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5767141 |
Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases
Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Propane derivatives of the formula I ##STR1## in which the radicals have the...
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5756504 |
Tocolytic oxytocin receptor antagonists
Compounds of the formula X--Y--R, or the pharmaceutically acceptable salts and esters thereof, wherein X is ##STR1## Y is --SO 2 --, --(CH 2 ) p -- or --CO--(CH 2 ) p --; R is unsubstituted or...
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5756529 |
Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
A method of using pyrazolyl benzenesulfonamide compounds in treating inflammation and inflammation-related disorders in companion animals is disclosed.
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5753661 |
Fused benzo compounds containing a nitrogen heterocycle for the treatment of central nervous system disorders
Fused benzo compounds of formula I are provided, wherein A is a 2 to 6 membered hydrocarbon spacer group, B is a polar divalent group selected from a group (a); U is C, N or CH; X is a divalent 3-4...
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5728700 |
Sulfonamide compounds of azolones anti-helicobacter agents
The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R 1 ,...
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5716993 |
Anthranilic acid derivatives
The present invention provides an anthranilic acid derivative having a cGMP-PDE inhibitory activity. An anthranilic acid derivative represented by the general formula (I) or a pharmacologically...
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5716958 |
Amino acid derivative having anti-CCK activity
A compound represented by the formula (1): ##STR1## wherein, m is an integer of 1 to 3; n is an integer 0 or 1; A represents CH or N atom, and forms together with the N atom bonded to the...
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5710153 |
Tetrazole compound
A tetrazole derivatives of formula (I) ##STR1## a non-toxic salt thereof, an acid addition salt thereof or a hydrate thereof which has an inhibitory effect on interleukin-1β converting enzyme (ICE).
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5710156 |
Ester and carbamate derivatives of azolones
The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric form thereof, wherein X and Y are CH...
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5710160 |
Diphenyl pyridyl ethane derivatives as PDE IV inhibitors
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the...
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5693643 |
Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
Compounds of formula (I) wherein X is (a) or (b), R is Het as defined in the description. These compounds are oxytocin and vasopressin antagonists useful in the treatment of preterm labor,...
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5691335 |
Imidazolidine derivative and use thereof
The invention relates to an imidazolidine derivative represented by the following general formula (1): ##STR1## wherein A and B mean individually an aromatic hydrocarbon group which may be...
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5686454 |
Camphorcarbonyl
The invention is directed to a series of novel compounds of the formula ##STR1## where Y is carbonyl or sulfonyl; R 7 and R 8 are alkyl, or R 7 and R 8 , together with the carbon to which they...
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5684006 |
Isoxazole and pyrazole derivatives as dopamine receptor subtype ligands
A class of substituted isoxazole and pyrazole derivatives of formula (I), or a salt thereof of or a prodrug thereof, wherein the broken circle represents two non-adjacent double bonds whereby the...
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5658904 |
1,2-ethanediol derivative and salt thereof and cerebral function-improving agent comprising the same
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
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5656606 |
Camphor compounds promote release of growth hormone
The present invention is directed to certain novel compounds identified as camphor derivatives of the general structural formula: ##STR1## wherein A, X, Y, R 2a , R 4 , and R 5 are as defined...
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5648352 |
Piperazinylcamphorsulfonyl oxytocin antagonists
The invention is directed to a series of novel piperazinylcamphorsulfonyl compounds where the camphor ring is substituted by amides, amines, alkanes, alkenes, alkylamines, halogens, hydroxy,...
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5646172 |
Method of inducing antiandrogenic activity using imidazolidines substituted with a heterocycle
Novel imidazoles of the formula ##STR1## wherein the substituents are as defined in the disclosure and their non-toxic, pharmaceutically acceptable addition salts with acids and bases having...
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5643784 |
Indan derivatives
The subject invention relates to 5-Substituted trans-1-piperazinoindan derivatives having general formula (I), ##STR1## wherein X is halogen, trifluromethyl, alkyl, alkylthio, alkyloxy, hydroxy,...
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5637592 |
Acyl derivatives of azolones
The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R 1 ,...
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5633250 |
Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
Disclosed us a compound of Formula 1.0: ##STR1## or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable...
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5627177 |
Piperazine derivatives
Piperazine derivatives of formula (I) and their pharmaceutically acceptable salts are 5-HT 1A binding agents and may be used, for example, as anxiolytics. In the formula, A is an optionally...
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5622953 |
1-amino-3-phenoxy propane derivatives as modulator agents and their applications
This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: ##STR1## (in which A, B, R, R x , X and Z are defined as in the specification described) and methods for their...
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5614524 |
Piperazine derivatives as 5-HT.sub.1 Agonists
A class of substituted piperazine derivatives of formula I ##STR1## are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular...
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5612339 |
2-Hydroxy-3-aminopropylsulfonamides
2-Hydroxy-3-aminopropylsulfonamides are provided along with methods for synthesizing and using such compounds, and chemical intermediates employed in the synthetic methods.
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5607934 |
Piperazine derivatives and salts thereof
Piperazine compounds and salts thereof having inhibitory effect against superoxide radicals (O 2 - ). The piperazine compounds have the general formula: ##STR1## wherein R 1 is a lower alkyl...
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5607936 |
Substituted aryl piperazines as neurokinin antagonists
Disclosed are substituted aryl piperazines of Formula I ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis. In...
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5605902 |
5-HT.sub.2 receptor antagonist compositions useful in treating venous conditions
Methods of employing compositions containing 5-hydroxytryptamine-2 (5-HT 2 ) receptor antagonists for the treatment of such venous conditions as varicose veins, venous insufficiency and wounds are...
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5599809 |
Method for improving reproductive efficiency in farm animals
Oxytocin receptor antagonists of the formula ##STR1## wherein R 12 is hydrogen, alkoxycarbonyl or unsubstituted of substituted alkyl; R 13 is hydrogen, alkoxyl, aralkoxyl, alkoxycarbonyl,...
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5576342 |
Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives
Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives are prepared by reacting phenylacetic acids with glycinamides. The compounds can be used as active compounds in...
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5569659 |
4-arylpiperazines and 4-arylpiperidines
Compounds of the general formula I: ##STR1## are disclosed as novel antipsychotic agents.
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5554641 |
Nonpeptides as tachykinin antagonists
The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK 3 antagonists expected to be useful in the treatment of pain,...
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5552402 |
Five-membered heteroaromatic compounds as 5-HT receptor agonists
A class of substituted five-membered heteroaromatic compounds are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular...
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5545652 |
Triazole and imidazole compounds and their use as antifungal therapeutic agents
The present invention provides an azole compound represented by the formula (I): ##STR1## wherein Ar is an optionally-substituted phenyl group; R 1 and R 2 are, the same or different, a hydrogen...
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5538973 |
Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
An imidazole derivative of the formula (I) ##STR1## wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof is described. A method for producing the...
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5538988 |
Benzocycloalkylazolethione derivatives
The present invention relates to novel benzocycloalkylazolethione compounds which are dopamine β-hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from...
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5532234 |
Use of 1-[4-[4-aryl (or heteroaryl)-1-piperazinyl]-butyl)-1H-azole derivatives for the preparation of medicaments intended for the treatment of disorders of gastric secretion
The present invention relates to the use of 1-{4-[4-aryl(or heteroaryl)-1-piperazinyl]butyl}-1H-azole derivatives and of their physiologically acceptable salts for the manufacture of medicaments...
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5504086 |
Intraoral dosing method of administering trifluorobenzodiazepines, propoxyphene, and nefazodone
A method of therapeutically administering certain BZ 1 specific trifluorobenzodiazepines in order to maximize the BZ 1 effects and minimize the BZ 2 effects on the human central nervous system...
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5500426 |
Substituted piperazines for treatment of non-insulin-dependant diabetes
A compound selected from those of formula (I): ##STR1## in which A represents ##STR2## X represents N--R 4 or oxygen, and R 1 , R 2 , R 3 , R 4 , R 5 , n and m are as defined in the description,...
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5492912 |
Substituted piperazines for treatment of non-insulin dependent diabetes
A compound selected from those of formula (I): ##STR1## in which A represents ##STR2## X represents N-R 4 or oxygen, and R 1 , R 2 , R 3 , R 4 , R 5 , n and m are as defined in the description,...
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5462931 |
Fungicidal 2-heterocyclic-2,2-disubstituted-ethyl 1,2,4-triazoles
2-Aryl or 2-heterocyclyl-2, 2-disubstituted ethyl-1,2,4-triazoles have been shown to have fungicidal activity.
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5462940 |
4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents
The 4-oxocyclic ureas and the pharmaceutically acceptable salts and esters thereof, of the present invention are useful as antiarrhythmic and antifibrillatory agents and have the following general...
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5461049 |
Amide tetrazole ACAT inhibitors
Amide tetrazoles of the formula ##STR1## wherein aryl includes phenyl and naphthyl, unsubstituted or substituted, X is O, N--R 5 , or --NR 3 R 4 , where R 2 , R 4 , and R 5 include alkyl...
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5447929 |
Method of treating joint disorders using hydroxamic derivatives
Hydroxamic acid derivatives of the fdrrnula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint...
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5444082 |
3,9-disubstituted-spiro(5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same
3,9-disubstituted-spiro[5.5]undecanes and ##STR1## wherein, R, Y, A, B and n are defined in the specification, pharmaceutical compositions containing same for the treatment of cardiovascular...
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5432179 |
Piperazine derivatives and pharmaceuticals containing the same
A piperazine derivative represented by the following formula: ##STR1## or a pharmaceutically acceptable salt thereof. The compound according to the present invention has strong anti-histaminic and...
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5424309 |
N-substituted acylamino acid compounds, process for their production and their use
The present invention provides an N-substituted acylamino acid compound of the formula: ##STR1## a process for their production and pharmaceutical uses, and intermediates useful for their production.
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RE34918 |
Azaazulene compounds which are useful as antiallergic and antiinflammatory agents
An azaazulene derivative having the general formula (I): ##STR1## wherein R 1 is hydrogen atom or isopropyl group; the bond C N between C at the 2-position and N at the 1-position is single bond...
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5389663 |
1-(1h-1,2,4-triazole-yl)-2-propanol compounds
An azole compound represented by the formula (I): ##STR1## wherein X is a nitrogen atom; Ar is a phenyl group substituted by halogen or a halogenated C 1 -4 alkyl group; R 1 and R 2 independently...
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5389635 |
4- or 5-heterocyclic substituted imadazoles as angiotensin-II antagonists
Heterocycle substituted imidazoles of Formula (I), which are useful as angiotensin-II antagonists, are disclosed: ##STR1##
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