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7625904 |
Methods for the treatment of sleep disorders
The invention relates to methods for the treatment of a sleep disorder in a mammal comprising administering to said mammal an effective amount of a compound of formula (I):
wherein all...
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7618970 |
3-aminocyclopentanecarboxamides as modulators of chemokine receptors
The present invention is directed to compounds of Formula I:
which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment...
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7612076 |
Piperazinyl-pyridine derivatives
The present invention relates to compounds of formula I
wherein R 1 , R 2 , X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as...
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7598392 |
2-amido-4-phenylthiazole derivatives, the preparation and the therapeutic use thereof
The disclosure relates to 2-amido-4-phenylthiazole derivatives of general formula (I) below:
in which R 1 , R 2 , R 3 , Y, m, n, and p are as defined in the disclosure; as well as to their...
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7595314 |
Benzoyl-piperazine derivatives
A compound of formula
wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia,...
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7592344 |
NK1 and NK2-antagonists and compositions and methods of using the same
3-cyanonaphthalene-1-carboxylic acid perhydroxyalkylmethyl-piperazine compounds of formula I
which are antagonistic to tachykinin receptors, pharmaceutical compositions containing such...
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7592332 |
Cytokine inhibitors
Disclosed are compounds of formula (I)
which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving...
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7566717 |
Substituted heterocyclic compounds
Disclosed are novel heterocyclic compounds having the structure
which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and...
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7566718 |
Amine-linked pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity
The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of...
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7560553 |
Use of fuse nicotinamides to promote neurogenesis
The present invention provides a group of compounds found to increase the number of neurons derived from stem cells for use as a therapeutic agent in neurological conditions or diseases. In one...
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7553815 |
Therapeutic use
A method of chemoprevention of the onset of invasive breast cancer in a high risk patient comprises administering to the patient an effective amount of an EGFR tyrosine kinase inhibitor.
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7528135 |
Pyridine derivatives as H3 antagonists
The present invention relates to compounds of formula I
wherein R 1 , R 2 and A are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to...
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7524848 |
Diaza heterocyclic amide compounds and their uses
Diaza heterocyclic amide derivatives according to Formula (I) have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
where R 5 , R 6...
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7494994 |
Phenylpyridylpiperazine compounds
A compound selected from those of formula (I):
wherein:
X represents a C(O) or SO 2 group, R 1 represents an aryl group or a group NR 3 R 4 wherein R 3 and R 4 are as defined in the...
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7491727 |
Arylpiperazinyl compounds
The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formula I, and synthesis and uses thereof for treating diseases including...
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7482346 |
Derivatives of alkylpiperazine and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors
The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido...
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7482347 |
Piperazine derivatives with CCR-3 inhibiting activity
Compounds of formula I
in free or salt form, wherein Ar, R 1 , R 2 , R 3 , X and T have the meanings as indicated in the specification, are useful for treating a condition mediated by CCR-3,...
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7462617 |
Substituted acylpiperazine derivatives
The invention relates to compounds of formula
wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof.
The invention further...
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7456175 |
Piperazinyl-pyridine derivatives
The present invention relates to compounds of formula I
wherein R 1 , R 2 , X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as...
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7449466 |
Cyclic aminophenyl sulfamate derivative
This invention provides cyclicamino-phenyl sulfamate derivatives represented by a formula
wherein each of R 1 and R 2 stands for hydrogen or lower alkyl; each of R 3 and R 4 stands for...
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7449467 |
3-aminocyclopentanecarboxamides as modulators of chemokine receptors
The present invention is directed to compounds of Formula I:
which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment...
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7442692 |
Indanyl-piperazine compounds
A compound selected from those of formula (I):
wherein:
R 3 represents a hydrogen atom, and R 1 and R 2 together with the carbon atoms carrying them form a benzene, naphthalene or...
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7439360 |
Vanilloid receptor ligands and their use in treatments
Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular...
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7432269 |
Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents
The invention relates to compounds of the general formula (I):
to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands...
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7429599 |
Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
This invention generally relates to methods for treating or preventing a condition responsive to JNK inhibition, such as a metabolic condition, comprising administering to a patient in need thereof...
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7427612 |
Benzoyl-piperazine derivatives
A compound of formula
wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia,...
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7419980 |
Fused-aryl and heteroaryl derivatives and methods of their use
The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions...
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7414047 |
Piperazinyl and diazapanyl benzamides and benzthioamides
Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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7396854 |
Use of serotonergic compound for a method of treatment of hot flushes in post-menopausal women
The present invention relates to a method of treatment of hot flushes with a 5-HT 2C receptor agonist and in particular to the use of the selective 5-HT 2C receptor agonists...
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7396834 |
4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders
Compounds of general formula: wherein R 1 and R 2 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared....
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7384944 |
Piperazine derivatives useful as CCR5 antagonists
The use of CCR5 antagonists of the formula
or a pharmaceutically acceptable salt thereof, wherein
R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R 1 is hydrogen or...
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7365068 |
Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
The invention provides compounds and pharmaceutically acceptable salts of Formula I
wherein the variables A 1 , A 2 , R 1 , R 2 , V, W, X, Y, and Z are defined herein. Certain compounds of...
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7345041 |
Chemical compounds
The invention relates to methods for the treatment of a sleep disorder comprising administering a compound of formula (I):
wherein all variables are as defined herein.
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7338950 |
Amide compounds as ion channel ligands and uses thereof
Compounds are disclosed that have a formula represented by the following:
The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a...
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7320979 |
N-[(piperazinyl)hetaryl]arylsulfonamide compounds
The invention relates to N-[(piperazinyl)hetaryl]arylsulfonamide compounds of the general formula I
in which
Q is a bivalent, 6-membered heteroaromatic radical which possesses 1 or 2 N atoms...
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7319099 |
Benzoyl-piperazine derivatives
The invention relates to compounds of formula
wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such...
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7314879 |
Melanocortin receptor agonists
The present invention relates to melanocortin receptor agonist of the formula (I): which is useful in the treatment for obesity, diabetes, and male and/or female sexual dysfunction
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7314880 |
Cardioprotective delta opioid receptor agonists and methods of using same
The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective...
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7312235 |
Benzamide inhibitors of factor Xa
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
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7288545 |
Piperazinedione compounds
This invention relates to a method for treating an angiogenesis-related disease. The method includes administering to a subject in need thereof an effective amount of a piperazinedione compound...
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7285552 |
Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient
A pharmaceutical composition for prevention and/or treatment for HIV infection or AIDS induced by the infection which comprises, as an active ingredient, a triazaspiro[5.5]undecane derivative, a...
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7279470 |
Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The...
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7276491 |
Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors
Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
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7276571 |
Process for making phenylene dioxydiacetic acid and use thereof
A process for making phenylene dioxydiacetic acid comprises (a) contacting a dihydroxybenzene under reaction conditions with a salt of haloacetic acid in a solution without adding a haloacetic acid...
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7271168 |
Piperazine derivatives having SST1 antagonistic activity
The invention provides compounds of formula ( 1 )
wherein X, R 1 and R 2 are as defined in the specification, their, preparation and to their use in treating, e.g., depression, anxiety and...
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7262193 |
Triazaspiro[5.5]undecane derivative and pharmaceutical composition comprising the same as active ingredient
Triazaspiro[5.5]undecane derivatives of the formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as active...
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7256187 |
Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
The invention relates to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the rifamycin derivatives having an oxime...
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7253172 |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
Compounds having Formula I, including pharmaceutically acceptable salts and prodrugs thereof: (I) are inhibitors of the dipeptidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of...
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7247631 |
Pegylated interferon alfa-CCR5 antagonist combination HIV therapy
Methods for treating treatment-naive as well as treatment-experienced adult and pediatric patients having HIV-1 infections as well as patients co-infected with HIV-1 and HCV involving administering...
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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