, or a pharmaceutically acceptable salt thereof, The compounds of the present invention are suitable for the treatment of pain and migraine. Also disclosed are method for...
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6794377 |
Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them
Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic...
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6794386 |
β-amino acid compounds as integrin antagonists
The present invention relates to a compound of the general formula (I), wherein R 1 together with the C atom to which it is attached, and R 2 together with the N atom to which it is attached,...
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6794398 |
Preventive/remedies for liver diseases
The invention provides an agent for the prophylaxis and treatment of liver disease and an activation inhibitor of hepatic stellate cells, which contains a compound having a Rho kinase inhibitory...
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6794370 |
Method for treating cancer using camptothecin derivatives and 5-fluorouracil
A combination therapy for treating cancer including administering at least one camptothecin derivative in conjunction with another anticancer agent. The combination therapy is preferably used as a...
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6787542 |
Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising...
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6787552 |
PPAR delta activators
Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient:...
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6787551 |
Thiazolidinedione derivatives and pharmaceutical composition comprising the same
The present invention relates to a thiazolidinedione derivative, represented in formula (1) below, pharmaceutically acceptable salts thereof, and/or pharmaceutically acceptable solvates thereof....
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6784184 |
5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones useful for inhibition of farnesyl-protein transferase
This invention relates to a method of using novel 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones of Formula (I), wherein Ar, Ar′, R 6 , m and n are as defined in...
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6780860 |
Azabicyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta&lsqb a&rsqb naphthalene as 5-ht1a antagonists
Compounds of the formula are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia and are also...
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6777403 |
Method and structure for inhibiting activity of serine elastases
Therefore, it is critical that the roles these enzymes play in biological processes outside of extracellular matrix degradation or remodeling be understood in order to assess their potential as...
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6777418 |
Retinoid compounds (I)
The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical...
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6767909 |
Compounds useful for treatment or prevention of disease mediated by alpha-2B-adrenoceptor
A compound, suitable as an alpha-2B-adrenoceptor antagoist, having a structure of formula (I) or a pharmaceutically acceptable salt thereof wherein R 1 , R 2 , R 3 , R 4 and R 5 are...
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6767908 |
Substituted imidazoles having cytokine inhibitory activity
There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which may be useful for the treatment of cytokine mediated diseases such as arthritis.
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6762198 |
Dihetero-substituted metalloprotease inhibitors
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have...
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6762197 |
Difluoromethyltriazolone compounds, use of the same and intermediates for the production thereof
A triazolone compound of the formula [I]: wherein; R 1 represents optionally substituted phenyl or the like, T represents m-phenylene optionally substituted by methyl or the like; and a...
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6756391 |
Antiviral compounds
The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
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6756367 |
Benzo-oxadiazoles, -thiadiazoles and -1,4-diazines, pharmaceutical compositions containing them and a process for preparing them
The invention provides a compound of formula I wherein X, R 1 , R 2 and Het are as defined in the description, and a process for preparing them. The compounds of formula I are useful as...
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6750219 |
&OHgr -amino-α-hydroxycarboxylic acid derivatives having integrin α&ngr β3 antagonistic activity
An objective of the present invention is to provide highly water-soluble compounds having integrin α v β 3 antagonistic activity. The compounds according to the present invention are compounds...
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6750220 |
Amine salt of an integrin receptor antagonist
The tris(hydroxymethyl)aminomethane (“TRIS”) salt of 3-(pyrimidin-5-yl)-9-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-
2-yl)-nonanoic acid is a potent antagonist of the integrin αvβ3 receptor and...
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