Matches 251 - 300 out of 344 < 1 2 3 4 5 6 7 >
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5055466 N-morpholino derivatives and their use as anti-hypertensive agents  
Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
5051422 2-substituted-1(4)-aryl piperazines and the process for their preparation  
This invention relates to novel 2-substituted-1(4)-aryl piperazines and to a process for their preparation. The compounds of this invention have been found to have cardiovascular, primarily...
5051423 Derivatized alkanolamines as cardiovascular agents  
Novel derivatized alkanolamines of the following structural formula ##STR1## are described as useful cardiovascular agents. Most especially described is their usefulness as cardiovascular agents...
5045540 Amino acid derivatives with angiotensin II antagonist properties  
This invention relates to novel amino acid derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart failure,...
5043349 Substituted pyrrole angiotensin II antagonists  
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
5035878 Use of dithiocarbamates to counteract myelosuppression  
Various types of biological treatments, including antineoplastic treatments with antineoplastic drugs, can result in damage to the blood-forming function of the bone marrow. This damage can be...
5023258 Triazole antifungal agents  
The invention provides triazole antifungal compounds of the formula: ##STR1## wherein R is either (a) a phenyl group optionally substituted with 1 to 3 substituents, each selected independently...
5015651 Treatment of hypertension with 1,2,4-angiotensin II antagonists  
Substituted pyrroles, pyrazoles and traizoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
4999365 Method of reducing reperfusion injury with imidazol-2-thiones  
Certain imidazol-2-thiones are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to...
4987146 N-hetaryl imidazole derivatives  
N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R 3 represents hydrogen, a...
4968714 Fungicidal substituted 3-amino-2-pyrazolin-5-ones, compositions and use  
Fungicidal substituted 3-amino-2-pyrazolin-5-ones of the formula ##STR1## in which R 1 represents unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl or alkinyl, or...
4960798 Methods for the treatment of angina  
Acetylene compounds of the formula (I): ##STR1## wherein Y, R 1 , R 2 R 3 , and R 4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The...
4931445 Agents for treatment of male impotence  
Etoperidone and its pharmaceutically acceptable salts are useful in the treatment of male sexual impotence.
4931444 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols  
4-(4-phenyl-1-piperazinyl)phenols for use as 5-lipoxygenase inhibitors and a method of treating warm-blooded animals suffering from leukotriene mediated diseases and disorders using the same....
4921855 New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same  
A compound of the formula: ##STR1## wherein R 1 is lower alkyl optionally substituted with a substituent selected from the group consisting of acyl, hydroxy, lower alkoxy, aryl, lower alkylthio...
4904660 Histidine derivatives as superior renin inhibitors  
Novel compounds of the following formula (I) and their salts: A compound of the formula (I) ##STR1## These compounds are expected to be useful for renin inhibitors. Thus, the compounds are useful...
4898880 N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use  
N-[(heterocycle)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of...
4898863 Heterocyclic carboxamides  
This invention provides a series of novel heterocyclic carboxamides of formula I in which the group --Y--Z< is selected from --C(Ra)C<, --NC<, and --CH(Ra)--CH< and the other...
4894385 Imidazole derivatives as inhibitors of TXA.sub.2 synthesis  
Compounds of formula (I): ##STR1## (wherein n is 0, 1 or 2 and R 1 , R 2 , R 4 , R 5 , R 6 , X, Y and Z are a variety of groups and atoms) have the ability to inhibit the synthesis of thromboxane A...
4891375 Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds  
Arylpiperazinyl-alkylenephenyl-p-heterocyclic compounds, and the pharmaceutically acceptable acid addition salts thereof are neuroleptic agents. They are useful in the treatment of psychotic...
RE33125 3- and 5-[3-(1-arylureido)]-1,2,4-triazoles  
4885294 2-aryl-3-(substituted piperazinyl)-1-(1H-1,2,4-triazolyl)propanol-2-ol antifungal agents  
An antifungal agent of the formula: ##STR1## wherein R is phenyl group which may be substituted by 1 to 3 substituents each independently selected from halo and CF 3 ; R 1 is either (a) a phenyl...
4880808 N-aryl-piperazinealkanamides useful for improving sleep  
A method of improving sleep in warm-blooded animals suffering from sleep disorders, which method comprises the administration of particular N-aryl-piperazinealkanamide derivatives and compositions...
4871737 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants muscle relaxants and anxiolytics  
A novel method of controlling epilepsy, muscle tension, muscular spasticity, and anxiety in living animal bodies by administering compounds of the formula: ##STR1## wherein: R 1 is hydrogen,...
4870088 1-[1-aryl-1-hydroxy-2-azolyl-ethyl]-1-aryl-cyclopropane derivatives, and their fungicidal use thereof  
Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R 1 where X=oxygen or sulfur and R 1 equals (cyclo)alkyl or...
4845096 Benzofuran derivatives and antiulcerogenic agents containing same  
Benzofuran derivatives of the general formula I ##STR1## where R 1 and R 2 are each hydrogen, alkyl or phenylalkyl, where alkyl in each case is of 1 to 4 carbon atoms, R 3 and R 4 are identical...
4835154 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors  
Potent dopamine-β-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-β-hydroxylase activity, pharmaceutical compositions including these inhibitors, and...
4814332 Antimicrobial 1,3-disubstituted/imidazolium salts  
The imidazolium compounds of the formula ##STR1## wherein the various substituents are defined hereinbelow and their pharmaceutically acceptable acid addition salts, which possess valuable...
4804662 Substituted 4-(1H-imidazol-1-yl)benzamides as antiarrhythmic agents  
Novel substituted 4-[1H-imidazol-1-yl]benzamides and their use in the treatment of cardiac arrthythmias especially as Class III or combination Class I/III antiarrhythmic agents is described....
4788196 Phenyl piperazine anti-arrhythmia agents  
A series of pyridyl or imidazolyl substituted phenyl piperazines having utility as anti-arrhythmic agents is disclosed.
4772604 Phenyl-substituted (N-piperazinyl) methylazoles for treating affections in the central nervous system  
The invention relates to new aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having interesting pharmacological, notably antipsychotic, properties. The compounds may be...
4766120 Tetrazole derivatives, having a further unsaturated heterocyclic ring anti-ulcer composition containing the same and method for treating ulcers  
Tetrazole derivatives of the formula: ##STR1## wherein R 1 is an optional defined substituent; A is sulfur or a lower alkylene-thio, l is 0 or 1; B is a lower alkylene; R 2 is hydroxy, a lower...
4738962 Piperazinylmethyl-1,2,4-triazolylmethyl-carbinol fungicides  
Fungicidally active novel piperazinylmethyl-1,2,4-triazolylmethyl-carbinols of the formula ##STR1## in which R represents optionally substituted alkyl, optionally substituted alkenyl, optionally...
4684650 Antihypertensive fluorophenylindanyl imidazolidinoneethylpiperazines  
The present invention relates to indane derivatives with the following formula: ##STR1## wherein R 1 is H, Halogen, an alkyl group having from one to three carbon atoms inclusive, methoxy, a...
4683228 Guanidinopyrazolylamides, guanidimoimidazolylamides, compositions containing them, and method of using them to inhibit gastric acid secretion  
A guanidine derivative of the formula I: ##STR1## in which R 1 , R 2 , R 3 , R 4 , ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is...
4672063 Antiallergic 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds  
5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds of the Formula ##STR1## in which R 1 is a straight-chain, branched or cyclic alkyl group with up to 6 carbon atoms, Z is an alkylene...
4663323 Tetrazole derivatives, anti-ulcer composition containing the same and method for treating ulcers  
Tetrazole derivatives of the formula: ##STR1## wherein R 1 is an optional defined substituent; A is sulfur or a lower alkylene-thio, l is 0 or 1; B is a lower alkylene; R 2 is hydroxy, a lower...
4647557 Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them  
This invention relates to novel heterocyclic derivatives bearing an amino group and to processes for making said compounds. More particularly this invention provides novel heterocyclic compounds...
4619929 Phenylpiperazine derivatives of hetarylphenols and hetarylanilines, their preparation, and therapeutic agents containing these compounds  
Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula ##STR1## where R 1 is hydrogen or alkyl of 1 to 4 carbon atoms, R 2 is hydrogen,...
4613600 Antidepressant 1,2,4-triazolone compounds  
2-[3-[4-(3-Halophenyl)-1-piperazinyl]propyl]-5-(1-hydroxyeth yl)-2,4-dihydro -[4-phenoxyalkyl-3H-1,2,4-triazol-3-ones and closely related compounds are psychotropic agents having promise as...
4610983 N-acyl acidic amino acid diamide derivative, a salt thereof, and an anti-ulcer agent containing the same  
This invention relates to a novel N-acyl acidic amino acid diamide derivative represented by the general formula or a salt thereof: ##STR1## wherein each of R 1 , R 2 , R 3 and R 4 , which may be...
4598077 Amidine derivatives and cardiotonic compositions  
Amidine derivatives of the formula ##STR1## wherein R 1 and R 2 , which may be the same or different, represent each a hydrogen atom or a lower alkyl group, or R 1 and R 2 together with an...
4570000 Nitrogen heterocycles  
The invention relates to nitrogen heterocycles which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of...
4562189 Pyrazolylpiperazines  
This disclosure describes novel pyrazolylpiperazines useful as hypotensive agents in mammals and as intermediates for the preparation of certain pyrazolo[1,5-a]pryrimidines.
4487773 1,2,4-Triazol-3-one antidepressants  
Phenoxyalkyl substituted-1,2,4-triazolones having anti-depressant properties typified by 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2- phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one...
4486439 Treatment of coccidiosis  
A method for the preventive and curative treatment of coccidial infections in humans and other animals comprising the administration thereto of an amidinourea of amidinothiourea.
4469693 2-(4-Substituted alkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives  
2-(4-Substituted alkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the...
4469694 2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives  
2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and...
4452798 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents  
Certain substituted phenylpiperazine compounds useful as antihypertensive agents are described. Methods for their preparation and use are disclosed.
4443448 Indane derivatives, pharmaceutical compositions thereof and method of preparation  
The present invention relates to novel 1-piperazino-3-phenyl-indane derivatives which have pronounced psychopharmacological activity such as neuroleptic activity, analgesic activity, antidepressant...
Matches 251 - 300 out of 344 < 1 2 3 4 5 6 7 >