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8183239 |
Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor
The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to...
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8153637 |
Phenyl-alkyl piperazines having TNF-modulating activity, preparation method, and therapeutic use thereof
The present invention relates to phenyl-alkyl piperazines of formula (I): in which A, R1, R2 and R3 are as defined herein, having TNF-modulating activity. The invention also relates to the...
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8138192 |
Injectable meclizine formulations and methods
Methods of treating or preventing a vertigo, nausea, or vomiting condition comprising injecting a subject with a pharmaceutically acceptable formulation consisting essentially of an effective...
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8076342 |
Malonate salt of 4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and uses of same
4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiper
azine hydrogen malonate salt and pharmaceutical comprising and uses of the same, including for the treatment of schizophrenia and other...
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8076326 |
N-phenyl- (piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor
The present invention relates to N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds, pharmaceutical compositions...
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8034818 |
Therapeutic uses of derivatives of piperidinyl- and piperazinyl-alkyl carbamates
Therapeutic uses of a compound corresponding to the general formula (I): in which A=N or CR2; R2=H, F, OH, CN, CF3, C1-6-alkyl, C1-6-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when...
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8022074 |
4-(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
The invention relates to at least one compound of general formula I wherein R1 is phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, or pyridine N-oxide, where each R1...
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8012982 |
Modulators of HCV replication
The present invention is directed to compounds of formula (I): where X, Y, R1, R2 and R3 are defined therein, which can act as modulators of viral replication and/or virus production, especially of...
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7985752 |
Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof
The present invention relates to novel piperazine derivatives or pharmaceutically acceptable salts thereof, a process for preparing the same, and in particular, a high binding for Serotonin...
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7973039 |
Sulfonyl amino cyclic derivatives and use thereof
The present invention is related to derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular...
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7968538 |
Substituted arylamine compounds and methods of treatment
The invention relates to 5-HT6 receptor antagonists. Novel arylamine compounds and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention...
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7964605 |
Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof
The present invention relates to a novel piperazine derivative or pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition for treating central...
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7915253 |
Sulfonyl-substituted bicyclic compounds as modulators of PPAR
Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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7879836 |
Pharmaceutical composition comprising a 1-(3-chlorophenyl)-3-alkylpiperazine for treating appetite disorder
Use of a 1-(3-chlorophenyl)-3-alkylpiperazine of formula (I), in racemic (R,S) form or in the form of the (S) enantiomer, in which R is a linear or branched alkyl group having from 1 to 3 carbon...
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7875617 |
3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands
The invention relates to 3,4-dihydro-2-naphthamide derivatives of formula (I), pharmaceutical compositions containing them and their therapeutic applications as partial agonists or antagonists of...
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7829569 |
Solvate and crystalline forms of carbamoyl-cyclohexane derivatives
The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of...
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7825122 |
Diaza heterocyclic sulfonamide derivatives and their uses
Diaza heterocyclic sulfonamide derivatives according to formula I have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: where R7, R8,...
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7799824 |
Quaternary salt CCR2 antagonists
Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory...
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7790727 |
Benzenesulfonanilide compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor
The present invention relates to novel benzenesulfonanilide compounds of the formulae I and I′ and physiologically tolerated acid addition salts and the N-oxides thereof. The compounds possess v...
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7772240 |
Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine
A compound 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-2,2-dimethylpiperazi
ne and salts thereof, pharmaceutical compositions comprising the compound and salts, and medical use thereof, including for...
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7767683 |
Hydrogen succinate salts of trans-4-((1R, 3S)-6-chloro-3-phenylindan-1-YL)-1,2,2-trimethylpiperazine and the use as a medicament
4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiper
azine hydrogen succinate, pharmaceutical compositions containing the salt and the medical use thereof, including for the treatment of...
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7767684 |
Apoptosis promoters
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating...
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7763657 |
Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salt thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRRPV1) antagonist; and a...
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7750012 |
Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation
The present invention relates to a chemical genus of biaryl nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general formula They are...
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7737142 |
(Thio) carbamoyl-cyclohexane derivatives as D3/D2 receptor antagonists
The present invention relates to new D3 and D2 dopamine receptor subtype preferring ligands of formula (I): wherein R1 and R2 represent independently a substituent selected from hydrogen, alkyl,...
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7723337 |
3-cinnolinecarboxamide derivatives and their use for treating cancer
The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their...
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7718704 |
Immunosuppressant compounds and compositions
The invention provides a novel class of cyclic oximes of Formula I: wherein A, X, Y, Z, W, R1, R2, R3 and n are as described in the summary of the invention; useful in the treatment or prevention...
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7705003 |
Cyclohexylamides as dopamine D3, D2 and 5-HT1A Antagonists
The present invention relates to new dopamine D3 and D2 and serotonin 5-HT1A receptor subtype preferring ligands of formula (I); wherein A represents alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or...
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7687600 |
Invertible amphiphilic polymers
Amphiphilic monomeric compounds and corresponding homopolymers and copolymers capable of assembly and invertible configuration in introduction to and change in fluid medium.
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7671055 |
Insecticidal 3-(dihaloalkenyl) phenyl derivatives
Certain novel 3-(dihaloalkenyl)phenyl derivatives have unexpected insecticidal activity. These compounds are represented by formula (I), where R through R5, a, b, D, E, G and U are fully described...
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7671058 |
N-(3,4-disubstituted phenyl) salicylamide derivatives
A compound represented by the following formula (I) or a salt thereof: wherein R1, R2, R3 and R4 represent hydrogen atom, a halogen atom, cyano group, nitro group, a C1-4 alkyl group, a halogenated...
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7659277 |
Ubiquitin ligase inhibitors and methods related thereto
The application discloses compounds that inhibit ubiquitin ligase activity. The application further discloses antiviral compounds, anticancer compounds, and compounds useful for the treatment of...
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7648991 |
Crystalline base of trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine
Crystalline base of compound trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpi
perazine, processes for the preparation of purified free base or salts of this compound, pharmaceutical...
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7645760 |
1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives
A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically...
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7642262 |
Arylipiperdinopropanol and arylipiperazinopropanol derivatives and pharmaceuticals containing the same
A compound having the formula (I) or its salt, hydrate, hydrate salt or solvate: wherein R1 to R4 independently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl...
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7632838 |
11-beta HSD1 inhibitors
This invention relates to inhibiting 11βHSD1.
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7625904 |
Methods for the treatment of sleep disorders
The invention relates to methods for the treatment of a sleep disorder in a mammal comprising administering to said mammal an effective amount of a compound of formula (I): wherein all variables...
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7601720 |
Nicotinic receptor agonists for the treatment of inflammatory diseases
This invention relates to the use of nicotine receptor agonists for treating inflammatory diseases, including a variety of pulmonary diseases. Such agonists have fewer side effects than other...
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7572787 |
Substituted naphthalene sulfonamides
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
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7563795 |
Phenyl-piperazine derivatives as modulators of muscarinic receptors
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic...
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7544716 |
Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists
This invention relates to tetrahydro-naphthalene derivatives of formula (I) in which the variable groups are as defined in the specification and claims, and tautomeric and stereoisomeric forms and...
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7517885 |
Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds
The present invention relates to substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor m...
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7517884 |
Sulfonyl-substituted bicyclic compounds as modulators of PPAR
Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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7494999 |
Sulfonyl-substituted bicyclic compounds as modulators of PPAR
Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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7491727 |
Arylpiperazinyl compounds
The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formula I, and synthesis and uses thereof for treating diseases including...
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7488730 |
N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands
A series of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealk
ylamides was prepared and their affinity for serotonin 5-HT7, 5-HT1A, and 5-HT2A receptors was measured using in vitro...
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7485644 |
N-{'4-substituted piperazine-1-sulfonylmethylalkyl}-n-hydroxyfomamide compounds as metalloproteinase inhibitors
The invention provides compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein ring B represents a monocyclic aryl ring having six ring atoms or a...
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7482346 |
Derivatives of alkylpiperazine and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors
The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido...
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7473692 |
Sulfonamide derivatives as D3-receptor ligands
The present invention relates to new D3 dopamine receptor subtype selectice ligands of formula (I) to pharmacological compositions containing the same and to their use in therapy and/or prevention...
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7452891 |
MCH antagonists and their use in the treatment of obesity
The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention...
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