Patents in Class 514/254.080

Matches 1 - 50 out of 111

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Match	Document	Document Title
1	7297711	Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tetracyclic arylalkyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically...
2	7153848	Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions...
3	7144883	Bicyclic sulfonamide compounds The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
4	7141568	Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions...
5	7074782	Carbamate caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; Y is an electronegative leaving group; R 2...
6	6998403	Benzoindoline compounds A compound of formula (I): wherein: R 1 and R 2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino...
7	6916812	Alpha-aminoamide derivatives as melanocortin agonists Novel piperazine and homopiperazine derivatives are agonists of melanocortin receptor(s) and are useful for the treatment, control, or prevention of diseases and disorders responsive to the...
8	6914064	1,4-Disubstituted piperazine derivatives useful as uro-selective α1-adrenoceptor blockers The present invention relates to a novel 1,4-disubstituted piperazine derivatives of Formula I, and their pharmaceutically acceptable acid addition salts having excellent uro-selective α 1...
9	6890921	Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
10	6861432	Piperazine derivatives that destabilize androgen receptors This invention relates to new piperazine derivatives of general formula I, in which V, W, n, R, R′, i, j, Y and Z have the meaning that is indicated in the description. The compounds...
11	6849631	Semicarbazides and their uses The present invention relates to the synthesis of a new class of indeno [1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent...
12	6841552	3a,4,5,9b-tetrahydro-1H-benz[e]indol-2-yl amine-derived neuropeptide Y receptors ligands useful in the treatment of obesity and other disorders Compounds of the formula: are disclosed as ligands for neuropeptide Y receptors and as such are useful in the treatment of obesity and disorders of the central nervous system.
13	6812230	Non-peptide CCR1 receptor antagonists for the treatment of progressive renal fibrosis This invention is directed to pharmaceutical compositions useful in treating progressive renal fibrosis in mammals comprising a pharmaceutically acceptable excipient and a therapeutically effective...
14	6740636	Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection This invention is directed to pharmaceutical compositions useful in treating heart transplant rejection in mammals comprising a pharmaceutically acceptable excipient, a therapeutically effective...
15	6713473	Tricyclic compounds A compound represented by the formula (I) [A represents a 5- to 7-membered hydrocarbon ring group; L represents —NR 3 —CO—, —CO—NR 3 — and the like (R 3 represents a hydrogen atom, a...
16	6689784	Carbamate caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; Y is an electronegative leaving group; R 2...
17	6664258	Spirocyclic dopamine receptor subtype ligands This invention relates to novel, pharmaceutically active compounds of formula (I) wherein a, b and R 1 through R 6 are as defined in the specification These compounds exhibit central...
18	6498251	Tetrahydrobenzindole derivatives Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling...
19	6407112	Optically active tetrahydrobenzindole derivative Optically active tetrahydrobenzindole type compounds having affinity for a 5-HT receptor, useful for prevention and treatment of mental diseases. A species compound is...
20	6365584	Arylysulphonamide-substituted benzimidazoles having tryptase-inhibiting activity Arylsulphonamide-substituted benzimidazole derivatives of formula (I) having tryptase-inhibiting activity. Exemplary are:...
21	6355644	Benzylpiperazinyl-indolinylethanones Disclosed are benzylpiperazinyl-indolinylethanone compounds which are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania,...
22	6355642	Tetrahydrobenzindole compounds A compound of formula (I) for use in the treatment or prevention of mental diseases A is N, CH, C having a double bond or CR 5 ; each of B and Z is independently N, CH or CR 1 , with the proviso...
23	6340682	Diamide compound and drugs containing the same The present invention provides diamide derivatives represented by the following general formula (1): wherein A is a phenyl group or the like, which may be substituted, B is —CH═CH—,...
24	6306876	4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives 4-[aryl(8-azabicyclo[3.2.1]octan-3yl)]aminobenzoic acid derivatives are delta-opioid receptor modulators. As delta-opioid receptor agonists, such compounds are useful as analgesics. Depending on...
25	6150129	Antimicrobial determination of N-(aminoalkyl) and/or N-(Amidoalkyl) dinitrogen heterocyclic compositions Compositions are provided comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups. An additional situs of functionality is also provided. The...
26	6087364	Dopamine D4 receptor antagonists Compounds that are antagonists of dopamine D4 receptors, methods of treating psychosis and schizophrenia using the compounds, and pharmaceutically acceptable compositions that contain the dopamine...
27	6080745	Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands
28	6051575	Piperazino derivatives as neurokinin antagonists The invention relates to compounds of the formula ##STR1## wherein Z, R c , y, m, u, Ar 2 , n, X, R c ', I and Ar 2 are as described herein. These compounds are neurokinin antagonists. These...
29	6040331	Nerve cell protective agents The invention provides novel benzindole derivatives, processes for producing them, as well as a neuroprotective agent, an agent to prevent or treat diseases involving the degeneration, retraction...
30	6030992	Methods of treating or preventing sleep apnea
31	5919802	Methods of preventing and/or treating temporal lobe epilepsy A method of preventing and/or treating epileptic seizures in a mammal in need of such treatment, which comprises administration to said mammal of a therapeutic amount of a 5HT1A antagonist.
32	5902812	Pharmaceutical piperazine compounds Diketopiperazines of formula (A): ##STR1## wherein each of R 1 to R 8 is H or an organic radical as described herein and the pharmaceutically acceptable salts thereof have activity as inhibitors...
33	5874435	4-heteroaryl-1-piperazinealkanols and derivatives thereof and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
34	5869490	Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one The compounds of formula I: ##STR1## wherein X is H 2 or O; R 1 is hydrogen, hydroxy, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono- or...
35	5856323	Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl...
36	5852018	Pharmaceutical piperazine compounds Piperazine derivatives of formula (A): ##STR1## wherein - ------- denotes an optional bond, provided that either - --- a - --- and - --- c - --- are both bonds and - --- b - --- and - --- d -...
37	5840725	Substituted oximes, hydrazones and olefins as neurokinin antagonists Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or3; b, d and e are independently 0, 1 or 2; R is H, C 1 -6 alkyl,...
38	5817684	Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke This invention provides methods for the treatment or prevention of cerebral focal ischemia which comprises administering to a mammal in need thereof an effective amount of a compound having...
39	5801176	Substituted benzothienylpiperazines and their use This invention relates to compounds of the formula ##STR1## wherein X is halogen, hydroxy, (C 1 -C 6 )alkoxy, amino or trifluoromethyl; and Y is --CN or --NR 1 R 2 ; where l is an integer of 0,...
40	5795894	Piperazino derivatives as neurokinn antagonists The invention relates to compounds of the formula ##STR1## These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.
41	5783579	Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists The invention relates to compounds of the formula ##STR1## wherein Z, R c , y, m, u, Ar 2 , n, X, R c ', I and Ar 2 are as described herein. These compounds are neurokinin antagonists. These...
42	5753660	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention...
43	5731309	Substituted heteroalkyleneamine neurokinin antagonists Compounds of formula I ##STR1## wherein Q 1 , Q 2 , Q 3 , and Q 4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide...
44	5703080	Method for stabilizing duocarmycin derivatives Stabilized duocarmycin derivatives represented by formula (I): ##STR1## wherein R is lower alkyl, allyl or benzyl, and X is Cl or Br, are prepared by adding at least a compound selected from the...
45	5693643	Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists Compounds of formula (I) wherein X is (a) or (b), R is Het as defined in the description. These compounds are oxytocin and vasopressin antagonists useful in the treatment of preterm labor,...
46	5688518	Antidepressive therapy A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient.
47	5686466	Tricyclic condensed heterocyclic compounds their production and use A novel compound of the formula: ##STR1## wherein Ar represents an optionally substituted tricyclic condensed benzene ring group which includes at least one heterocyclic ring as a component ring; n...
48	5674867	Indolocarbazole derivatives and therapeutic method for stimulating megakaicyocyte production The present invention relates to therapeutic agents for thrombocytopenia which contain an indolocarbazole derivative represented by the formula (I) given below or a pharmaceutically acceptable salt...
49	5670492	DC-89 derivatives Provided are DC-89 derivatives represented by the formula: ##STR1## wherein X represents Cl or Br, R represents hydrogen or COR 1 , and W represents ##STR2## and pharmaceutically acceptable salts...
50	5656632	1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; dopamine receptor subtype specific ligands Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently...

Matches 1 - 50 out of 111

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