|
Match
|
Document |
Document Title |
|
|
7390812 |
N, N'-disubstituted piperazine compounds and their use as analgesics
N,N′-disubstituted piperazine compounds, processes for the production thereof, and pharmaceutical preparations containing these compounds. The use of N,N′-disubstituted piperazine compounds for...
|
|
|
7381728 |
Piperazine derivatives useful for the treatment of gastrointestinal disorders
The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R a , R b , R c , R d , R e , R f and Y are as defined in the specification. The compounds are...
|
|
|
7345041 |
Chemical compounds
The invention relates to methods for the treatment of a sleep disorder comprising administering a compound of formula (I):
wherein all variables are as defined herein.
|
|
|
7319099 |
Benzoyl-piperazine derivatives
The invention relates to compounds of formula
wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such...
|
|
|
7319097 |
Compounds
The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the...
|
|
|
7291621 |
Substituted biaryl amides C5a receptor modulators
Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C 5 a receptor activity in vivo or in vitro, and are particularly useful in the...
|
|
|
7285553 |
Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
Compounds with 5HT 7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating...
|
|
|
7262188 |
Phenyl sulfone derivatives and their use in the treatment of CNS disorders
This invention relates to novel phenyl sulfone compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS...
|
|
|
7238693 |
Aryl carbamate derivatives, preparation and use thereof
The present invention relates to novel compounds, the preparation and use, particularly therapeutic, thereof. More specifically, it relates to compounds derived from aryl carbamates, the...
|
|
|
7226925 |
Compounds, their use and preparation
The invention relates to compounds of the general Formula (I):
The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from...
|
|
|
7214714 |
20-hydroxyeicosatetraenoic acid production inhibitors
A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof
[wherein R 1 represents a substituted morpholino group, a substituted...
|
|
|
7173035 |
Arylsulfonamide compounds
The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the...
|
|
|
7153858 |
Arylpiperazinyl compounds
The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formulae I: and II, and synthesis and uses of those compounds for treating...
|
|
|
7148238 |
Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I
wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective...
|
|
|
7144884 |
Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder,...
|
|
|
7138407 |
Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I
wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective...
|
|
|
7135472 |
3-Heterocyclic benzylamide derivatives as potassium channel openers
The present invention provides novel 3-heterocyclic benzylamides and related derivatives having the general Formula I
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A and Het are as defined in the...
|
|
|
7105521 |
Eugenosedin-A based pharmacoligical agents
The present invention provides isoeugenol derivative compounds having the moiety
and having α 2 -adrenergic/5-HT 2A antagonist, 5-HT re-uptake inhibition, and anti-oxidant activities.
|
|
|
7105507 |
Cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
|
|
|
7101887 |
1-phenyl-4-benzylpiperazines dopamine receptor subtype specific ligands
Disclosed are compounds of the formula:
or the pharmaceutically acceptable addition salts thereof wherein:
R 1 is halogen or C 1 –C 4 alkyl; and R 2 and R 3 are the same or...
|
|
|
7074820 |
Amidino derivatives and their use as thrombin inhibitors
There is provided compounds of formula I,
wherein R 1 , R 2 , R 3 , Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such...
|
|
|
7074796 |
4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I
wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C...
|
|
|
7071197 |
N,N-disubstituted diazocycloalkanes
N,N-Disubstituted diazocycloalkanes of the formula I
(R 1 =halogen, R 2 =(C 3 –C 8 )-cycloalkyl, R 3 =(C 1 –C 4 )-alkoxy or (C 1 –C 4 )-haloalkoxy group, m is 1 or 2 and n is 1 or 2,...
|
|
|
7071196 |
Chemical compounds
The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of...
|
|
|
7067501 |
Aryloxyphenyl and arylsulfanylphenyl derivatives
The invention provides compounds of the formula
wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors.
|
|
|
7056922 |
Acylamino cyclopropane derivatives
A compound of the formula
wherein D, E, F, G, L, T, W, X, Y, Z, U, A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 R 7 are as defined in the specification, pharmaceutical compositions thereof, and...
|
|
|
7037914 |
Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient
A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I)
(wherein all symbols are as defined in the specification), a non-toxic acid...
|
|
|
7030122 |
1,4-disubstituted piperazine ligands for neurotransmitter receptors
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various...
|
|
|
7019007 |
CCR-3 receptor antagonists (I)
The invention provides compounds of Formula (I):
wherein: R 1 –R 4 , A, D, and L have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical...
|
|
|
7001908 |
Arylpiperazines having activity at the serotonin 1A receptor
A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1 A receptor; the compounds are particularly effective...
|
|
|
7001907 |
Peptide-containing α-ketoamide cysteine and serine protease inhibitors
This invention relates to peptide-containing α-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same.
|
|
|
6969713 |
Piperidine and piperazine acetamide derivatives
The invention provides piperidine and piperazine derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the...
|
|
|
6951860 |
Calcium channel blockers
The invention involves the identification of a family of compounds which block calcium channels. The compounds can be formulated in pharmaceutical carriers and administered to subjects. The...
|
|
|
6916816 |
Phenanthryl piperazinyl dicarboxylic acids as selective NMDA receptor modulating agents
Disclosed are compounds of formula (I) wherein: L is (a) optionally substituted by replacement of one or more of the hydrogen atoms on the phenanthrene ring system by one or more groups other than...
|
|
|
6906074 |
2-phenylpiperazine derivatives
A 2-phenylpiperazine derivative represented by the formula (I) or a pharmaceutically acceptable salt, hydrate, or complex thereof:
wherein each of X 1 and X 3 is oxygen or two hydrogen...
|
|
|
6906073 |
Piperazine CCR-3 receptor antagonists
The invention provides compounds of Formula (I):
wherein: R 1 -R 4 , A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical...
|
|
|
6894053 |
Serotonergic agents with long-acting in vivo effects
Compounds of the formula
have a long duration of action and are useful for the treatment of chronic diseases resulting from the dysfunction of the serotonergic 5-HT 1A system, such as...
|
|
|
6894052 |
Diarylalkylpiperazines active on the lower urinary tract
Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are diarylalkylpiperazine derivatives. The methods comprise the...
|
|
|
6887878 |
KMST isoeugenol derivatives and pharmaceutical activity
A compound having the following formula I:
where R 1 is an alkyl group or an alkenyl group, X represents
R 2 is selected from the group consisting of a halogen (o, m, p) group such...
|
|
|
6887876 |
Benzamidine derivatives
Benzamidine derivatives
are useful delta-opioid receptor modulators, agonists useful as analgesics and antagonists useful as immunosuppressants, antiinflammatory agents, agents for the...
|
|
|
6881738 |
Analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders
The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease,...
|
|
|
6878707 |
Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion
Compounds of formula (I) wherein R 2 —C, R 3 —C, R 4 —C or R 5 —C may be replaced by N; and wherein n is 1, 2 or 3; R 1 is aryl, heteroaryl or (aryl or heteroaryl)-lower alkoxy; R 2 , R 3...
|
|
|
6864262 |
1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine and pharmaceutically acceptable salts and solvents thereof
The present invention provides a compound of the formula (I)
and the pharmaceutically acceptable salts and solvates thereof, which is useful for treating bladder over-activity or urinary...
|
|
|
6858624 |
Aryl fused azapolycyclic compounds
This invention is directed to compounds of the formula (I):
and their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of...
|
|
|
6831084 |
Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity
This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzheimer's Disease, Huntington's...
|
|
|
6831080 |
Cinnamide derivatives as KCNQ potassium channel modulators
There is provided novel cinnamide derivatives of Formula I: wherein R is C 1-4 alkyl or trifluoromethyl; R 1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl,...
|
|
|
6825202 |
Arylsulfonyl derivatives with 5-HT6 receptor affinity
This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I): wherein Ar, R 1 , R 2 , R 3 or R 4 are as defined in the...
|
|
|
6821967 |
Substituted piperazine derivatives, the preparation thereof and their use as medicaments
The present invention relates to substituted piperazine derivatives of general formula wherein R a , R b , R c , R f , R g , X, m and n are defined as in claim 1, the isomers and salts thereof,...
|
|
|
6806278 |
Amino-tetralin derivatives as muscarinic receptor antagonists
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein R 1 , R 2 , R 3 and R 4 are as defined in the...
|
|
|
6777414 |
Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same
Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing...
|