Matches 201 - 250 out of 344 < 1 2 3 4 5 6 7 >
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5382586 Aryl (or heteroaryl)piperazinylalkylazole derivatives, their preparation and their application as medicaments  
The present invention relates to heterocyclic compounds, characterized in that they have the general formula I ##STR1## wherein Ar, n, and Z 1 and Z 6 are defined in the specification, are...
5382584 Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles  
A series of 1-piperazinyl-N-phenylacetamide derivatives of 4,5-diphenyl-oxazoles, thiazoles, and imidazoles which are novel adenosine transport inhibitors have been found to provide effective...
5380726 Substituted dialkylthio ethers  
Substituted dialkylthio ethers of formula I ##STR1## wherein R 1 -R 6 , alk, X and Y are as defined in the description, and salts thereof, exhibit properties inhibiting the biosynthesis of...
5358939 Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles  
2-Aryl or 2-heterocyclyl-2,2-disubstituted ethyl-1,2,4,-triazoles have been shown to have fungicidal activity.
5358946 Heterocycle-substituted amides, carbamates and ureas as agents for the treatment of atherosclerosis  
This invention relates to imidazoles, namely, heterocycle-substituted amides, carbamates and ureas as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), pharmaceutical compositions...
5348955 N,N-diacylpiperazines  
Diacylpiperazines of general structural formula: ##STR1## are: angiotensin II (A-II) antagonists with affinity for both AT 1 and AT 2 receptors useful in the treatment of hypertension, congestive...
5340809 New 1-(alkoxybenzyl)piperazine amide compounds  
A compound selected from those of formula (I): ##STR1## with R 1 , R 2 and n as defined in the description, and medicinal products containing the same useful in treating or in preventing a...
5340810 Benzanilide derivatives  
The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt or solvate thereof wherein R 1 represents a hydrogen atom or a halogen atom or a group selected from...
5332738 Imidazolidine antipsychotic agents  
Compounds of the general formula I ##STR1## are disclosed as novel antipsychotic agents. Pharmaceutical compositions and methods of treating convulsions employing such compounds of formula I.
5332742 Renin inhibitors  
A renin inhibiting compound of the formula: ##STR1## wherein R 1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-l-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or...
5328916 Heterocyclic compounds useful for inhibition of renin  
New heterocyclic compounds of the formula X--W--CR 1 R 2 --CO--Y--NR 3 --CHR 4 --CR 5 --CH 2 --(CR 6 R 7 ) r --Z--Het I in which R 1 to R 7 , W, X, Y, Z, r and Het...
5318980 Sulphonylbenzyl-substituted imidazoles  
Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary...
5281594 Substituted 1-(alkoxyphenyl)piperazines with ons and antihypertensive activity  
Substituted 1-(alkoxyphenyl)piperazines are disclosed as partial dopamine agonists useful in the treatment of dopaminergic dysregulation. The compounds...
5281614 Substituted 1,2,4-triazoles bearing acidic functional groups as angiotensin II antagonists  
Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of the formula I are useful as angiotensin II antagonists. ##STR1##
5270312 Substituted piperazines as central nervous system agents  
Substituted piperazines and derivatives of Formula I ##STR1## are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous...
5266571 Treatment of hemorrhoids with 5-HT.sub.2 antagonists  
This invention relates to a method for treating or preventing hemorrhoids, comprising administering to a susceptible animal a 5-hydroxytryptamine 2 (5-HT 2 ) receptor antagonist at an...
5258381 2-substituted-2-imidazolines  
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain novel 2-substituted-2-imidazolines. Accordingly, a composition is...
5256664 Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones  
2-(3-[4-(3-Halophenyl)-1-piperazinyl]propyl derivatives of certain 4-alkyl- or 4-phenoxyalkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones and triazol-3,5-diones are psychotropic agents having promise as...
5256657 Succinamide derivative matrix-metalloprotease inhibitors  
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH 2 R 1 has the R-configuration, the carbon atom bearing CH 2 R 2 has...
5254553 4-[4- [4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-o ne derivatives  
2-[2-(4-chlorophenyl)-2-(hydroxy or oxo)ethyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazin yl]phenyl]-5-m ethyl-3H-1,2,4-triazol-3-one having the formula ##STR1## wherein X represents C=O or...
RE34299 1-(4'-fluorophenyl)-3,5-substituted indoles useful in the treatment of psychic disorders and pharmaceutical compositions thereof  
The present invention relates to novel indole derivatives which have interesting pharmacodynamic effects indicating pronounced activity in the treatment of psychic disorders, especially psychoses...
5219856 Angiotensin-II receptor blocking, heterocycle substituted imidazoles  
Novel heterocycle substituted imidazoles of Formula (I), which are useful as angiotensin-II antagonists, are disclosed: ##STR1##
5217985 Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension  
Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs...
5208235 Indole- and benzimidazole-substituted imidazole derivatives  
Novel compounds having the formula ##STR1## where X R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore for...
5208234 Substituted imidazole phosphonic and phosphinic acid derivatives  
Novel compounds having the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for...
5202346 Piperidinyl and piperazinyl derivatives  
Compounds of the formula: ##STR1## in which R 1 is alkylsulfonamido of 1 to 6 carbon atoms, arylsulfonamido of 6 to 10 carbon atoms, --NO 2 ,--CN, 1-imidazolyl or 1,2,4-triazol-1-yl; Y is...
5196546 Selective pyrazoline insecticides and fungicides  
Certain pyrazolines have been found to be useful as aphicides and fungicides.
5190942 Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives  
Novel compounds are disclosed having the formula ##STR1## wherein X, Y, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful,...
5189048 Substituted 1,2,3 triazole angiotensin II antagonists  
This invention includes substituted pyrroles, pyrazoles and triazoles, processes for their preparation, pharmaceutical compositions containing them, and their use as antihypertensive agents, and as...
5189036 Imidazolylbenzoyl substituted heterocycles  
Novel imidazolybenzoyl substituted heterocycles and their use as cardiovascular agents most especially as Class III antiarrhythmic agents is described. Pharmaceutical formulations containing such...
5185358 3-heteroatom containing urea and thiourea ACAT inhibitors  
Compounds useful in treating hypercholesterolemia and atherosclerosis having the formula ##STR1## wherein X is oxygen or sulfur, Het is a monocyclic heterocyclic group having three hetero atoms...
5182284 Piperazine compounds, processes for preparation thereof and medical uses thereof  
Disclosed are a piperazine compound of the formula below or a pharmaceutically acceptable salt thereof, medical uses thereof, and processes for preparing the same: ##STR1## wherein each of R and R'...
5177078 Piperazine derivatives  
Compounds of formula ##STR1## where A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, R is hydrogen or lower alkyl, R 1 is an aryl or...
5166205 Derivatives of 1-diphenylmethyl piperazine and their use as antihistamines  
The present invention relates to novel derivatives of 1-diphenylmethyl piperazinyl, characterized in that they correspond to the general formula I, and their therapeutically acceptable salts,...
5155118 Method and composition for preventing NSAID-induced renal failure  
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
5152988 Imidazole compounds in compositions and methods in thrombolytic therapy  
The use of imidazoles of the formula ##STR1## and imidazolium salts of the formula ##STR2## in thromobolytic therapy are described.
5153197 Treatment of hypertension with angiotensin II blocking imidazoles  
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
5135928 Triazolo derivatives and process for their preparation  
This invention relates to novel triazolo derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said triazolo derivatives for the...
5134142 Pyrazole derivatives, and pharmaceutical composition comprising the same  
The present invention concerns pyrazole derivatives of formula: ##STR1## used for the treatment of inflammation, pain, thrombosis and rheumatism.
5128355 Treatment of congestive heart failure with angiotensin 11 receptor blocking imidazoles  
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
5120718 Candida acid protease inhibiting compounds  
Compounds which inhibit Candida acid protease are disclosed which have the formula: ##STR1## wherein R 1 is loweralkyl, loweralkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl,...
5118685 Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds  
Aminopropanol derivatives of the formula: ##STR1## where R 1 and R 2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6...
5116835 Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof  
Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof. The present invention relates to compounds of the formula I...
5106845 Calcium antagonists  
The present invention is directed to a new class of cyclic guanidines of the formula: ##STR1## in which Q is represented by a substituent selected from the group consisting of (CH 2 ) n in which n...
5093346 Substituted 1,2,4-triazole angiotensin II antagonists  
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
5081127 Substituted 1,2,3-triazole angiotensin II antagonists  
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
5066652 Thiomethyl and sulfinylmethyl derivatives having gastric acid antisectetory activity and pharmaceutical compositions containing them  
Compounds of the formula Het-S(O) n -CH 2 -A (I) wherein Het is a substituted imidazolyl, purinyl, thieno-imidazolyl or imidazo-pyridyl group, n is 0 or 1, A is...
5063220 Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl )piperazine  
A pharmaceutical formulation suitable for parenteral (preferably intravenous) administration includes an effective amount of...
5059601 Imidazolone derivatives with activity on central nervous system and antihypertensive activity, preparation methods thereof, and pharmaceutical compositions containing them  
Invention concerns 4,5-bisubstituted-2-imidazolone derivatives of formula I ##STR1## and pharmaceutically acceptable salts thereof, having high affinity in vitro for D 2 , 5-HT 2 , 1 receptors...
5055482 N-phenylpyrazol-4-yl ether derivatives  
An N-phenylpyrazol-4-yl ether derivative of the formula: ##STR1## wherein R 1 represents halogen, alkyl or alkoxy unsubstituted or substituted by halogen, alkylthio or alkylsulphinyl substituted...
Matches 201 - 250 out of 344 < 1 2 3 4 5 6 7 >