|
Match
|
Document |
Document Title |
|
|
7335660 |
Isochroman compounds for treatment of CNS disorders
This invention relates to compounds of formula (I)
where R 1 to R 12 , —W—V—, —X—Y—, p and n have the values defined in claim 1 , their preparation and use as pharmaceuticals for...
|
|
|
7329652 |
Diaminotriazole compounds useful as protein kinase inhibitors
The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the...
|
|
|
7291642 |
Bradykinin-B1 antagonists, process for their preparation and their use as medicaments
The present invention provides bradykinin-B1 antagonists of the formula
in which A, Ar, G, Q, R 1 and R 4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and...
|
|
|
7279469 |
Diaminotriazoles useful as inhibitors of protein kinases
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the...
|
|
|
7241787 |
Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments
The invention relates to substituted N-cyclohexylheterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to processes for their preparation and...
|
|
|
7214679 |
Piperidine/piperazine-type inhibitors of p38 kinase
Compounds of the formula:
wherein the substituents are as defined herein are useful for treating conditions mediated by p38 kinase.
|
|
|
7169775 |
Amino methyl imidazoles as C5a receptor modulators
Amino methyl imidazoles of Formula I are provided:
wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are defined herein.
Such compounds are ligands of C5a receptors. Preferred compounds of...
|
|
|
7160886 |
Acylated piperazine derivatives as melanocortin-4 receptor agonists
Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
|
|
|
7125887 |
Pyrrolidine modulators of CCR5 chemokine receptor activity
Pyrrolidine compounds of Formula (I), (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 and R 8 are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor...
|
|
|
7119086 |
Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use
The invention relates to compounds of formula:
and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards...
|
|
|
7098212 |
Piperazine derivatives
The present invention relates to compounds of the formula I
and the pharmaceutically acceptable forms thereof; wherein X, Y, a, b, c, d, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein....
|
|
|
7087610 |
Benzothiazole antiviral agents
The invention encompasses a series of benzothiazole compounds which inhibit HIV entry and are useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions...
|
|
|
7074794 |
Proline derivatives and the use thereof as drugs
The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that...
|
|
|
7026322 |
Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
Methods of using a compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, to treat cancer, and methods for isolating, for formulating, and for administering...
|
|
|
7026314 |
Therapeutic chromone compounds
Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating,...
|
|
|
7019004 |
Hydantoin derivatives with affinity for somatostatin receptors
The invention provides compounds of formula (I) wherein X, Y, R 1 , R 2 , R 3 and R 4 are as defined in the description, and the preparation thereof. The compounds of the formula bind to...
|
|
|
6989383 |
Method of treating cancer
The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase,...
|
|
|
6982264 |
Substituted alcohols useful in treatment of Alzheimer's disease
The invention relates to substituted alcohol compounds of the formula (I):
wherein X, R 1 , R 2 , R 3 , R N , R 20 and R C are defined herein. The compounds are useful in the treatment or...
|
|
|
6979686 |
Substituted pyrazoles as p38 kinase inhibitors
A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (IA), wherein R 1 , R 2 , R 3 and R 4 are...
|
|
|
6972289 |
Cell division inhibitor and a production method thereof
The present invention relates to a cell division inhibitor comprising various dehydrodiketopiperazines such as dehydrophenylahistin, or analogs thereof as an active ingredient, and a dehydrogenase...
|
|
|
6969713 |
Piperidine and piperazine acetamide derivatives
The invention provides piperidine and piperazine derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the...
|
|
|
6916812 |
Alpha-aminoamide derivatives as melanocortin agonists
Novel piperazine and homopiperazine derivatives are agonists of melanocortin receptor(s) and are useful for the treatment, control, or prevention of diseases and disorders responsive to the...
|
|
|
6916797 |
α-arylethylpiperazine derivatives as neurokinin antagonists
The invention relates to new α-arylethylpiperazine of the formula
wherein
Z represents 0 or S; n′ represents 1 or 2; R 2 represents a hydrogen atom or a methyl group; W, Ar 1 and...
|
|
|
6908922 |
Linear cyclic ureas
Compound of formula (I):
wherein:
V represents a single bond or an alkylene chain, M represents a single bond or an alkylene chain, A and E each represents nitrogen or CH, but at least...
|
|
|
6906074 |
2-phenylpiperazine derivatives
A 2-phenylpiperazine derivative represented by the formula (I) or a pharmaceutically acceptable salt, hydrate, or complex thereof:
wherein each of X 1 and X 3 is oxygen or two hydrogen...
|
|
|
6894041 |
Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
|
|
|
6869945 |
Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
|
|
|
6861432 |
Piperazine derivatives that destabilize androgen receptors
This invention relates to new piperazine derivatives of general formula I,
in which V, W, n, R, R′, i, j, Y and Z have the meaning that is indicated in the description.
The compounds...
|
|
|
6838461 |
N-(indolcarbonyl-)piperazine derivatives
Compounds of the formula I
in which R 1 , R 2 , R 4 and R 5 have the meanings indicated in claim 1 , are potent 5-HT 2A antagonists and are suitable for the treatment of psychoses,...
|
|
|
6812230 |
Non-peptide CCR1 receptor antagonists for the treatment of progressive renal fibrosis
This invention is directed to pharmaceutical compositions useful in treating progressive renal fibrosis in mammals comprising a pharmaceutically acceptable excipient and a therapeutically effective...
|
|
|
6806279 |
Small-molecule inhibitors of interleukin-2
Compounds of formulae I and I′, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of IL-2/IL-2R binding; and are useful...
|
|
|
6747030 |
Piperazine derivatives as 5-HT1B antagonists
Piperazine derivatives of formula(1), processes for their preparation, pharmaceutical compositions containing them in the treatment of CNS and other disorders and in their use in therapy as 5-HT...
|
|
|
6740661 |
Farnesyl protein transferase inhibitors
Disclosed are compounds of the formula: wherein R 13 represents an imidazole ring; R 14 represents a carbamate, urea, amide or sulfonamide group; R 8 represents H when the alkyl chain between...
|
|
|
6720317 |
Inhibitors of factor Xa
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
|
|
|
6713480 |
Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
Methods of using a compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, to treat cancer, and methods for isolating, for formulating, and for administering...
|
|
|
6710049 |
Azole compounds as anti-fungal agents
The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared with presently available agents in this class and the...
|
|
|
6699864 |
Substituted phenyl-piperazine derivatives, their preparation and use
The present invention provides compounds of the formula: wherein R 1 -R 8 , X, Y, Z, n and m are defined in the application. The compounds of the invention have affinity for the 5-HT 1A receptor.
|
|
|
6696447 |
Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the treatment of pain
The present application describes compounds of general formula I where R 1 is selected from any one of pyridinyl, thienyl, furanyl, imidazolyl, and triazolyl; and where each R 1 heteroaromatic...
|
|
|
6670363 |
Azole compounds as therapeutic agents for fungal infections
The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole...
|
|
|
6660732 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
|
|
|
6656933 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
|
|
|
6649611 |
Piperazine derivatives
A compound of the formula or the pharmaceutically acceptable salt thereof; wherein a, b, c, d, e, j, R 1 , R 2 , R 3 , and R 4 are as defined herein and are useful to treat inflammation and...
|
|
|
6632828 |
Substituted imidazole neuropeptide Y Y5 receptor antagonists
Compounds of the formula I or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is ═CH— or ═N—; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl,...
|
|
|
6620826 |
Endothelin receptor antagonists
Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
|
|
|
6596745 |
Method for treating fibrotic diseases with azolium chroman compounds
Provided is a method of treating or ameliorating hypertension in an animal comprising administering an effective amount of a compound of formula I:
|
|
|
6589953 |
Indole derivatives as 5-HT1B and 5-HT1D agonists
The invention concerns novel indole piperazine derivatives of formula (I). It also concerns a method for preparing said compounds and their use as therapeutically active substances, in particular...
|
|
|
6586437 |
(S)-hydroxynefazodone antipsychotic therapy
Treatment of psychoses with (S)-hydroxynefazodone is disclosed.
|
|
|
6586418 |
Thrombin or factor Xa inhibitors
This invention relates generally to heteroaryl-phenyl substituted compounds that are inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical...
|
|
|
6583155 |
Method for treating allergies using substituted pyrazoles
A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
|
|
|
6573262 |
Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
The invention comprises substituted indoleoxoacetic piperazine derivatives of general Formula I, compositions thereof and their use as antiviral agents, and particularly for treating HIV infection.
|