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4565816 |
Piperazine derivatives and pharmaceutical composition containing them
Piperazine derivatives or pharmaceutically acceptable acid addition salts thereof are useful as neuroleptic, anti-hypertensive or bradycardic agents.
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4556657 |
6-(1,8-Naphthyridin-2-yl)-dithiino[1,4][2,3-c]-pyrroles useful as tranquillizing and anticonvulsant agents
New compounds of the formula: ##STR1## wherein X represents hydrogen, halogen, alkyl (1 to 4 C), alkoxy (1 to 4 C), cyano or nitro, R represents alkyl (1 to 4 C) optionally substituted by hydroxy,...
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4530927 |
Antiinflammatory and anxiolytic isoxazole-[5,4-b]pyridines
New isoxazole[5,4-b]pyridines having antiinflammatory, CNS-depressant and cardiovascular activity.
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4500525 |
Pharmacologically active pyrazolo/4,3-c/pyridines
The present invention is directed to new pyrazolo/4,3-c/pyridines, the process for their preparation, the pharmaceutical compositions containing them and their use as pharmocologically active...
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4496566 |
Naphthyridine derivatives
A 1,8-naphthyridine compound of the formula ##STR1## wherein R 1 is a lower alkyl group, and the esters and salts thereof. The 1,8-naphthyridine compound of the formula (I) in which R 1 is a...
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4465683 |
Anti-psychotic agents
2-[4-[4-Arylpiperazin-1-yl]butyl]-1,2,4-triazolo[4,3-a]pyrid
in-3(2H)-ones are anti-psychotic agents.
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4442101 |
Sesquihydrate of naphthyridine derivative, and process for the preparation thereof
Novel 1-ethyl-6-fluoro-1,4-dihyono-4-oxo -7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid.sesquihydrate (ATT-2266.sesquihydrate). The aforesaid compound can be prepared by heating...
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4402956 |
2-[3-[4-(3-Chl oro-4-fluorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3( 2H)-one
Novel compounds selected from the group consisting of 2-[3-[4-(3-chloro-4-fluorophenyl)-1-piperazinyl]propyl]-1,2,
4-triazolo[4,3 -a]pyridine-3(2H)-one (I) and from its non-toxic pharmaceutically...
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4352803 |
Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof
This invention relates to 1,8-naphthyridine compounds of the formula ##STR1## wherein X is a halogen atom especially fluorine atom, R 1 is an ethyl group or a vinyl group, and R 2 is a...
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4330543 |
Imidazoazines and imidazodiazines
Novel imidazopyridines, -pyrazines, -pyrimidines and -pyridazines having a 3-amino-2-OR-propoxy substituent, are disclosed. The compounds have β-adrenergic blocking activity.
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4327095 |
Methoxy derivatives of 1,4-dithiepino-[2,3-c]-pyrrole
Compounds of the formula: ##STR1## wherein A represents pyrid-2-yl, quinol-2-yl or 1,8-naphthyridin-2-yl, each such radical being optionally substituted by a halogen atom, or an alkyl or alkoxy...
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4325952 |
Method of treating abstinence syndrome with cycloaklyltriazoles
Compounds of the general formula: ##STR1## in which alk and alk' represent the bivalent radicals; aliphatic alkyl chains; and R and R' represent the alkyl, halogen, hydrogen, alkyloxy, --OH, --CF 3...
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4307096 |
Method of treating glaucoma with cycloalkyltriazoles
Compounds of the general formula: ##STR1## in which alk and alk' represent the bivalent radicals: aliphatic alkyl chains; and R and R' represent the alkyl, halogen, hydrogen, alkyloxy, --OH, --CF 3...
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4307095 |
Method of treating schizophrenia with cycloalkltriazoles
Compounds of the general formula: ##STR1## in which alk and alk' represent the bivalent radicals aliphatic alkyl chains; and R and R' represents the alkyl, halogen, hydrogen, alkyloxy, --OH, --CF 3...
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4254124 |
Antidepressant agent
2-[3-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]propyl]-1,
2,4-triazolo[4, 3-a]pyridin-3(2H)-one and its pharmaceutically acceptable acid addition salts are antidepressant agents.
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4250174 |
3-Substituted imidazo [1,2-A] pyridines
Imidazo pyridines with a carbamate group in the 2-position and a phenylthio, or phenylsulfinyl group in the 6-position are disclosed which also are substituted at the 3-position. The 3-position...
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4220646 |
Heterocyclic compounds
Heterocyclic compounds of the formula: ##STR1## wherein the pyrroline ring and the symbols R 1 and R 2 together form an isoindoline, 6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazine,...
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4206117 |
Pyridinyl aminoalkyl ethers
New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these...
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4195087 |
Derivatives of naphthyridine
The present invention deals with derivatives of naphthyridine, process for their preparation and their utility, inter alia, as anti-bacterides and as feed-additives.
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4176183 |
Novel naphthyridines
Novel naphthyridines having a 3-amino-2-OR-propoxy substituent are disclosed. The compounds have β-adrenergic blocking and immediate onset antihypertensive activities.
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4162318 |
Use of trazodone and etoperidone in Parkinsonism and in other extrapyramidal syndromes characterized by tremors
Treatment of tremors in Parkinsonism and in other extrapyramidal syndromes by administering an amount of trazodone of the formula ##STR1## AND OR OF ETOPERIDONE OF THE FORMULA: ##STR2## in the...
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4154832 |
Novel treatment for acute organic cerebral syndromes (strokes)
S-Triazolo-[4,3-a]-pyridine derivatives and their nontoxic salts have been found to have pharmaceutical activity in the treatment of individuals suffering from the acute phases of the organic...
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4131675 |
Use of combinations of L-DOPA with trazodone and L-DOPA with etoperidone in Parkinsonism
A combination of trazodone or etoperidone with L-DOPA is used in the treatment of Parkinsonism by oral administration to a patient.
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4124711 |
Derivatives of dithiepino[1,4][2,3-C]pyrrole
Compounds of the formula: ##STR1## wherein A represents a phenyl, pyrid-2-yl, quinol-2-yl or 1,8-naphthyridin-2-yl radical, each such radical being optionally substituted by a halogen atom, an...
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4081544 |
Certain 2-(alpha(2-pyridyl)-benzyl)imidazolines and derivatives thereof
The present 2-substituted imidazolines and 2-substituted-3,4,5,6-tetrahydropyrimidines possess valuable anti-depressant and anti-inflammatory properties. The compounds are prepared by the...
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4038391 |
6-(1,8-Naphthyridin-2-yl)-5-piperazino carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazines and related pyridines
Compounds of the formula: ##STR1## wherein one of the symbols =X- represents =N- and the other three each represent a group ##STR2## in which Y represents hydrogen, halogen, alkyl, alkoxy, cyano or...
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4024255 |
Tetrazole containing naphthyridine-3-carboxamides
Compounds of the general formulae I and II and pharmaceutically acceptable salts thereof: ##STR1## in which: R 1 represents a hydrogen atom, a halogen atom, an alkenyl or alkyl group; or a group...
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4021554 |
1,4-Oxathiino[2,3-c]pyrrole derivatives
1,4-Oxathiino[2,3-c]pyrrole derivatives of the formula: ##STR1## wherein A represents a phenyl, 2-pyridyl, 3-pyridazinyl, 2-quinolyl or naphthyridinyl radical, or a said radical substituted by one...
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4017622 |
Piperazine derivatives
Piperazine derivatives of the following formula ##STR1## wherein A and B are a carbon atom or a nitrogen atom except the case where both A and B are nitrogen atoms, R 1 is hydrogen atom, an...
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3966931 |
1,4-Dithino[2,3-c]pyrrole compositions
New compounds of the formula: ##SPC1## Wherein A is a phenyl, pyridyl, pyridazinyl, 2-, 3- or 4-quinolyl or naphthyridinyl radical, or a said radical substituted by one or two atoms or radicals...
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3325358 |
Method of treating inflammation
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