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RE40387 |
Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones
The invention relates to methods of increasing the bioavailability of orally administered epothilones. Epothilones administered by the methods of the invention are sufficiently bioavailable to have...
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7335660 |
Isochroman compounds for treatment of CNS disorders
This invention relates to compounds of formula (I)
where R 1 to R 12 , —W—V—, —X—Y—, p and n have the values defined in claim 1 , their preparation and use as pharmaceuticals for...
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7081255 |
Antifungal compositions with improved bioavailability
The present invention is concerned with novel pharmaceutical compositions of itraconazole which can be administered to a mammal suffering from a fungal infection, whereby a single such dosage form...
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7026308 |
Topical anti-microbial compositions
Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed...
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6958337 |
Crystalline antifungal polymorph
The crystalline polymorph Form I of...
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6861432 |
Piperazine derivatives that destabilize androgen receptors
This invention relates to new piperazine derivatives of general formula I,
in which V, W, n, R, R′, i, j, Y and Z have the meaning that is indicated in the description.
The compounds...
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6770306 |
Drugs for reducing vaginal acidity and treatment of vaginitis, and the use thereof
The present invention relates to a pharmaceutical composition for reducing vaginal acidity, treating abnormal enhancement of vaginal acidity, and high acidity vaginitis associated with abnormal...
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6680318 |
Piperazinomethylbenzamides as delta-opioid receptor agonists
The present application is directed to compounds having the general formula: and to the use of these compounds in therapeutic methods.
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6673373 |
Antifungal formulation and the methods for manufacturing and using the same
The present invention provides novel pharmaceutical compositions for azole antimicrobial drugs such as itraconazole, saperconazole, ketoconazole, and fluconazole. The pharmaceutical compositions...
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6670363 |
Azole compounds as therapeutic agents for fungal infections
The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole...
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6585963 |
Nail compositions and methods of administering same
Nail compositions and methods of use thereof are disclosed. Additionally, nail kits comprising a nail composition and pre-treatment compositions are disclosed. Further, supportive devices such as...
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6583136 |
Antifungal ethers
The present invention concerns compounds of formula the N-oxide forms, the salts, the quaternary amines and stereochemically isomeric forms thereof, wherein D represents a tetrahydrofuran or...
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6576161 |
Polyphosphate ester morpholides, mixtures thereof, and thermoplastic resin compositions containing polyphosphate ester morpholides as flame retardants
The present invention relates to polyphosphate ester morpholides, compositions comprising mixtures thereof and thermoplastic resin compositions containing the polyphosphate ester morpholide...
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6552014 |
Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
The present invention pertains to methods for reducing the platelet activation state in an individual comprising administering a selective serotonin reuptake inhibitor (SSRI). The platelet...
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6551583 |
Antibiofouling method and apparatus for optical sensors
An antibiofouling material, a method for making said antibiofouling material, a sensor apparatus employing said antibiofouling material, and a method of making said sensor apparatus. The disclosed...
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6511681 |
Aqueous solubility pharmaceutical formulations
A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally...
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6509038 |
Antifungal compositions with improved bioavailability
The present invention is concerned with novel pharmaceutical compositions of itraconazole which can be administered to a mammal suffering from a fungal infection, whereby a single such dosage form...
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6482826 |
Method of treating alopecia
Method of treating individuals with alopecia or having inferior quality hair, by administering to the scalp of said individuals an effective amount of ketoconazole. Novel compositions comprising as...
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6479495 |
Aminoalkylphenol derivatives and related compounds
Novel aminoalkylphenols, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the aminoalkylphenols or compositions thereof are disclosed.
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6455530 |
2R,4S,S,S- and 2S,4R,S,S-hydroxyitraconazole
A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (S,S)-isomer, and to phosphate and sulfate derivatives...
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6455507 |
Benzimidazole derivatives
Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of...
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6451802 |
S-oxide lipid lowering compounds
The present invention relates to compounds of formula (I) the N-oxides, the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts, wherein n is 1 or 2,...
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6448244 |
Water soluble azoles as broad-spectrum antifungals
The present invention concerns novel water-soluble azole compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof;...
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6391879 |
Therapeutic anti-fungal nail preparation
A therapeutic solution and application procedure for curing and preventing nail fungus and athlete's foot infections or Onychomycosis comprising a combination of an anti-fungal agent with DMSO in a...
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6380236 |
Method of treating onychomycosis
A method of treating onychomycosis is described which includes administration to an infected area around a nail of a patient a tissue softening composition containing urea and an antifungal...
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6376497 |
Antifungal azole derivatives having a fluorinated vinyl group and process for preparing same
An antifungal compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: X is CH or N; Y is O, R 1 and R 2 are each independently F or Cl; R 3 is a thiophenyl, naphthyl,...
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6346533 |
Intraconazole exhibiting an improved solubility, a method of preparing the same and a pharmaceutical composition for oral administration comprising the same
The particle diameter of itraconazole, insoluble drug, is reduced and crystallinity thereof is changed from crystalline into amorphous, increasing water solubility and a dissolution rate thereof....
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6346518 |
Itraconazole and saperconazole stereoisomers
The present invention is concerned with the stereoisomeric forms of itraconazole (X=Cl) and saperconazole (X=F), which may be represented by the formula and the pharmaceutically acceptable acid...
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6342245 |
Compositions of lipid lowering agents
The present invention is concerned with novel pharmaceutical compositions of lipid lowering agents which can be administered to a mammal suffering from hyperlipidemia, obesitas or atherosclerosis,...
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6329369 |
Methods of treating pain and other conditions
Methods of treating glaucoma or elevated pressure and other diseases with reduced side effects by treating a mammal in need thereof an agonist of the alpha 2B or alpha 2B/2C adrenergic receptor(s)....
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6218394 |
4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophene-methyl) piperazines
4-Aryl-1-(indanmethyl, dihydrobenzofuramethyl or dihydrobenzothiophenemethyl) piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I) ##STR1## wherein one of X and Y is CH 2...
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6153616 |
Triazoles as therapeutic agents for fungal infections
A compound of formula I, or an optical isomer or pharmaceutically acceptable salt thereof, ##STR1## is disclosed as well as a pharmaceutical composition and a method of treating or preventing a...
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6147077 |
2R,4S-hydroxyitraconazole isomers
A method of treating fungal infections with a mixture of isomers of 2R,4S-hydroxyitraconazole and their sulfate and phosphate derivatives is disclosed. Pharmaceutical compositions containing these...
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6140331 |
Fused benzo compounds for the treatment of central nervous system disorders
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6114334 |
Piperazine derivatives as therapeutic agents
Substituted piperazine compounds of formula I ##STR1## in which HET is a substituted pyrazole, imidazole or 1,2,4-triazole have utility in the treatment of central nervous system disorders, for...
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6103768 |
Fatty acid based compositions and methods for the control of plant infections and pests
The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination...
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6080744 |
Topical antifungal treatment
A topical mycological treatment composition for medical, veterinarian, or dental use contains as active ingredients clotrimazole, ketoconazole, micanazole, nystatin, tolnaftate, propionic acid,...
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6069172 |
(R)-2-(3-benzoylphenyl) propionic acid salts and pharmaceutical preparations containing them
A new use of the enantiomer (R)-ketoprofen and of its salts with suitable organic and inorganic bases in the therapy of neutrophil-dependent diseases and phlogistic processes is described as well...
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6043245 |
Tetrahydrofuran antifungal phosphate
A compound of the formula I ##STR1## wherein G is H or PO 3 H 2 or a pharmaceutical acceptable salt thereof, pharmaceutical compositions containing such compounds and method of using such...
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6042845 |
Anti fungal treatment of nails
There is disclosed a method for the treatment of fungal diseases in nails, which comprises the topical administration to the nail and, if desired, also to the surrounding skin, of (1) a sulfhydryl...
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6040307 |
Methods ad compositions of (-) ketoconazole for treating fungal yeast and dermatophyte infections
Methods and compositions are disclosed utilizing the optically pure (-) isomer of ketoconazole. This compound is a potent drug for the treatment of local and systemic fungal, yeast, and...
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6039981 |
Antifungal oral composition containing itraconazole and process for preparing same
An antifungal oral composition comprising a fused mixture of itraconazole and phosphoric acid provides a high in vivo bioavailability of itraconazole.
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6017920 |
Antifungal composition for external use being retentive in stratum corneum
An antifungal composition for external use being retentive in the stratum corneum containing as an active ingredient an antifungal agent having a high affinity for keratin, wherein the penetration...
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5998415 |
Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT.sub.1 -like receptors
A class of piperazinones, homopiperazinones and thione analogues thereof, substituted at the 1-position by an optionally substituted alkenyl, alkynyl, aryl-alkyl or heteroaryl-alkyl moiety, and...
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5998413 |
Itraconazole and stereoisomers
Anti-infective compositions for the treatment of a human in need of therapy for a systemic or topical fungal infection which comprise a pharmaceutically acceptable carrier and a therapeutically...
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5998394 |
Compositions for treating skin conditions by enhancing the activity of 1,25(OH).sub.2 D.sub.3 using an RXR ligand and/or a 24-hydroxylase inhibitor
Described are in vivo methods for testing the activity of vitamin D 3 (1,25-dihydroxyvitamin D 3 ) and analogs thereof in human skin and for testing the effect of a test compound on said activity....
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5998393 |
Methods for assessing 1,25(OH).sub.2 D.sub.3 activity in skin and for enhancing the therapeutic use of 1,25(OH).sub.2 D.sub.3
Described are in vivo methods for testing the activity of vitamin D 3 (1,25-dihydroxyvitamin D 3 ) and analogs thereof in human skin and for testing the effect of a test compound on said activity....
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5994357 |
Method of treatment for interstitial cystitis
A method of treating patients suffering from interstitial cystitis comprising the administration to such patients of an inhibitor of neurohormonal activation of mast cell secretion selected from...
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RE36419 |
Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx
The present invention provides novel methods for prevention or treatment of primary and recurring squamous cell carcinoma of the oral cavity or oropharynx comprising topical administration, to the...
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5929075 |
Apolipoprotein-B synthesis inhibitors
The present invention provides novel compounds of formula ##STR1## the N-oxides, the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof,...
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