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7381402 |
Stable pharmaceutical solution formulations for pressurized metered dose inhalers
Aerosol solution formulations for use in an aerosol inhaler which comprise 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-m
ethylethyl]amino]-ethyl]-2(1H)-quinolinone or a salt thereof,...
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7320985 |
Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an...
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7273870 |
Stabilized difloxacin injectable solution
An antibacterial formulation suitable for injection into animals containing approximately 2-10% w/v difloxacin HCl, L-arginine base, propylene glycol, ethanol and/or benzyl alcohol, and water. The...
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7265107 |
Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
The current invention relates to a series of rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the 3,4-cyclo-rifamycin...
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7256187 |
Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
The invention relates to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the rifamycin derivatives having an oxime...
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7247641 |
Compounds, derivatives, compositions, preparation and uses
This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
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7247634 |
Rifamycin derivatives effective against drug-resistant microbes
Rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms are claimed in this invention. The inventive rifamycin derivatives are uniquely...
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7241746 |
Method and composition for treating periodontal disease
The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is...
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7238694 |
Rifamycin imino derivatives effective against drug-resistant microbes
The present invention relates to rifamycin 3-iminomethylenyl (—CH═N—) derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. The claimed...
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7176206 |
Antibiotics
The invention provides compounds of the general formula:
wherein
X is selected from the group consisting of oxygen, sulfur and nitrogen-containing groups selected from azine, oxime,...
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7105519 |
Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF...
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7084141 |
Inhibitors of macrophase migration inhibitory factor and methods for identifying the same
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF...
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7064123 |
Compounds and compositions as cathepsin inhibitors
The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
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6979471 |
Composition comprising pharmaceutical/nutraceutical agent and a bio-enhancer obtained from Glycyrrhiza glabra
The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and...
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6949241 |
Use of lacrophyl preparation in eye drops containing therapeutically active compounds
The invention refers to the use of a lacrophyl preparation containing lysozyme, tris(hydroxymethyl)aminomethane, if desired other lacrophyl components, preferably ascorbic acid and/or citric acid...
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6890526 |
Methods and reagents for the treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in...
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6818645 |
Benzocycloalkylenylamine derivatives as muscarinic receptor antagonists
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S, or NR 4 , and the other...
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6806256 |
Taste masked liquid pharmaceutical compositions
This invention is directed to a taste masked liquid pharmaceutical composition comprising a pharmaceutically active agent and a taste masking composition. In particular, the taste masking...
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6803369 |
Compounds and methods for the treatment of neoplastic disease
A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with...
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6699492 |
Quinolone carboxylic acid compositions and related methods of treatment
The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release...
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6613770 |
Quinoline derivatives as NK-2 and NK-3 receptor ligands
A compound, or a solvate or a salt thereof, of formula (I): wherein R is linear or branched alkyl; R 1 represents hydrogen or up to four optional substituents selected from the list consisting...
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6605295 |
Storage-stable ophthalmic compositions comprising diclofenac and ofloxacin
The invention relates to stable ophthalmic preparations including the penetrant antiphlogistic diclofenac or salts thereof and the penetrant antibiotic ofloxacin present in the form of the...
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6589955 |
Pediatric formulation of gatifloxacin
There is provided in accordance with the present invention the quinolone antibacterial gatifloxacin adequately taste-masked so that it can be utilized for pediatric formulations. A crystalline...
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6534508 |
Methods and compositions for treating infection using optically pure (S)-lomefloxacin
Methods and compositions are disclosed utilizing the optically pure (S)-isomer of lomefloxacin to treat bacterial infection. In particular, this compound is a potent drug for the treatment of...
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6528517 |
Synthesis of quinobenzoxazine analogues with topoisomerase II and quadruplex interactions for use as antineoplastic agents
The present invention discloses a novel quinobenzoxazine self-assembly complex on DNA and on the topoisomerase II-DNA complex. The related model is used to design a new series of quinobenzoxazines,...
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6503906 |
Method for optimizing ciprofloxacin treatment of anthrax-exposed patients according to the patient's characteristics
The present invention relates to a method for optimizing ciprofloxacin treatment of anthrax-exposed patients according to the patient's characteristics. More particularly, the invention optimizes...
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6492373 |
6-fluoro-1,4-dihydro-7-&lsqb 4-(2-hydroxyiminoethyl)-1-piperazinyl&rsqb -4-oxoquinoline-3-carboxylic acid derivatives, their preparation and pharmaceutical compositions
The present invention discloses a novel 6-fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperaziny
l]-4-oxoquinoline-3-carboxylic acid derivatives (formula I), with a process for their...
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6492361 |
Antibiotic compositions and methods for using same
Compositions including a quinolone component in an amount effective as an antibiotic when the composition is placed in a mammalian eye, and a carrier component in an amount effective to act as a...
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6413969 |
Gatifloxacin pentahydrate
There are provided in accordance with the present invention crystalline gatifloxacin pentahydrate represented by the formula in a highly homogeneous form with respect to other crystalline forms...
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6413956 |
Substituted 4-oxo-quinoline-3-carboxamides
Disclosed are compounds of Formula I: or the pharmaceutically acceptable salts thereof where, R 1 , R 2 , and W are defined herein. These compounds are highly selective agonists, antagonists or...
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6403591 |
1-azatricyclic-4-benzylpiperazines
Disclosed are 1-Azatricyclic-4-benzylpiperazine compounds which are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania,...
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6369116 |
Composition and method for treating glaucoma
Implants and methods are provided for modulating wound healing and controlling infection to improve the success of glaucoma filtration surgery. Formulations of one or more therapeutically active...
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6309662 |
Use of anti-inflammatory drugs for treatment of dermatological conditions
A method of treating or preventing recurrence of warts including a step of administering to a patient an anti-inflammatory drug, particularly, ciprofloxacin.
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6291462 |
Oral medicinal preparations with reproducible release of the active ingredient gatifloxacin or its pharmaceutically suitable salts or hydrates
Solid medicinal forms having a multiphase structure for oral administration, containing gatifloxacin or pharmaceutically acceptable salts or hydrates thereof and auxiliary substances selected from...
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6172069 |
Method for preventing or reducing photosensitivity and or photoxicity reaction to medications
The present invention provides a method for preventing or reducing a photosensitivity and/or phototoxicity reaction which may be caused by a once-per-day dose of a medication which causes a...
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6143742 |
Treatment for necrotizing infections
The treatment of for arresting the destructive effects of proteolytic enzymes produced by a host infecting organism, such as "flesh eating bacteria", is carried out using therapy with includes the...
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6093417 |
Composition to treat ear disorders
A topical ear composition that uses penetration enhancers to diffuse the therapeutic agents through the tympanic membrane into the middle and inner ear for the purpose of reducing the inflammation...
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6075024 |
Methods for treating infection using optically pure (S)-lomefloxacin
Methods and compositions are disclosed utilizing the optically pure (S)-isomer of lomefloxacin to treat bacterial infection. In particular, this compound is a potent drug for the treatment of...
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6060474 |
Method for preventing scar tissue formation
Disclosed herein are methods for reducing or preventing scar tissue formation by administering an antifibrotic amount of a fluoroquinolone. Also disclosed are means for inhibiting the activity of...
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6043225 |
Diagnosis and treatment of arterial chlamydial granuloma
Method of diagnosing arterial chlamydial granuloma by detecting in a biological sample both a first marker associated with Chlamydia pneumoniae and a second marker associated with arterial...
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6034100 |
Method for inhibiting cytokine secretion
A method for the prophylaxis and treatment of diseases induced by acceleration of secretion of cytokines (e.g. TNF-α, IL-1, IL-6, IL-8, and IFN-γ) which comprises administering a...
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6034086 |
Trifluoromethylquinolinecarboxylic acid derivative
This invention relates to a 8-trifluoromethylquinolinecaboxylic acid derivative represented by the following formula (I): ##STR1## (wherein R 1 represents a lower alkyl group, a halogeno-lower...
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6017912 |
Topical fluoroquinolone antibiotics in an alcohol and acetone vehicle
A method of treating bacterial infections of the skin comprising topically administering a pharmaceutical composition comprising fluoroquinolones selected from the group consisting of...
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5998418 |
Enrofloxacine injection or infusion solutions
The present invention relates to novel injection and infusion solutions of the following composition: a) 0.1 to 20% by weight of enrofloxacin, based on the total weight of the solution, in the...
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5965549 |
Ciprofloxacin-hydrocortisone suspension
The invention is directed to an aqueous non-ototoxic, topical, otic pharmaceutical composition of matter for treating a mammal consisting essentially of: ciprofloxacin or a pharmaceutically...
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5912255 |
Topical fluoroquinolone antibiotics combined with benzoyl peroxide
A pharmaceutical composition of all fluoroquinolones, including but not limited to, ciprofloxacin, ofloxacin, enoxacin, cinoxacin, pefloxacin, lomefloxacin, norfloxacin, tosufloxacin, fleroxacin,...
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5889009 |
Method of inhibiting cell adhesion
A composition comprises a 1,7-disubstituted-4-oxo-3 -quinolinecarboxylic acid or 1,7-disubstituted-4-oxo-3 -naphthyridinecarboxylic acid derivative which is useful as a prophylactic and/or...
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5843930 |
Method of treating otitis with ciprofloxacin-hydrocortisone suspension
The invention is directed to a method of treating otitis which comprises introducing an antibacterially-effective amount of a composition comprising a non-ototoxic, topical, otic pharmaceutic...
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5830874 |
Compositions and methods for the treatment of arterial chlamydial granuloma
Method of diagnosing arterial chlamydial granuloma by detecting in a biological sample both a first marker associated with Chlamydia pneumoniae and a second marker associated with arterial...
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5795897 |
Oxohexyl methylxanthine compounds
There is disclosed a pharmaceutical composition comprising 1-(5-oxohexyl)-3-methylxanthine in admixture with a pharmaceutically acceptable excipient, wherein the pharmaceutical composition is...
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