Patents in Class 514/252.190

Matches 1 - 50 out of 198

1 2 3 4 >

Match	Document	Document Title
1	7622473	'N-(2-chloro-6-methylphenyl)-2-[[(6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites The present invention is directed to metabolites of ′N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-p iperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxam ide, the compound of...
2	7592450	Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein t, R 1 , R 2 , L, Q, X, Y, Z and (a) have defined meanings, having histone deacetylase inhibiting enzymatic activity; their...
3	7589199	Substituted piperazines Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in...
4	7579349	4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer A compound of Formula (I); wherein the substituents are as defined in the text for use in modulating insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
5	7576087	Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
6	7557106	Substituted pyrimidines useful as protein kinase inhibitors The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora...
7	7541359	N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase Certain N-heteroarylpiperazinyl urea compounds of Formula (I), as defined in the specification, are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical...
8	7511044	Vanilloid receptor ligands and their use in treatments Pyrimidine ethers and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and...
9	7504396	Substituted heterocyclic compounds and methods of use The present invention relates to pyrimidine or pyridine carboxamides or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell...
10	7491725	Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors The invention relates to processes for preparing compounds having the formula, and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R 2 ,...
11	7473691	Pyrazole compounds useful as protein kinase inhibitors This invention describes novel protein kinase inhibitors of formula VII: wherein G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or...
12	7465732	(2S,4S)-4-(piperazin-1-yl)pyrrolidine-2-methanone derivatives The invention provides compounds of formula (I), or a pharmaceutically acceptable salt of said compound, or a solvate of said compound or salt, wherein R 1 , R 2 , R 3 , HET, n, Q, X, Y, and Z...
13	7384944	Piperazine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R 1 is hydrogen or...
14	7358253	Indolylmaleimide derivatives Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ...
15	RE40245	Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase...
16	7342015	Indole derivatives A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder,...
17	7291618	Therapeutic compounds The invention provides compounds of formula (I), prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein R 1 , R 2 ,...
18	7276502	Thiazoles useful as inhibitors of protein kinases The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
19	7179806	Δ1-pyrrolines used as pesticides The invention relates to novel Δ 1 -pyrrolines of the formula (I) in which R 1 , R 2 , R 3 , m, and Q have the meanings given in the disclosure, to a plurality of processes for preparing these...
20	7151103	Method of treating female hypoactive sexual desire disorder with flibanserin The invention relates to the use of flibanserin, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of disorders of sexual desire.
21	7125875	Cyclic protein tyrosine kinase inhibitors Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders...
22	7119086	Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards...
23	7115597	Tyrosine kinase inhibitors The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to...
24	7098214	Dopamine D3 receptor ligands or antagonists for use in the treatment of renal function disorders Dopamine D 3 receptor ligands or antagonists are disclosed for use in the treatment of renal function disorders, such as diabetic nephropathy.
25	7094783	Bicyclic pyrimidinones as coagulation cascade inhibitors The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel amino-bicyclic pyrimidinone compounds of Formula (I): or a stereoisomer...
26	7045519	Inhibitors of glycogen synthase kinase 3 New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are...
27	6995159	5-HT receptor ligands and uses thereof Compounds of Formula (IC) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT 2 receptors in animals are described herein .
28	6953803	Pyrimidine compounds Pyrmidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA 2 and of use in therapy, in particular for treating atherosclerosis.
29	6946466	Aromatic sulfonamides as peroxynitrite-rearrangement catalysts The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the...
30	6936613	Benzimidazole derivatives and pharmaceutical compositions comprising these compounds The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are...
31	6919342	Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor The invention relates to triazole compounds of the general formula I wherein R 1 is hydrogen or methyl, and R 2 is C 3 -C 4 alkyl or C 1 -C 2 fluoroalkyl, as well as the physiologically...
32	6908920	Pyrimidine derivatives Compounds of formula (I), wherein R 1 , p, R 2 , q, R 3 and R 4 are defined within, and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are...
33	6838461	N-(indolcarbonyl-)piperazine derivatives Compounds of the formula I in which R 1 , R 2 , R 4 and R 5 have the meanings indicated in claim 1 , are potent 5-HT 2A antagonists and are suitable for the treatment of psychoses,...
34	6833369	Angiogenesis inhibiting 5-substituted-1,2,4,-thiadiazolyl derivatives This invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; R 1 is...
35	6803368	Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta&lsqb a&rsqb naphthalene Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced...
36	6756380	5-phenyl-pyrimidine derivatives Compounds of the general formula are described: wherein R 1 is hydrogen or halogen; R 2 is hydrogen, halogen, lower alkyl or lower alkoxy; R 3 is halogen, trifluoromethyl, lower alkoxy or...
37	6743817	Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
38	6734183	Compounds Compounds of the formula I useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13.
39	6716837	Heterocyclic compounds for the treatment of migraine Described herein are compounds useful in the treatment of migraine, which have the general formula: wherein: W is a CH group or a N atom; Z is N or C—R4; B and D are selected independently...
40	6713474	Pyrrolopyrimidines as therapeutic agents Chemical compounds having structural formula I and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the...
41	6689778	Inhibitors of Src and Lck protein kinases The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein A—B is N—O or O—N and G, R 1 , R 2 , R 3 , and R 4 are as described in...
42	6686360	N-benzylpiperazine compounds The present invention relates to a compound selected from those of formula (I): wherein: R 1 represents alkyl, R 2 represents hydroxy, alkoxy, or amino, n represents an integer from 1 to 12...
43	6653312	Amidine derivatives, their preparation and application as medicines and pharmaceutical compositions containing same Amidine compounds of the formula wherein the substituents are defined as in the application useful as NO-synthase enzyme inhibitors.
44	6630468	Disubstituted pyrazolines and triazolines as factor Xa inhibitors The present application describes disubstituted pyrazolines and triazolines of formulae I and II: or pharmaceutically acceptable salt forms thereof, wherein one of M 1 and M 2 maybe N and D...
45	6627632	Compositions and methods for the treatment of anorectal disorders Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O 2 − ) scavengers, β-adrenergic agonists,...
46	6602874	Heterocyclic carboxamides A compound of the formula wherein X, Y, Z, R 2 and R 3 are as defined above, useful in treating or preventing migraine, depression and other disorders for which a 5-HT 1 , agonist or...
47	6589953	Indole derivatives as 5-HT1B and 5-HT1D agonists The invention concerns novel indole piperazine derivatives of formula (I). It also concerns a method for preparing said compounds and their use as therapeutically active substances, in particular...
48	6586435	Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors Compound of formula (I) wherein: R 1 is hydrogen or C 1 -C 6 -alkyl optionally substituted by C 3 -C 6 -cycloylalkyl; R 2 and R 3 together with the nitrogen form a saturated or unsaturated 5-...
49	6579874	Substituted azoles Compounds of formula I wherein the symbols have meaning as defined herein, are p38 MAP kinase inhibitors, and are useful pharmaceutically for treating TNFα and IL-1 mediated diseases, such as...
50	6573262	Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives The invention comprises substituted indoleoxoacetic piperazine derivatives of general Formula I, compositions thereof and their use as antiviral agents, and particularly for treating HIV infection.

Matches 1 - 50 out of 198

1 2 3 4 >