Patents in Class 514/252.140

Matches 1 - 50 out of 279

1 2 3 4 5 6 >

Match	Document	Document Title
1	7384944	Piperazine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R 1 is hydrogen or...
2	7381719	Diaryl ethers as opioid receptor antagonist A compound of the formula (I) wherein the variables X 1 to X 10 , R 1 to R 7 including R 3′ , E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer,...
3	7365069	Pyrimidone derivatives The present invention relates to novel pyrimidones of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their...
4	RE40245	Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase...
5	7351700	Aminomethylpyrimidines as allosteric enhancers of the GABA_B receptors The present invention relates to compounds of formula wherein X is —S— or —NH—; R 3 /R 4 together with the N-atom to which they are attached form a non aromatic 5, 6 or 7...
6	7335659	Substituted 10-aryl-11H-benzo[b]fluorenes and 7-aryl-5, 6-dihydro-benzo[a]anthracenes for selective effects on estrogen receptors This invention provides a compound, or its possible salt, having the formula, wherein: R e and ′R e are OH, optionally independently etherified or esterified; Z is —CH 2 CH 2 — or...
7	7335657	Cytokine inhibitors Disclosed are compounds of formula (I) Where Ar 1 , X, Y, Q, W, R 3 , R 4 , R 5 , R 6 and R y are defined herein. The compounds of the invention inhibit production of cytokines involved in...
8	7332494	Method for treating allergies using substituted pyrazoles A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
9	7323464	Pyridine and pyrimidine derivatives Compounds of formula (1) are described in which R a and R b is each independently a hydrogen atom or a group R c , or R a and R b together form an oxo (═O) or thio (═S) group; X is a N atom...
10	7320979	N-[(piperazinyl)hetaryl]arylsulfonamide compounds The invention relates to N-[(piperazinyl)hetaryl]arylsulfonamide compounds of the general formula I in which Q is a bivalent, 6-membered heteroaromatic radical which possesses 1 or 2 N atoms...
11	7319099	Benzoyl-piperazine derivatives The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such...
12	7314878	Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or CNS disorders The present invention is related to piperazine henzothiazole derivatives, notably for use in the treatment and/or prophylaxis of cerebral ischemic disorders or CNS disorders. The present invention...
13	7314873	(Halo-benzo carbonyl)heterobi cyclic p38 linase inhibiting agents Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of...
14	7300937	Derivatives of cyano-aryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines, their preparation and application as medication New derivatives of cyanoaryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines (I), where R 1 represents an OR 3 radical, where R 3 represents a radical derived from a saturated hydrocarbon,...
15	7297698	N-phenyl-(2R,5S) dimethylpiperazine derivative The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with...
16	7288544	Pyrimidine compounds useful as N-type calcium channel antagonists Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when...
17	7273856	Linear basic compounds having NK-2 antagonist activity and formulations thereof Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of...
18	7259162	Benzazole derivatives and their use as JNK modulators The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said...
19	7253172	Dipeptidyl peptidase inhibitors for the treatment of diabetes Compounds having Formula I, including pharmaceutically acceptable salts and prodrugs thereof: (I) are inhibitors of the dipeptidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of...
20	7253165	Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D 4 antagonists. Said compounds are useful for the treatment of medical...
21	7247633	Pyrimidine compounds and their use A compound of the general formula (I): wherein R 1 , R 2 , X, Y and Z are as described in the specification.
22	7244735	Heterocyclic protein kinase inhibitors and uses thereof Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z 1 , Z 2 , U, p, Q, R 1 , R 2 , R 3 ,...
23	7238525	Strategy for leukemia therapy The chimeric Bcr-Abl oncoprotein is the molecular hallmark of chronic myelogenous leukemia (CML). In the cytoplasm, the protein transduces a growth signal that is responsible for overexpansion of...
24	7235556	Methods of treating dry eye disorders Fused pyridazine derivatives are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
25	7229995	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: ...
26	7208489	2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent...
27	7205304	Sulfonyl-Derivatives as novel inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein n, m, t, R 1 , R 2 , R 3 , R 4 , L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic...
28	7205297	Substituted 5-alkynyl pyrimidines having neurotrophic activity The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy,...
29	7176199	Aryl-substituted alicyclic compound and medical composition comprising the same An aryl-substituted alicyclic compound of the formula (I): wherein U is 1,4,5,6-tetrahydropyrimidin-2-yl, etc., A is phenylene, etc., B is piperidine-1,4-diyl, etc., Z is —CONH—, etc., R 3 ...
30	7173028	Pyrimidine derivatives The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0R a to R e are defined as in claim 1, which are suitable for the treatment of illnesses characterised by...
31	7166599	Trisubstituted pyrimidines The present invention relates to trisubstituted pyrimidines of formula wherein R a to R e are defined as in claim 1, which are suitable for the treatment of illnesses in which β-amyloid...
32	7160886	Acylated piperazine derivatives as melanocortin-4 receptor agonists Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
33	7151101	Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention relates to compounds...
34	7135467	HIV integrase inhibitors Compounds useful for treating HIV are disclosed having the general formula wherein R 1 , R 2 , and B are as defined in the specification. Compositions containing the compounds and methods for...
35	7132421	CIS-imidazoles The present invention provides compounds according to formula I and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction...
36	7112589	Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine structure and cathepsin k inhibitory activity for the treatment of inflammations and other diseases The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof (I), wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find...
37	7112585	Pyrimidine derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF...
38	7105520	Phenylalanine derivatives Phenylalanine derivatives of the following formulae and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4...
39	7105507	Cyclohexane derivatives and their use as therapeutic agents The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
40	7101873	Pyrimidinedione derivatives Pyrimidinedione derivatives of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and...
41	7098214	Dopamine D3 receptor ligands or antagonists for use in the treatment of renal function disorders Dopamine D 3 receptor ligands or antagonists are disclosed for use in the treatment of renal function disorders, such as diabetic nephropathy.
42	7098212	Piperazine derivatives The present invention relates to compounds of the formula I and the pharmaceutically acceptable forms thereof; wherein X, Y, a, b, c, d, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein....
43	7094785	Method of treating polycythemia vera The invention is directed to the use of imatinib mesylate for treating polycythemia vera. Imatinib mesylate is surprisingly effective at controlling the symptoms of polycythemia vera and reducing...
44	7094783	Bicyclic pyrimidinones as coagulation cascade inhibitors The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel amino-bicyclic pyrimidinone compounds of Formula (I): or a stereoisomer...
45	7087614	Pyrimidine inhibitors of phosphodiesterase (PDE) 7 Pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula wherein R 1 , R 2 , Z, J and L are described herein, and analogs thereof are provided which are useful in treating...
46	7087608	Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy The present invention relates to the use of PDGF receptor tyrosine kinase inhibitors, especially of N-phenyl-2-pyrim-idine-amine derivatives of formula (I), in which the symbols and substituents...
47	7067514	Pyrimidine compounds This invention features pyrimidine compounds of formula (I): R 1 is aryl, or heteroaryl; each of R 2 and R 4 , independently, is R c , halogen, nitro, cyano, isothionitro, SR c ,...
48	7056922	Acylamino cyclopropane derivatives A compound of the formula wherein D, E, F, G, L, T, W, X, Y, Z, U, A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 R 7 are as defined in the specification, pharmaceutical compositions thereof, and...
49	7022728	Benzimidazoles that are useful in treating male sexual dysfunction The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual...
50	7015226	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: ...

Matches 1 - 50 out of 279

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