|
Match
|
Document |
Document Title |
|
|
7638536 |
2-Acylaminothiazole derivative or salt thereof
A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on...
|
|
|
7625889 |
Substituted bis aryl and heteroaryl compounds as selective 5HT2A antagonists
The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I):
Wherein X, Y, Z, A, B, D, Ar, R 1 and R 2 are as defined herein. The compounds of...
|
|
|
7618961 |
Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
The present invention relates to compounds with the formula (II) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the...
|
|
|
7605162 |
Phenylpiperazine
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D 2 receptor and/or the serotonin reuptake site,...
|
|
|
7566717 |
Substituted heterocyclic compounds
Disclosed are novel heterocyclic compounds having the structure
which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and...
|
|
|
7544687 |
Substituted α-piperazinyl phenylpropionic acid derivatives as hPPAR α and/or hPPAR γ agonists
The present invention relates to a compound of formula I, racemates, optically active isomers, or pharmaceutically acceptable salts or solvates thereof, and a pharmaceutical composition comprising...
|
|
|
7531542 |
Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists.
|
|
|
7524848 |
Diaza heterocyclic amide compounds and their uses
Diaza heterocyclic amide derivatives according to Formula (I) have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
where R 5 , R 6...
|
|
|
7514439 |
Oxime derivative and preparations thereof
The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]:
wherein Ring A is aryl or heteroaryl;
...
|
|
|
7504400 |
MTP inhibiting aryl piperydines or piperazines substituted with 5-membered heterocycles
The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant...
|
|
|
7501418 |
Fused heterocyclic isoxazoline derivatives and their use as anti-depressants
The invention concerns fused heterocyclic isoxazoline derivatives of Formula (I), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof...
|
|
|
7501421 |
Benzoxazole and benzothiazole derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
|
|
|
7498327 |
Indolylalkylamine metabolites as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
|
|
|
7494998 |
Benzisoxazole piperazine compounds and methods of use thereof
The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.
|
|
|
7482346 |
Derivatives of alkylpiperazine and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors
The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido...
|
|
|
7456182 |
Phenylpiperazines
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D 2 receptor and/or the serotonin reuptake site,...
|
|
|
7452889 |
Substituted heterocyclic compounds
Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I:
The compounds are useful for the treatment of various disease states, in particular cardiovascular...
|
|
|
7449468 |
Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
The present invention provides a compound of formula (I):
wherein R 1 -R 5 , R 25 , R 26 , Y, y, and X 2 are as defined herein. The compounds activate human peroxisome proliferater...
|
|
|
7435738 |
Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
The invention relates to a stable polymorphic form of the compound 7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2 (3H)-benzoxazolone monomethanesulfonate (INNM bifeprunox mesylate), a method...
|
|
|
7432269 |
Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents
The invention relates to compounds of the general formula (I):
to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands...
|
|
|
7405217 |
N-aroyl piperazine derivatives as orexin receptor antagonists
This invention relates to N-aroyl cyclic amino derivatives and their use as pharmaceuticals.
|
|
|
7396830 |
Piperazine amidines as antiviral agents
This disclosure provides compounds of Formula I
as described herein having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure...
|
|
|
7396834 |
4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders
Compounds of general formula: wherein R 1 and R 2 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared....
|
|
|
7365077 |
Piperazine bis-amide derivatives and their use as antagonists of the orexin receptor
Disclosed are piperazine bis-amide derivatives useful as antagonists of the orexin receptor and pharmaceutical compositions containing the same.
|
|
|
7361654 |
Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...
|
|
|
7345043 |
Inhibitors of histone deacetylase
Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions,...
|
|
|
7335660 |
Isochroman compounds for treatment of CNS disorders
This invention relates to compounds of formula (I)
where R 1 to R 12 , —W—V—, —X—Y—, p and n have the values defined in claim 1 , their preparation and use as pharmaceuticals for...
|
|
|
7319097 |
Compounds
The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the...
|
|
|
7300934 |
Benzamide nitriles
Compounds of the formula (I)
wherein m, n, A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein, together with methods for making the compounds and using the compounds for treatment...
|
|
|
7300939 |
Substituted 1-propiolylpiperazine compounds, their preparation and use
Substituted 1-propiolylpiperazine compounds corresponding to formula I
in which X denotes N or C—R 2 , and n is an integer from 0 to 8, a method for producing such substituted...
|
|
|
7297699 |
Piperazine and piperidine compounds
The invention relates to a group of novel piperazine and piperidine derivatives of the formula wherein Y is hydrogen, halogen, alkyl (1-3C), or CN, CF 3 , OCF 3 , SCF 3 , alkoxy(1-3C), amino or...
|
|
|
7271169 |
Substituted heterocyclic compounds
Disclosed are novel heterocyclic compounds having the structure
which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and...
|
|
|
7265134 |
Tyrosine kinase inhibitors
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to...
|
|
|
7256187 |
Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
The invention relates to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the rifamycin derivatives having an oxime...
|
|
|
7238689 |
Isoxazoline derivative and herbicide comprising the same as active ingredient
An isoxazoline derivative represented by the following general formula [I]:
wherein R 1 and R 2 may be the same or different and are each an alkyl group;
R 3 , R 4 , R 5 and R 6 are...
|
|
|
7229998 |
Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
The present invention provides a compound of formula (I):
wherein R 1 –R 5 , R 25 , R 26 , Y and X 2 are as defined herein. The compounds activate human peroxisome proliferator...
|
|
|
7220744 |
Monocyclic substituted phenyl methanones
The present invention relates to compounds of formula I
wherein
R 1 , R 2 , X 1 , and X 2 are as defined in the specification
and to pharmaceutically acceptable acid addition salts...
|
|
|
7214679 |
Piperidine/piperazine-type inhibitors of p38 kinase
Compounds of the formula:
wherein the substituents are as defined herein are useful for treating conditions mediated by p38 kinase.
|
|
|
7214694 |
3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors
Compounds of formula (I):
wherein the substituents are as defined herein, and their salt, solvates, and prodrugs are procollagen C-proteinase (PCP) inhibitors useful in treating conditions...
|
|
|
7189712 |
1,3-Oxazole compounds for the treatment of cancer
Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods...
|
|
|
7163952 |
Azole compound and medicinal use thereof
The present invention relates to an azole compound represented by the formula [I]
wherein W is S or O; R is —COOR 7 , —X 1 -A 1 -COOR 7 (R 7 is H, alkyl) or tetrazolyl; R 1 , R 2 , R 3 ...
|
|
|
7160886 |
Acylated piperazine derivatives as melanocortin-4 receptor agonists
Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
|
|
|
7151103 |
Method of treating female hypoactive sexual desire disorder with flibanserin
The invention relates to the use of flibanserin, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of disorders of sexual desire.
|
|
|
7135473 |
Cyclic diamine compound with condensed-ring groups
A cyclic diamine compound of formula (1):
wherein R 1 and R 2 are individually a hydrogen atom or a methoxy group, provided R 1 is a methoxy group when R 2 is a hydrogen atom, or a hydrogen...
|
|
|
7125865 |
Therapeutic compounds for treating dyslipidemic conditions
The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic...
|
|
|
7125876 |
Substituted heterocyclic compounds
Disclosed are novel heterocyclic compounds having the structure
which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and...
|
|
|
7119086 |
Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use
The invention relates to compounds of formula:
and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards...
|
|
|
7115610 |
Substituted heterocyclic compounds
Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I:
The compounds are useful for the treatment of various disease states, in particular cardiovascular...
|
|
|
7098212 |
Piperazine derivatives
The present invention relates to compounds of the formula I
and the pharmaceutically acceptable forms thereof; wherein X, Y, a, b, c, d, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein....
|
|
|
7094778 |
Heterocyclylalkylamines as muscarinic receptor antagonists
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I:
wherein X, Y, and Z are O, S or NR 5 , and the other...
|