Matches 101 - 150 out of 281 < 1 2 3 4 5 6 >
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6306859 N-substituted imide derivatives with serotonergic activity  
Compounds of the Formula (I) ##STR1## wherein R 2 , Y, X and n are as defined in the specification which compounds are useful in the treatment of disorders associated with serotonergic...
6303625 Triazolopyridines for the treatment of thrombosis disorders  
The invention is directed to novel triazolopyridine derivatives which are useful as antagonists of GPIIb/IIIa. Pharmaceutical compositions comprising the triazolopyridine derivatives of the present...
6277872 Oxadiazoles, processes for their preparation and their use as medicaments  
The invention relates to oxadiazole derivatives of general formula (I) ##STR1## wherein X, Y, Z and R 1 are defined as described in the specification and claims, processes for preparing them...
6248755 Pyrrolidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine compounds of the formula I: ##STR1## (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 14 and n are defined herein) which are useful as modulators of...
6211229 Treatment of transient and short term insomnia  
The invention is directed to a method for the treatment of a patient suffering from transient or short term insomnia. The claimed method comprises the administration of a compound selected from the...
6191133 Treatment of depression and pharmaceutical preparations therefor  
It has been found that the treatment of depression using known serotonin reuptake inhibitors (SRIs) and noradrenaline reuptake inhibitors (NRIs) may be improved by the administration therewith of...
6187774 Fused heterocyclic compounds and pharmaceutical applications thereof  
The present invention relates to a fused heterocyclic compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, an optical isomer thereof, a pharmaceutically...
6166020 Aryl and heteroaryl alkoxynaphthalene derivatives  
Compounds of the formula ##STR1## wherein R 1 , R 2 , R 4 , R 23 , R 24 , R 25 and R 26 are defined as in the specification. These compounds are useful psychotherapeutics and are potent serotonin...
6131226 1,4-dihydropyridine compounds as bradykinin antagonists  
A compound of formula (I) and its pharmaceutically acceptable salts, wherein A 1 and A 2 are each halo; X is direct bond, CH 2 , CO, O, S, S(O) or S(O) 2 ; R 1 is selected from a variety of...
6103724 2-methoxyphenylpiperazine derivatives  
The invention relates to fused heterocyclic compounds with ring junction nitrogen atom of the formula: ##STR1## wherein Q stands for 2-indolizinyl, 2-imidazo[1,2-a]pyridinyl,...
6051575 Piperazino derivatives as neurokinin antagonists  
The invention relates to compounds of the formula ##STR1## wherein Z, R c , y, m, u, Ar 2 , n, X, R c ', I and Ar 2 are as described herein. These compounds are neurokinin antagonists. These...
6037346 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction  
A method is provided for treating erectile dysfunction in a mammalian male individual. The method involves the local administration of a phosphodiesterase inhibitor or a pharmaceutically acceptable...
6034091 Method for treating emotional or mental illness and emotional or mental illness concomitant with seizures  
Disclosed herein is a method for treating depression associated with alcoholism in a patient comprising administering to the patient a pharmacologically effective dose of an opioid antagonist, and...
6013654 Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases  
The present invention relates to imidazo[1,2-a]pyridine compounds of formula I which are dopamine D-4 antagonists and useful as anti-psychotic agents. ##STR1##
5998417 N-[(4-heteroaryl-1-piperazinyl) alkyl]phthalimides and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5985873 Certain substituted benzylamine derivatives a new class of Neuropeptide-Y1 specific ligands  
This invention encompasses compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein X 1 , X 2 , X 3 represent organic or inorganic substituents, n is 1, 2, or 3,...
5976497 Dopamine D4 receptor ligands  
Described herein are D4 receptor-selective compounds of the formula: ##STR1## wherein R 1 is selected from H and an acid labile protecting group; and R 2 and R 3 are independently selected from...
5962455 Certain substituted benzylamine derivatives a new class of neuropeptide Y1 specific ligands  
This invention encompasses compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein X 1 , X 2 , X 3 represent organic or inorganic substituents, n is 1, 2, or 3,...
5958924 Quinolein-2 (1H)-one derivatives as serotonin antagonists  
Compounds of formula (I) ##STR1## in which A represents a 4-(thieno 3,2-c! pyridin-4-yl)-1-piperazinyl or 4-(4-fluorobenzoyl)-1-piperidyl group, R 1 and R 2 each represent, independently of one...
5952342 6-aryl naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation  
6-Aryl naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating...
5922720 Piperazinothiopyridines for the control of Helicobacter bacteria  
Compounds of formula I are piperazinothiopyridines which are useful for controlling Helicobacter bacteria. They are useful as active compounds for treating diseases based on such bacteria, and are...
5919783 Indoline and azaindoline derivatives as 5-HT.sub.1D alpha receptor agonists  
Compounds of formula (I), or a salt or prodrug thereof, wherein Z represents an optionally substituted five-membered heteroaromatic ring selected from furan, thiophene, pyrrole, oxazole, thiazole,...
5908842 Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase  
Substituted 2-acylaminopyridine compounds and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders.
5889009 Method of inhibiting cell adhesion  
A composition comprises a 1,7-disubstituted-4-oxo-3 -quinolinecarboxylic acid or 1,7-disubstituted-4-oxo-3 -naphthyridinecarboxylic acid derivative which is useful as a prophylactic and/or...
5872117 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same  
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
5869499 Benzyloxyquinuclidines as substance P antagonists  
A compound of chemical formula (I) and its pharmaceutically acceptable salt: ##STR1## wherein X and Y are each hydrogen, halogen, C 1 -C 6 alkyl, halosubstituted C 1 -C 6 alkyl, C 1 -C 6 ...
5861402 1,4-dihydropyridine compounds  
A compound of the formula: ##STR1## and its pharmaceutically acceptable salts, wherein A 1 and A 2 are each halo or H; X 1 is CH 2 , CO, SO or SO 2 ; X 2 is CH 2 or CO; Y is piperazinyl-(CH 2...
5859011 Dihydropyridine derivatives as bradykinin antagonist  
Compound of formula (1) and their pharmaceutically acceptable salts wherein A1,A2,R1, R2,R3,R4,X are as defined in the specification have excellent bradykinin antagonistic activity. ##STR1##
5821245 Use of naphthalene derivatives in treating lung carcinoma  
A method of inhibiting cell growth in human small cell lung carcinoma comprising administering to a mammal in need of such treatment a cell growth inhibitory amount of a compound of the formula...
5817665 Composition and method of treating depression using naloxone or naltrexone in combination with a serotonin reuptake inhibitor  
This invention relates to a composition and method for treating depression by administering to a patient a pharmacologically effective dose of an opioid antagonist having a pentacyclic nucleus...
5807841 HIV protease inhibitors useful for the treatment of AIDS  
Compounds of formula ##STR1## are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds,...
5807857 Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT.sub.1D-α agonists  
Compounds of formula (I), or a salt or prodrug thereof, wherein Z represents an optionally substituted five-membered heteroaromatic ring selected from furan, thiophene, pyrrole, oxazole, thiazole,...
5795895 Combination anorexiant drug therapy for obesity using phentermine and an SSRI drug  
This is a new therapy and method used to treat moderate and severe exogenous obesity by combining generic phentermine with an SSRI (selective serotonin reuptake inhibitor) drug in specific doses...
5783579 Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists  
The invention relates to compounds of the formula ##STR1## wherein Z, R c , y, m, u, Ar 2 , n, X, R c ', I and Ar 2 are as described herein. These compounds are neurokinin antagonists. These...
5767128 1,3-dihydro-2H-pyrrolo 2,3-b!pyridin-2-one compounds  
The invention relates to a compound selected from those of formula (I): ##STR1## wherein R 1 , W and Y are as defined in the description, its geometric and/or optical isomers, and its...
5760029 Spirocycle integrin inhibitors  
This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3- 8-(2-pyridinylaminomethyl)-!-1-oxa-2-azaspi ro- 4,5!-dec-2-en-3-yl!carbonylamino! propionic acid, which are...
5760028 Integrin receptor antagonists  
This invention relates to novel heterocycles including 3- 1- 3-(imidazolin-2-ylamino)propyl!indazol-5-ylcarbonylamino!-2- (benzylo xycarbonylamino)propionic acid, which are useful as antagonists of...
5739136 Intraoral dosing method of administering medicaments  
A method of therapeutically administering certain medicaments in order to maximize the desired effects and minimize the unwanted metabolite effects on the human body, including the central nervous...
5719135 Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation  
The present invention relates to compound of formula (I) ##STR1## wherein A is benzene, naphthalene, 5,6,7,8,-tetrahydronaphthalene, quinoline, isoquinoline, indole or 7-azaindole; R 1 is --H,...
5712273 Amino acid derivatives, processes for the manufacture thereof and pharmaceutical compositions (II) containing these compounds  
The invention relates to new amino acid derivatives of general formula I R 1 -R 11 --A 1 --B (I) and the pharmaceutically acceptable salts thereof, wherein group B...
5703081 Quinolonecarboxylic acid derivatives, their production and use  
A composition comprises a 1,7-disubstituted-4-oxo-3-quinolinecarboxylic acid or 1,7-disubstituted-4-oxo-3-naphthyridinecarboxylic acid derivative which is useful as a prophylactic and/or...
5700802 Furopyridine derivatives  
A class of substituted furo 2,3-b!pyridine derivatives are ligands for dopamine receptor subtypes within the body, in particular the D 4 subtype, and are therefore useful in the treatment and/or...
5686454 Camphorcarbonyl  
The invention is directed to a series of novel compounds of the formula ##STR1## where Y is carbonyl or sulfonyl; R 7 and R 8 are alkyl, or R 7 and R 8 , together with the carbon to which they...
5674878 Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparations  
Compound of general formula I ##STR1## wherein A is a benzo or thieno group; R 1 is (C 4 -6)cycloalkyl, (C 4 -6)cycloalkyl-(C 1 -5)alkyl or ##STR2## R 2 , m, R 3 , R 4 , R and u are defined as...
5672600 Antimicrobial dithiocarbamoyl quinolones  
Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A 1 , A 2 , A 3 , R 1 , R 3 , R 4 , and R 6 form any of a variety of quinolone and related...
5668131 Substituted aminoalkylaminopyridines  
Compounds of formula I ##STR1## wherein R1, R2, R3, R4, R5, R6, X, n and A have the meanings as given in the description, can be used for combatting Helicobacter bacteria.
5658924 1,8-naphthyridin-2-one derivative and use thereof  
The present invention relates to 1,8-naphthyridin-2-one derivatives, pharmaceutically acceptable acid addition salts and therapeutic agents comprising said compound as an active ingredient, which...
5658904 1,2-ethanediol derivative and salt thereof and cerebral function-improving agent comprising the same  
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
5654305 Indole piperazine platelet activating factor antagonists  
The present invention provides compounds of formula ##STR1## wherein Y is >CO or >S(O) t wherein t is 1 or 2 and the pharmaceutically acceptable salts thereof which are potent antagonists...
5631256 Antimicrobial quinolone thioureas  
Antimicrobial quinolone thiourea compounds of the general formula: ##STR1## wherein (1) A 1 , A 2 , A 3 , R 1 , R 3 , R 4 , and R 6 form any of a variety of quinolone and related heterocyclic...
Matches 101 - 150 out of 281 < 1 2 3 4 5 6 >