|
Match
|
Document |
Document Title |
|
|
7371756 |
Use of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and its physiologically acceptable salts
1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-y
l)-piperazine or a physiologically acceptable salt thereof, for the treatment of sub-type anxiety disorders chosen from the sub-types:...
|
|
|
7365077 |
Piperazine bis-amide derivatives and their use as antagonists of the orexin receptor
Disclosed are piperazine bis-amide derivatives useful as antagonists of the orexin receptor and pharmaceutical compositions containing the same.
|
|
|
7358253 |
Indolylmaleimide derivatives
Provided are compounds of formula (I)
which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ...
|
|
|
7319098 |
1,3-dioxoisoindole derivatives having selective antagonism of T-type calcium channel
The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel...
|
|
|
7314879 |
Melanocortin receptor agonists
The present invention relates to melanocortin receptor agonist of the formula (I): which is useful in the treatment for obesity, diabetes, and male and/or female sexual dysfunction
|
|
|
7304064 |
1-[(indol-3-yl)carbonyl]piperazine derivatives
The present invention relates to 1-[(indol-3-yl)carbonyl]piperazine derivative according to the general formula I
or a pharmaceutically acceptable salt thereof. The invention also relates to...
|
|
|
7300936 |
α-(N-sulfonamido)acetamide derivatives as β-amyloid inhibitors
There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I)
wherein R, R 1 , R 2 and R 3 are defined herein, which are inhibitors of β-amyloid peptide...
|
|
|
7268139 |
Methods of promoting osteogenesis
The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting,...
|
|
|
7253172 |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
Compounds having Formula I, including pharmaceutically acceptable salts and prodrugs thereof: (I) are inhibitors of the dipeptidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of...
|
|
|
7244730 |
2-iminopyrrolidine derivatives
A 2-iminopyrrolidine derivative represented by the formula:
{wherein ring B represents a benzene ring, pyridine ring, etc.; R 101 –R 103 represent hydrogen, halogen, C 1-6 alkyl, etc.; R 5 ...
|
|
|
7223765 |
4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I
wherein
W is C, CH or N, and the dotted line emanating from W indicates a bond when W...
|
|
|
7186724 |
Heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands
The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D 3 receptors. In another aspect, the invention relates to a method for treating...
|
|
|
7186715 |
Piperazine- and piperidine-derivatives as melanocortin receptor agonists
The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
|
|
|
7173027 |
Receptor selective cannabimimetic aminoalkylindoles
Disclosed are cannabimimetic aminoalkylindole compounds and methos for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoinds. Also disclosed are methods of...
|
|
|
7157463 |
Substituted piperidines/piperazines as melanocortin receptor agonists
The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
|
|
|
7144883 |
Bicyclic sulfonamide compounds
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
|
|
|
7135473 |
Cyclic diamine compound with condensed-ring groups
A cyclic diamine compound of formula (1):
wherein R 1 and R 2 are individually a hydrogen atom or a methoxy group, provided R 1 is a methoxy group when R 2 is a hydrogen atom, or a hydrogen...
|
|
|
7119093 |
3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition
The present invention relates to the compound...
|
|
|
7115607 |
Substituted piperazinyl amides and methods of use
Selected substituted piperazine compounds of Formula I
are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds,...
|
|
|
7109201 |
Piperazine derivatives, their preparation and uses in therapy
Compounds of formula (I) or a pharmaceutically acceptable salt thereof are disclosed:
in which R a is a group of formula (i)
wherein P 2 is phenyl, naphthyl, heteroaryl or a 5 to 7...
|
|
|
7101875 |
Methods for treating arthritic disorders
This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms...
|
|
|
7094779 |
Piperazine oxime dervatives having NK-1 receptor antagonistic activity
The present invention relates to a group of novel piperazine oxime derivatives having interesting NK-1 antagonistic activity. The invention relates to compounds of the general formula (1) wherein:...
|
|
|
7084143 |
N-(indolecarbonyl) piperazine derivatives
The invention relates to compounds of formula (I) wherein R 1 , R 2 , R 4 and R 5 have the meaning given in Claim 1 . Said compounds are potent 5-HT 2A -antagonists and are suitable for the...
|
|
|
7074796 |
4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I
wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C...
|
|
|
7074782 |
Carbamate caspase inhibitors and uses thereof
This invention provides caspase inhibitors of formula I:
wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; Y is an electronegative leaving group; R 2...
|
|
|
7067513 |
Phenylpiperazines
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D 2 receptor and/or the serotonin reuptake site,...
|
|
|
7060704 |
Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
Compounds with 5HT 7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating...
|
|
|
7060703 |
Indolinone derivatives
Compounds of formula (I)
in which R 1 , R 2 , R 3 and R 4 have the meanings given in the specification, are receptor tyrosine kinase inhibitors useful in the treatment of proliferative...
|
|
|
7041668 |
Substituted benzimidazole compounds and their use for the treatment of cancer
The present invention discloses and claims benzimidazole compounds of formula (I):
in which A is aryl or heteroaryl; R 1 is selected from optionally substituted alkyl, alkoxy, aryl or...
|
|
|
7030123 |
Indole derivatives with vascular damaging activity
The invention provides a compound of Formula (I).
Wherein R1, R2, R3, R10 and R11 have the meanings given in the description. Such compounds are predicted to cause the selective destruction of...
|
|
|
7026314 |
Therapeutic chromone compounds
Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating,...
|
|
|
7022708 |
4-piperazinyl benzenesulfonyl indoles and uses thereof
This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I:
wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein; or...
|
|
|
6958338 |
4-,5-,6-and 7-indole derivatives useful for the treatment of CNS disorders
The present invention relates to 4-, 5-, 6- or 7-methylene substituted indolyl derivatives of formula I
wherein R is aryl or heteroaryl, where said aryl or heteroaryl groups may be substituted...
|
|
|
6916812 |
Alpha-aminoamide derivatives as melanocortin agonists
Novel piperazine and homopiperazine derivatives are agonists of melanocortin receptor(s) and are useful for the treatment, control, or prevention of diseases and disorders responsive to the...
|
|
|
6911463 |
3-substituted oxindole β-3 agonists
The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and,...
|
|
|
6903104 |
Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following...
|
|
|
6900206 |
Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with sulfonylureido...
|
|
|
6894052 |
Diarylalkylpiperazines active on the lower urinary tract
Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are diarylalkylpiperazine derivatives. The methods comprise the...
|
|
|
6875439 |
Formulation containing amphipathic weak base and/or amphipathic cation and multiple drug resistance inhibitor
Methods are provided relating to the enhanced cytoplasmic accumulation of amphipathic weakly basic or amphipathic cationic molecules in prokaryotes and eukaryotes under conditions of high...
|
|
|
6869957 |
Non-peptide tachykinin receptor antagonists
This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention...
|
|
|
6864266 |
4-piperidinyl alkyl amine derivatives as muscarinic receptor antagonists
This invention relates to the (R)-isomers of compounds which are generally muscarinic receptor antagonists and which are represented by Formula I:
wherein p, R 1 , R 2 , R 3 and A are as...
|
|
|
6855710 |
Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs
The present invention relates to new substituted indolinones of general formula
wherein
X and R 1 to R 5 are defined as in claim 1, the isomers and the salts thereof which have valuable...
|
|
|
6849632 |
Heteroaryl alkyl piperazine derivatives
Novel compounds of the general formula:
and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage...
|
|
|
6846820 |
Substituted N-(indole-2-carbonyl) -amides and derivatives as glycogen phosphorylase inhibitors
This invention relates to certain indole-2-carboxamides of formula (I) and the pharmaceutically acceptable salts and prodrugs thereof, wherein R 6 is carboxy, (C 1 -C 8 )alkoxycarbonyl, C(O)NR 8 R...
|
|
|
6846818 |
Selective inhibitors of cyclooxygenase-2
The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I:
pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The...
|
|
|
6844346 |
Chromogenic substrates of sialidase and methods of making and using the same
The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and...
|
|
|
6838461 |
N-(indolcarbonyl-)piperazine derivatives
Compounds of the formula I
in which R 1 , R 2 , R 4 and R 5 have the meanings indicated in claim 1 , are potent 5-HT 2A antagonists and are suitable for the treatment of psychoses,...
|
|
|
6825201 |
Indole, azaindole and related heterocyclic amidopiperazine derivatives
The invention comprises substituted indole, azaindole and related heterocyclic amidopiperazine derivatives of general Formula I wherein: Q is —may represent a bond; A is selected from the...
|
|
|
6809098 |
Compounds
The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use...
|
|
|
6800649 |
Method for inhibiting c-jun expression using JAK-3 inhibitors
The invention provides a method for inhibiting c-jun activation in mammalian or avian cells comprising contacting the cells with a substance that inhibits the activity of Janus family kinase 3...
|