Patents in Class 514/252.180

Matches 1 - 50 out of 196

1 2 3 4 >

Match	Document	Document Title
1	7365069	Pyrimidone derivatives The present invention relates to novel pyrimidones of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their...
2	7361691	Method of treating cancers using β-lapachone or analogs or derivatives thereof Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint activator, which is preferably β-lapachone, or a derivative or analog thereof, combined with an oncogenic...
3	7354924	Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl...
4	7345046	Heteroaryl-fused pyrimidinyl compounds as anticancer agents Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the...
5	7329661	N-phenyl-3-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to...
6	7312216	N-phenyl-2-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to...
7	7307081	Piperidine derivatives useful as CCR5 antagonists The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present...
8	7300938	Polymorphs of imatinib mesylate The present invention relates to novel polymorphs of imatinib mesylate, to processes for their preparation and to pharmaceutical compositions containing them.
9	7300937	Derivatives of cyano-aryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines, their preparation and application as medication New derivatives of cyanoaryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines (I), where R 1 represents an OR 3 radical, where R 3 represents a radical derived from a saturated hydrocarbon,...
10	7238525	Strategy for leukemia therapy The chimeric Bcr-Abl oncoprotein is the molecular hallmark of chronic myelogenous leukemia (CML). In the cytoplasm, the protein transduces a growth signal that is responsible for overexpansion of...
11	7232825	Phenylaminopyrimidine derivatives and methods of use The present invention relates to phenylaminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of...
12	7196080	Phenylpyridinecarbonylpiperazinederivative The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. ...
13	7186723	Tyrosine kinase inhibitors The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to...
14	7173025	Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents Compounds of formula (I), wherein G 1 is CH or N; G 2 is CH or N; R 1 is a variety of optional substituents; L 1 is (1-4C)alkylene; T 1 is CH or N; R 2 and R 3 are independently hydrogen or...
15	7166597	Fused pyrazole derivatives being protein kinase inhibitors Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R 1 , R 2 , and R 4 are various substituent groups, are protein kinase...
16	7163940	Pyrazolopyridinyl pyrimidine therapeutic compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
17	7157455	4-Aminopyrimidine-5-one derivatives Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically...
18	7141569	Antiviral pyrazolopyridine compounds The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
19	7109197	N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives The present invention relates to a method of protecting plants against attack or infestation by phytopathogenic organisms, such as nematodes or especially microorganisms, preferably fungi, bacteria...
20	7098213	CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R 4 –R 7 and R 13 are H or alkyl; R 1 is H, alkyl, fluoroalkyl,...
21	7094785	Method of treating polycythemia vera The invention is directed to the use of imatinib mesylate for treating polycythemia vera. Imatinib mesylate is surprisingly effective at controlling the symptoms of polycythemia vera and reducing...
22	7087608	Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy The present invention relates to the use of PDGF receptor tyrosine kinase inhibitors, especially of N-phenyl-2-pyrim-idine-amine derivatives of formula (I), in which the symbols and substituents...
23	7064127	Treatment of hepatic fibrosis with imatinib mesylate Disclosed herein is a method for treating hepatic fibrosis comprising administering to a patient in need of such treatment an amount effective to treat hepatic fibrosis of imatinib mesylate. This...
24	7060701	CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R 4 –R 7 and R 13 are H or alkyl; R 1 is H, alkyl, fluoroalkyl,...
25	7045523	Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and telomerase inhibitor A method of treating BCR-ABL positive leukemia in a warm-blooded animal comprising administering the combination of...
26	7045519	Inhibitors of glycogen synthase kinase 3 New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are...
27	7022695	Thioether-substituted benzamides as inhibitors of Factor Xa Thioether-substituted benzamide compounds having the formula: are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding.
28	7008946	CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R 4 –R 7 and R 13 are H or alkyl; R 1 is H, alkyl, fluoroalkyl,...
29	6995159	5-HT receptor ligands and uses thereof Compounds of Formula (IC) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT 2 receptors in animals are described herein .
30	6974816	Combination for the treatment of endothelial damage The invention relates to a combination of (a) an inhibitor of platelet-derived growth factor (PDGF) activity and (b) a vector for vascular endothelial growth factor (VEGF-, especially VEGF-C) gene...
31	6958335	Treatment of gastrointestinal stromal tumors 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3- yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula I or a pharmaceutically acceptable salt thereof can be used in the...
32	6953803	Pyrimidine compounds Pyrmidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA 2 and of use in therapy, in particular for treating atherosclerosis.
33	6949552	Remedial agent for anxiety neurosis or depression and piperazine derivative There are provided a therapeutic preparation for anxiety neurosis or depression which comprises a MC 4 receptor antagonist as an effective ingredient; and a piperazine derivative represented by...
34	6916804	Pyrimidine A2b selective antagonist compounds, their synthesis and use The subject invention provides compounds having the structure: wherein R 1 is substituted or unsubstituted phenyl or a 5-6 membered heterocyclic or heteroaromatic ring containing from 1 to 5...
35	6908920	Pyrimidine derivatives Compounds of formula (I), wherein R 1 , p, R 2 , q, R 3 and R 4 are defined within, and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are...
36	6818645	Benzocycloalkylenylamine derivatives as muscarinic receptor antagonists This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S, or NR 4 , and the other...
37	6794386	β-amino acid compounds as integrin antagonists The present invention relates to a compound of the general formula (I), wherein R 1 together with the C atom to which it is attached, and R 2 together with the N atom to which it is attached,...
38	6777415	Methods of inducing cancer cell death and tumor regression Methods are provided for treating cancer, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an additional Ras signaling pathway inhibitor to induce...
39	6756380	5-phenyl-pyrimidine derivatives Compounds of the general formula are described: wherein R 1 is hydrogen or halogen; R 2 is hydrogen, halogen, lower alkyl or lower alkoxy; R 3 is halogen, trifluoromethyl, lower alkoxy or...
40	6734183	Compounds Compounds of the formula I useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13.
41	6727254	Heteroaryl tropane derivatives as superior ligands for nociceptin receptor ORL-1 Novel compounds of the formula wherein R is optionally substituted heteroaryl or R 1 is H or C 1 -C 6 alkyl; and R 2 and R 3 are —CH 3 , —OCH 3 or halo; or a pharmaceutically...
42	6727249	Azabicyclic ether derivatives and their use as therapeutic agents The present invention relates compounds of the formula (I): wherein X represents hydrogen, C 1-4 alkyl optionally substituted by a hydroxy, methoxy or benzyloxy group, or CO 2 (C 1-2 alkyl); Z...
43	6713474	Pyrrolopyrimidines as therapeutic agents Chemical compounds having structural formula I and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the...
44	6696449	Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors This invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some...
45	6696439	5-HT1F agonists The present invention relates to substituted furo[3,2-b]pyridine compounds of formula I: or a pharmaceutical acid addition salt thereof; where; R is E—D is C═CH or CH—CH 2 ; R 1 is...
46	6689783	Aryl oxime-piperazines useful as CCR5 antagonists In one embodiment, this invention provides a novel class of aryl oxime-piperazine compounds as antagonists of the CCR5 receptor, methods of preparing such compounds, pharmaceutical compositions...
47	6656957	Pyridine derivatives A compound of formula I wherein X represents an optionally halo-substituted (C 2-4 )alkynylene group bonded via vicinal unsaturated carbon atoms.
48	6645972	Methods of treating leukemia The present invention provides a novel method for treating leukemia in a host that has been previously treated with a Bcr-Abl tyrosine kinase inhibitor comprising administering to the host a...
49	6638935	Heteroary1 derivatives and their use as medicaments The invention relates to novel pyridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors
50	6593331	Method for treatment of pain A method of treating pain with acetaminophen comprises the concurrent administration of a hydroxyazapirone selected from 6-hydroxybuspirone or 3-hydroxygepirone. This combination of agents results...

Matches 1 - 50 out of 196

1 2 3 4 >