Patents in Class 514/254.110

Matches 1 - 50 out of 348

1 2 3 4 5 6 7 >

Match	Document	Document Title
1	7378421	Chromenone derivatives Novel compounds of the formula I in which R 1 , R 2 , R 3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for the treatment of...
2	7335660	Isochroman compounds for treatment of CNS disorders This invention relates to compounds of formula (I) where R 1 to R 12 , —W—V—, —X—Y—, p and n have the values defined in claim 1 , their preparation and use as pharmaceuticals for...
3	7312242	Use of parthenolide derivatives as antileukemic and cytotoxic agents Compounds of the formula having anti-tumor activity, wherein R 1 and R 2 are as described herein
4	7271168	Piperazine derivatives having SST1 antagonistic activity The invention provides compounds of formula ( 1 ) wherein X, R 1 and R 2 are as defined in the specification, their, preparation and to their use in treating, e.g., depression, anxiety and...
5	7256187	Rifamycin C-11 oxime derivatives effective against drug-resistant microbes The invention relates to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the rifamycin derivatives having an oxime...
6	7253172	Dipeptidyl peptidase inhibitors for the treatment of diabetes Compounds having Formula I, including pharmaceutically acceptable salts and prodrugs thereof: (I) are inhibitors of the dipeptidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of...
7	7208497	Substituted piperazines and diazepanes A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor....
8	7189726	Benzofuran derivatives as inhibitors of p38-α kinase The invention is directed to methods to inhibit p38-α kinase using compounds which contain an aromatic residue coupled to an benzofuran moiety through a piperidine.
9	7186752	Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.
10	7176236	Water-soluble etoposide analogs and methods of use thereof Etoposide analogs with improved water-solubility such as 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-n itroanilino)-4-desoxy-podophyllotoxin (8) and...
11	7144883	Bicyclic sulfonamide compounds The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
12	7135473	Cyclic diamine compound with condensed-ring groups A cyclic diamine compound of formula (1): wherein R 1 and R 2 are individually a hydrogen atom or a methoxy group, provided R 1 is a methoxy group when R 2 is a hydrogen atom, or a hydrogen...
13	7084144	Sulfonyl group containing compounds and their use for the treatment of erectile dysfunction A compound having the general formula (I): wherein: X is N or C; R 0 is H, a lower alkyl group, a lower O-alkyl group, lower alkyl group, a benzyl group, a phenyl group, a heterocyclic...
14	7067513	Phenylpiperazines The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D 2 receptor and/or the serotonin reuptake site,...
15	7026314	Therapeutic chromone compounds Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating,...
16	6995153	Fused bicyclic pyrimidine derivatives A novel fused bicyclic pyrimidine derivative or a salt thereof that acts as a tachykinin receptor antagonist and, in particular, as an NK1 receptor antagonist is represented by the following...
17	6967201	Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R 1 , R 2 , R 3 , R 4 , R 5 , R 5′ , R 6 , R 6′ , R 7...
18	6916831	Flavone acetic acid analogs and methods of use thereof Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O...
19	6916812	Alpha-aminoamide derivatives as melanocortin agonists Novel piperazine and homopiperazine derivatives are agonists of melanocortin receptor(s) and are useful for the treatment, control, or prevention of diseases and disorders responsive to the...
20	6900213	Bisaryl derivatives having FSH modulatory activity The invention relates to bisaryl derivatives of the formula I, wherein (R,R) is selected from (H,H), O, (H,CH 3 ), (H,OH) and (H,CN); Ar is substituted phenyl and A is a group of formula II,...
21	6894052	Diarylalkylpiperazines active on the lower urinary tract Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are diarylalkylpiperazine derivatives. The methods comprise the...
22	6867230	Hygromycin A derivatives This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 and R 10 are as defined herein. The...
23	6852723	Aralkyl substituted piperazine compounds Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage...
24	6825202	Arylsulfonyl derivatives with 5-HT6 receptor affinity This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I): wherein Ar, R 1 , R 2 , R 3 or R 4 are as defined in the...
25	6825201	Indole, azaindole and related heterocyclic amidopiperazine derivatives The invention comprises substituted indole, azaindole and related heterocyclic amidopiperazine derivatives of general Formula I wherein: Q is —may represent a bond; A is selected from the...
26	6821977	Antidiabetic agents A compound of the formula whereon R 1 is: R 5 is: and n, m, Z, R 8 , R 9 , R 10 and R 11 are as defined herein, useful in the treatment of diabetes, insulin resistance, diabetic...
27	6821967	Substituted piperazine derivatives, the preparation thereof and their use as medicaments The present invention relates to substituted piperazine derivatives of general formula wherein R a , R b , R c , R f , R g , X, m and n are defined as in claim 1, the isomers and salts thereof,...
28	6777414	Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing...
29	6770649	1-&lsqb 1-(hetero)aryl-1-perhydroxyalkylmethyl&rsqb -piperazine compounds, process for their preparation and pharmaceutical compositions containing them Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds which are antagonistic to tachykinin receptors, of the general formula I, wherein R 6 , R 7 , A and Z have the meanings...
30	6753331	Heterocyclic derivatives which inhibit factor Xa The invention relates to heterocyclic derivatives of formula (I), or pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties and are accordingly useful...
31	6699864	Substituted phenyl-piperazine derivatives, their preparation and use The present invention provides compounds of the formula: wherein R 1 -R 8 , X, Y, Z, n and m are defined in the application. The compounds of the invention have affinity for the 5-HT 1A receptor.
32	6699858	Halogen substituted tetracyclic tetrahydrofuran derivatives This invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero, 1, 2,...
33	6680318	Piperazinomethylbenzamides as delta-opioid receptor agonists The present application is directed to compounds having the general formula: and to the use of these compounds in therapeutic methods.
34	6677343	Substituted piperazine compounds Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage...
35	6664258	Spirocyclic dopamine receptor subtype ligands This invention relates to novel, pharmaceutically active compounds of formula (I) wherein a, b and R 1 through R 6 are as defined in the specification These compounds exhibit central...
36	6645951	Benzopyran or thiobenzopyran derivatives The present invention provides novel benzopyran compounds, pharmaceutically acceptable salts thereof and stereoisomers thereof where the benzopyran compounds of the invention are compounds...
37	6638972	Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
38	6638936	Benzofurylpiperazine serotonin agonists The present invention provides serotonergic benzofurans of Formula I: where R is methyl or ethyl, or pharmaceutically acceptable acid addition salts thereof.
39	6620843	Anticancer treatment using triptolide prodrugs Water soluble triptolide prodrugs are used as anticancer agents, and are found to be more effective in vivo, at lower doses, in reducing tumor size than the widely used chemotherapeutic agents...
40	6608089	Derivatives of flavones, xanthones and coumarins Compounds having the formula (I) Z—OCH 2 —C≡CCH 2 —NRR 1 (I) or a pharmaceutically acceptable salt or solvate thereof wherein Z can represent the formula (1A) or (1B). The compounds...
41	6599904	Sulphonamide derivatives, process for their preparation, and their use as medicaments Novel sulphonamide derivatives having CNS activity, processes for their preparation and their use as medicaments are disclosed. The present compounds are of formula (I) or a salt thereof: ...
42	6596745	Method for treating fibrotic diseases with azolium chroman compounds Provided is a method of treating or ameliorating hypertension in an animal comprising administering an effective amount of a compound of formula I:
43	6596722	Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use A piperidine, tetrahydropyridine or piperazine derivative having formula (I), any of its enantiomers or any mixture thereof, or an acid addition salt thereof, wherein B is C 1-10 -alkylene, C...
44	6552022	Benzamide derivatives and their use as ApoB-100 secretion inhibitors The invention relates to therapeutic benzamide compounds of formula (I) wherein A, X, Z, R 1 , Y, R 2 , R 3 , are as defined herein, and physiologically acceptable salts, solvates or derivatives...
45	6514967	Compound for preparing medicines for treating pathologies involving extracellular glutamate, and methods for obtaining same The invention relates to compounds of the following general formula (I): in which: R 1 and R 2 represent a hydrogen atom, or form a ring, especially a benzene ring, R 3 represents a hydrogen...
46	6506555	Use of HIV protease inhibiting compounds The invention relates to the use of at least one compound that inhibits HIV (human immunodeficiency virus) protease, selected from ritonavir, saquinavir or one of the pharmaceutically acceptable...
47	6492368	Benzamidine derivatives as factor XA inhibitors Novel compounds of the formula I in which X, Y, R 1 , R 2 and R 3 are as defined in Patent Claim 1 are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
48	6486164	6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands Disclosed are compounds of the formula: or the pharmaceutically acceptable acid addition salts thereof wherein: R 1 , R 2 , R 3 , R 4 and R 5 are the same or different and represent hydrogen,...
49	6486163	Thienopyranecarboxamide derivatives The invention relates to novel N-(substituted phenyl)-N′-[ω-(5-substituted-7-oxo-7H-thieno[3,2-b]pyran- 3-carbonylamino)alkyl]piperazines their N-oxides and pharmaceutically acceptable salts...
50	6482827	Matrix metalloproteinase inhibitors A compound, which is an amine derivative of formula (I) wherein W is —CNHOH or —COOH: R 1 and R 2 are each hydrogen or an organic residue, R 3 is an organic group, Q is a secondary or...

Matches 1 - 50 out of 348

1 2 3 4 5 6 7 >