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8183244 |
Glycine transporter-1 inhibitors
The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition...
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8163734 |
Use of a mast cell activation or degranulation blocking agent in the manufacture of a medicament for the treatment of a patient subjected to thrombolyses
The invention concerns the use of a mast cell activation- or degranulation-blocking agent in the manufacture of a medicament for preventing and treating cerebral complications caused by...
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8138192 |
Injectable meclizine formulations and methods
Methods of treating or preventing a vertigo, nausea, or vomiting condition comprising injecting a subject with a pharmaceutically acceptable formulation consisting essentially of an effective...
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8129393 |
Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
Compounds of general formula: as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management...
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7960389 |
4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders
Compounds of general formula: wherein R1, R2 and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared....
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7700600 |
Methods for treating cardiac arrhythmia
Disclosed are methods of preventing or treating cardiac arrhythmia comprising administering to a mammal in need thereof, such as a human, an effective amount of vanoxerine (GBR 12909) or a...
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7538114 |
Glycine transporter-1 inhibitors
The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition...
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7531543 |
Phenylpiperazine cycloalkanol derivatives and methods of their use
The present invention is directed to phenylpiperazine cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions...
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7498334 |
Pyrrolopyrimidines as phosphodiesterase VII inhibitors
Pyrrolopyrimidine derivatives of the formula I in which R3, R4, R5, R6 and X are as defined in claim 1, act as phosphodiesterase VII inhibitors and can be employed for the treatment of...
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7396834 |
4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders
Compounds of general formula: wherein R1 and R2 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They...
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7384929 |
N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl or heteroaryl azaspiroalkene/alkane compounds,...
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7375106 |
Synergistic combination of an opioid analgesic and a NSAID
The invention relates to a combined pharmaceutical preparation comprising an opioid diarylmethyl piperazine compounds and a NSAID. Such a preparation in which the compounds are either given...
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7314880 |
Cardioprotective delta opioid receptor agonists and methods of using same
The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective...
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7141573 |
Polypharmacophoric agents
One aspect of the present invention relates to polypharmacophoric compounds. In certain embodiments, the polyphamacophore compounds comprise individual pharmacophore units selected from the group...
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7135473 |
Cyclic diamine compound with condensed-ring groups
A cyclic diamine compound of formula (1): wherein R1 and R2 are individually a hydrogen atom or a methoxy group, provided R1 is a methoxy group when R2 is a hydrogen atom, or a hydrogen atom when...
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7101572 |
Taste masked aqueous liquid pharmaceutical composition
A substantially taste masked liquid pharmaceutical composition containing a pharmaceutically effective amount of an unpleasant tasting drug dissolved or dispersed in an aqueous excipient base, said...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7030124 |
Method of treating depression with delta receptor agonist compounds
Methods for treatment of depression or other affective mood disorders, such as bipolar manic depression or seasonal affective disorder, are disclosed by administration to a subject suffering or...
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6951860 |
Calcium channel blockers
The invention involves the identification of a family of compounds which block calcium channels. The compounds can be formulated in pharmaceutical carriers and administered to subjects. The...
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6919350 |
Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed...
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6890927 |
Tartrate salts of 5,8, 14-triazateracyclo[10.3.1.02,11 04.9]-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof
The present invention is directed to the tartrate salts of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,
5,7,9-pentaene: and pharmaceutical compositions thereof. The present...
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6790847 |
Topical application of cetirizine and loratadine
The present invention relates to a drug composition containing the non-sedating H1 antihistamines cetirizine, loratadine, mixtures or pharmaceutically acceptable salts thereof for topical...
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6790849 |
Methods and compositions using optically pure (-) cetirizine in combination with leukotriene inhibitors or decongestants
Methods and pharmaceutical compositions employing (+) cetirizine, (−) cetirizine, or racemic cetirizine, or a pharmaceutically acceptable salt thereof, and a leukotriene inhibitor, or a p...
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6770649 |
1-&lsqb 1-(hetero)aryl-1-perhydroxyalkylmethyl&rsqb -piperazine compounds, process for their preparation and pharmaceutical compositions containing them
Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds which are antagonistic to tachykinin receptors, of the general formula I, wherein R6, R7, A and Z have the meanings given in...
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6686353 |
Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
Cyclic diamines of formula (I) or their pharmacologically acceptable acid addition salts, and their medical applications are described. These compounds inhibit the action of chemokines such as...
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6680321 |
Compounds with analgesic effect
Compounds of the formula (I) as well as their pharmaceutically acceptable salts, and pharmaceutical compositions comprising the novel compounds. The novel compounds of the formula (I) are useful in...
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6649602 |
Use of an H1 antagonist and a safe steroid to treat eye conditions
Composition and method of treating VKC, GPC, and AKC with H1 antagonists and ocularly safe steroids are disclosed.
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6521254 |
Single-dose antihistamine/decongestant formulations for treating rhinitis
Pharmaceutical dosage forms for oral administration of an antihistamine and a decongestant are disclosed. The dosage forms provide an antihistamine in an amount and formulation to exhibit...
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6503950 |
Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms
A triple drug, pharmaceutical kit, composition, and method of treatment containing a combination of effective amounts of at least one anxiolytic agent, at least one centrally acting alpha...
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6489329 |
Pharmaceutical compositions for the treatment of rhinitis
A pharmaceutical composition comprising a therapeutically effective amount of a mixture consisting essentially of (i) pseudoephedrine, an individual optical isomer or a pharmaceutically acceptable...
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6436942 |
Enantiomers of 1&lsqb (4-chloro-phenyl) phenylmethyl&rsqb -4-&lsqb (4-methylphenyl) sulfony&rsqb piperazine
Levorotatory and dextrorotatory enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl
]piperazine of the formula their preparation and use for the preparation of substantially...
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6432961 |
Method for preventing the onset of asthma
The present invention relates to a method for preventing the onset of asthma which comprises administering to a patient a therapeutically effective amount of cetirizine, an individual optical...
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6417184 |
Triple drug therapy for the treatment and prevention of acute or chronic pain
A triple drug therapy, pharmaceutical kit, composition, and method of treatment regimen utilized as a combination of effective amounts of an anxiolytic agent, centrally acting alpha antiadrenergic...
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6413959 |
Method of treating depression with arylglycinamide derivatives
The invention relates to new arylglycinamide derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a...
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6410537 |
Compositions having neuroprotective and analgesic activity
Compounds of the formula: wherein R1 and R2 are alkyl of 1-8 carbons have been shown to have both neuroprotective and analgesic activities. The compounds of the invention may be used in treatment...
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6403589 |
Method of treating pain with draflazine-analogues
This invention concerns the use of nucleoside transport inhibitors, more particularly compounds of formula an N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically...
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6387910 |
Drug of improving optic nerve head circulation disorder
A novel drug for improving the circulation in the optic nerve head, which comprises as an active ingredient Lomerizine (I): or a pharmaceutically acceptable acid addition salt. The optic nerve head...
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6387389 |
Sustained-release derivatives of hydroxylated analogs of substituted 1-&lsqb 2&lsqb bis(aryl)methoxy&rsqb ethyl&rsqb -piperazines and -homopiperazines and their use
The present invention provides sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines, pharmaceutical compositions...
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6384038 |
Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants
Methods and pharmaceutical compositions employing (+) cetirizine, (−) cetirizine, or racemic cetirizine, or a pharmaceutically acceptable salt thereof, and a leukotriene inhibitor, or a p...
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6335331 |
Pseudopolymorphic forms of 2-&lsqb 2-&lsqb 4-&lsqb Bis (4-fluorophenyl) methyl&rsqb -1-piperazinyl&rsqb ethoxy&rsqb acetic acid dihydrochloride
The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis (4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous...
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6300332 |
Methods for reducing respiratory depression and attendant side effects of mu opioid compounds
A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed...
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6262057 |
Pseudopolymorphic forms of 2-[2-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]ace
tic acid dihydrochloride, namely, anhydrous...
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6258816 |
Anti-allergy anti-inflammatory composition
A novel composition of Nimesulide and salts thereof and Cetrizine possessing antileukotriene, antihistaminic, antiallergic and antiinflammatory action is disclosed. The composition is useful in the...
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6242450 |
5-HT1F antagonists
This invention provides 5-HT1f antagonists of Formula I: ##STR1##where AR1, AR2, R, and R' are as defined in the specification.
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6177427 |
Treatment of glaucoma and ocular hypertension
Compositions of non-steroidal glucocorticoid antagonists for treating glaucoma or ocular hypertension and methods for their use are disclosed.
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6140324 |
Use of a tachykinin antagonist and a muscarinic antagonist and/or an antihistamine to treat motion sickness
The present invention relates to the use of a tachykinin antagonist and a muscarinic antagonist and/or an antihistamine for the treatment or prevention of motion sickness. There is also provided...
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6100280 |
Narcotic antagonist
A narcotic antagonist comprising, as its active component, a compound represented by the following formula (1) or a physiologically acceptable salt thereof: wherein each of R1 and R2, which may be...
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5910499 |
Antiallergic agent having an anti-oxidant action
An antiallergic agent having leucotriene production inhibiting action and antihistaminic action, which can be orally administered is provided; the antiallergic agent comprises a hydroquinone...
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5874436 |
Triphenylalkyl antimicrobial agents
The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use....
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5869479 |
Treatment of upper airway allergic responses
Relief from the symptoms of rhinitis is obtained by treatment with: (a) an antihistaminic effective amount of a histamine H1 receptor antagonist; together with (b) a sufficient amount of a...
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