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7238693 |
Aryl carbamate derivatives, preparation and use thereof
The present invention relates to novel compounds, the preparation and use, particularly therapeutic, thereof. More specifically, it relates to compounds derived from aryl carbamates, the...
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7214676 |
Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
The invention provides compounds which are PDE7 inhibitors, having the following formula (I), (II) and (III)
in which X 1 , X 2 , X 3 , X 4 , X, Y, Z, A and Z 1 are as defined in the...
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7071194 |
Method for improving respiratory function and inhibiting muscular degeneration
The present invention provides a method for improving respiratory function and inhibiting muscular degeneration (e.g., dystrophy and atrophy). Alternative embodiments of the invention provide a...
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6821976 |
S-6-hydroxy-buspirone
The S-stereoisomer of 6-hydroxy-buspirone is an effective treatment for anxiety, depression, and other psychogenic disorders. The S-isomer may provide reduced potential for adverse effects and a...
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6803368 |
Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta&lsqb a&rsqb naphthalene
Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced...
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6743798 |
Substituted pyrazole derivatives condensed with six-membered heterocyclic rings
The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R 1 , R 2 , R 3 and A are each as defined, and to processes for their preparation and...
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6686361 |
R-6-hydroxy-buspirone
The R-stereoisomer of 6-hydroxy-buspirone is an effective treatment for anxiety, depression, and other psychogenic disorders. The R-isomer exhibits greater receptor specificity than the S-isomer...
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6649614 |
Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent for treatment of depression or anxiety
The present invention relates to the treatment of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or...
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6617329 |
Aminoquinazolines and their use as medicaments
Compounds of the formula having an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the...
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6579899 |
Composition for treatment of stress
A method of treating stress in a patient showing stress related symptoms is disclosed, where the method comprises administering to the patient an effective amount of a serotoninergic drug or...
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6566361 |
Azapirone pain treatment
A method of treating pain with acetaminophen comprises the concurrent administration of an azapirone such as buspirone. This combination of agents surprisingly results in a strengthened analgesic...
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6541478 |
Smoking cessation treatments using naltrexone and related compounds
Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of...
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6511982 |
Treatment of pain
A method of treating pain with acetaminophen comprises the concurrent administration of buspirone. This combination of agents surprisingly results in a morphine-like analgesic response...
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6268368 |
Anionic exchange polymer complexes of buspirone
A controlled release form of buspirone medicament is described. This medicament comprises a buspirone in intimate admixture with an anionic exchange polymer complexing agent. These components form...
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6218395 |
Centrally-acting beta-blockers and serotonin-enhancers for the treatment of anxiety disorders and adjustment disorders with anxiety
A combination of medicines are administered daily for the relief of the symptoms of an Anxiety Disorder or an Adjustment Disorder With Anxiety. The combination comprises a centrally-acting...
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6150365 |
Anxiety method
6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-piperazinyl]-butyl]-8-azas
piro[4.5]-7,9-d ione and its pharmaceutically acceptable salts and hydrates are useful in the alleviation of anxiety.
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6022869 |
Aminoheterocyclic compounds with antithrombotic/anticoagulant effect
The invention relates to compounds of formula (I), and pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties; processes for preparing compounds of...
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6013644 |
Spiro-substituted azacycles as modulators of chemokine receptor activity
The present invention is directed spiro-substituted azacycles of formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , k, l and m are defined herein) which are useful as modulators of chemokine...
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6008222 |
Method for oral administration of buspirone and nefazodone
An improved method for orally administering buspirone to a human subject wherein the bioavailability of buspirone is increased and its elimination, metabolite formation, and variability of these...
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5955459 |
Fatty acid-antipsychotic compositions and uses thereof
The invention provides compositions that include conjugates of a fatty acid molecule, preferably cis-docosahexaenoic acid, and antipsychotic agents. The conjugates are usefull in treating psychotic...
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5837280 |
Transdermal administration of azapirones
In accordance with the present invention, a method and device is provided for administering therapeutically effective doses of the drug azospirone transdermally for treating psychogenic...
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5521183 |
Use of 5-HT ligands as anti-pruritic agents
The present invention is based on the finding that 5-HT receptor ligands are useful in treating experimental models of clinically encountered pruritus (itch). A 5-HT ligand as used in this...
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5468749 |
Method for treatment of substance addiction
Certain azapirone compounds and their pharmaceutically acceptable salts are useful in the treatment of substance addiction.
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5461054 |
Anthracene-spiro-pyrrolindines
The anthracene-spiro-pyrrolidines according to the invention are prepared by reacting either anthracene-spiro-furans or unsubstituted anthracene-spiropyrrolidines with appropriately substituted...
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5444082 |
3,9-disubstituted-spiro(5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same
3,9-disubstituted-spiro[5.5]undecanes and ##STR1## wherein, R, Y, A, B and n are defined in the specification, pharmaceutical compositions containing same for the treatment of cardiovascular...
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5417987 |
Method for controlling bivalves such as zebra mussels
A method for enhancing the effect of a toxicant such as chlorine or potassium on bivalve molluscs such as zebra mussels. Application of serotonin or a serotonin agonist in low concentrations...
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5371087 |
3-<4-substituted-4-piperazinyl)buty]-4-thiazolidinone and related compounds
There are disclosed compounds of the formula, ##STR1## where n is 0, 1 or 2; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy,...
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5314888 |
Veterinary method for treating inappropriate elimination of urine in household pets
The present invention provides a veterinary treatment method for animals suffering from a high arousal state. The treatment employs a class of pharmacologically active compounds having a...
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5098889 |
Method for preventing or inhibiting loss of cognitive function employing a combination of an ace inhibitor and a drug that acts at serotonin receptors
A method is provided for imhibiting loss of cognitive functon, including memory, which may or may not be associated with Alzheimer's disease, by administering an ACE inhibitor, such as captopril,...
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5032578 |
Method for preventing or treating depression employing a combination of an ace inhibitor and a drug that acts at serotonin receptors
A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or ceranapril in combination with a drug that acts...
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5015646 |
Pharmaceutically useful polymorphic modification of buspirone
"Buspirone hydrochloride can exist in two polymorphic forms and the newly discoverd lower melting form, which is thermodynamically favored at pharmaceutically relevant temperatures, offers...
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4994455 |
Anti-anxiety agents
Anti-anxiety agents; namely, 1-(heterocyclylcarbonyl)-3-[4-(2-pyrimidinyl)-1-piperazinyl]
propanes and 1-(heterocyclylsulfonyl)-3-[4-(2-pyrimidinyl)-1-(piperazinyl
)]propanes; and methods for their...
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4883795 |
Piperazinyl-heterocyclic compounds
Arylpiperazinyl-ethyl (or butyl)-heterocyclic compounds and their pharmaceutically acceptable acid addition salts are neuroleptic agents. They are useful in the treatment of psychotic disorders.
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4871738 |
Use of 2-pyrimidinyl-1-piperazine derivatives in the treatment of dependence on nicotine
A method of treating warm-blooded animals to reduce their dependency upon nicotine comprising administering to such animals a medicament containing a 2-pyrimidinyl-1-piperazine derivative of the...
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4826846 |
Arylpiperazinylalkoxy derivatives of cyclic imides to treat anxiety
There are disclosed compounds of the formula ##STR1## wherein the group A is ##STR2## where R 1 and R 2 are each independently or loweralkyl, or R 1 +R 2 =(CH 2 ) m , m being 2 to 6, p is 1 or...
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4788189 |
Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking
Administering divided dose of oral Clonidine potentiated by an intramuscular tricyclic antidepressant alleviates the abstinence syndrome resulting from withdrawal of nicotine by smoking cessation....
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4780466 |
Arylpiperazinylalkoxy derivatives of cyclic imides
There are disclosed compounds of the formula ##STR1## wherein the group A is ##STR2## where R 1 and R 2 are each independently hydrogen or loweralkyl, or R 1 +R 2 =(CH 2 ) m , m being 2 to 6, p...
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4777173 |
Method for treatment of alcohol abuse
Buspirone and its pharmaceutically acceptable salts are useful in the treatment of alcohol abuse.
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4696927 |
4-(2-pyrimidinyl)-1-piperazinyl heterocyclic carbonyl derivatives
This invention relates to 4-(2-pyrimidinyl)-1-piperazinyl heterocyclic carbonyl derivatives, to a process for their preparation, and to their use as anxiolytic agents.
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4640921 |
Treatment of sexual dysfunction with buspirone
Buspirone and its pharmaceutically acceptable salts are useful in treating patients of both sexes suffering from sexual dysfunction.
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4639453 |
Substituted 1-(4-amino-6,7-dialkoxyquinazolinyl)-4 cyclohexenyl derivatives of piperazine and homopiperazine, processes for their preparation and their use, formulations containing these compounds and intermediates
New substituted 1-(4-amino-6,7-dialkoxyquinazolinyl)-4-cyclohexenyl derivatives of piperazine and homopiperazine, of the general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 and R 5 , which...
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4634703 |
Method for alleviation of panic disorders
Buspirone and its pharmaceutically acceptable salts are useful in alleviation of panic disorders which can take the form of clinical syndromes comprising, for example, panic attacks, agoraphobia...
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4581357 |
Antipsychotic 5-fluoro-pyrimidin-2-yl piperazine compound
8-[4-[4-(5-Fluoro-pyrimidin-2-yl)-1-piperazinyl]butyl]-8-aza
spiro[4.5]decan e-7,9-dione and its pharmaceutically acceptable salts demonstrate antipsychotic activity.
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4543355 |
Substituted succinimides, compositions and method of use
Succinimide derivatives representable by the following formula: ##STR1## wherein X and Y are combined to form a group of the formula: ##STR2## (wherein A is an oxygen atom, a methylene group or an...
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4438119 |
Method for alleviation of extrapyramidal motor disorders
Buspirone and its pharmaceutically acceptable salts are useful in alleviation of extrapyramidal motor disorders which can take the form of clinical syndromes such as Parkinsonism and...
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4182763 |
Buspirone anti-anxiety method
Buspirone hydrochloride is an effective anti-anxiety agent for the palliative treatment of neurotic patients in which symptoms of anxiety are predominant at doses which are without observable...
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3976776 |
Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
The present invention concerns the class of heterocyclic carbon compounds comprised of N-(heteroarcyclic)piperazinylalkyl derivatives of azaspiroalkanediones which have potent and specific...
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