Patents in Class 514/253.100

Matches 1 - 50 out of 148

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Match	Document	Document Title
1	7384944	Piperazine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R 1 is hydrogen or...
2	7361654	Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...
3	7300939	Substituted 1-propiolylpiperazine compounds, their preparation and use Substituted 1-propiolylpiperazine compounds corresponding to formula I in which X denotes N or C—R 2 , and n is an integer from 0 to 8, a method for producing such substituted...
4	7297693	Nitrogen-containing heterocyclic compounds and their use as Raf inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
5	7247631	Pegylated interferon alfa-CCR5 antagonist combination HIV therapy Methods for treating treatment-naive as well as treatment-experienced adult and pediatric patients having HIV-1 infections as well as patients co-infected with HIV-1 and HCV involving administering...
6	7238688	Piperidine compounds Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or...
7	7214679	Piperidine/piperazine-type inhibitors of p38 kinase Compounds of the formula: wherein the substituents are as defined herein are useful for treating conditions mediated by p38 kinase.
8	7101886	Phenylalkyl and pyridylalkyl piperazine derivatives This invention relates to compounds of the formula 1 wherein R 1 , R 3 , R 4 , X 1 , and X 2 are defined as in the specification, pharmaceutical compositions containing them and their use in...
9	7101885	Piperazinyl-aryloxy and piperazinyl-heteroaryloxy-n-aryl lactams The present invention relates to compounds of formula I wherein Ar, Y and G are as defined in the specification, a is 1 to 4, Z and W are carbon or nitrogen and n is 1, 2 or 3; and to...
10	RE39265	Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
11	7094778	Heterocyclylalkylamines as muscarinic receptor antagonists This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR 5 , and the other...
12	7087610	Benzothiazole antiviral agents The invention encompasses a series of benzothiazole compounds which inhibit HIV entry and are useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions...
13	7026314	Therapeutic chromone compounds Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating,...
14	6979690	Oxo or oxy-pyridine compounds as 5-HT4 receptor modulators This invention provides compounds of the formula (I) and (II): or the pharmaceutically acceptable esters thereof, and the pharmaceutically acceptable salts thereof: wherein R 1 is hydrogen or...
15	6875767	(5-cyano-2-thiazolyl)amino-4-pyridine tyrosine kinase inhibitors The present invention relates to compounds having the formula I: which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and...
16	6872724	Polymorphs with tyrosine kinase activity The present invention relates to active polymorphs of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperaz ine-1-carboxylic acid methylamide which inhibit, regulate and/or modulate tyrosine...
17	6833369	Angiogenesis inhibiting 5-substituted-1,2,4,-thiadiazolyl derivatives This invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; R 1 is...
18	6825200	Substituted dipeptides having nos inhibiting activity The present invention a compound represented by the formula (I): where the structural variables R 1 -R 6 are defined herein.
19	6821972	3-heterocyclylpropanohydroxamic acid PCP inhibitors Compounds of formula (I): and their salts, solvates, hydrates and prodrugs are useful PCP inhibitors, processes for making the same, compositions comprising the same, and methods of treating a...
20	6784173	Aromatic dicarboxylic acid derivatives Compounds of formula I wherein A, R 1 and R 2 are defined in the specification. These compounds are useful as HDAC inhibitors. Also disclosed are methods of making and using said compounds.
21	6756374	Diaminothiazoles having antiproliferative activity Disclosed are novel diaminothiazoles of formula wherein R 1 , R 2 , R 3 , R 4 and R 5 are as herein disclosed. These compounds and their pharmaceutically acceptable salts and esters are...
22	6638935	Heteroary1 derivatives and their use as medicaments The invention relates to novel pyridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors
23	6617339	Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and...
24	6610707	Heterocyclic compounds as inhibitors of rotomase enzymes Compounds of the formula: wherein R 1 , Y, W, A and R 2 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal...
25	6596745	Method for treating fibrotic diseases with azolium chroman compounds Provided is a method of treating or ameliorating hypertension in an animal comprising administering an effective amount of a compound of formula I:
26	6596724	Oxadiazole and thiadiazole derivatives of dihydropyridine NPY antagonists A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of oxadiazole, thiadiazole and thiadiazole oxide derivatives of dihydropyridines of Formula I. wherein B is...
27	6579880	Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8 The invention relates to isoxazole and oxadiazole compounds of Formulae I and II, pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds...
28	6576630	Compounds and compositions as protease inhibitors The present invention relates to novel alkanoyl-substituted heterocyclic derivatives which are cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses...
29	6573262	Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives The invention comprises substituted indoleoxoacetic piperazine derivatives of general Formula I, compositions thereof and their use as antiviral agents, and particularly for treating HIV infection.
30	6569878	Substituted 4-amino-thiazol-2-yl compounds as cyclin-dependent kinase inhibitors Pharmaceutical compositions containing effective amounts of CDK-inhibiting diaminothiazole compounds of the following formula (where R 1 and R 2 are as defined in the specification) or their...
31	6465456	Isoxazolinone antibacterial agents This invention describes isoxazolinone derivatives which possess antibacterial activity and are useful in the treatment of bacterial diseases. More particularly, new isoxazolinones are provided...
32	RE37886	1-(1,2-Disubstituted piperidinyl)-4-substituted piperazine derivatives This invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, as substance-P antagonists; their...
33	6458790	Substituted piperidines as melanocortin receptor agonists Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
34	6444677	5-membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein A is independently halo; Y 1 is —(CH 2 ) m —, C(O) or S(O); Y 2 is N or CH;...
35	6432958	2-piperazinoalkylaminobenzoazole derivatives: dopamine receptor subtype specific ligands Disclosed are compounds of the formula: or pharmaceutically acceptable salts thereof, wherein: A is (un)substituted alkylene; R 1 and R 2 are the same or different and represent hydrogen,...
36	6369063	Selective factor Xa inhibitors Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
37	6355643	Inhibitors of prenyl-protein transferase The present invention comprises unsubstituted and substituted piperazine-containing compounds having alkanoyl, alkylsulfonyl, alkylamido or alkoxycarbonyl substituents, and having the formula A, ...
38	6284775	3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds There are disclosed compounds of the formula, ##STR1## where n is 0, 1 or 2; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy,...
39	6284759	2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable salts thereof, wherein: A is (un)substituted alkylene; R 1 and R 2 are the same or different and represent...
40	6277872	Oxadiazoles, processes for their preparation and their use as medicaments The invention relates to oxadiazole derivatives of general formula (I) ##STR1## wherein X, Y, Z and R 1 are defined as described in the specification and claims, processes for preparing them...
41	6239134	Diazole derivatives as serotonergic agents The present invention provides compounds of the general formula (1): ##STR1## wherein: two atoms of X, Y, or Z are nitrogen and the third atom is sulfur or oxygen; R is H, halogen, OH, SH, C...
42	6218394	4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophene-methyl) piperazines 4-Aryl-1-(indanmethyl, dihydrobenzofuramethyl or dihydrobenzothiophenemethyl) piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I) ##STR1## wherein one of X and Y is CH 2...
43	6211183	Selective factor Xa inhibitors Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
44	6166033	2-carbonylthiazole derivatives and use of the same This invention provides a 2-carbonylthiazole derivative represented by formula (I): ##STR1## wherein each of Ar 1 and Ar 2 represents a phenyl group or a substituted phenyl group; R 1 represents...
45	6130217	Compounds enhancing antitumor activity of other cytotoxic agents This invention relates to certain heterocyclic compounds and their pharmaceutically acceptable salts, which are useful for sensitizing multidrug-resistant tumor cells to anticancer agents and...
46	6114328	Isoxazoline and isoxazole fibrogen receptor antagonists This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to...
47	6090813	Use of oxido-squalene cyclase inhibitors to lower blood cholesterol A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein G, T 1 , T 2 and T 3 are selected from CH and N; provided that T 2 and T 3 are not both CH; A is selected from...
48	6090807	Use of heterocyclic compounds The present invention relate to the use of heterocyclic compounds of the following formula: Het--A--B--Ar where Het, A, B and Ar have the meanings stated in the description. The compounds...
49	6066631	Chroman derivatives The present invention relates to chroman derivatives of the formula (I): ##STR1## [wherin R 1 represents a hydrogen atom, a halogen atom, a C 1 -6 alkyl group, a C 1 -6 alkoxy group, a C 3 -6...
50	6060472	Thiadiazole compounds useful as inhibitors of H.sup.+ /K.sup.+ atpase Novel 3,5-disubstituted 1,2,4-thiadiazole compounds are provided, which are effective in treating peptic ulcers by the inhibition of H + /K + -ATPase. The compounds of the present invention are...

Matches 1 - 50 out of 148

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